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The Journal of Cell Biology, ISSN 0021-9525, 4/2009, Volume 185, Issue 2, pp. 305 - 321
Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes... 
Starvation | Transferrins | 3T3 cells | Small interfering RNA | HeLa cells | Antibodies | CHO cells | Endosomes | Golgi apparatus | P branes | CORE MACHINERY | TRANSPORT | UNFOLDED PROTEIN RESPONSE | MULTIVESICULAR BODIES | MEMBRANE | EPSILON-COP | ENDOCYTIC PATHWAYS | BETA-COP | CELL MUTANT | GOLGI-COMPLEX | CELL BIOLOGY | Mannose-Binding Lectins - metabolism | RNA, Small Interfering - genetics | Membrane Glycoproteins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Ubiquitin - metabolism | Autophagy - physiology | Coat Protein Complex I - metabolism | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Lysosomal-Associated Membrane Protein 1 - genetics | Membrane Proteins - metabolism | Protein Subunits - genetics | Biomarkers - metabolism | Cell Line | Membrane Proteins - genetics | Lysosomal-Associated Membrane Protein 2 - genetics | Phagosomes - metabolism | Ubiquitin - genetics | Coat Protein Complex I - genetics | Membrane Glycoproteins - genetics | Animals | Mannose-Binding Lectins - genetics | Adaptor Proteins, Signal Transducing - genetics | Recombinant Fusion Proteins - genetics | Golgi Apparatus - metabolism | Lysosomal-Associated Membrane Protein 1 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Transferrin - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | RNA, Small Interfering - metabolism | Ubiquitin | Gas vesicles | Physiological aspects | Research | Phagocytosis
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 02/2010, Volume 6, Issue 2, pp. 217 - 227
VCP (VCP/p97) is a ubiquitously expressed member of the AAA + -ATPase family of chaperone-like proteins that regulates numerous cellular processes including... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | ERAD | Ubiquitin | IBMPFD | VCP | Autophagy | p97 | CLEARANCE | COMPLEX | autophagy | ENDOPLASMIC-RETICULUM STRESS | MYOPATHY | ubiquitin | PAGET-DISEASE | HDAC6 | CELL BIOLOGY | AAA-ATPASE | DEGRADATION | PROTEASOME SYSTEM
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 49, Issue 4, pp. 489 - 502
Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques... 
PROTEINS | STEMCELL | HUMDISEASE | CELLS | PROGENITORS | ORIGIN | PHAGOCYTOSIS | GLUCOCORTICOIDS | AMYLOID-BETA-PEPTIDE | ALPHA | APPSW TRANSGENIC MICE | NEUROSCIENCES | BRAIN | NEUROPROTECTION | Tumor Necrosis Factor-alpha - metabolism | Presenilin-1 | Age Factors | Gene Expression - drug effects | Amyloid beta-Peptides - pharmacology | Humans | Imaging, Three-Dimensional - methods | Bone Marrow Cells - physiology | Peptide Fragments - pharmacology | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Bone Marrow Transplantation - methods | Alzheimer Disease - pathology | Microglia - physiology | Time Factors | Amyloid beta-Protein Precursor - metabolism | Membrane Cofactor Protein - metabolism | Membrane Proteins - metabolism | Indoles | In Situ Hybridization - methods | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Green Fluorescent Proteins - metabolism | Interleukin-1 - metabolism | Microglia - drug effects | Plaque, Amyloid - pathology | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Phagocytosis - physiology | Mice, Transgenic | Toll-Like Receptor 2 - metabolism | Microscopy, Confocal - methods | Immunohistochemistry - methods | Whole-Body Irradiation - methods | Amyloid beta-Protein Precursor - genetics | Animals | Microfilament Proteins | Alzheimer Disease - metabolism | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Injections, Intraventricular - methods | Lysosomal-Associated Membrane Protein 2 - metabolism | Proteins | Physiological aspects | Neurons | Alzheimer's disease | Analysis | Studies | Medical research | Brain | Neurotoxicity | Brain research | Microscopy | Transgenic animals | Software | Nonsteroidal anti-inflammatory drugs | Alzheimers disease | Exports | Immune system | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1530 - 1534
Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor KB (NF-KB)-dependent... 
T lymphocytes | Molecules | Cytokines | Microscopy | Genes | REPORTS | Toll like receptors | Agonists | Macrophages | Cells | Endosomes | LOCALIZATION | ACTIVATION | DENDRITIC CELLS | TRAF3 | MULTIDISCIPLINARY SCIENCES | TLR9 | TOLL-LIKE-RECEPTOR-9 | INDUCTION | INTERFERON-ALPHA PRODUCTION | I INTERFERON | AP-3 ADAPTER | Recombinant Fusion Proteins - immunology | Dendritic Cells - immunology | Transcriptional Activation | Interferon Type I - immunology | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - immunology | Cytoplasmic Vesicles - metabolism | Interferon Type I - metabolism | Membrane Transport Proteins - metabolism | Cytokines - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Cytokines - immunology | Oligodeoxyribonucleotides - immunology | Cytokines - metabolism | Signal Transduction | Vesicle-Associated Membrane Protein 3 - metabolism | Mice, Inbred C57BL | Cells, Cultured | TNF Receptor-Associated Factor 3 - metabolism | Adaptor Protein Complex beta Subunits | Interferon Regulatory Factor-7 - metabolism | Adaptor Protein Complex 3 - metabolism | Protein Transport | Animals | Adaptor Protein Complex 3 - genetics | Interferon Type I - genetics | Mice | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Cellular control mechanisms | Physiological aspects | TLR7 | Research | Health aspects | Immune system | Proteins | Signal transduction | Interferon | Cellular biology | Receptors | Compartments | Bifurcations | Activation
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 33, pp. 13599 - 13614
Autophagy comprises the processes of autophagosome synthesis and lysosomal degradation. In certain stress conditions, increased autophagosome synthesis may be... 
APOPTOSIS | COMPLEX | BECLIN 1 | INHIBITION | INTERACTING PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROAUTOPHAGY | MATURATION | HUNTINGTONS-DISEASE | CELL-DEATH | PARKINSONS-DISEASE | Neurons - pathology | TOR Serine-Threonine Kinases - metabolism | Vesicular Transport Proteins - metabolism | Humans | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Vesicular Transport Proteins - antagonists & inhibitors | Lysosomes - metabolism | Neurons - ultrastructure | TOR Serine-Threonine Kinases - genetics | RNA Interference | HEK293 Cells | Qa-SNARE Proteins - genetics | Lysosomes - pathology | Neurons - metabolism | Tumor Cells, Cultured | Green Fluorescent Proteins - metabolism | Microscopy, Electron, Transmission | Nerve Tissue Proteins - antagonists & inhibitors | Lysosome-Associated Membrane Glycoproteins - metabolism | Cell Survival | Lysosomal-Associated Membrane Protein 2 - genetics | Vesicular Transport Proteins - genetics | Cells, Cultured | Autophagosomes - metabolism | Recombinant Fusion Proteins - chemistry | Nerve Tissue Proteins - genetics | Autophagosomes - pathology | Autophagosomes - ultrastructure | Mice, Knockout | Lysosomes - ultrastructure | Nerve Tissue Proteins - metabolism | Animals | Embryo, Mammalian - cytology | Qa-SNARE Proteins - metabolism | Cell Line, Tumor | Lysosome-Associated Membrane Glycoproteins - genetics | Qa-SNARE Proteins - antagonists & inhibitors | Mice | Lysosomal-Associated Membrane Protein 2 - metabolism | autophagy | neurodegenerative disease | cell death | lysosome | Cell Biology | mTOR complex (mTORC)
Journal Article
Cancer Research, ISSN 0008-5472, 08/2008, Volume 68, Issue 16, pp. 6623 - 6633
Journal Article
Journal Article
Science, ISSN 0036-8075, 10/2015, Volume 350, Issue 6257, pp. 211 - 217
Journal Article