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The Plant Cell, ISSN 1040-4651, 5/2012, Volume 24, Issue 5, pp. 2225 - 2236
Journal Article
Nature Genetics, ISSN 1061-4036, 2012, Volume 44, Issue 2, pp. 133 - 139
Journal Article
Blood, ISSN 0006-4971, 06/2011, Volume 117, Issue 23, pp. 6287 - 6296
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and... 
B-CELLS | CLL | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | APOPTOTIC CELL-DEATH | RITUXIMAB | SURVIVAL SIGNALS | LYMPHOMA | DRUG-RESISTANCE | INHIBITOR | HEMATOLOGY | EXPRESSION | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | B-Cell Activating Factor - metabolism | CD40 Ligand - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Receptors, Antigen, B-Cell - genetics | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Leukemic - genetics | Protein-Tyrosine Kinases - genetics | CD40 Ligand - metabolism | MAP Kinase Signaling System - genetics | Female | Interleukin-4 - genetics | Protein-Tyrosine Kinases - biosynthesis | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Neoplasm Proteins - biosynthesis | Interleukin-4 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Cell Proliferation - drug effects | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2012, Volume 318, Issue 16, pp. 2105 - 2115
The activation of transforming growth factor-β1(TGF-β1)/Smad signaling pathway and increased expression of connective tissue growth factor (CTGF) induced by... 
TGFβ1 | Angiotensin II | Atrial fibroblasts | TRAF6 | CTGF | MAPKs | TGFΒ1 | Heart Atria - pathology | Gene Expression - drug effects | Heart Atria - drug effects | Transforming Growth Factor beta1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Fibrosis - metabolism | MAP Kinase Kinase 4 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 4 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | TNF Receptor-Associated Factor 6 - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Fibroblasts - metabolism | Angiotensin II - pharmacology | Fibrosis - genetics | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Heart Atria - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | TNF Receptor-Associated Factor 6 - metabolism | MAP Kinase Kinase 4 - genetics | Connective Tissue Growth Factor - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Angiotensin II - physiology | Connective Tissue Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 16, pp. 11216 - 11232
Understanding the regulation of cardiomyocyte growth is crucial for the management of adverse ventricular remodeling and heart failure. MicroRNA-378 (miR-378)... 
MUTATIONS CAUSE NOONAN | SIGNALING PATHWAYS | PRESSURE-OVERLOAD | CARDIOMYOCYTE | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPEUTIC TARGET | HEART-FAILURE | GENE-EXPRESSION | DIACYLGLYCEROL-BINDING MOTIFS | NUCLEOTIDE-RELEASING PROTEIN | FOCAL ADHESION KINASE | ras Proteins - genetics | ras Proteins - metabolism | Cardiomegaly - pathology | Glycogen Synthase Kinase 3 beta | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Adrenergic alpha-1 Receptor Agonists - adverse effects | Adrenergic alpha-1 Receptor Agonists - pharmacology | MAP Kinase Signaling System | MAP Kinase Kinase 1 - genetics | Phenylephrine - adverse effects | Phenylephrine - pharmacology | GRB2 Adaptor Protein - genetics | Muscle Proteins - metabolism | Proto-Oncogene Proteins c-raf | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation - genetics | MAP Kinase Kinase Kinases - genetics | Cells, Cultured | Rats | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase Kinases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins c-akt | Animals | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | GRB2 Adaptor Protein - biosynthesis | Cardiomegaly - chemically induced | MicroRNAs - genetics | Cardiomegaly - genetics | Cardiomegaly - metabolism | Index Medicus | Molecular Bases of Disease | MAP Kinases (MAPKs) | Molecular Biology | RNA | Ras | Cell Signaling | MicroRNA-378 | Grb2 | Cardiac Hypertrophy
Journal Article
Science, ISSN 0036-8075, 02/2017, Volume 355, Issue 6327, pp. 836 - 842
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 03/2012, Volume 11, Issue 3, pp. 720 - 729
The MEK1 and MEK2 inhibitor GSK1120212 is currently in phase II/III clinical development. To identify predictive biomarkers, sensitivity to GSK1120212 was... 
ONCOLOGY | SELUMETINIB AZD6244 | PATHWAY | COLORECTAL-CANCER | TYROSINE KINASE | BCR-ABL | MARKERS | CELL-LINES | TUMOR-GROWTH | EGF RECEPTOR | ADDICTION | ras Proteins - genetics | Dual Specificity Phosphatase 6 - genetics | Prognosis | Oligonucleotide Array Sequence Analysis | Humans | Transcriptome | Cell Survival - genetics | ras Proteins - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | raf Kinases - metabolism | Pyrimidinones - chemistry | MAP Kinase Kinase 1 - genetics | Protein Kinase Inhibitors - chemistry | Biomarkers, Tumor - metabolism | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Gene Expression Regulation, Neoplastic - drug effects | raf Kinases - genetics | MAP Kinase Kinase 2 - genetics | Cell Survival - drug effects | MAP Kinase Kinase 1 - antagonists & inhibitors | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - metabolism | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Antineoplastic Agents - chemistry | Blotting, Western | Phosphatidylinositol 3-Kinases - genetics | Dual Specificity Phosphatase 6 - metabolism | Drug Resistance, Neoplasm - genetics | MAP Kinase Kinase 2 - antagonists & inhibitors | Cell Line, Tumor | Biomarkers, Tumor - genetics | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Mutation | Pyridones - chemistry | Pyridones - pharmacology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2007, Volume 9, Issue 3, pp. 324 - 330
The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that regulates cell fate by transducing a myriad of growth-factor signals.... 
ACTIVATION | PROTEIN | SPECIFICITY | PHOSPHORYLATION | DYNAMICS | RAF-1 | CASCADE | IDENTIFICATION | SIGNAL-REGULATED KINASE | TRANSIENT | CELL BIOLOGY | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Tetradecanoylphorbol Acetate - pharmacology | Receptor, trkA - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | MAP Kinase Kinase 1 - genetics | Flow Cytometry | Mitogen-Activated Protein Kinase 1 - genetics | Phosphorylation - drug effects | Cell Differentiation - physiology | Proto-Oncogene Proteins B-raf - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | Nerve Growth Factor - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Protein Kinase C - antagonists & inhibitors | Proto-Oncogene Proteins c-raf - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Models, Biological | Proto-Oncogene Proteins B-raf - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Cell Cycle - drug effects | Monte Carlo Method | Mitogen-Activated Protein Kinase 1 - metabolism | Cell proliferation | Evaluation | Pheochromocytoma | Physiological aspects | Cell differentiation | Properties | Protein kinases | Growth factors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e100893 - e100893
Long non-coding RNAs (lncRNAs) have been shown to be implicated in the complex network of cancer including malignant melanoma and play important roles in... 
CELLS | EPIDERMAL NEOPLASIA | METASTASIS | MULTIDISCIPLINARY SCIENCES | KINASE | DISEASE | GROWTH | TUMOR | INHIBITOR U0126 | MECHANISMS | CANCER | Cell Proliferation | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Gene Knockdown Techniques | MAP Kinase Signaling System | Heterografts | MAP Kinase Kinase 4 - metabolism | Melanoma - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Disease Models, Animal | Melanoma - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | p38 Mitogen-Activated Protein Kinases - genetics | RNA, Long Noncoding - genetics | Melanoma - pathology | Proto-Oncogene Proteins c-raf - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Aged | Mice | Neoplasm Staging | Melanoma - mortality | Mitogen-Activated Protein Kinase 1 - metabolism | RNA | Melanoma | Cell proliferation | Disease | Pathogenesis | Metastasis | Kinases | Cancer therapies | Skin cancer | Proteins | Ethics | Cell growth | Transfection | Animal tissues | Tumorigenesis | Trends | Inhibition | Dermatology | Tumor cells | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Tumorigenicity | Gene expression | Ribonucleic acid--RNA | Patients | Pathology | Hospitals | Cell lines | Non-coding RNA | Cancer | Index Medicus | Ribonucleic acid
Journal Article