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Current Medicinal Chemistry, ISSN 0929-8673, 01/2015, Volume 22, Issue 3, pp. 373 - 404
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2017, Volume 25, Issue 12, pp. 3006 - 3017
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2017, Volume 25, Issue 2, pp. 633 - 645
In the brains of patients with Alzheimer's disease, the enzymatic activities of butyrylcholinesterase (BChE) and monoamine oxidase B (MAO-B) are increased.... 
MAO-B inhibitors | Multitarget-directed ligands | Alzheimer's disease | Butyrylcholinesterase inhibitors | CHOLINESTERASE | TARGET | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PLAQUES | DISCOVERY | STRATEGIES | DISEASE | MAO | INHIBITORS | Amyloid beta-Peptides - pharmacology | Humans | Cholinesterase Inhibitors - chemistry | Peptide Fragments - pharmacology | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Dose-Response Relationship, Drug | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Molecular Structure | Cell Death - drug effects | Naphthalenes - chemical synthesis | Naphthalenes - chemistry | Cell Line | Monoamine Oxidase Inhibitors - pharmacology | Peptide Fragments - metabolism | Piperidines - chemistry | Sulfonamides - chemistry | Alzheimer Disease - drug therapy | Piperidines - chemical synthesis | Sulfonamides - pharmacology | Naphthalenes - pharmacology | Sulfonamides - chemical synthesis | Amyloid beta-Peptides - antagonists & inhibitors | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Monoamine Oxidase Inhibitors - chemistry | Monoamine Oxidase - metabolism | Drug therapy | Sulfonamides | Index Medicus | Life Sciences | Biomolecules | Biochemistry, Molecular Biology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2007, Volume 50, Issue 23, pp. 5848 - 5852
Journal Article
CNS and Neurological Disorders - Drug Targets, ISSN 1871-5273, 05/2017, Volume 16, Issue 4, pp. 425 - 439
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 33 - 47
A series of novel propargylamine-modified pyrimidinylthiourea derivatives ( ) were designed and synthesized as multifunctional agents for Alzheimer's disease... 
Multifunctional agents | MAO-B inhibitors | Metal chelating agents | Alzheimer's disease | AChE inhibitors | MONOAMINE-OXIDASE | CHEMISTRY, MEDICINAL | A-BETA PEPTIDE | CHOLINESTERASE-INHIBITORS | DIRECTED LIGANDS | NEURODEGENERATIVE DISEASES | ACETYLCHOLINESTERASE | CHELATION-THERAPY | AMYLOID-BETA | HYPOTHESIS | BRAIN | Pyrimidines - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Imidazoles - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Thiourea - pharmacology | Monoamine Oxidase Inhibitors - chemical synthesis | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Pargyline - analogs & derivatives | Butyrylcholinesterase - metabolism | Thiourea - chemical synthesis | Scopolamine Hydrobromide | Molecular Structure | Cognitive Dysfunction - drug therapy | Propylamines - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Pargyline - chemistry | Alzheimer Disease - drug therapy | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Thiourea - chemistry | Drug Discovery | Animals | Cholinesterase Inhibitors - pharmacology | Pargyline - pharmacology | Mice | Monoamine Oxidase Inhibitors - chemistry | Propylamines - pharmacology | Cognitive Dysfunction - chemically induced | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Antioxidants | Monoamine oxidase | Enzyme inhibitors | Pharmacy | Permeability | Drug therapy | Derivatives (Financial instruments)
Journal Article