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PLoS Pathogens, ISSN 1553-7366, 02/2016, Volume 12, Issue 2, p. e1005418
Journal Article
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2017, Volume 13, Issue 4, p. e1006337
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2018, Volume 14, Issue 9, p. e1007322
Lassa fever virus (LASV) is endemic in West Africa and causes severe hemorrhagic fever and sensorineural hearing loss. We identified a small molecule inhibitor... 
ALPHA-DYSTROGLYCAN | ENVELOPE GLYCOPROTEIN | MICROBIOLOGY | DEPENDENCE | NIEMANN-PICK C1 | VIROLOGY | LOW PH | PATHWAY | INFECTION | PROTEINS | CELL ENTRY | BINDING | PARASITOLOGY | Lysosome-Associated Membrane Glycoproteins - antagonists & inhibitors | Lassa virus - drug effects | Humans | Cercopithecus aethiops | Receptors, Virus - genetics | Virus Internalization - drug effects | Lysosome-Associated Membrane Glycoproteins - physiology | Receptors, Virus - physiology | Antiviral Agents - chemistry | HEK293 Cells | Protein Stability | Vero Cells | Adamantane - analogs & derivatives | Protein Structure, Tertiary | Cell Line | Viral Envelope Proteins - physiology | Adamantane - pharmacology | Antiviral Agents - pharmacology | Viral Envelope Proteins - genetics | Models, Molecular | Cholesterol - metabolism | Lassa virus - pathogenicity | Lassa virus - physiology | Animals | Host-Pathogen Interactions - genetics | Viral Envelope Proteins - chemistry | Lysosome-Associated Membrane Glycoproteins - genetics | Adamantane - chemistry | Lassa Fever - etiology | Mutation | Receptors, Virus - antagonists & inhibitors | Host-Pathogen Interactions - physiology | Lassa fever | Cell receptors | Physiological aspects | Development and progression | Genetic aspects | Research | Drug therapy | Hemorrhagic fever | Target recognition | Hematology | Glycoprotein | Viruses | Infections | Glycoproteins | Hemorrhage | Cholesterol | Fever | Medical schools | Hearing loss | Membrane proteins | Proteins | Medicine | Ebola virus | Hospitals | Inhibitors | Antiviral activity | Docking | Binding sites
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 28, pp. 20616 - 20623
Mature dolichol-linked oligosaccharides (mDLOs) needed for eukaryotic protein N-glycosylation are synthesized by a multistep pathway in which the biosynthetic... 
TRANSLOCATION | TRYPANOSOMA-BRUCEI | GENE | ASSISTED CARBOHYDRATE ELECTROPHORESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOVEMENT | ENDOPLASMIC-RETICULUM | N-GLYCOSYLATION | QUALITY-CONTROL | EXPRESSION | LIPID-LINKED OLIGOSACCHARIDES | Protein Biosynthesis | Membrane Glycoproteins - metabolism | Saccharomyces cerevisiae - genetics | Glycoproteins - metabolism | Endoplasmic Reticulum - metabolism | Eukaryotic Cells - metabolism | Protozoan Proteins - genetics | Saccharomyces cerevisiae - metabolism | Polyisoprenyl Phosphate Oligosaccharides - metabolism | Flow Cytometry | Protozoan Proteins - metabolism | Membrane Transport Proteins - genetics | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Trypanosoma brucei brucei - growth & development | Glycoproteins - genetics | Transformation, Genetic | Lysosome-Associated Membrane Glycoproteins - metabolism | Trypanosoma brucei brucei - metabolism | Membrane Proteins - genetics | Electrophoresis, Polyacrylamide Gel | Glucose - pharmacology | Glycosylation | Saccharomyces cerevisiae Proteins - genetics | Trypanosoma brucei brucei - genetics | Membrane Glycoproteins - genetics | Polysaccharides - metabolism | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Mutation | Microscopy, Fluorescence | Saccharomyces cerevisiae - growth & development | Membrane Proteins | Glycobiology | Glycoprotein Biosynthesis | Lipid Synthesis | Glycobiology and Extracellular Matrices | Trypanosoma brucei | Flippase | Endoplasmic Reticulum (ER)
Journal Article
Antiviral Research, ISSN 0166-3542, 02/2017, Volume 138, pp. 32 - 39
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 20471 - 20479
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 9, pp. 6406 - 6420
Journal Article