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Apoptosis (London), ISSN 1360-8185, 3/2008, Volume 13, Issue 3, pp. 343 - 353
Journal Article
Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
... and progression to invasive and metastatic lung tumors. These studies revealed that SRC is activated in Lkb1-deficient primary and metastatic lung tumors, and that the combined inhibition of SRC, PI3K, and MEK1/2 resulted in synergistic tumor regression... 
CELLCYCLE | SIGNALING | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer | Index Medicus
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 1522-1539, 02/2005, Volume 288, Issue 2, pp. H971 - H976
Pharmacological activation of the prosurvival kinases Akt and ERK-1/2 at reperfusion, after a period of lethal ischemia, protects the heart against ischemia-reperfusion injury... 
Myocardial infarction | Phosphatidylinositol 3-kinase-Akt | Reperfusion injury | Mitogen-activated protein kinases | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Phosphorylation | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Myocardial Reperfusion Injury - pathology | Myocardial Infarction - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Myocardium - pathology | MAP Kinase Kinase 2 - metabolism | Myocardial Infarction - metabolism | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-akt | Myocardial Reperfusion Injury - metabolism | Myocardium - enzymology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Ischemic Preconditioning, Myocardial | MAP Kinase Kinase 2 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 10/2004, Volume 64, Issue 19, pp. 7099 - 7109
Journal Article
Nature (London), ISSN 1476-4687, 03/2019, Volume 567, Issue 7749, pp. 521 - 524
Histiocytic neoplasms are a heterogeneous group of clonal haematopoietic disorders that are marked by diverse mutations in the mitogen-activated protein kinase (MAPK) pathway(1,2). For the 50... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | MAP Kinase Kinase 1 - antagonists & inhibitors | Histiocytic Disorders, Malignant - pathology | Histiocytosis - drug therapy | Proto-Oncogene Proteins c-raf - genetics | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Azetidines - pharmacology | Histiocytic Disorders, Malignant - drug therapy | Histiocytic Disorders, Malignant - enzymology | Histiocytic Disorders, Malignant - genetics | MAP Kinase Signaling System - drug effects | Azetidines - therapeutic use | Piperidines - pharmacology | MAP Kinase Kinase 2 - antagonists & inhibitors | Piperidines - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Progression-Free Survival | Histiocytosis - genetics | Histiocytosis - pathology | Mutation | MAP Kinase Kinase 2 - genetics | Histiocytosis - enzymology | Care and treatment | Histiocytosis | Patient outcomes | Tumors | Genetic aspects | Protein kinases | Mitogens | Therapy | Nuclear magnetic resonance--NMR | Clinical trials | Raf protein | Kinases | Cancer therapies | Neoplasms | Confidence intervals | Proteins | Signal transduction | Dependence | Inhibition | Genotypes | Effectiveness | Melanoma | Extracellular signal-regulated kinase | MAP kinase | Patients | Survival analysis | Protein kinase | Medical prognosis | Response rates | Index Medicus
Journal Article
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 08/2017, Volume 18, Issue 16, pp. 1593 - 1598
Journal Article
PloS one, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e106725 - e106725
...Author(s): Weiwei Yang [sup.1] [sup.*], Qinghua Li [sup.2], Zhifang Pan [sup.1] Introduction Invasion of maternal tissues at the maternal-fetal interface... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA, Small Interfering - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Collagen - chemistry | Proteoglycans - chemistry | MAP Kinase Kinase 1 - genetics | Trophoblasts - drug effects | Mitogen-Activated Protein Kinase 1 - genetics | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | Biological Assay | Trophoblasts - cytology | Receptors, Lysosphingolipid - metabolism | MAP Kinase Kinase 2 - genetics | Cell Line | MAP Kinase Kinase 1 - antagonists & inhibitors | Trophoblasts - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Sphingosine - pharmacology | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Sphingosine - analogs & derivatives | Diffusion Chambers, Culture | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Receptors, Lysosphingolipid - agonists | Laminin - chemistry | Protein Kinase Inhibitors - pharmacology | Drug Combinations | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Phosphates | Enzymes | RNA | Sphingosine | Enzyme activity | Extracellular signal-regulated kinase | Activation | mRNA | siRNA | Kinases | Gene expression | Tissues | Sphingosine 1-phosphate | Cell adhesion & migration | Gelatinase A | Pregnancy | Proteins | Signaling | Receptors | Molecular modelling | Pathways | Enzymatic activity | Gelatin | Pharmacy | Receptor mechanisms | Cell migration | Cancer | Index Medicus
Journal Article
Journal Article