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Journal Article
Hepatology, ISSN 0270-9139, 06/2018, Volume 67, Issue 6, pp. 2397 - 2413
unc‐51‐like autophagy activating kinase 1 and 2 (Ulk1/2) regulate autophagy initiation under various stress conditions. However, the physiological functions of... 
ACTIVATION | GLUTATHIONE | PATHWAY | PHOSPHORYLATION | FIP200 | AUTOPHAGOSOME FORMATION | ULK1 | MECHANISMS | GASTROENTEROLOGY & HEPATOLOGY | TERMINAL KINASE | INDUCED HEPATOTOXICITY | TOR protein | Phosphorylation | Phenotypes | Liver | Rapamycin | Kinases | Autophagy | Hepatocytes | Analgesics | Cell death | Protein kinase | Acetaminophen | Rodents | Hepatotoxicity | Phagocytosis | Index Medicus
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 10/2008, Volume 295, Issue 4, pp. 833 - 842
Alcoholic fatty liver is associated with inhibition of sirtuin 1 (SIRT1) and AMP-activated kinase (AMPK), two critical signaling molecules regulating the... 
Sirtuin 1 | Alcoholic liver steatosis | Acetylation | Lipid metabolism | Peroxisome proliferator-activated receptor γ coactivator α | AMP-activated kinase | Sterol regulatory element-binding protein 1c | sirtuin 1 | DIETARY SATURATED FAT | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | LIPID-METABOLISM | alcoholic liver steatosis | lipid metabolism | MITOCHONDRIAL-FUNCTION | ENDOPLASMIC-RETICULUM STRESS | peroxisome proliferator-activated receptor gamma coactivator alpha | acetylation | sterol regulatory element-binding protein 1c | MAMMALIAN SIRTUIN-1 | TRANSCRIPTION FACTOR FOXO1 | INDUCED OXIDATIVE STRESS | ADIPONECTIN SECRETION | GASTROENTEROLOGY & HEPATOLOGY | CALORIE RESTRICTION | Up-Regulation | Ethanol - toxicity | Stilbenes - therapeutic use | Mice, Inbred C57BL | Receptors, Adiponectin - metabolism | Male | Sirtuins - biosynthesis | Animals | Adenylate Kinase - metabolism | Fatty Liver, Alcoholic - drug therapy | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | Adiponectin - metabolism | Trans-Activators - metabolism | Mice | Transcription Factors | Oxidative Stress - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Index Medicus | Liver and Biliary Tract | peroxisome proliferator-activated receptor γ coactivator α
Journal Article
Cell Cycle, ISSN 1538-4101, 06/2015, Volume 14, Issue 11, pp. 1631 - 1642
Apoptosis is a primary characteristic in the pathogenesis of liver disease. Hepatic apoptosis is regulated by autophagic activity. However, mechanisms... 
apoptosis | liver injury | autophagy | mechanism | cross-talk | Autophagy | Mechanism | Cross-talk | Apoptosis | Liver injury | HBV, hepatitis B virus | Atg, autophagy-related gene | AMBRA-1, activating molecule in Beclin-1-regulated autophagy | PROTEIN | CHAPERONE-MEDIATED AUTOPHAGY | ER stress, endoplasmic reticulum stress | CELL BIOLOGY | DRAM, damage regulated autophagic modulator | BECLIN | mTOR, mammalian target of rapamycin | FADD, Fas-associated protein with death domain | MDBs, Mallory-Denk bodies | DISC, death-inducing signaling complex | BH3, Bcl-2 homology domain-3 | RNA, ribonucleic acid | Drp1, dynamin-related protein 1 | REGULATES AUTOPHAGY | Bcl-x(L), B-cell lymphoma extra long | CELL-DEATH | DNA, DNA | TNF alpha, tumor necrosis factor-alpha | LAMP-2, lysosome-associated membrane protein 2 | Vps34, vacuolar protein sorting-34 | HSC, hepatic stellate cells | TUMOR-SUPPRESSOR | DEGRADATION | STRESS-INDUCED AUTOPHAGY | PCD, programmed cell death | BNIP, Bcl-2/adenovirus E1B 19 k(d)-interacting protein | HCV, hepatitis C virus | LD, lipid droplets | UVRAG, UV-resistance-associated gene | TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling | APAP, N-acetyl-p-aminophenol | Bcl-2, B-cell lymphoma-2 | HEPATOCELLULAR-CARCINOMA | FFA, free fatty acids | ROS, reactive oxygen species | Microtubule LC3, microtubule light chain 3 | ATP, adenosine triphosphate | Beclin-1, Bcl-2-interacting protein-1 | c-FLIP, cellular FLICE-like inhibitor protein | ALT, alanine aminotransferase | MOMP, mitochondrial outer membrane permiabilization | HBx, hepatitis B X protein | Barkor, Beclin-1-associated autophagy-related key regulator | CSE, cigarette smoke extract | PI3KC3, phosphatidylinositol-3-kinase class-3 | siRNA, small interfering RNA | HCC, hepatocellular carcinoma | C-FLIPL | Models, Biological | Humans | Signal Transduction - physiology | Autophagy - physiology | Apoptosis - physiology | Liver Diseases - physiopathology | Receptor Cross-Talk - physiology | Disease Progression
Journal Article
Journal Article