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Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer | Index Medicus
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 12/2004, Volume 11, Issue 12, pp. 1192 - 1197
Journal Article
Science, ISSN 0036-8075, 02/2017, Volume 355, Issue 6327, pp. 836 - 842
Journal Article
Journal Article
ChemBioChem, ISSN 1439-4227, 08/2017, Volume 18, Issue 16, pp. 1593 - 1598
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2015, Volume 290, Issue 44, pp. 26661 - 26674
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2017, Volume 474, Issue 4, pp. 597 - 609
Cyclic AMP (cAMP)-specific phosphodiesterase-4 (PDE4) enzymes underpin compartmentalised cAMP signalling by localising to distinct signalling complexes. PDE4... 
CELLS | SIGNALING PATHWAYS | ACTIVATION | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-MEDIATED PHOSPHORYLATION | BETA-ARRESTIN | BINDING-SITES | ROLIPRAM INHIBITION | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Intracellular Signaling Peptides and Proteins - genetics | 1-Alkyl-2-acetylglycerophosphocholine Esterase - chemistry | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Recombinant Proteins - chemistry | Ubiquitin-Conjugating Enzymes - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | Molecular Docking Simulation | Protein-Serine-Threonine Kinases - chemistry | src-Family Kinases - genetics | COS Cells | Mitogen-Activated Protein Kinase 1 - metabolism | Microtubule-Associated Proteins - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | beta-Arrestins - metabolism | Cercopithecus aethiops | Ubiquitin-Conjugating Enzymes - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics | HEK293 Cells | src-Family Kinases - metabolism | Protein Interaction Domains and Motifs | Mitogen-Activated Protein Kinase 3 - chemistry | beta-Arrestins - chemistry | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Catalytic Domain | Protein Structure, Secondary | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - genetics | Amino Acid Motifs | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | beta-Arrestins - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | src-Family Kinases - chemistry | Index Medicus | protein–protein interactions | cAMP | cyclic nucleotide phosphodiesterases
Journal Article
FEBS Letters, ISSN 0014-5793, 01/2016, Volume 590, Issue 1, pp. 148 - 160
Coordination and cross talks of MAPK pathways are critical for signaling efficiency, but their mechanisms are not well understood. Slt2, the MAP kinase of cell... 
Slt2 | heat stress | budding yeast | Ste11 | pheromone stress | Nst1 | the cell wall integrity pathway | Saccharomyces cerevisiae | Mkk1/2 | MAP kinase cascades | budding yeast Saccharomyces cerevisiae | Mkk1 | HOG | PROTEIN-KINASE-C | SIGNALING PATHWAYS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | YEAST SACCHAROMYCES-CEREVISIAE | HEAT-STRESS | MODULES | BIOPHYSICS | GENE | GROWTH | PCR | Mitogen-Activated Protein Kinase Kinases - genetics | Green Fluorescent Proteins - genetics | Cell Wall - enzymology | Recombinant Fusion Proteins - metabolism | MAP Kinase Kinase 1 - chemistry | Mitogen-Activated Protein Kinases - chemistry | MAP Kinase Kinase 1 - genetics | MAP Kinase Kinase Kinases - chemistry | Mitogen-Activated Protein Kinase Kinases - metabolism | Gene Deletion | Protein Interaction Domains and Motifs | Stress, Physiological - drug effects | Phosphorylation - drug effects | Green Fluorescent Proteins - chemistry | Peptide Fragments - genetics | Green Fluorescent Proteins - metabolism | Hemagglutinins, Viral - metabolism | Peptide Fragments - metabolism | Saccharomyces cerevisiae - physiology | Pheromones - pharmacology | Hot Temperature - adverse effects | MAP Kinase Kinase Kinases - genetics | Hemagglutinins, Viral - genetics | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase Kinases - metabolism | Recombinant Fusion Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Mitogen-Activated Protein Kinase Kinases - chemistry | Peptide Fragments - chemistry | Hemagglutinins, Viral - chemistry | MAP Kinase Signaling System - drug effects | Cell Wall - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Mitogen-Activated Protein Kinases - genetics | Protein Processing, Post-Translational | Mutation | Saccharomyces cerevisiae Proteins - agonists | Amino Acid Substitution | Mitogen-Activated Protein Kinases - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2014, Volume 25, Issue 5, pp. 697 - 710
MEK inhibitors are clinically active in BRAF melanomas but only marginally so in KRAS mutant tumors. Here, we found that MEK inhibitors suppress ERK signaling... 
LUNG-CANCER | CELLS | MELANOMA | ONCOLOGY | KINASE | C-RAF | IMPROVED SURVIVAL | BRAF | B-RAF | MUTATIONS | FEEDBACK INHIBITION | CELL BIOLOGY | Surface Plasmon Resonance | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Melanoma - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | MAP Kinase Kinase 1 - chemistry | MAP Kinase Kinase 1 - genetics | Diphenylamine - analogs & derivatives | RNA Interference | Melanoma - genetics | TNF Receptor-Associated Factor 3 - genetics | HEK293 Cells | Indoles - pharmacology | Pyrimidinones - pharmacology | Benzamides - pharmacology | Phosphorylation - drug effects | Cell Line | MAP Kinase Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | TNF Receptor-Associated Factor 3 - metabolism | Sulfonamides - pharmacology | Coumarins - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Pyridones - pharmacology | Analysis | Melanoma | Tumors | Index Medicus
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 10/2017, Volume 15, Issue 10, pp. 1431 - 1444
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2004, Volume 381, Issue 3, pp. 675 - 683
Many intracellular signalling events are accompanied by generation of reactive oxygen species in cells. Oxidation of protein thiol groups is an emerging theme... 
Redox | Oxidative stress | Glutathionylation | Apoptosis signal-regulating kinase 1 (ASK1) | MEKK1 | S-thiolation | apoptosis signal-regulating kinase 1 (ASK1) | ACTIVATED PROTEIN-KINASE | glutathionylation | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYSTEINE SULFENIC ACID | redox | MENADIONE 2-METHYL-1,4-NAPHTHOQUINONE | CYTO-TOXICITY | TYROSINE-PHOSPHATASE 1B | ISOLATED HEPATOCYTES | REDOX REGULATION | CELL-MIGRATION | GROWTH-FACTOR | NF-KAPPA-B | oxidative stress | Catalytic Domain - drug effects | Oxidants - pharmacology | Lymph Nodes - pathology | Glutathione - metabolism | Humans | Oxidative Stress - physiology | Molecular Sequence Data | Male | Amino Acid Sequence - genetics | Alkylation | Lymph Nodes - enzymology | Mutation - physiology | Peptides - metabolism | MAP Kinase Kinase Kinase 1 - chemistry | Adenosine Triphosphate - metabolism | Binding Sites - physiology | Ethylmaleimide - pharmacology | Cysteine - metabolism | MAP Kinase Kinase Kinase 1 - antagonists & inhibitors | MAP Kinase Kinase Kinase 1 - physiology | Dithiothreitol - pharmacology | MAP Kinase Kinase Kinase 1 - metabolism | Protein Structure, Tertiary | Prostatic Neoplasms - pathology | Oxidation-Reduction | Peptides - chemistry | Peptides - physiology | Enzyme Inhibitors - pharmacology | Amino Acid Sequence - physiology | Oxidants - antagonists & inhibitors | Valine - metabolism | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Oxidative Stress - drug effects | Amino Acid Substitution | Index Medicus | TNF, tumour necrosis factor | cAPK, cyclic AMP-dependent protein kinase | CBD, chitin-binding domain | JNK, c-Jun N-terminal kinase | ERK kinase | DTT, dithiothreitol | MEKK1, MAPK (mitogen-activated protein kinase) | SAPK, stress-activated protein kinase | ASK1, apoptosis signal-regulating kinase 1 | EE epitope tag, MHEEEEYMPMEGPG (in the one-letter amino acid code) | SEK-KR, a catalytically inactive mutant of SEK in which K (lysine) has been mutated to arginine (R) | NEM, N-ethylmaleimide | GST, glutathione S-transferase | SNAP, S-nitroso-N-acetylpenicillamine | SEK, SAPK | IL1, interleukin 1 | ERK (extracellular-signal-regulated kinase) kinase kinase 1 | MS, tandem MS | LNCaP, lymph-node carcinoma of the prostate | HA, haemagglutinin | C1238V (etc.), Cys1238→Val (etc.) | MKK4, mitogen-activated protein kinase kinase 4 | NF-κB, nuclear factor NF-κB
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 9932 - 9943
G protein-coupled receptor 30 (GPR30), also called G protein-coupled estrogen receptor 1 (GPER1), is thought to play important roles in breast cancer and... 
ACTIVATION | COMPLEX | 30 GPR30 | CANCER CELLS | KINASE-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCINEURIN | SCAFFOLDS | ENDOCYTOSIS | PLASMA-MEMBRANE | ANCHORING PROTEIN | GTP-Binding Protein alpha Subunits, Gi-Go - agonists | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Receptors, Estrogen - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Receptors, G-Protein-Coupled - agonists | Recombinant Fusion Proteins - metabolism | GTP-Binding Protein alpha Subunits, Gi-Go - chemistry | Quinolines - pharmacology | Mitogen-Activated Protein Kinase 1 - chemistry | A Kinase Anchor Proteins - genetics | Protein Processing, Post-Translational - drug effects | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Phosphorylation - drug effects | Radioligand Assay | Mitogen-Activated Protein Kinase 3 - chemistry | Phosphatidylinositol 3-Kinase - metabolism | A Kinase Anchor Proteins - metabolism | A Kinase Anchor Proteins - antagonists & inhibitors | Receptors, Estrogen - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Cyclopentanes - pharmacology | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Phosphatidylinositol 3-Kinase - chemistry | Up-Regulation - drug effects | MAP Kinase Signaling System - drug effects | Receptors, Estrogen - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Phosphatidylinositol 3-Kinase - genetics | PDZ Domains | Receptors, G-Protein-Coupled - genetics | Mutation | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Signal Transduction | GPER1 | A-kinase-anchoring protein (AKAP) | G protein-coupled receptor (GPCR) | GPR30 | PDZ domain | calcineurin | extracellular signal-regulated kinase (ERK) | G protein
Journal Article
Journal Article