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1. Brain dead, brain absent, brain donors
: human subjects or human objects?
by McCullagh, P. J. (Peter John)
1993, ISBN 9780471937364, vi, 261
Anencephaly | Brain Death | Ethics, Medical | Organ Procurement | Moral and ethical aspects | Transplantation | Fetal brain | Tissue Donors
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2. Full Text Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood–brain barrier maturation
by Amaraneni, Manoj and Pang, Jing and Mortuza, Tanzir B and Muralidhara, Srinivasa and Cummings, Brian S and White, Catherine A and Vorhees, Charles V and Zastre, Jason and Bruckner, James V
Neurotoxicology, ISSN 0161-813X, 09/2017, Volume 62, pp. 24 - 29
Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased... 
Pyrethroids | Plasma protein binding | Developmental neurotoxicity | Brain uptake | Deltamethrin | Blood–brain barrier | PENETRATION | PYRETHROID INSECTICIDES | CEREBROSPINAL-FLUID | Blood brain barrier | REFERENCE-VALUES | NEUROTOXICITY | NEUROSCIENCES | ADULT | CHILDREN | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPOSURE | AGE | Brain - embryology | Age Factors | Embryo, Mammalian | Humans | Brain - enzymology | Child, Preschool | Infant | Male | Blood Proteins - metabolism | Nitriles - pharmacokinetics | Brain - metabolism | Dose-Response Relationship, Drug | Protein Binding - drug effects | Female | Fetus | Blood-Brain Barrier - growth & development | Pyrethrins - metabolism | Infant, Newborn | Animals, Newborn | Nitriles - metabolism | Blood-Brain Barrier - embryology | Rats | Rats, Sprague-Dawley | Pyrethrins - pharmacokinetics | Blood-Brain Barrier - metabolism | Brain - drug effects | Pregnancy | Albumins - pharmacology | Animals | Insecticides - metabolism | Insecticides - pharmacokinetics | Brain | Medical colleges | Permeability | Blood proteins | Protein binding | Albumin | Insecticides | Binding | Human serum albumin | Permethrin | Membrane permeability | Serum albumin | Blood plasma | Studies | Neurotoxicity | Blood-brain barrier | Agrochemicals | Rodents | Adults | Carotid artery | Deposition | Age | Index Medicus
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3. Full Text Genetic architecture supports mosaic brain evolution and independent brain-body size regulation
by Hager, Reinmar and Lu, Lu and Rosen, Glenn D and Williams, Robert W
Nature Communications, ISSN 2041-1723, 2012, Volume 3, Issue 1, pp. 1079 - 1079
The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is... 
RECOMBINANT INBRED MICE | MULTIDISCIPLINARY SCIENCES | VOLUME | COMPLEX TRAIT ANALYSIS | MAMMALIAN BRAINS | PRIMATES | HOMO-FLORESIENSIS | Biological Evolution | Brain - metabolism | Animals | Brain - anatomy & histology | Body Size - physiology | Organ Size - genetics | Organ Size - physiology | Body Size - genetics | Mice | Index Medicus
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4. Full Text Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
by Qian, Xuyu and Nguyen, Ha Nam and Song, Hongjun and Song, Mingxi M and Hadiono, Christopher and Ogden, Sarah C and Hammack, Christy and Yao, Bing and Hamersky, Gregory R and Jacob, Fadi and Zhong, Chun and Yoon, Ki-jun and Jeang, William and Lin, Li and Li, Yujing and Thakor, Jai and Berg, Daniel A and Zhang, Ce and Kang, Eunchai and Chickering, Michael and Nauen, David and Ho, Cheng-Ying and Wen, Zhexing and Christian, Kimberly M and Shi, Pei-Yong and Maher, Brady J and Wu, Hao and Jin, Peng and Tang, Hengli and Ming, Guo-li
Cell, ISSN 0092-8674, 05/2016, Volume 165, Issue 5, pp. 1238 - 1254
Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new platform to investigate human brain development. High cost, variability,... 
HUMAN NEOCORTEX | MICROGRAVITY | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE | DYSREGULATION | NEURONS | SCHIZOPHRENIA | DIFFERENTIATION | SELF-ORGANIZATION | HYPOTHALAMUS | CELL BIOLOGY | Brain - cytology | Embryo, Mammalian | Zika Virus Infection - physiopathology | Humans | Zika Virus - physiology | Neurons - cytology | Embryonic Development | Neurogenesis | Zika Virus Infection - virology | Bioreactors | Cell Culture Techniques - economics | Models, Biological | Induced Pluripotent Stem Cells | Organoids - virology | Antiviral agents | Medical colleges | Neurosciences | Developmental biology | Neurons | Cell death | Analysis | Models | Gene expression | Health aspects | Biomedical engineering | Index Medicus
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5. Full Text Brain reorganization, not relative brain size, primarily characterizes anthropoid brain evolution
by Smaers, J.B and Soligo, C
Proceedings of the Royal Society B: Biological Sciences, ISSN 0962-8452, 05/2013, Volume 280, Issue 1759, pp. 20130269 - 20130269
Comparative analyses of primate brain evolution have highlighted changes in size and internal organization as key factors underlying species diversity. It... 
Cerebellum | Primates | Brain evolution | Variable rates method | Prefrontal | Hippocampus | primates | hippocampus | WHITE-MATTER | PRIMATE | ENCEPHALIZATION | BASAL-GANGLIA | MAMMALIAN BRAINS | INTRINSIC FUNCTIONAL CONNECTIVITY | CEREBELLAR LOOPS | cerebellum | PREFRONTAL CORTEX | CEREBRAL-CORTEX | EVOLUTIONARY BIOLOGY | CELLULAR SCALING RULES | prefrontal | BIOLOGY | brain evolution | ECOLOGY | variable rates method | Biological Evolution | Motor Cortex - anatomy & histology | Multivariate Analysis | Animals | Haplorhini - anatomy & histology | Prefrontal Cortex - anatomy & histology | Female | Male | Cerebellum - anatomy & histology | Phylogeny | Principal Component Analysis | Index Medicus | 133 | 1001
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6. Full Text Cerebral organoids model human brain development and microcephaly
by Lancaster, Madeline A and Renner, Magdalena and Martin, Carol-Anne and Wenzel, Daniel and Bicknell, Louise S and Hurles, Matthew E and Homfray, Tessa and Penninger, Josef M and Jackson, Andrew P and Knoblich, Juergen A
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7467, pp. 373 - 379
The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human... 
HUMAN NEOCORTEX | IN-VITRO | OUTER SUBVENTRICULAR ZONE | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | SPINDLE ORIENTATION | MOUSE NEOCORTEX | 3-DIMENSIONAL CULTURE | SELF-FORMATION | MAMMALIAN NEUROGENESIS | EXTRINSIC SIGNALS | Neurons - pathology | Brain - anatomy & histology | Humans | Cerebral Cortex - pathology | Neurons - cytology | Brain - growth & development | Neural Stem Cells - cytology | Cerebral Cortex - cytology | Neurogenesis | Microcephaly - pathology | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - pathology | Brain - cytology | Organoids - pathology | Organoids - cytology | Neural Stem Cells - pathology | Animals | Cerebral Cortex - embryology | Organoids - growth & development | Models, Biological | Brain - pathology | Cerebral Cortex - growth & development | Mice | Organoids - embryology | Tissue Culture Techniques - methods | Research | Brain diseases | Brain | Population | Kinases | Pathogenesis | Methods | Index Medicus
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7. Full Text An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers
by Bomfim, Theresa R and Forny-Germano, Leticia and Sathler, Luciana B and Brito-Moreira, Jordano and Houzel, Jean-Christophe and Decker, Helena and Silverman, Michael A and Kazi, Hala and Melo, Helen M and McClean, Paula L and Holscher, Christian and Arnold, Steven E and Talbot, Konrad and Klein, William L and Munoz, Douglas P and Ferreira, Sergio T and De Felice, Fernanda G
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1339 - 1353
Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer's disease (AD). Although a connection... 
MAMMALIAN TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | INTRANASAL INSULIN | RECEPTOR-DEPENDENT MECHANISM | AMYLOID-BETA | AXONAL-TRANSPORT | TNF-ALPHA | SYNAPTIC PLASTICITY | CULTURED HIPPOCAMPAL-NEURONS | PEPTIDE OLIGOMERS | TRANSGENIC MICE | Phosphorylation | Insulin - physiology | Humans | Middle Aged | Macaca fascicularis | Memory Disorders - metabolism | Male | Hippocampus - drug effects | Insulin Receptor Substrate Proteins - metabolism | Infliximab | Alzheimer Disease - prevention & control | Aged, 80 and over | Female | Neurons - metabolism | Neurons - drug effects | Alzheimer Disease - psychology | Hypoglycemic Agents - therapeutic use | Cells, Cultured - drug effects | Amyloid beta-Peptides - toxicity | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Insulin Resistance | Rats | Mice, Transgenic | Hippocampus - pathology | Hippocampus - cytology | Maze Learning - drug effects | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Hippocampus - metabolism | Memory Disorders - prevention & control | Animals | MAP Kinase Signaling System - drug effects | Memory Disorders - etiology | Alzheimer Disease - metabolism | Venoms - therapeutic use | Aged | Cells, Cultured - metabolism | Mice | Protein Processing, Post-Translational | Venoms - pharmacology | Alzheimer Disease - genetics | Peptides - therapeutic use | Index Medicus | Abridged Index Medicus
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8. Full Text The human brain in numbers: A linearly scaled-up primate brain
by Herculano-Houzel, Suzana
Frontiers in Human Neuroscience, ISSN 1662-5161, 11/2009, Volume 3, pp. 31 - 31
The human brain has often been viewed as outstanding among mammalian brains: the most cognitively able, the largest-than-expected from body size, endowed with... 
Brain scaling | Human | Encephalization | Number of neurons | brain scaling | number of neurons | COGNITIVE-ABILITY | WHITE-MATTER | FRONTAL-CORTEX | MAMMALIAN BRAINS | encephalization | VON ECONOMO NEURONS | NEUROSCIENCES | CEREBRAL-CORTEX | PSYCHOLOGY | CELLULAR SCALING RULES | EVOLUTION | CEREBELLAR CORTEX | GREAT APES | human
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9. Full Text Methylomic trajectories across human fetal brain development
by Spiers, Helen and Hannon, Eilis and Schalkwyk, Leonard C and Smith, Rebecca and Wong, Chloe C. Y and O'Donovan, Michael C and Bray, Nicholas J and Mill, Jonathan
Genome Research, ISSN 1088-9051, 03/2015, Volume 25, Issue 3, pp. 338 - 352
Epigenetic processes play a key role in orchestrating transcriptional regulation during development. The importance of DNA methylation in fetal brain... 
MEMORY FORMATION | TRANSCRIPTOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN PREFRONTAL CORTEX | MAMMALIAN DEVELOPMENT | INTRAGENIC DNA METHYLATION | AUTISM SPECTRUM DISORDERS | HUMAN GENOME | DE-NOVO MUTATIONS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | EPIGENETIC REGULATION | SEX-DIFFERENCES | Autistic Disorder - genetics | Brain - embryology | Genome-Wide Association Study | Epigenesis, Genetic | Humans | Regulatory Sequences, Nucleic Acid | Male | Gene Expression Profiling | Brain - metabolism | Pregnancy | DNA Methylation | Schizophrenia - genetics | Epigenomics - methods | Base Composition | Organogenesis - genetics | Sex Factors | CpG Islands | Female | Fetal Development - genetics | Cluster Analysis | Index Medicus | Research
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10. Full Text Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce -Synuclein Phosphorylation in Rat Brain
by Aubele, DL and Hom, RK and Adler, M and Galemmo, RA and Bowers, S and Truong, AP and Pan, H and Beroza, P and Neitz, RJ and Yao, NH and Lin, M and Tonn, G and Zhang, H and Bova, MP and Ren, Z and Tam, D and Ruslim, L and Baker, J and Diep, L and Fitzgerald, K and Hoffman, J and Motter, R and Fauss, D and Tanaka, P and Dappen, M and Jagodzinski, J and Chan, WM and Konradi, AW and Latimer, L and Zhu, YL and Sham, HL and Anderson, JP and Bergeron, M and Artis, DR
CHEMMEDCHEM, ISSN 1860-7179, 08/2013, Volume 8, Issue 8, pp. 1295 - 1313
Polo-like kinase-2 (Plk-2) has been implicated as the dominant kinase involved in the phosphorylation of alpha-synuclein in Lewy bodies, which are one of the... 
CHEMISTRY, MEDICINAL | Parkinson's disease | POLO-LIKE-KINASE-1 | ALPHA-SYNUCLEIN | computational chemistry | SYNAPTIC PLASTICITY | MAMMALIAN-CELLS | CANCER-THERAPY | SNK | kinase inhibitors | polo-like kinase-2 | DNA | IN-VIVO | PHARMACOLOGY & PHARMACY | FREE-ENERGY | medicinal chemistry | PARKINSONS-DISEASE | Brain | Sports injuries | Polo | Lubrication and lubricants | Phosphorylation | Parkinsons disease
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11. Full Text Mesenchymal Stem Cells Protect Against Hypoxia‐Ischemia Brain Damage by Enhancing Autophagy Through Brain Derived Neurotrophic Factor/Mammalin Target of Rapamycin Signaling Pathway
by Zheng, Zhen and Zhang, Li and Qu, Yi and Xiao, Guoguang and Li, Shiping and Bao, Shan and Lu, Q. Richard and Mu, Dezhi
STEM CELLS, ISSN 1066-5099, 07/2018, Volume 36, Issue 7, pp. 1109 - 1121
Hypoxic‐ischemic encephalopathy (HIE) is a serious disease for neonates. However, present therapeutic strategies are not effective enough for treating HIE.... 
Brain damage | Brain derived neurotrophic factor | Autophagy | Hypoxia‐ischemia | Mammalian target of rapamycin | Mesenchymal stem cells | Hypoxia-ischemia | APOPTOSIS | DEVELOPING RAT-BRAIN | DEATH | MTOR | NEUROPROTECTION | BETA | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DISEASE | NEURONS | HEMATOLOGY | PROMOTES | Ischemia | Neurons | Cell death | Analysis | Stem cells | Rapamycin | TOR protein | Neonates | Neuroprotection | Brain | Mesenchyme | Stem cell transplantation | Transplantation | Signal transduction | Allografts | Encephalopathy | Rodents | Cortex | Lactate dehydrogenase | L-Lactate dehydrogenase | Injury prevention | Brain-derived neurotrophic factor | Hypoxia | Lactic acid | Brain injury | Phagocytosis
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12. Full Text Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis
by Taliaz, D and Stall, N and Dar, D.E and Zangen, A
Molecular Psychiatry, ISSN 1359-4184, 01/2010, Volume 15, Issue 1, pp. 80 - 92
Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. In addition, animal studies suggest an... 
Depression | Lentiviral vector | Brain-derived neurotrophic factor | Short hairpin RNA | Neurogenesis | Hippocampus | hippocampus | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SHORT-INTERFERING RNAS | MAJOR DEPRESSION | ANTIDEPRESSANT DRUGS | MAMMALIAN-CELLS | NEUROSCIENCES | lentiviral vector | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | MESSENGER-RNA | GRANULE CELL PRECURSORS | short hairpin RNA | neurogenesis | brain-derived neurotrophic factor | depression | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | Brain-Derived Neurotrophic Factor - antagonists & inhibitors | Brain-Derived Neurotrophic Factor - genetics | Depression - physiopathology | Depression - pathology | Microtubule-Associated Proteins - metabolism | Humans | Microinjections - methods | Male | Brain - metabolism | Transfection - methods | Swimming - psychology | Glioma - pathology | Exploratory Behavior - drug effects | Statistics, Nonparametric | Brain-Derived Neurotrophic Factor - metabolism | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Disease Models, Animal | Locomotion - drug effects | Sucrose - administration & dosage | Cell Line | Food Preferences - drug effects | RNA, Small Interfering - pharmacology | Rats | Neuropeptides - metabolism | Maze Learning - drug effects | Rats, Sprague-Dawley | Brain - drug effects | Animals | Neurogenesis - physiology | RNA, Small Interfering - therapeutic use | Depression - therapy | Locomotion - physiology | Sweetening Agents - administration & dosage | Depression, Mental | Physiological aspects | Research | Drug therapy | Risk factors | Index Medicus | Original
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