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The Plant Cell, ISSN 1040-4651, 5/2012, Volume 24, Issue 5, pp. 2225 - 2236
Journal Article
Cancer Research, ISSN 0008-5472, 10/2004, Volume 64, Issue 19, pp. 7099 - 7109
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1897 - 1897
The cellular decision regarding whether to undergo proliferation or death is made at the restriction (R)-point, which is disrupted in nearly all tumors. The... 
UBIQUITINATION | AML1-ETO | ACETYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PROTEINS | QUANTITATIVE-ANALYSIS | POLYCOMB | CANCER | KINASES | FAMILY | Chromatin - metabolism | RNA, Small Interfering - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | TOR Serine-Threonine Kinases - metabolism | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Polycomb-Group Proteins - metabolism | TOR Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Chromatin - chemistry | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Signal Transduction | Epithelial Cells - pathology | MAP Kinase Kinase 1 - metabolism | Imidazoles - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Cell Cycle Checkpoints - drug effects | Polycomb-Group Proteins - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA, Small Interfering - metabolism | ras Proteins - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Epithelial Cells - metabolism | Nitriles - pharmacology | Cyclin-Dependent Kinase 4 - genetics | Epithelial Cells - drug effects | ras Proteins - metabolism | Drosophila melanogaster - genetics | Chromatin Assembly and Disassembly - drug effects | Drosophila melanogaster - metabolism | MAP Kinase Kinase 1 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | HEK293 Cells | MAP Kinase Kinase 4 - antagonists & inhibitors | Chromatin - drug effects | Histone-Lysine N-Methyltransferase - genetics | Drosophila melanogaster - cytology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Sirolimus - pharmacology | Animals | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Core Binding Factor Alpha 3 Subunit - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 9/2008, Volume 148, Issue 1, pp. 212 - 222
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2012, Volume 318, Issue 16, pp. 2105 - 2115
The activation of transforming growth factor-β1(TGF-β1)/Smad signaling pathway and increased expression of connective tissue growth factor (CTGF) induced by... 
TGFβ1 | Angiotensin II | Atrial fibroblasts | TRAF6 | CTGF | MAPKs | TGFΒ1 | Heart Atria - pathology | Gene Expression - drug effects | Heart Atria - drug effects | Transforming Growth Factor beta1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Fibrosis - metabolism | MAP Kinase Kinase 4 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 4 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | TNF Receptor-Associated Factor 6 - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Fibroblasts - metabolism | Angiotensin II - pharmacology | Fibrosis - genetics | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Heart Atria - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | TNF Receptor-Associated Factor 6 - metabolism | MAP Kinase Kinase 4 - genetics | Connective Tissue Growth Factor - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Angiotensin II - physiology | Connective Tissue Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2006, Volume 103, Issue 18, pp. 7136 - 7141
Sustained activation of poly(ADP-ribose) polymerase-1 (PARP-1) and extracellular signal-regulated kinases 1/2 (ERK1/2) both promote neuronal death. Here we... 
Cell culture techniques | Phosphorylation | Neurons | Astrocytes | Cell death | DNA damage | Small interfering RNA | Gene expression regulation | Hypoglycemia | Down regulation | APOPTOSIS | ACTIVATED PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | FOCAL CEREBRAL-ISCHEMIA | DNA-DAMAGE | neuron | MAP KINASES | CELL-DEATH | mitogen-activated protein kinase | INHIBITION | hypoglycemia | CORTICAL NEURON CULTURES | BRAIN INJURY | astrocyte | ERK | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Neurons - cytology | Hypoglycemia - pathology | MAP Kinase Kinase 1 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cell Death | Neurons - metabolism | MAP Kinase Kinase 2 - genetics | Fibroblasts - metabolism | Recombinant Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Cells, Cultured | Rats | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Recombinant Proteins - genetics | Hypoglycemia - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Enzyme Activation | Poly (ADP-Ribose) Polymerase-1 | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Research | Protein kinases | Neurology | Signal transduction | Enzymes | Inhibitor drugs | Index Medicus | Biological Sciences
Journal Article
Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer | Index Medicus
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 12/2004, Volume 11, Issue 12, pp. 1192 - 1197
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2007, Volume 9, Issue 3, pp. 324 - 330
The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that regulates cell fate by transducing a myriad of growth-factor signals.... 
ACTIVATION | PROTEIN | SPECIFICITY | PHOSPHORYLATION | DYNAMICS | RAF-1 | CASCADE | IDENTIFICATION | SIGNAL-REGULATED KINASE | TRANSIENT | CELL BIOLOGY | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Tetradecanoylphorbol Acetate - pharmacology | Receptor, trkA - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | MAP Kinase Kinase 1 - genetics | Flow Cytometry | Mitogen-Activated Protein Kinase 1 - genetics | Phosphorylation - drug effects | Cell Differentiation - physiology | Proto-Oncogene Proteins B-raf - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | Nerve Growth Factor - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Protein Kinase C - antagonists & inhibitors | Proto-Oncogene Proteins c-raf - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Models, Biological | Proto-Oncogene Proteins B-raf - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Cell Cycle - drug effects | Monte Carlo Method | Mitogen-Activated Protein Kinase 1 - metabolism | Cell proliferation | Evaluation | Pheochromocytoma | Physiological aspects | Cell differentiation | Properties | Protein kinases | Growth factors | Index Medicus
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 8, pp. 773 - 781
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2005, Volume 288, Issue 2, pp. 971 - 976
Pharmacological activation of the prosurvival kinases Akt and ERK-1/2 at reperfusion, after a period of lethal ischemia, protects the heart against... 
Myocardial infarction | Phosphatidylinositol 3-kinase-Akt | Reperfusion injury | Mitogen-activated protein kinases | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | phosphatidylinositol 3-kinase-Akt | HEARTS | myocardial infarction | INJURY | reperfusion injury | MITOCHONDRIAL PERMEABILITY TRANSITION | mitogen-activated protein kinases | PORE | PERIPHERAL VASCULAR DISEASE | RADICALS | Phosphorylation | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Myocardial Reperfusion Injury - pathology | Myocardial Infarction - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Myocardium - pathology | MAP Kinase Kinase 2 - metabolism | Myocardial Infarction - metabolism | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-akt | Myocardial Reperfusion Injury - metabolism | Myocardium - enzymology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Ischemic Preconditioning, Myocardial | MAP Kinase Kinase 2 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article