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Journal of Clinical Investigation, ISSN 0021-9738, 12/2014, Volume 124, Issue 12, pp. 5368 - 5384
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain... 
INTESTINAL INFLAMMATION | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | INFLAMMATORY-BOWEL-DISEASE | SPHINGOSINE KINASE 1 | EPITHELIAL-CELLS | GENE | INDUCED COLITIS | CELL-PROLIFERATION | PERSISTENT STAT3 ACTIVATION | CANCER | Lysophospholipids - metabolism | Colonic Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Aldehyde-Lyases - biosynthesis | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | Inflammatory Bowel Diseases - metabolism | RNA, Neoplasm - metabolism | Colonic Neoplasms - metabolism | Neoplasms, Experimental - pathology | Cell Transformation, Neoplastic - genetics | Gene Deletion | Inflammatory Bowel Diseases - genetics | Neoplasms, Experimental - genetics | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Neoplasm Proteins - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Mice, Transgenic | Signal Transduction - genetics | Anion Transport Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Gene Expression Regulation, Enzymologic | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Animals | Biopsy | Colonic Neoplasms - pathology | RNA, Neoplasm - genetics | Sphingosine - genetics | Mice | MicroRNAs - genetics | Neoplasms, Experimental - metabolism | Anion Transport Proteins - genetics | Colon cancer | MicroRNA | Physiological aspects | Development and progression | Genetic aspects | Lyases | Research | Inflammatory bowel disease | Medical research | Kinases | Rodents | Colorectal cancer | Index Medicus | Abridged Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 691 - 702
Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis.... 
ADIPOSE TRIGLYCERIDE LIPASE | COMPARATIVE GENE IDENTIFICATION-58 | LIPID-METABOLISM | MESSENGER-RNA EXPRESSION | FATTY LIVER-DISEASE | FAMILY-MEMBERS | ENZYMES | ENDOCRINOLOGY & METABOLISM | PNPLA3 | CONGENITAL GENERALIZED LIPODYSTROPHY | CHANARIN-DORFMAN-SYNDROME | CELL BIOLOGY | 1-Acylglycerol-3-Phosphate O-Acyltransferase - genetics | Lysophospholipids - metabolism | Up-Regulation | Lipids - genetics | Humans | Cercopithecus aethiops | Acyl Coenzyme A - genetics | Male | Lipids - biosynthesis | Acyltransferases - metabolism | Acyltransferases - genetics | 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism | Cysteine Endopeptidases - metabolism | Liver - drug effects | Lipid Metabolism - genetics | Membrane Proteins - metabolism | Dietary Sucrose - metabolism | Phospholipids - metabolism | Acyl Coenzyme A - metabolism | CHO Cells | Fatty Liver - genetics | Phosphatidic Acids - genetics | Cricetinae | Fatty Liver - metabolism | Membrane Proteins - genetics | Liver - metabolism | Models, Molecular | Phospholipids - genetics | Hep G2 Cells | Mice, Knockout | Polymorphism, Genetic | Triglycerides - metabolism | Lysophospholipids - genetics | Animals | Cysteine Endopeptidases - genetics | Mice | Phosphatidic Acids - metabolism | Triglycerides - genetics | COS Cells | Physiological aspects | Medical colleges | Disease susceptibility | Liver diseases | Liver cirrhosis
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 08/2017, Volume 77, Issue 2, pp. 268 - 273.e6
Journal Article
Journal Article
Immunobiology, ISSN 0171-2985, 2012, Volume 217, Issue 12, pp. 1301 - 1314
Abstract We analyzed global gene expression profiles of IL-4 induced alternatively activated as well as IFNγ + TNFα stimulated classically activated human... 
Allergy and Immunology | Advanced Basic Science | ENPP2 | PPARγ ligand | Serotonin | MAOA | Alternative macrophage activation markers | FACTOR PATHWAY INHIBITOR-2 | DENDRITIC CELLS | PPAR gamma ligand | RECEPTOR | IMMUNOLOGY | HUMAN MONOCYTES | CANCER | INFLAMMATION | GENE-EXPRESSION | TUMOR-ASSOCIATED MACROPHAGES | T-CELLS | ADIPOSE-TISSUE | Tumor Necrosis Factor-alpha - metabolism | Lysophospholipids - metabolism | Reactive Oxygen Species - metabolism | Gene Expression - genetics | Humans | Transcriptional Activation | Tumor Necrosis Factor-alpha - genetics | Interferon-gamma - metabolism | Monoamine Oxidase - genetics | PPAR gamma - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Cell Differentiation - genetics | Inflammation - metabolism | Interleukin-4 - pharmacology | Lipid Metabolism - genetics | Membrane Proteins - metabolism | Interferon-gamma - genetics | Interleukin-4 - genetics | PPAR gamma - genetics | Biomarkers - metabolism | Phosphoric Diester Hydrolases - metabolism | Membrane Proteins - genetics | Cells, Cultured | Gene Expression Profiling - methods | Phosphoric Diester Hydrolases - genetics | Transcription Factors - genetics | Arachidonate 15-Lipoxygenase - metabolism | Linoleic Acids - metabolism | PPAR gamma - biosynthesis | Macrophage Activation | Transcription Factors - metabolism | Hydroxyeicosatetraenoic Acids - metabolism | Lysophospholipids - genetics | Macrophages - metabolism | Arachidonate 15-Lipoxygenase - genetics | Cell Differentiation - drug effects | Proto-Oncogene Proteins pp60(c-src) - genetics | Proto-Oncogene Proteins pp60(c-src) - metabolism | Adaptor Proteins, Signal Transducing - genetics | Hydroxyeicosatetraenoic Acids - genetics | Inflammation - genetics | Ligands | Macrophages - drug effects | Linoleic Acids - genetics | Adaptor Proteins, Signal Transducing - metabolism | Monoamine Oxidase - metabolism
Journal Article
Circulation Research, ISSN 0009-7330, 11/2008, Volume 103, Issue 10, pp. 1164 - 1172
The lipid mediator sphingosine-1-phosphate (S1P), the product of sphingosine kinase (SPHK)-induced phosphorylation of sphingosine, is known to stabilize... 
Sphingosine kinase | PAR-1 | S1P | RhoGTPases | Lung vascular permeability | S1P1 | Thrombin | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | thrombin | PHOSPHORYLATION | sphingosine kinase | INJURY | BARRIER INTEGRITY | PROTEIN-C | CYTOKINE PRODUCTION | FTY720 | IN-VIVO | PERIPHERAL VASCULAR DISEASE | lung vascular permeability | HEMATOLOGY | 1-PHOSPHATE | Lysophospholipids - metabolism | Receptor, PAR-1 - metabolism | Humans | Capillary Permeability - drug effects | rac GTP-Binding Proteins - metabolism | Hemostatics - pharmacology | Capillary Permeability - genetics | Thrombin - pharmacology | Inflammation Mediators - pharmacology | rac GTP-Binding Proteins - genetics | Inflammation Mediators - metabolism | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | Lung - metabolism | Sphingosine - metabolism | Neuropeptides - genetics | Receptors, Lysosphingolipid - metabolism | Pulmonary Edema - metabolism | Pulmonary Edema - genetics | Lipopolysaccharides - toxicity | Cells, Cultured | Intercellular Junctions - metabolism | Paracrine Communication - genetics | Neuropeptides - metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Signal Transduction - genetics | Enzyme Activation - drug effects | Intercellular Junctions - genetics | Receptor, PAR-1 - genetics | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Hemostatics - adverse effects | Sphingosine - pharmacology | Lysophospholipids - genetics | Pulmonary Edema - chemically induced | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Paracrine Communication - drug effects | Sphingosine - genetics | Mice | Thrombin - adverse effects | Enzyme Activation - genetics | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 39, pp. 28344 - 28352
Journal Article
Science Signaling, ISSN 1945-0877, 08/2015, Volume 8, Issue 389, p. ra79
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 02/2016, Volume 98, Issue 2, pp. 331 - 338
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2013, Volume 288, Issue 52, pp. 37355 - 37364
Studies in cell culture and mouse models of cancer have indicated that the soluble sphingolipid metabolite sphingosine 1-phosphate (S1P) promotes cancer cell... 
SURVIVAL | Sphingosine-1-Phosphate | BIOCHEMISTRY & MOLECULAR BIOLOGY | Glioblastoma | Sphingolipid | SPHINGOLIPIDS | KINASE-1 EXPRESSION | TEMOZOLOMIDE | Angiogenesis | IN-VITRO | INHIBITION | GROWTH | Ceramide | glioma | CELL | PROGRESSION | Cancer | Follow-Up Studies | Humans | Brain Neoplasms - pathology | Male | Vascular Endothelial Growth Factor A - genetics | Brain Neoplasms - metabolism | Ceramides - biosynthesis | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor A - secretion | Glioblastoma - genetics | Neoplasm Proteins - secretion | Lysophospholipids - biosynthesis | Angiogenesis Inhibitors - therapeutic use | Glioblastoma - metabolism | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Phosphoric Monoester Hydrolases - genetics | Membrane Proteins - genetics | Brain Neoplasms - genetics | Lipid Metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Brain Neoplasms - drug therapy | Enzyme Inhibitors - therapeutic use | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Ceramides - genetics | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Animals | Membrane Proteins - antagonists & inhibitors | Sphingosine - biosynthesis | Neovascularization, Pathologic - drug therapy | Glioblastoma - pathology | Sphingosine - genetics | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Glioblastoma - drug therapy | Phosphoric Monoester Hydrolases - metabolism | Lipids
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 52, pp. 44380 - 44390
Sphingosine 1-phosphate (S1P) and ceramide have been implicated in both autophagy and apoptosis. However, the roles of these sphingolipid metabolites in the... 
SURVIVAL | ACTIVATION | INHIBITION | DOXORUBICIN-INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER-CELL-LINES | DEATH | GENERATION | ENDOPLASMIC-RETICULUM STRESS | CERAMIDE | SPHINGOSINE 1-PHOSPHATE | Lysophospholipids - metabolism | Endoribonucleases - genetics | Calpain - metabolism | Antibiotics, Antineoplastic - pharmacology | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | eIF-2 Kinase - metabolism | Humans | Autophagy - physiology | Calpain - genetics | Activating Transcription Factor 6 - genetics | Autophagy - drug effects | Ceramides - biosynthesis | Proteolysis | Female | Membrane Proteins - metabolism | Sphingosine - metabolism | Protein-Serine-Threonine Kinases - metabolism | Phosphoric Monoester Hydrolases - antagonists & inhibitors | eIF-2 Kinase - genetics | Phosphoric Monoester Hydrolases - genetics | Adenine - analogs & derivatives | Endoribonucleases - metabolism | Membrane Proteins - genetics | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Adenine - pharmacology | Down-Regulation - drug effects | Down-Regulation - physiology | Ceramides - genetics | Activating Transcription Factor 6 - metabolism | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Autophagy-Related Protein 5 | Membrane Proteins - antagonists & inhibitors | Cell Line, Tumor | Sphingosine - genetics | Apoptosis - physiology | Phosphoric Monoester Hydrolases - metabolism | Doxorubicin - pharmacology | Signal Transduction | ER Stress | Sphingolipid | SPP1 | Ceramide | Calpain | Autophagy | Doxorubicin | Apoptosis | Sphingosine 1-phosphate
Journal Article
Genome Research, ISSN 1088-9051, 08/2009, Volume 19, Issue 8, pp. 1441 - 1449
Interactions between viruses and phytoplankton, the main primary producers in the oceans, affect global biogeochemical cycles and climate. Recent studies are... 
MAXIMUM-LIKELIHOOD | PHOTOSYNTHESIS GENES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MARINE VIRUSES | EMILIANIA-HUXLEYI | CERAMIDE | GIANT VIRUSES | GENOME SEQUENCE | EVOLUTION | CELLULAR-RESPONSES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | PROTEINS | Sphingolipids - biosynthesis | Sphingolipids - chemistry | Lysophospholipids - metabolism | Phosphoric Monoester Hydrolases - classification | Molecular Sequence Data | Eukaryotic Cells - metabolism | Serine C-Palmitoyltransferase - genetics | Phylogeny | DNA Viruses - genetics | Biosynthetic Pathways - genetics | Eukaryotic Cells - virology | Polymerase Chain Reaction | Molecular Structure | Sphingosine - metabolism | DNA Viruses - physiology | Eukaryota - virology | Phosphoric Monoester Hydrolases - genetics | Oxidoreductases - metabolism | Lysophospholipids - chemistry | Oxidoreductases - genetics | Oxidoreductases - classification | Gene Transfer, Horizontal | Serine C-Palmitoyltransferase - metabolism | Sequence Analysis, DNA | Host-Pathogen Interactions | DNA, Viral - chemistry | Sphingosine - analogs & derivatives | Eukaryota - genetics | DNA, Algal - genetics | Serine C-Palmitoyltransferase - classification | DNA, Algal - chemistry | Mutation | DNA, Viral - genetics | Phosphoric Monoester Hydrolases - metabolism | Sphingosine - chemistry | Usage | Cladistic analysis | Genetic transformation | Algae | Analysis | Environmental aspects | Genetic aspects | Host-virus relationships | DNA viruses | Life Sciences | Environmental Sciences | Letter
Journal Article
Cellular Signalling, ISSN 0898-6568, 03/2014, Volume 26, Issue 3, pp. 629 - 638
Our previous studies have confirmed that the sphingosine kinase 1 (SphK1)–sphingosine 1-phosphate (S1P) signaling pathway in the kidney under diabetic... 
c-Fos | c-Jun | Diabetic nephropathy | Sphingosine kinase 1 | S1P2 receptor | Sphingosine 1-phosphate | C-Jun | C-Fos | HUMAN TGF-BETA-1 PROMOTER | DIABETIC-NEPHROPATHY | PROLIFERATION | CELL BIOLOGY | FIBRONECTIN EXPRESSION | SIGNALING PATHWAY | ENDOTHELIAL-CELLS | GENE-EXPRESSION | ACTIVATOR PROTEIN-1 | NF-KAPPA-B | Diabetes Mellitus - pathology | Fibronectins - biosynthesis | Protein Binding - genetics | Transcription Factor AP-1 - genetics | JNK Mitogen-Activated Protein Kinases - biosynthesis | Proto-Oncogene Proteins c-fos - biosynthesis | Male | Promoter Regions, Genetic - genetics | Mesangial Cells - drug effects | Phosphorylation - genetics | RNA Interference | Lysophospholipids - biosynthesis | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | JNK Mitogen-Activated Protein Kinases - genetics | DNA-Binding Proteins | Diabetic Nephropathies - pathology | Sweetening Agents - pharmacology | Cells, Cultured | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Phosphotransferases (Alcohol Group Acceptor) - genetics | Glucose - pharmacology | Binding Sites - genetics | Mesangial Cells - metabolism | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Transcription Factor AP-1 - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Sphingosine - biosynthesis | Proto-Oncogene Proteins c-fos - genetics | RNA, Small Interfering | Phosphotransferases (Alcohol Group Acceptor) - biosynthesis | Fibronectins | Glucose metabolism | Promoters (Genetics) | Sphingosine | Genetic research | Genetic transcription | Glucose | Dextrose | Index Medicus | Phosphorylation | Kidneys | Pathways | Activation | Kinases | Gene expression | Positive feedback
Journal Article