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Hypertension, ISSN 0194-911X, 02/2011, Volume 57, Issue 2, pp. 245 - 254
Vascular oxidative stress and inflammation play an important role in angiotensin II–induced hypertension, and mitogen-activated protein kinases participate in... 
vascular inflammation | arterial | MK2 | hypertension | angiotensin II | oxidative stress | NADPH OXIDASE | ENDOTHELIAL DYSFUNCTION | ORGAN DAMAGE | SUPEROXIDE ANION PRODUCTION | BLOOD-PRESSURE | P38 MAP KINASE | NAD(P)H OXIDASE | DIFFERENTIAL ACTIVATION | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | Inflammation - chemically induced | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Oxidative Stress | Blood Pressure - genetics | NADPH Oxidases - metabolism | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Aorta - metabolism | Inflammation - metabolism | RNA Interference | Hypertension - chemically induced | Superoxides - metabolism | Blood Pressure - physiology | Chemokine CCL2 - metabolism | Aorta - physiopathology | Angiotensin II | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Chemokine CCL2 - genetics | Muscle, Smooth, Vascular - cytology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Hypertension - physiopathology | Hypertension - metabolism | Mice, Knockout | Animals | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Inflammation - physiopathology | Index Medicus
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 07/2006, Volume 145, Issue 1, pp. 162 - 172
The Th2 cytokines interleukin (IL)‐4 and IL‐13 and chemokine monocyte chemoattractant protein‐1 (MCP‐1) are significantly involved in bronchial hyperreactivity... 
chemokines/monokines | allergy | epithelial cells | cytokines/interleukins | signalling/signal transduction | Allergy | Cytokines/interleukins | Epithelial cells | Chemokines/monokines | Signalling/signal transduction | ALLERGIC INFLAMMATION | CYTOKINES | CHEMOKINES | KAPPA-B | RELEASE | IMMUNOLOGY | HUMAN EOSINOPHILS | EOTAXIN-2 | ASTHMA PATHOGENESIS | ALVEOLAR MACROPHAGES | AIRWAY HYPERRESPONSIVENESS | Up-Regulation | Epithelial Cells - metabolism | Gene Expression - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Interleukins - metabolism | MAP Kinase Signaling System | Dose-Response Relationship, Drug | Janus Kinase 2 | Bronchi - metabolism | Chemokine CCL2 - metabolism | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Interleukin-4 - metabolism | Imidazoles - pharmacology | Tyrphostins - pharmacology | Interleukin-13 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Pyridines - pharmacology | Enzyme Activation | Cell Line, Transformed | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Mutual fund industry | Protein kinases | Index Medicus | signal transduction | monokines | cytokines | Basic Immunology | chemokines | signalling | interleukins
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2013, Volume 70, pp. 758 - 767
The benzo[ ]pyrimido-[5,4- ]diazepine-6(11 )-one core was discovered as a novel ERK5 (also known as MAPK7 and BMK1) inhibitor scaffold, previously. Further... 
ERK5 inhibitor | Benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-one | Kinase selectivity | Benzo[e]pyrimido-[5,4-b]diazepine-6(11H)- one | CELLS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | INHIBITOR SELECTIVITY | POLO-LIKE-KINASE-1 | LRRK2 | PARKINSON DISEASE | PROSTATE-CANCER | IN-VIVO | EXPRESSION | CARCINOMA | Protein Kinase Inhibitors - chemical synthesis | Pyrimidines - chemical synthesis | Humans | Cells, Cultured | Azepines - chemical synthesis | Models, Molecular | Structure-Activity Relationship | Mitogen-Activated Protein Kinase 7 - metabolism | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Pyrimidines - chemistry | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Azepines - pharmacology | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Azepines - chemistry | Mitogen-Activated Protein Kinase 7 - antagonists & inhibitors | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Molecular Structure | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Serine-Threonine Kinases - metabolism | Medical colleges | Phosphotransferases | Epidermal growth factor | Index Medicus | PLK, polo-like kinase | EGF, epidermal growth factor | PML, promyelocytic leukemia protein | X-phos, 2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-biphenyl | DIEA, N,N-diisopropylethylamine | DMA, N,N-dimethylacetamide | ERK5, extracelluar-signal-regulated kinase 5 | LRRK2, leucine rich repeat kinase 2 | BMK1, big MAP kinase 1 | ERK5, mitogen-activated protein kinase 7 | RSK, ribosomal S6 kinase | SAR, structure–activity relationship | Pd2(dba)3, tris(dibenzylideneacetone)dipalladium- | HCC, hepatocellular carcinoma | Original | DCAMKL2, doublecortin and CaM kinase-like 2 | MAPK, mitogen-activated protein kinase | MEK5, MAP kinase kinase 5
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/1999, Volume 18, Issue 18, pp. 4969 - 4980
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 42, pp. 17408 - 17413
Contact of Mycobacterium tuberculosis (M.tb) with the immune system requires interactions between microbial surface molecules and host pattern recognition... 
Untranslated regions | RNA stability | Cell culture techniques | Messenger RNA | MicroRNA | Mycobacterium tuberculosis | Infections | Biosynthesis | Physiological regulation | Macrophages | Innate immunity | Intracellular pathogen | Cell signaling | Lipoglycans | CONTAINING MESSENGER-RNAS | IMMUNE-RESPONSE | STABILITY | MULTIDISCIPLINARY SCIENCES | P38 MAPK | lipoglycans | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | RICH ELEMENT | innate immunity | intracellular pathogen | cell signaling | INFECTION | BINDING | EXPRESSION | Promoter Regions, Genetic | Phosphorylation | Humans | Tumor Necrosis Factor-alpha - genetics | Mycobacterium tuberculosis - immunology | MicroRNAs - metabolism | MAP Kinase Kinase 2 - metabolism | Toll-Like Receptor 2 - metabolism | RNA Stability | Lipopolysaccharides - immunology | MAP Kinase Signaling System - immunology | Mycobacterium tuberculosis - pathogenicity | Macrophages - metabolism | Virulence - immunology | Lipopolysaccharides - pharmacology | Macrophages - drug effects | MicroRNAs - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | In Vitro Techniques | Proto-Oncogene Proteins c-akt - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Macrophages - immunology | Macrophages - microbiology | Tumor necrosis factor | Physiological aspects | Genetic aspects | Research | Mitogen-activated protein kinases | Gram-positive bacteria | Signal transduction | Kinases | Ribonucleic acid--RNA | Gene expression | Index Medicus | 1-Phosphatidylinositol 3-kinase | Biological Sciences
Journal Article
Hepatology, ISSN 0270-9139, 11/2011, Volume 54, Issue 5, pp. 1753 - 1766
Journal Article