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index medicus (85) 85
mafbx (80) 80
animals (77) 77
atrophy (56) 56
murf1 (47) 47
muscle proteins - metabolism (45) 45
muscle, skeletal - metabolism (44) 44
biochemistry & molecular biology (41) 41
mice (40) 40
skp cullin f-box protein ligases - metabolism (37) 37
cell biology (36) 36
male (36) 36
ubiquitin (36) 36
atrogin-1 (34) 34
humans (32) 32
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atrogin-1/mafbx (30) 30
muscles (29) 29
skeletal-muscle (29) 29
muscle proteins - genetics (28) 28
muscle, skeletal - pathology (28) 28
gene-expression (27) 27
muscular atrophy - metabolism (27) 27
skeletal muscle (27) 27
ligases (26) 26
skp cullin f-box protein ligases - genetics (26) 26
foxo transcription factors (25) 25
ubiquitin-protein ligases - metabolism (25) 25
muscle atrophy (24) 24
proteolysis (24) 24
rats (24) 24
hypertrophy (22) 22
ubiquitin ligases (22) 22
murf-1 (20) 20
musculoskeletal system (19) 19
phosphorylation (19) 19
signal transduction (19) 19
tripartite motif proteins (19) 19
cell line (18) 18
gene expression (18) 18
activation (17) 17
mafbx/atrogin-1 (17) 17
physiology (16) 16
proteins (16) 16
ubiquitin ligase (16) 16
analysis (15) 15
muscle fibers, skeletal - metabolism (15) 15
protein (15) 15
skeletal-muscle atrophy (15) 15
female (14) 14
mice, inbred c57bl (14) 14
muscular atrophy - pathology (14) 14
proteasome endopeptidase complex - metabolism (14) 14
degradation (13) 13
growth (13) 13
muscular atrophy - genetics (13) 13
pathway (13) 13
rna, messenger - metabolism (13) 13
ubiquitin-protein ligases - genetics (13) 13
article (12) 12
exercise (12) 12
identification (12) 12
insulin (12) 12
protein biosynthesis (12) 12
rodents (12) 12
ubiquitin ligase atrogin1/mafbx (12) 12
akt (11) 11
apoptosis (11) 11
autophagy (11) 11
biology (11) 11
cachexia (11) 11
physiological aspects (11) 11
ubiquitin-proteasome system (11) 11
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cancer (10) 10
muscle, skeletal - drug effects (10) 10
proteasome pathway (10) 10
proto-oncogene proteins c-akt - metabolism (10) 10
rna (10) 10
ubiquitin-proteasome pathway (10) 10
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health aspects (9) 9
in-vivo (9) 9
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proteasome (9) 9
protein-degradation (9) 9
rna, messenger - genetics (9) 9
ubiquitin - metabolism (9) 9
cancer cachexia (8) 8
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chicken (8) 8
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FASEB Journal, ISSN 0892-6638, 11/2008, Volume 22, Issue 11, pp. 3836 - 3845
Heat shock protein 70 (Hsp70) is a highly conserved and ubiquitous protein that is reported to provide cytoprotection in various cell types and tissues.... 
Immobilization | Atrogin-1/MAFbx | MuRF1 | DISUSE ATROPHY | OXIDATIVE STRESS | ACTIVATION | immobilization | PROTEIN | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SOLEUS MUSCLE | CELL BIOLOGY | DEPENDENT PROTEOLYSIS | MESSENGER-RNA | BIOLOGY | GENE-EXPRESSION | DEGRADATION | atrogin-1/MAFbx | Research Communications | atrogin-1 | MAFbx
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2011, Volume 25, Issue 1, pp. 99 - 110
Cachectic muscle wasting is a frequent complication of many inflammatory conditions, due primarily to excessive muscle catabolism. However, the pathogenesis... 
Autophagosomes | Lactacystin | Atrogin-1/MAFbx | p38 MAPK | 3-Methyladenine | RAT SKELETAL-MUSCLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | FOXO TRANSCRIPTION FACTORS | lactacystin | CELL BIOLOGY | MESSENGER-RNAS | autophagosomes | PROTEIN-DEGRADATION | SIGNALING PATHWAY | AMINO-ACIDS | IN-VIVO | BIOLOGY | atrogin-1/MAFbx | 3-methyladenine | INNATE IMMUNITY | C2C12 MYOTUBES | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin - metabolism | Male | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Autophagy - drug effects | Lysosomes - metabolism | RNA Interference | Muscle Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Muscles - metabolism | Phagosomes - drug effects | Cell Line | Muscular Atrophy - metabolism | Mice, Inbred C57BL | Phagosomes - metabolism | Enzyme Inhibitors - pharmacology | Toll-Like Receptor 4 - genetics | Muscular Atrophy - genetics | Imidazoles - pharmacology | SKP Cullin F-Box Protein Ligases - metabolism | Toll-Like Receptor 4 - metabolism | Blotting, Western | Mice, Knockout | Muscle Proteins - genetics | Animals | Signal Transduction - drug effects | Muscles - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Proteasome Endopeptidase Complex - metabolism | Research Communications | atrogin-1 | MAFbx
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2008, Volume 27, Issue 8, pp. 1266 - 1276
Journal Article
FASEB Journal, ISSN 0892-6638, 10/2009, Volume 23, Issue 10, pp. 3415 - 3423
Heat shock protein 25/27 (Hsp25/27) is a cytoprotective protein that is ubiquitously expressed in most cells, and is up-regulated in response to cellular... 
Immobilization | Atrogin-1/MAFbx | MuRF1 | DISUSE ATROPHY | OXIDATIVE STRESS | ACTIVATION | immobilization | STRESS-PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | ALPHA | CELL BIOLOGY | HEAT-SHOCK PROTEINS | BIOLOGY | GENE-EXPRESSION | DEGRADATION | KINASE IKK | atrogin-1/MAFbx | Research Communications | atrogin-1 | MAFbx
Journal Article
Skeletal Muscle, ISSN 2044-5040, 03/2013, Volume 3, Issue 1, pp. 6 - 6
Background: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a... 
Atrophy | Tuberous sclerosis complex (TSC) | FoxO | PKB/Akt | MuRF1 | Mammalian target of rapamycin complex 1 (mTORC1) | Atrogin-1/MAFbx | Raptor | Skeletal muscle | Hypertrophy | CELL BIOLOGY | Ligases | Proteolysis | Analysis | Muscles | Tuberous sclerosis | Protein biosynthesis | Health aspects | Life Sciences
Journal Article
The Journal of Poultry Science, ISSN 1346-7395, 2017
The expression of atrogin-1/MAFbx, a muscle-specific E3 ubiquitin ligase, is increased in catabolic conditions that result in muscle atrophy. The expression of... 
IGF-I | chick myotubes | Akt | atrogin-1/MAFbx | FOXO1
Journal Article
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 09/2017, Volume 211, pp. 1 - 6
Adrenaline changes expression of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α), which is known as a... 
PGC-1α | Chicken | Atrogin-1/MAFbx | Skeletal muscle | β-Adrenergic receptor
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2010, Volume 392, Issue 1, pp. 1 - 3
Menopause, the age-related loss of ovarian hormone production, promotes increased adiposity and associated metabolic pathology, but molecular mechanisms remain... 
Musclin | Myogenin | Atrogin-1/MAFbx | MuRF-1 | Menopause | Estrogen | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA | OBESITY | BIOPHYSICS | METABOLISM | ACCUMULATION | MAFbx | menopause | Atrogin-1 | myogenin
Journal Article
Gastroenterology, ISSN 0016-5085, 02/2019, Volume 156, Issue 3, pp. 722 - 734.e6
Cachexia, which includes muscle wasting, is a frequent complication of pancreatic cancer. There are no therapies that reduce cachexia and increase patient... 
Signal Transduction | Muscle Loss | Pancreas | Mouse Model | PATHOGENESIS | RESECTION | GROWTH | UBIQUITIN LIGASE ATROGIN1/MAFBX | RAB27B | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Cachexia | Analysis | Pancreatic cancer | Cancer cells
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 01/2019, Volume 126, pp. 1 - 12
Muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, is a crucial mediator of skeletal muscle atrophy and cardiac hypertrophy in response to... 
Myocardial infarction | Inflammasome | Muscle atrophy F-box | Cardiac rupture | Neutrophils | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | IDENTIFICATION | CELL BIOLOGY | HYPERTROPHY | INHIBITION | MAFBX | INFLAMMATION | ATROGIN-1 | DYSFUNCTION | PROTEINS | EXPRESSION
Journal Article
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