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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
The Plant cell, ISSN 1532-298X, 2012, Volume 24, Issue 5, pp. 2225 - 2236
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1897 - 17
...-Won Jang1, Tae-Geun Park1, Soo-Hyun Song1, You-Soub Lee1, Xin-Zi Chi1, Il Yeong Park2, Jin-Won Hyun3, Yoshiaki Ito4 and Suk-Chul Bae 1 The cellular decision... 
UBIQUITINATION | AML1-ETO | ACETYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PROTEINS | QUANTITATIVE-ANALYSIS | POLYCOMB | CANCER | KINASES | FAMILY | Chromatin - metabolism | RNA, Small Interfering - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | TOR Serine-Threonine Kinases - metabolism | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Polycomb-Group Proteins - metabolism | TOR Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Chromatin - chemistry | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Signal Transduction | Epithelial Cells - pathology | MAP Kinase Kinase 1 - metabolism | Imidazoles - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Cell Cycle Checkpoints - drug effects | Polycomb-Group Proteins - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA, Small Interfering - metabolism | ras Proteins - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Epithelial Cells - metabolism | Nitriles - pharmacology | Cyclin-Dependent Kinase 4 - genetics | Epithelial Cells - drug effects | ras Proteins - metabolism | Drosophila melanogaster - genetics | Chromatin Assembly and Disassembly - drug effects | Drosophila melanogaster - metabolism | MAP Kinase Kinase 1 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | HEK293 Cells | MAP Kinase Kinase 4 - antagonists & inhibitors | Chromatin - drug effects | Histone-Lysine N-Methyltransferase - genetics | Drosophila melanogaster - cytology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Sirolimus - pharmacology | Animals | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Core Binding Factor Alpha 3 Subunit - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Polycomb group proteins | Regulators | Molecular modelling | S phase | Genes | Cell cycle | Loci | Runx3 protein | Recruitment | Tumors | Chromatin remodeling
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2006, Volume 103, Issue 18, pp. 7136 - 7141
Sustained activation of poly(ADP-ribose) polymerase-1 (PARP-1) and extracellular signal-regulated kinases 1/2 (ERK1/2... 
Cell culture techniques | Phosphorylation | Neurons | Astrocytes | Cell death | DNA damage | Small interfering RNA | Gene expression regulation | Hypoglycemia | Down regulation | APOPTOSIS | ACTIVATED PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | FOCAL CEREBRAL-ISCHEMIA | DNA-DAMAGE | neuron | MAP KINASES | CELL-DEATH | mitogen-activated protein kinase | INHIBITION | hypoglycemia | CORTICAL NEURON CULTURES | BRAIN INJURY | astrocyte | ERK | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Neurons - cytology | Hypoglycemia - pathology | MAP Kinase Kinase 1 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cell Death | Neurons - metabolism | MAP Kinase Kinase 2 - genetics | Fibroblasts - metabolism | Recombinant Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Cells, Cultured | Rats | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Recombinant Proteins - genetics | Hypoglycemia - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Enzyme Activation | Poly (ADP-Ribose) Polymerase-1 | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Research | Protein kinases | Biological Sciences
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 183 - 196
Journal Article
Oncology reports, ISSN 1021-335X, 02/2011, Volume 25, Issue 2, pp. 537 - 544
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1938 - 1938
...http://www.mdpi.com/journal/ijms Web End =International Journal of http://www.mdpi.com/journal/ijms Web End =Molecular Sciences Xueqin Li 1,, Jun Shen 2... 
Sesquiterpene | Sarcandra glabra | Chloranthalactone B | Inflammation | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | P38 MAPK | RAW 264.7 CELLS | INDUCED INFLAMMATION | IL-6 EXPRESSION | sesquiterpene | CHEMISTRY, MULTIDISCIPLINARY | AP-1 INACTIVATION | inflammation | SIGNALING PATHWAY | SESQUITERPENE LACTONE | SARCANDRA-GLABRA | NF-KAPPA-B | chloranthalactone B | Tumor Necrosis Factor-alpha - genetics | MAP Kinase Kinase 3 - genetics | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Lactones - pharmacology | MAP Kinase Kinase 6 - genetics | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Interleukin-6 - metabolism | Nitric Oxide - biosynthesis | Interleukin-6 - genetics | Macrophages - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | MAP Kinase Kinase 6 - antagonists & inhibitors | Models, Molecular | MAP Kinase Kinase 3 - metabolism | Macrophages - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 3 - chemistry | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Inflammation - prevention & control | Mice | Dinoprostone - antagonists & inhibitors | MAP Kinase Kinase 6 - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dinoprostone - biosynthesis | MAP Kinase Kinase 3 - antagonists & inhibitors | Transcription Factor AP-1 - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Transcription Factor AP-1 - metabolism | MAP Kinase Kinase 6 - metabolism | Cell Line | Nitric Oxide - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Transcription Factor AP-1 - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | Macrophages - drug effects | Sesquiterpenes - pharmacology | Herbal medicine | Polymerase chain reaction | Kinases
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), PKC, S6K p70 (ribosomal S6 kinase), RSK... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Oncogene, ISSN 1476-5594, 2007, Volume 26, Issue 22, pp. 3227 - 3239
The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein (MAP... 
Signal transduction | MAP kinase | ERK1/2 | Cell cycle | G1 phase | SIGNAL-TRANSDUCTION PATHWAYS | signal transduction | cell cycle | EARLY GENE-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE ARREST | INITIATION-FACTOR 4E | DNA-SYNTHESIS | CELL BIOLOGY | NIH 3T3 CELLS | DEPENDENT KINASE | ONCOLOGY | GENETICS & HEREDITY | SMOOTH-MUSCLE-CELLS | MESSENGER-RNA TRANSPORT | MAP Kinase Signaling System - physiology | Cell Proliferation | Mitogen-Activated Protein Kinase 1 - physiology | Mitogen-Activated Protein Kinase 3 - genetics | Humans | Mitogen-Activated Protein Kinase 1 - deficiency | G1 Phase - physiology | S Phase - genetics | Mitogen-Activated Protein Kinase 3 - physiology | Animals | MAP Kinase Signaling System - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | S Phase - physiology | Mitogen-Activated Protein Kinase 3 - deficiency | G1 Phase - genetics | Enzyme Activation - genetics | Enzyme Activation - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Control | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Protein kinases | Genetics | Kinases | Mammals | Cancer | Life Sciences | G1 Phase | S Phase | Biochemistry, Molecular Biology | Enzyme Activation | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | MAP Kinase Signaling System
Journal Article