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1. Full Text Efficient and Selective Formation of Macrocyclic Disubstituted Z Alkenes by Ring‐Closing Metathesis (RCM) Reactions Catalyzed by Mo‐ or W‐Based Monoaryloxide Pyrrolide (MAP) Complexes: Applications to Total Syntheses of Epilachnene, Yuzu Lactone, Ambrettolide, Epothilone C, and Nakadomarin A
by Wang, Chenbo and Yu, Miao and Kyle, Andrew F and Jakubec, Pavol and Dixon, Darren J and Schrock, Richard R and Hoveyda, Amir H
Chemistry – A European Journal, ISSN 0947-6539, 02/2013, Volume 19, Issue 8, pp. 2726 - 2740
The first broadly applicable set of protocols for efficient Z‐selective formation of macrocyclic disubstituted alkenes through catalytic ring‐closing... 
olefin metathesis | synthesis | catalysis | tungsten | macrocyclic Z alkenes | molybdenum | IMIDO ALKYLIDENE COMPLEXES | ALKYNE METATHESIS | ENANTIOSELECTIVE SYNTHESIS | OLEFIN CROSS-METATHESIS | MACROLIDES | CHEMISTRY, MULTIDISCIPLINARY | MICROTUBULE-STABILIZING AGENTS | NATURAL-PRODUCT SYNTHESIS | ENYNE METATHESIS | (-)-NAKADOMARIN | Molybdenum - chemistry | Carbolines - chemical synthesis | Macrocyclic Compounds - chemistry | Cycloparaffins - chemistry | Epothilones - chemistry | Stereoisomerism | Alkaloids - chemical synthesis | Epothilones - chemical synthesis | Macrocyclic Compounds - chemical synthesis | Ruthenium - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Carbolines - chemistry | Lactones - chemical synthesis | Bridged-Ring Compounds - chemistry | Cyclization | Cycloparaffins - chemical synthesis | Molecular Structure | Catalysis | Kinetics | Bridged-Ring Compounds - chemical synthesis | Alkaloids - chemistry | Lactones - chemistry | Chemical synthesis | Molybdenum | Olefins | Isomerization | Macrocyclic compounds | Alkenes | Catalysts | Decomposition reactions | Metathesis | Selectivity | RCM
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2. Full Text Macrocyclic lactone resistance in Dirofilaria immitis
by Bourguinat, Catherine and Keller, Kathy and Bhan, Aron and Peregrine, Andrew and Geary, Timothy and Prichard, Roger
Veterinary Parasitology, ISSN 0304-4017, 09/2011, Volume 181, Issue 2-4, pp. 388 - 392
Microfilariae were isolated from a Katrina rescue dog that remained microfilariaemic despite successful adulticidal treatments and repeated treatment with high... 
Heartworm preventative | Anthelmintic resistance | Macrocyclic lactone | Heartworm | Dirofilaria immitis | Ivermectin | IVERMECTIN RESISTANCE | EFFICACY | MARKER | PARASCARIS-EQUORUM | ONCHOCERCA-VOLVULUS | DRUG-RESISTANCE | NEMATODES | VETERINARY SCIENCES | INFECTION | SELECTION | PARASITOLOGY | Dirofilaria immitis - drug effects | Drug Resistance - genetics | Animals | Anthelmintics - pharmacology | Dogs | Male | Dirofilaria immitis - genetics | Dirofilariasis - parasitology | Lactams, Macrocyclic - pharmacology | Dog Diseases - parasitology | Polymorphism, Genetic | Nematoda | Indexing in process
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3. Full Text Immunoassays for the detection of macrocyclic lactones in food matrices – A review
by Wang, Zhanhui and Beier, Ross C and Shen, Jianzhong
Trends in Analytical Chemistry, ISSN 0165-9936, 07/2017, Volume 92, pp. 42 - 61
Macrocyclic lactones including the avermectins, macrolides, and milbemycins are a group of antimicrobial agents that have been widely used in food-producing... 
Immunoassay | Residues | Bioconjugation | Macrocyclic lactones | Hapten synthesis | Antibody | IMMUNOAFFINITY COLUMN CLEANUP | MOLECULARLY IMPRINTED POLYMER | CHEMISTRY, ANALYTICAL | LINKED-IMMUNOSORBENT-ASSAY | IMMUNOCHROMATOGRAPHIC ASSAY | MASS-SPECTROMETRY | PERFORMANCE LIQUID-CHROMATOGRAPHY | BOVINE LIVER | MONOCLONAL-ANTIBODY PRODUCTION | MACROLIDE ANTIBIOTICS | SOLID-PHASE EXTRACTION | Viral antibodies | Biological products | Safety and security measures | Analysis | Antibodies | Lactones | Food
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4. Full Text Chemistry and biology of resorcylic acid lactones
by Winssinger, Nicolas and Barluenga, Sofia
Chemical Communications, ISSN 1359-7345, 2007, Issue 1, pp. 22 - 36
While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor... 
HSP90 INHIBITORS | POCHONIN-C | AIGIALOMYCIN-D | OXIME DERIVATIVES | GIBBERELLA-ZEAE | MODULAR ASYMMETRIC-SYNTHESIS | ANTITUMOR-ACTIVITY | CONVERGENT STEREOSPECIFIC SYNTHESIS | MONOCILLIN-I | CHEMISTRY, MULTIDISCIPLINARY | PROTEIN-KINASES | Macrocyclic Compounds - chemistry | Mycotoxins - chemistry | Zearalenone - chemical synthesis | Zearalenone - chemistry | Zearalenone - analogs & derivatives | Macrocyclic Compounds - chemical synthesis | Lactones - pharmacology | Mycotoxins - chemical synthesis | Macrocyclic Compounds - pharmacology | Lactones - chemical synthesis | Macrolides - chemistry | Mitogen-Activated Protein Kinases - antagonists & inhibitors | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Macrolides - chemical synthesis | Hydroxybenzoates - chemistry | Macrolides - pharmacology | Molecular Structure | Mycotoxins - pharmacology | Lactones - chemistry | Zearalenone - pharmacology
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5. Full Text Concurrent treatment with a macrocyclic lactone and benzimidazole provides season long performance advantages in grazing cattle harboring macrocyclic lactone resistant nematodes
by Edmonds, M.D and Edmonds, J.D and Vatta, A.F and Marchiondo, A.A and Vanimisetti, H.B
Veterinary Parasitology, ISSN 0304-4017, 03/2018, Volume 252, pp. 157 - 162
In 2013, a 118-day study was initiated to investigate the efficacy of concurrent treatment at pasture turnout with an injectable macrocyclic lactone with... 
Anthelmintic resistance | Nematodes | Efficacy | Macrocyclic lactone | Cattle | Benzimidazole | EXTENDED-RELEASE INJECTION | CONTROL STRATEGIES | VETERINARY SCIENCES | PARASITOLOGY | Beef cattle | Nematoda | Usage
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6. Full Text β-Resorcylic Acid Lactones from a Paecilomyces Fungus
by Xu, Liangxiong and He, Zhengxiang and Xue, Jinghua and Chen, Xiaoping and Wei, Xiaoyi
Journal of Natural Products, ISSN 0163-3864, 05/2010, Volume 73, Issue 5, pp. 885 - 889
Six new β-resorcylic acid lactones (1−6), named paecilomycins A−F, and five known compounds, aigilomycin B (7), zeaenol (8), aigialomycin D (9), aigialomycin F... 
METABOLITES | CHEMISTRY, MEDICINAL | RADICICOL | COMPOUND | PHARMACOLOGY & PHARMACY | MACROLIDES | AIGIALUS-PARVUS | ZEARALENONE | PLANT SCIENCES | Macrolides - isolation & purification | Parasitic Sensitivity Tests | Lactones - isolation & purification | Macrocyclic Compounds - chemistry | Molecular Conformation | Macrocyclic Compounds - isolation & purification | Crystallography, X-Ray | Plasmodium falciparum - drug effects | Lactones - pharmacology | Antimalarials - pharmacology | Macrocyclic Compounds - pharmacology | Hydroxybenzoates - isolation & purification | Hydroxybenzoates - pharmacology | Paecilomyces - chemistry | Macrolides - chemistry | Antimalarials - chemistry | Hydroxybenzoates - chemistry | Nuclear Magnetic Resonance, Biomolecular | Molecular Structure | Lactones - chemistry
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7. Full Text ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for marker development
by PRICHARD, R. K and ROULET, A
Parasitology, ISSN 0031-1820, 8/2007, Volume 134, Issue 8, pp. 1123 - 1132
Macrocyclic lactones (MLs) are highly lipophilic anthelmintics which are known to bind to and open ligand-gated ion channels. However, these anthelmintics, and... 
Macrocyclic lactone anthelmintics | Nematode | ABC transporters | Moxidectin | P-glycoproteins | Drug resistance | β-tubulin | Ivermectin | IVERMECTIN RESISTANCE | nematode | moxidectin | PARASCARIS-EQUORUM | ivermectin | GATED CHLORIDE CHANNEL | HAEMONCHUS-CONTORTUS | CAENORHABDITIS-ELEGANS | ONCHOCERCIASIS-ENDEMIC FOCI | macrocyclic lactone anthelmintics | drug resistance | beta-tubulin | P-GLYCOPROTEIN GENE | MULTIDRUG-RESISTANCE | MULTIPLE TREATMENTS | PARASITOLOGY | ANTHELMINTIC RESISTANCE | Helminths - drug effects | Helminths - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Phylogeny | Lactones - pharmacology | Macrocyclic Compounds - pharmacology | Tubulin - metabolism | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Anthelmintics - pharmacology | ATP-Binding Cassette Transporters - metabolism | Biomarkers | Helminths - metabolism | Drug Resistance
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8. Full Text Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after 6 years of macrocyclic lactone use
by Laing, Roz and Maitland, Kirsty and Lecová, Lenka and Skuce, Philip J and Tait, Andy and Devaney, Eileen
International Journal for Parasitology, ISSN 0020-7519, 09/2016, Volume 46, Issue 10, pp. 621 - 630
Sheep farmers in the UK rely on strategic anthelmintic use to treat and control gastrointestinal roundworms in their flocks. However, resistance to these drugs... 
Anthelmintic resistance | Parasite | Macrocyclic lactone | Nematode | Sheep | Ivermectin | IVERMECTIN RESISTANCE | COOPERIA-ONCOPHORA | MOXIDECTIN-SELECTED STRAINS | ONCHOCERCA-VOLVULUS | GATED CHLORIDE CHANNEL | SHEEP FARMS | CAENORHABDITIS-ELEGANS | GLUTAMATE | TELADORSAGIA-CIRCUMCINCTA | PARASITOLOGY
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9. Full Text Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance
by Bourguinat, Catherine and Lee, Alice C.Y and Lizundia, Regina and Blagburn, Byron L and Liotta, Janice L and Kraus, Marc S and Keller, Kathy and Epe, Christian and Letourneau, Louis and Kleinman, Claudia L and Paterson, Tara and Gomez, Elena Carreton and Montoya-Alonso, José Alberto and Smith, Hubert and Bhan, Aron and Peregrine, Andrew S and Carmichael, James and Drake, Jason and Schenker, Rudolf and Kaminsky, Ronald and Bowman, Dwight D and Geary, Timothy G and Prichard, Roger K
Veterinary Parasitology, ISSN 0304-4017, 06/2015, Volume 210, Issue 3-4, pp. 167 - 178
Macrocyclic lactone (ML) endectocides are used as chemoprophylaxis for heartworm infection ( ) in dogs and cats. Claims of loss of efficacy (LOE) of ML... 
Resistance | Genetic markers | Moxidectin | Macrocyclic lactones | Dirofilaria immitis | Ivermectin | EFFICACY | MILBEMYCIN OXIME | ONCHOCERCIASIS-ENDEMIC FOCI | DOGS | GHANA | VETERINARY SCIENCES | INFECTION | MULTIPLE TREATMENTS | VOLVULUS | PARASITOLOGY | ANTHELMINTIC RESISTANCE | Microfilariae | Male | Ivermectin - pharmacology | Lactones - pharmacology | Dirofilaria immitis - drug effects | Animals | Chemoprevention - veterinary | Genetic Markers - genetics | Dogs | Macrolides - pharmacology | Polymorphism, Single Nucleotide - genetics | Female | Filaricides - pharmacology | Dirofilaria immitis - genetics | Dirofilariasis - parasitology | Dog Diseases - parasitology | Drug Resistance | Analysis | Genomics | Genetic research | Single nucleotide polymorphisms | Nematoda | Investigations
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10. Full Text Development and validation of a method for simultaneous determination of trace levels of five macrocyclic lactones in cheese by HPLC-fluorescence after solid–liquid extraction with low temperature partitioning
by de Souza Santos Cheibub, Ana Maria and Silva Bahiense de Lyra, Eduardo and Pereira Netto, Annibal Duarte
Food Chemistry, ISSN 0308-8146, 01/2019, Volume 272, pp. 148 - 156
A highly sensitive analytical method was developed and validated, following international guidelines, for the determination of the residues of five macrocyclic... 
HPLC-fluorescence | Milbemycin | Solid-liquid extraction with low temperature partitioning (SLE-LTP) | Cheese analysis | Acrocyclic lactones | Avermectin | Veterinary drug residues | AVERMECTIN RESIDUES | FOOD SCIENCE & TECHNOLOGY | MILK EXCRETION | TANDEM MASS-SPECTROMETRY | DAIRY SHEEP | IVERMECTIN RESIDUES | LC-MS/MS | NUTRITION & DIETETICS | MOXIDECTIN | CHEMISTRY, APPLIED | MILBEMYCIN RESIDUES | FOOD | Cheese - analysis | Anti-Bacterial Agents - analysis | Cold Temperature | Limit of Detection | Lactones - isolation & purification | Macrocyclic Compounds - chemistry | Food Analysis - methods | Food Contamination - analysis | Spectrometry, Fluorescence | Anti-Bacterial Agents - isolation & purification | Chromatography, High Pressure Liquid | Lactones - analysis | Animals | Time Factors | Cattle | Anti-Bacterial Agents - chemistry | Solid Phase Extraction | Lactones - chemistry | Fluorescence | Analysis | High performance liquid chromatography | Methods | Lactones | Index Medicus
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11. Full Text Short communication: Macrocyclic lactone residues in butter from Brazilian markets
by Macedo, Fabio and Marsico, Eliane Teixeira and Conte-Júnior, Carlos Adam and Furtado, Leonardo de Almeida and Brasil, Taila Figueredo and Pereira Netto, Annibal Duarte
Journal of Dairy Science, ISSN 0022-0302, 06/2015, Volume 98, Issue 6, pp. 3695 - 3700
Macrocyclic lactones (ML) are commonly used in drug formulations for the treatment of parasites in cattle. In Brazil, except for drugs (or formulations) with... 
veterinary drug residue | commercial butter | liquid chromatography | macrocyclic lactone | Macrocyclic lactone | Liquid chromatography | Commercial butter | Veterinary drug residue | Drug Residues - analysis | Milk - chemistry | Food Analysis | Animals | Butter - analysis | Cattle | Brazil | Chromatography, Liquid - methods | Antiparasitic Agents - chemistry | Lactones - chemistry
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12. Full Text Macrocyclic lactone residues in butter from Brazilian markets
by Macedo, F and Marsico, ET and Conte, CA and Furtado, LD and Brasil, TF and Netto, ADP
JOURNAL OF DAIRY SCIENCE, ISSN 0022-0302, 06/2015, Volume 98, Issue 6, pp. 3695 - 3700
Macrocyclic lactones (ML) are commonly used in drug formulations for the treatment of parasites in cattle. In Brazil, except for drugs (or formulations) with... 
veterinary drug residue | AGRICULTURE, DAIRY & ANIMAL SCIENCE | LIQUID-CHROMATOGRAPHY | BOVINE-MILK | STABILITY | FOOD SCIENCE & TECHNOLOGY | SHEEP | commercial butter | liquid chromatography | macrocyclic lactone | IVERMECTIN RESIDUES
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13. Full Text Area‐wide impact of macrocyclic lactone parasiticides in cattle dung
by WALL, R and BEYNON, S
Medical and Veterinary Entomology, ISSN 0269-283X, 03/2012, Volume 26, Issue 1, pp. 1 - 8
Following the treatment of cattle with veterinary parasiticides and insecticides, residues are excreted into the dung in concentrations that may be toxic to... 
mitigation | community structure | Cattle | dung | insect | decomposition | macrocyclic lactone | Community structure | Mitigation | Macrocyclic lactone | Decomposition | Dung | Insect | COW-DUNG | APHODIUS | ENTOMOLOGY | FECAL RESIDUES | COPROPHAGOUS BEETLES | IVERMECTIN USAGE | GRASSLAND ECOSYSTEM | VETERINARY PARASITICIDES | VETERINARY SCIENCES | INSECT COMMUNITIES | TREATED CATTLE | Environmental Pollutants - adverse effects | Animals | Feces - chemistry | Environmental Pollutants - chemistry | Antiparasitic Agents - adverse effects | Lactones - adverse effects | Antiparasitic Agents - chemistry | Lactones - chemistry | Weather | Beef cattle | Insecticides | Ecosystems | Moisture content | Herbivores | Index Medicus
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14. Full Text A diagnostic algorithm for evaluating cases of potential macrocyclic lactone-resistant heartworm
by Moorhead, Andrew R and Evans, Christopher C and Kaplan, Ray M
Parasites and Vectors, ISSN 1756-3305, 11/2017, Volume 10, Issue Suppl 2, pp. 479 - 113
Background: The emergence of macrocyclic lactone resistance in canine heartworm poses a substantial threat to what is currently the only effective,... 
Resistance | Macrocyclic lactone | Heartworm | Dirofilaria immitis | EFFICACY | SAFETY | PREVENTIVES | TROPICAL MEDICINE | IMMITIS CIRCULATING MICROFILARIAE | MOXIDECTIN | DOGS | DIROFILARIA-IMMITIS | PARASITOLOGY | Dirofilaria immitis - physiology | Filaricides - chemistry | Dirofilariasis - drug therapy | Lactones - pharmacology | Dirofilaria immitis - drug effects | Algorithms | Animals | Dog Diseases - drug therapy | Dogs | Dirofilariasis - diagnosis | Filaricides - pharmacology | Dirofilaria immitis - isolation & purification | Dirofilariasis - parasitology | Dog Diseases - diagnosis | Dog Diseases - parasitology | Drug Resistance | Lactones - chemistry | Vector-borne diseases | Prevention | Drug resistance in microorganisms | Care and treatment | Analysis | Diagnosis | Drugs | Antigens | Compliance | Methodology | Laboratories | Identification methods | Diagnostic tests | Infections | Surveying | Drug resistance | Veterinarians | Biotypes | Experimental infection | Emergence | Diagnostic systems | Drug dosages
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