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Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 183 - 196
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 5, pp. 3381 - 3391
Journal Article
Journal Article
Journal Article
The Plant Cell, ISSN 1040-4651, 5/2012, Volume 24, Issue 5, pp. 2225 - 2236
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 4, pp. 1311 - 1321
Background & Aims: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure. C-jun N-terminal kinase (JNK) is thought to play a... 
Gastroenterology and Hepatology | JNK ACTIVATION | APOPTOSIS | GAMMA-RADIATION | PROTEIN-KINASE | MAP KINASES | TNF-ALPHA | STRESS | GASTROENTEROLOGY & HEPATOLOGY | ISOLATED MOUSE HEPATOCYTES | CELL-DEATH | INDUCED HEPATOTOXICITY | Drug Overdose - metabolism | Hepatocytes - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Mitogen-Activated Protein Kinase 9 - genetics | Drug Overdose - pathology | Acetaminophen - poisoning | Mitogen-Activated Protein Kinase 8 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinase 5 - metabolism | Chemical and Drug Induced Liver Injury - pathology | Disease Models, Animal | Drug Overdose - physiopathology | MAP Kinase Kinase Kinase 5 - genetics | Mitogen-Activated Protein Kinase 9 - metabolism | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 8 - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Chemical and Drug Induced Liver Injury - physiopathology | Mice, Knockout | Gene Expression Regulation, Enzymologic | Animals | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Signal Transduction - physiology | Mice | Analgesics, Non-Narcotic - poisoning | Hepatocytes - enzymology | Liver diseases | Protein kinases | Liver | Glutathione | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2008, Volume 26, Issue 13, pp. 2139 - 2146
Purpose To assess the tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of the mitogenactivated protein kinase kinase (MEK) 1/2 inhibitor... 
MEK INHIBITOR | POTENT | VIVO | ONCOLOGY | PATHWAY | GROWTH | COLON | TUMORS | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins p21(ras) | Humans | Middle Aged | Melanoma - enzymology | Male | Antineoplastic Agents - administration & dosage | Extracellular Signal-Regulated MAP Kinases - metabolism | Protein Kinase Inhibitors - adverse effects | Dose-Response Relationship, Drug | Benzimidazoles - administration & dosage | Neoplasms - genetics | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Melanoma - genetics | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Benzimidazoles - adverse effects | Protein Kinase Inhibitors - pharmacokinetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Leukocytes, Mononuclear - drug effects | Drug Administration Schedule | Administration, Oral | Benzimidazoles - pharmacokinetics | Neoplasms - enzymology | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins - genetics | Treatment Outcome | MAP Kinase Kinase 2 - metabolism | Melanoma - pathology | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Maximum Tolerated Dose | Ki-67 Antigen - analysis | MAP Kinase Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Leukocytes, Mononuclear - enzymology | Aged | Cell Proliferation - drug effects | Mutation | Neoplasm Staging | Neoplasms - pathology | Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3566 - 3578
The MAP kinase kinase kinase TGF beta-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGF beta and in turn activates IKK-NF-kappa beta and JNK,... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | HEPATOCELLULAR-CARCINOMA | ACTIVATED PROTEIN-KINASE | LIPID-METABOLISM | TAK1 | INSULIN-RESISTANCE | IN-VIVO | NF-KAPPA-B | CANCER | HEPATOCYTE-SPECIFIC DELETION | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Autophagy - physiology | Hepatocytes - metabolism | Liver Neoplasms, Experimental - prevention & control | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Liver Neoplasms, Experimental - metabolism | Multiprotein Complexes - metabolism | Hepatocytes - cytology | MAP Kinase Kinase Kinases - deficiency | Liver Neoplasms, Experimental - genetics | Fatty Acids - metabolism | Hepatocytes - drug effects | Fatty Liver - genetics | Fatty Liver - metabolism | Oxidation-Reduction | MAP Kinase Kinase Kinases - genetics | Mice, Inbred C57BL | Fatty Liver - prevention & control | Mice, Transgenic | MAP Kinase Kinase Kinases - metabolism | Sirolimus - pharmacology | Mice, Knockout | Animals | Mice | PPAR alpha - metabolism | Prevention | Autophagy (Cytology) | Liver diseases | Physiological aspects | Biological oxidation (Metabolism) | Research | Protein kinases | Studies | Phosphorylation | Rodents | Liver | Lipids | Biosynthesis | Tumorigenesis | Kinases | Laboratory animals | Gene expression | Autophagy
Journal Article
Journal of Diabetes Investigation, ISSN 2040-1116, 07/2017, Volume 8, Issue 4, pp. 434 - 445
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19900 - 19909
Accumulating evidence suggests that activation of mitogen-activated protein kinases (MAPKs) and nuclear factor NF-kappa B exacerbates early brain injury (EBI)... 
SIGNALING PATHWAYS | VASOSPASM | LEARNING-DEFICITS | PHOSPHORYLATION | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | MECHANISMS | NF-KAPPA-B | EXPRESSION | PROTECTS | Neurons - pathology | Phosphorylation | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Injections, Intraventricular | Male | Cerebrovascular Trauma - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Transcription Factor RelA - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | MAP Kinase Kinase 4 - metabolism | Neuroprotective Agents - pharmacology | I-kappa B Proteins - antagonists & inhibitors | MAP Kinase Kinase 4 - antagonists & inhibitors | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinases - antagonists & inhibitors | Neurons - drug effects | Subarachnoid Hemorrhage - drug therapy | Disease Models, Animal | NF-KappaB Inhibitor alpha | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Gene Expression Regulation | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Zearalenone - analogs & derivatives | MAP Kinase Kinase Kinases - metabolism | Subarachnoid Hemorrhage - genetics | Subarachnoid Hemorrhage - pathology | Rats, Sprague-Dawley | Stereotaxic Techniques | Subarachnoid Hemorrhage - metabolism | Animals | Transcription Factor RelA - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cerebrovascular Trauma - pathology | MAP Kinase Kinase 4 - genetics | Cerebrovascular Trauma - prevention & control | Protein Kinase Inhibitors - pharmacology | Cerebrovascular Trauma - genetics | Zearalenone - pharmacology | TAK1 | neuroprotection | 5Z-7-oxozeaenol | subarachnoid hemorrhage | Neurobiology | mitogen-activated protein kinase (MAPK) | apoptosis | brain | NF-κB (NF-KB)
Journal Article