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Neurotoxicology, ISSN 0161-813X, 09/2017, Volume 62, pp. 24 - 29
Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased... 
Pyrethroids | Plasma protein binding | Developmental neurotoxicity | Brain uptake | Deltamethrin | Blood–brain barrier | PENETRATION | PYRETHROID INSECTICIDES | CEREBROSPINAL-FLUID | Blood brain barrier | REFERENCE-VALUES | NEUROTOXICITY | NEUROSCIENCES | ADULT | CHILDREN | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPOSURE | AGE | Brain - embryology | Age Factors | Embryo, Mammalian | Humans | Brain - enzymology | Child, Preschool | Infant | Male | Blood Proteins - metabolism | Nitriles - pharmacokinetics | Brain - metabolism | Dose-Response Relationship, Drug | Protein Binding - drug effects | Female | Fetus | Blood-Brain Barrier - growth & development | Pyrethrins - metabolism | Infant, Newborn | Animals, Newborn | Nitriles - metabolism | Blood-Brain Barrier - embryology | Rats | Rats, Sprague-Dawley | Pyrethrins - pharmacokinetics | Blood-Brain Barrier - metabolism | Brain - drug effects | Pregnancy | Albumins - pharmacology | Animals | Insecticides - metabolism | Insecticides - pharmacokinetics | Brain | Medical colleges | Permeability | Blood proteins | Protein binding | Albumin | Insecticides | Binding | Human serum albumin | Permethrin | Membrane permeability | Serum albumin | Blood plasma | Studies | Neurotoxicity | Blood-brain barrier | Agrochemicals | Rodents | Adults | Carotid artery | Deposition | Age | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 2012, Volume 3, Issue 1, pp. 1079 - 1079
The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is... 
RECOMBINANT INBRED MICE | MULTIDISCIPLINARY SCIENCES | VOLUME | COMPLEX TRAIT ANALYSIS | MAMMALIAN BRAINS | PRIMATES | HOMO-FLORESIENSIS | Biological Evolution | Brain - metabolism | Animals | Brain - anatomy & histology | Body Size - physiology | Organ Size - genetics | Organ Size - physiology | Body Size - genetics | Mice | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 05/2016, Volume 165, Issue 5, pp. 1238 - 1254
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1339 - 1353
Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer's disease (AD). Although a connection... 
MAMMALIAN TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | INTRANASAL INSULIN | RECEPTOR-DEPENDENT MECHANISM | AMYLOID-BETA | AXONAL-TRANSPORT | TNF-ALPHA | SYNAPTIC PLASTICITY | CULTURED HIPPOCAMPAL-NEURONS | PEPTIDE OLIGOMERS | TRANSGENIC MICE | Phosphorylation | Insulin - physiology | Humans | Middle Aged | Macaca fascicularis | Memory Disorders - metabolism | Male | Hippocampus - drug effects | Insulin Receptor Substrate Proteins - metabolism | Infliximab | Alzheimer Disease - prevention & control | Aged, 80 and over | Female | Neurons - metabolism | Neurons - drug effects | Alzheimer Disease - psychology | Hypoglycemic Agents - therapeutic use | Cells, Cultured - drug effects | Amyloid beta-Peptides - toxicity | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Insulin Resistance | Rats | Mice, Transgenic | Hippocampus - pathology | Hippocampus - cytology | Maze Learning - drug effects | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Hippocampus - metabolism | Memory Disorders - prevention & control | Animals | MAP Kinase Signaling System - drug effects | Memory Disorders - etiology | Alzheimer Disease - metabolism | Venoms - therapeutic use | Aged | Cells, Cultured - metabolism | Mice | Protein Processing, Post-Translational | Venoms - pharmacology | Alzheimer Disease - genetics | Peptides - therapeutic use | Index Medicus | Abridged Index Medicus
Journal Article
Frontiers in Human Neuroscience, ISSN 1662-5161, 11/2009, Volume 3, pp. 31 - 31
The human brain has often been viewed as outstanding among mammalian brains: the most cognitively able, the largest-than-expected from body size, endowed with... 
Brain scaling | Human | Encephalization | Number of neurons | brain scaling | number of neurons | COGNITIVE-ABILITY | WHITE-MATTER | FRONTAL-CORTEX | MAMMALIAN BRAINS | encephalization | VON ECONOMO NEURONS | NEUROSCIENCES | CEREBRAL-CORTEX | PSYCHOLOGY | CELLULAR SCALING RULES | EVOLUTION | CEREBELLAR CORTEX | GREAT APES | human
Journal Article
CHEMMEDCHEM, ISSN 1860-7179, 08/2013, Volume 8, Issue 8, pp. 1295 - 1313
Polo-like kinase-2 (Plk-2) has been implicated as the dominant kinase involved in the phosphorylation of alpha-synuclein in Lewy bodies, which are one of the... 
CHEMISTRY, MEDICINAL | Parkinson's disease | POLO-LIKE-KINASE-1 | ALPHA-SYNUCLEIN | computational chemistry | SYNAPTIC PLASTICITY | MAMMALIAN-CELLS | CANCER-THERAPY | SNK | kinase inhibitors | polo-like kinase-2 | DNA | IN-VIVO | PHARMACOLOGY & PHARMACY | FREE-ENERGY | medicinal chemistry | PARKINSONS-DISEASE | Brain | Sports injuries | Polo | Lubrication and lubricants | Phosphorylation | Parkinsons disease
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 01/2010, Volume 15, Issue 1, pp. 80 - 92
Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. In addition, animal studies suggest an... 
Depression | Lentiviral vector | Brain-derived neurotrophic factor | Short hairpin RNA | Neurogenesis | Hippocampus | hippocampus | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SHORT-INTERFERING RNAS | MAJOR DEPRESSION | ANTIDEPRESSANT DRUGS | MAMMALIAN-CELLS | NEUROSCIENCES | lentiviral vector | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | MESSENGER-RNA | GRANULE CELL PRECURSORS | short hairpin RNA | neurogenesis | brain-derived neurotrophic factor | depression | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | Brain-Derived Neurotrophic Factor - antagonists & inhibitors | Brain-Derived Neurotrophic Factor - genetics | Depression - physiopathology | Depression - pathology | Microtubule-Associated Proteins - metabolism | Humans | Microinjections - methods | Male | Brain - metabolism | Transfection - methods | Swimming - psychology | Glioma - pathology | Exploratory Behavior - drug effects | Statistics, Nonparametric | Brain-Derived Neurotrophic Factor - metabolism | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Disease Models, Animal | Locomotion - drug effects | Sucrose - administration & dosage | Cell Line | Food Preferences - drug effects | RNA, Small Interfering - pharmacology | Rats | Neuropeptides - metabolism | Maze Learning - drug effects | Rats, Sprague-Dawley | Brain - drug effects | Animals | Neurogenesis - physiology | RNA, Small Interfering - therapeutic use | Depression - therapy | Locomotion - physiology | Sweetening Agents - administration & dosage | Depression, Mental | Physiological aspects | Research | Drug therapy | Risk factors | Index Medicus | Original
Journal Article