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Nature immunology, ISSN 1529-2916, 2014, Volume 15, Issue 8, pp. 727 - 737
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2012, Volume 8, Issue 4, p. e1002597
LPS-activated neutrophils secrete IL-1 beta by activation of TLR-4. Based on studies in macrophages, it is likely that ROS and lysosomal destabilization... 
B-CELL RECEPTOR | CYTOPLASMIC DOMAIN | APOPTOSIS | SIGNALING PATHWAYS | MICROBIOLOGY | NLRP3 INFLAMMASOME | NALP3 INFLAMMASOME | ADHESION | INHIBITION | VIROLOGY | SYK TYROSINE KINASE | PARASITOLOGY | LUMEN FORMATION | Neutrophil Activation - genetics | Inflammation - pathology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Protein-Tyrosine Kinases - metabolism | Lysosomes - genetics | Carcinoembryonic Antigen - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Interleukin-1beta - genetics | Carcinoembryonic Antigen - metabolism | Multiprotein Complexes - metabolism | Inflammation - metabolism | Phosphorylation - genetics | Toll-Like Receptor 4 - agonists | Phosphorylation - immunology | Phosphorylation - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Neutrophils - metabolism | Syk Kinase | Neutrophil Activation - immunology | Neisseria - immunology | Macrophages - pathology | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Lipopolysaccharides - pharmacology | Mice | Enzyme Activation - genetics | Lysosomes - immunology | Multiprotein Complexes - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Neisseriaceae Infections - genetics | Neutrophil Activation - drug effects | Intracellular Signaling Peptides and Proteins - immunology | Caspase 1 - immunology | Enzyme Activation - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | Lysosomes - metabolism | Reactive Oxygen Species - immunology | Lysosomes - pathology | Interleukin-1beta - biosynthesis | Neisseriaceae Infections - pathology | Macrophages - immunology | Neutrophils - pathology | Neisseriaceae Infections - metabolism | Carcinoembryonic Antigen - immunology | Neutrophils - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Enzyme Activation - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Inflammasomes - genetics | Animals | Neisseria - metabolism | Caspase 1 - genetics | Neisseriaceae Infections - immunology | Inflammasomes - immunology | Inflammation - genetics | Phosphorylation | Reactive oxygen species | SHP-1 protein | Leukocytes | Macrophages | Caspase-1 | Lipopolysaccharides | Cell activation | CEACAM1 protein | Interleukin 1 | Bone marrow | Toll-like receptors | Meningitis | Gram-negative bacteria | Immune system | Pathogens | RNA-mediated interference | Inflammation | Leukocytes (neutrophilic) | Gonorrhea | TLR4 protein | Infection | Stem cells | CD66 antigen | Syk protein
Journal Article
PLoS pathogens, ISSN 1553-7374, 2014, Volume 10, Issue 4, p. e1003989
Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to... 
DOUBLE-STRANDED-RNA | CYCLIC GMP-AMP | KAPPA-B KINASE | COMPLEX CLASS-II | DEPENDENT PROTEIN-KINASE | MICROBIOLOGY | ANTIGEN PRESENTATION | INTERFERON INDUCTION | INTRACELLULAR DNA | VIROLOGY | TOLL-LIKE RECEPTORS | INNATE IMMUNE SENSOR | PARASITOLOGY | Dendritic Cells - immunology | Lysosomes - genetics | Immunity, Innate - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Endosomes - metabolism | Bone Marrow Cells - virology | Phosphorylation - genetics | Bone Marrow Cells - immunology | Interferon-beta - genetics | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Nucleotidyltransferases - metabolism | Vaccinia - metabolism | Protein-Serine-Threonine Kinases - metabolism | Receptor, Interferon alpha-beta - metabolism | Endosomes - genetics | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | Viral Proteins - genetics | Mice, Knockout | Interferon-beta - metabolism | Receptor, Interferon alpha-beta - immunology | Vaccinia - immunology | Virulence Factors - metabolism | Mice | Lysosomes - immunology | RNA-Binding Proteins - metabolism | Endosomes - immunology | RNA-Binding Proteins - genetics | Interferon-beta - immunology | Virulence Factors - genetics | Viral Proteins - immunology | Virulence Factors - immunology | Interferon Regulatory Factor-3 - genetics | Vaccinia virus - immunology | Lysosomes - metabolism | Female | Membrane Proteins - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Interferon Regulatory Factor-3 - immunology | Vaccinia virus - metabolism | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | Vaccinia - genetics | Animals | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein-Serine-Threonine Kinases - immunology | Nucleotidyltransferases - immunology | Bone Marrow Cells - metabolism | Microbiological research | Dendritic cells | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Vaccinia | Health aspects | DNA sequencing | Proteins | Studies | Smallpox | Transcription factors | Genes | Deoxyribonucleic acid | DNA | Infections | Genomes | Vaccines | Viral infections | Immune system
Journal Article
Clinical and experimental immunology, ISSN 0009-9104, 2012, Volume 169, Issue 3, pp. 220 - 228
...‐associated vasculitis. Clinical and Experimental Immunology 2012, 169: 229–37. Summary Neutrophils are pivotal to host defence during infectious diseases... 
pathogenesis | ANCA | signal transduction | vasculitis | neutrophils | Signal transduction | Vasculitis | Pathogenesis | Neutrophils | WEGENERS-GRANULOMATOSIS | CRESCENTIC GLOMERULONEPHRITIS | SYSTEMIC VASCULITIS | FC-GAMMA-RIIIB | MEDIATED GLOMERULONEPHRITIS | IMMUNOLOGY | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | PLASMA-MEMBRANE | TUMOR-NECROSIS-FACTOR | ANCA-ASSOCIATED VASCULITIS | MEMBRANE PROTEINASE-3 EXPRESSION | Organelles - immunology | Intracellular Membranes - enzymology | Humans | Antigen-Antibody Reactions | Phosphatidylinositol 3-Kinases - immunology | Antibodies, Antineutrophil Cytoplasmic - immunology | Lysosome-Associated Membrane Glycoproteins - immunology | Signal Transduction - immunology | Immunoglobulin Fc Fragments - immunology | Organelles - enzymology | Intracellular Membranes - immunology | Neutrophil Activation - immunology | Peroxidase - immunology | GPI-Linked Proteins - immunology | Neutrophils - enzymology | Myeloblastin - immunology | Cytokines - secretion | Neutrophils - immunology | Receptors, IgG - immunology | Cell Membrane - enzymology | Animals | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology | Autoantigens - immunology | Cell Membrane - immunology | Antigens, Surface - immunology | Lysosomal-Associated Membrane Protein 2 | Autoimmunity | Analysis | Autoantibodies | Rodents | Animal models | Cell activation | antineutrophil cytoplasmic antibodies | Infectious diseases | Inflammation | Leukocytes (neutrophilic) | Inflammatory diseases | Review
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1560 - 1566
Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c). Group 1 CD1-restricted T cells are... 
Cell Line | Interferon-gamma | Mycobacterium | Dendritic Cells | T-Lymphocytes | Lymphocyte Activation | Tuberculosis Vaccines | Humans | Antibodies | Antigens, CD1 | Lysosomes | Antigens, Bacterial | Drug Delivery Systems | Nanoparticles | Antigens, Differentiation, Myelomonocytic | Endocytosis | Tuberculosis | Antigen Presentation | Glycolipids | Lectins | Liposomes | CD1 | IMMUNIZATION | REPERTOIRE | RECOGNITION | IMMUNE-RESPONSES | MACROPHAGES | LIPID ANTIGENS | TUBERCULOSIS INFECTION | IMMUNOLOGY | RECEPTORS | VACCINES | Liposomes - administration & dosage | Dendritic Cells - immunology | Antigens, Bacterial - immunology | Glycolipids - administration & dosage | Lymphocyte Activation - immunology | Antibodies - immunology | Tuberculosis Vaccines - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Endocytosis - immunology | Liposomes - immunology | Antigens, CD1 - immunology | Lectins - immunology | Mycobacterium - immunology | Interferon-gamma - secretion | Tuberculosis Vaccines - administration & dosage | Antigens, Bacterial - administration & dosage | Antigen Presentation - immunology | Tuberculosis - immunology | Tuberculosis - prevention & control | Glycolipids - immunology | T-Lymphocytes - immunology | Nanoparticles - administration & dosage | Drug Delivery Systems - methods | Lysosomes - immunology | CD1-restricted T cells | Siglecs | dendritic cell targeting | Antigen delivery
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2010, Volume 207, Issue 8, pp. 1791 - 1804
Studies of T cell responses to tumors have focused on the draining lymph node (LN) as the site of activation. We examined the tumor mass as a potential site of... 
MEDICINE, RESEARCH & EXPERIMENTAL | NODE ADDRESSIN | INDOLEAMINE 2,3-DIOXYGENASE | CO-STIMULATION | IMMUNE DYSFUNCTION | MATURE DENDRITIC CELLS | LYMPHOTOXIN-ALPHA | ANTIGEN CROSS-PRESENTATION | IMMUNOLOGY | CANCER | SPHINGOSINE 1-PHOSPHATE | SELF-TOLERANCE | CD8-Positive T-Lymphocytes - cytology | Cell Proliferation | Ovalbumin - immunology | Carcinoma, Lewis Lung - immunology | Interferon-gamma - metabolism | Cell Movement - immunology | Lymphocyte Activation - immunology | Peptide Fragments - immunology | Hyaluronan Receptors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Lymph Nodes - drug effects | Receptors, Antigen, T-Cell - immunology | CD11a Antigen - metabolism | Propylene Glycols - pharmacology | Antigen Presentation - genetics | Mice, Transgenic | Lymph Nodes - immunology | Antigen Presentation - immunology | Lymph Nodes - cytology | Mice, Knockout | Sphingosine - pharmacology | Cell Differentiation - immunology | Cell Movement - drug effects | Sphingosine - analogs & derivatives | Neoplasms - immunology | Carcinoma, Lewis Lung - pathology | Mice | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | beta 2-Microglobulin - genetics | T-Lymphocyte Subsets - immunology | Lymph Nodes - pathology | T-Lymphocyte Subsets - cytology | Granzymes - metabolism | Adoptive Transfer | Melanoma, Experimental - immunology | Neoplasms - genetics | Immunosuppressive Agents - pharmacology | Lysosome-Associated Membrane Glycoproteins - metabolism | Mice, Inbred C57BL | Fingolimod Hydrochloride | DNA-Binding Proteins - genetics | Antigen-Presenting Cells - immunology | Animals | Carcinoma, Lewis Lung - genetics | Integrin alpha4 - metabolism | Monophenol Monooxygenase - immunology | T-Lymphocyte Subsets - metabolism | Neoplasms - pathology
Journal Article
Journal Article
Blood, ISSN 1528-0020, 2007, Volume 110, Issue 3, pp. 962 - 971
Toll-like receptor 4 (TLR4) initiates both myeloid differentiation factor 88 (MyD88)-dependent and Toll/interleukin (IL)-1R domain–containing adapter, inducing... 
ACTIVATION | PROTEIN | EPIDERMAL-GROWTH-FACTOR | TOLL-LIKE RECEPTORS | GOLGI-APPARATUS | LIPOPOLYSACCHARIDE | TRAFFICKING | TRANSDUCTION | HEMATOLOGY | NF-KAPPA-B | ADAPTER MOLECULE | Endosomes - immunology | NF-kappa B - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Endosomes - metabolism | Extracellular Signal-Regulated MAP Kinases - immunology | Lysosome-Associated Membrane Glycoproteins - immunology | Protein Transport - immunology | Signal Transduction - immunology | Lysosomes - metabolism | Myeloid Differentiation Factor 88 - immunology | Macrophages - immunology | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Protein Structure, Tertiary | rab GTP-Binding Proteins - metabolism | Cell Line | Nitric Oxide - immunology | Lysosome-Associated Membrane Glycoproteins - metabolism | Toll-Like Receptor 4 - immunology | Down-Regulation - drug effects | Toll-Like Receptor 4 - metabolism | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Down-Regulation - immunology | rab GTP-Binding Proteins - immunology | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Mice | Nitric Oxide - metabolism | Lysosomes - immunology | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2009, Volume 31, Issue 1, pp. 99 - 109
Cytotoxic lymphocytes kill target cells by releasing the content of secretory lysosomes at the immune synapse. To understand the dynamics and control of... 
MOLIMMUNO | CELLIMMUNO | CELL IMMUNOLOGICAL SYNAPSE | RING JUNCTION | ACTIVATION | NK CELLS | RECOGNITION | COSTIMULATION | IMMUNOLOGY | RECEPTORS | POLARIZATION | CONTRIBUTES | T-CELLS | Antigens, CD - immunology | CD18 Antigens - immunology | Humans | NK Cell Lectin-Like Receptor Subfamily K - immunology | Lymphocyte Function-Associated Antigen-1 - metabolism | Immunological Synapses - metabolism | Antigens, CD - metabolism | Lymphocyte Function-Associated Antigen-1 - immunology | Lysosome-Associated Membrane Glycoproteins - immunology | Lysosomes - metabolism | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Killer Cells, Natural - immunology | Perforin - immunology | Receptors, Immunologic - immunology | Lysosome-Associated Membrane Glycoproteins - metabolism | Intercellular Adhesion Molecule-1 - immunology | Signaling Lymphocytic Activation Molecule Family | Transport Vesicles - immunology | Cell Degranulation - immunology | CD18 Antigens - metabolism | Killer Cells, Natural - cytology | Intercellular Adhesion Molecule-1 - metabolism | Immunological Synapses - immunology | Perforin - metabolism | Killer Cells, Natural - metabolism | Lysosomes - immunology | Receptors, Immunologic - metabolism | Cytotoxicity, Immunologic | Medical colleges | Immunogenetics | Lymphocytes | Integrins | Proteins | Antigens | Insects | Microscopy | Cloning | Lipids | Cytotoxicity | Ligands | Infections | Immune system
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2009, Volume 31, Issue 4, pp. 621 - 631
Killing by cytotoxic T lymphocytes (CTLs) is mediated by the secretion of lytic granules. The centrosome plays a key role in granule delivery, polarizing to... 
MOLIMMUNO | CELLIMMUNO | ACTIVATION | TCR | POSITIVE SELECTION | CYTOSKELETON | PHOSPHORYLATION | MICROTUBULE-ORGANIZING CENTER | CTL | IMMUNOLOGY | ANTIGEN RECEPTOR | ALTERED PEPTIDE LIGANDS | SECRETORY LYSOSOMES | Ovalbumin - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Immunological Synapses - metabolism | Extracellular Signal-Regulated MAP Kinases - immunology | Centrosome - ultrastructure | Signal Transduction - immunology | Cytoplasmic Granules - metabolism | Peptide Fragments - immunology | src-Family Kinases - metabolism | Female | Receptors, Antigen, T-Cell - immunology | Phosphorylation - immunology | T-Lymphocytes, Cytotoxic - immunology | Cell Polarity - immunology | Microscopy, Electron, Transmission | Immunological Synapses - ultrastructure | Centrosome - immunology | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Cell Degranulation - immunology | src-Family Kinases - immunology | Centrosome - metabolism | Animals | Cytoplasmic Granules - ultrastructure | T-Lymphocytes, Cytotoxic - metabolism | Immunological Synapses - immunology | Mice | Cytotoxicity, Immunologic - immunology | Cytoplasmic Granules - immunology | T-Lymphocytes, Cytotoxic - ultrastructure | T cells | Machinery | Magneto-electric machines | Scholarships & fellowships | Statistical analysis | Peptides | Cytokines | Microscopy | Cytotoxicity | Ligands | T cell receptors | Kinases | Variance analysis | Apoptosis
Journal Article