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Molecular Cell, ISSN 1097-2765, 01/2014, Volume 53, Issue 2, pp. 193 - 208
Journal Article
Science, ISSN 0036-8075, 2/2009, Volume 323, Issue 5915, pp. 802 - 806
Journal Article
Developmental Cell, ISSN 1534-5807, 11/2012, Volume 23, Issue 5, pp. 1020 - 1031
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2012, Volume 318, Issue 16, pp. 2105 - 2115
The activation of transforming growth factor-β1(TGF-β1)/Smad signaling pathway and increased expression of connective tissue growth factor (CTGF) induced by... 
TGFβ1 | Angiotensin II | Atrial fibroblasts | TRAF6 | CTGF | MAPKs | TGFΒ1 | Heart Atria - pathology | Gene Expression - drug effects | Heart Atria - drug effects | Transforming Growth Factor beta1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Fibrosis - metabolism | MAP Kinase Kinase 4 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 4 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | TNF Receptor-Associated Factor 6 - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Fibroblasts - metabolism | Angiotensin II - pharmacology | Fibrosis - genetics | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Heart Atria - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | TNF Receptor-Associated Factor 6 - metabolism | MAP Kinase Kinase 4 - genetics | Connective Tissue Growth Factor - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Angiotensin II - physiology | Connective Tissue Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
The Plant Journal, ISSN 0960-7412, 02/2014, Volume 77, Issue 4, pp. 547 - 557
Although grain size is one of the most important components of grain yield, little information is known about the mechanisms that determine final grain size in... 
grain size | cell proliferation | 1/Os | panicle size | rice | SMG | MKK | SMG1/OsMKK4 | SMG1 | SUBUNIT AGG3 | YIELD | GS3 | LENGTH | OsMKK4 | PLANT SCIENCES | ORGAN SIZE | MAJOR QTL | DWARF MUTANT | NATURAL VARIATION | ROLES | ELONGATION | Meristem - enzymology | Meristem - cytology | Plant Shoots - growth & development | Cell Proliferation | Seedlings - genetics | Seedlings - enzymology | Plant Shoots - enzymology | Recombinant Fusion Proteins | Seedlings - growth & development | Edible Grain - genetics | Oryza - growth & development | MAP Kinase Kinase 4 - metabolism | Meristem - genetics | Oryza - genetics | Brassinosteroids - metabolism | Plants, Genetically Modified | Gene Expression Regulation, Plant | Plant Proteins - metabolism | Plant Shoots - genetics | Genes, Reporter | Edible Grain - enzymology | Signal Transduction | Flowers - enzymology | Seedlings - cytology | Flowers - cytology | Chromosome Mapping | Oryza - enzymology | Plant Shoots - cytology | Flowers - growth & development | Meristem - growth & development | Plant Proteins - genetics | Edible Grain - growth & development | Phenotype | MAP Kinase Kinase 4 - genetics | Mutation | Chromosomes, Plant - genetics | Edible Grain - cytology | Flowers - genetics | Oryza - cytology | Fluorescence | Genetic engineering | Plants | Mitogens | Protein kinases | Proteins | Grain size | Crop science | Kinases | Rice | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e100893 - e100893
Long non-coding RNAs (lncRNAs) have been shown to be implicated in the complex network of cancer including malignant melanoma and play important roles in... 
CELLS | EPIDERMAL NEOPLASIA | METASTASIS | MULTIDISCIPLINARY SCIENCES | KINASE | DISEASE | GROWTH | TUMOR | INHIBITOR U0126 | MECHANISMS | CANCER | Cell Proliferation | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Gene Knockdown Techniques | MAP Kinase Signaling System | Heterografts | MAP Kinase Kinase 4 - metabolism | Melanoma - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Disease Models, Animal | Melanoma - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | p38 Mitogen-Activated Protein Kinases - genetics | RNA, Long Noncoding - genetics | Melanoma - pathology | Proto-Oncogene Proteins c-raf - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Aged | Mice | Neoplasm Staging | Melanoma - mortality | Mitogen-Activated Protein Kinase 1 - metabolism | RNA | Melanoma | Cell proliferation | Disease | Pathogenesis | Metastasis | Kinases | Cancer therapies | Skin cancer | Proteins | Ethics | Cell growth | Transfection | Animal tissues | Tumorigenesis | Trends | Inhibition | Dermatology | Tumor cells | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Tumorigenicity | Gene expression | Ribonucleic acid--RNA | Patients | Pathology | Hospitals | Cell lines | Non-coding RNA | Cancer | Index Medicus | Ribonucleic acid
Journal Article
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 2014, Volume 10, Issue 2, pp. e1003470 - e1003470
Interleukin-1 (IL-1) is a large cytokine family closely related to innate immunity and inflammation. IL-1 proteins are key players in signaling pathways such... 
DATA-BANK | KINASE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | INTERFACES | PROTEIN-PROTEIN INTERACTIONS | RECEPTOR | SCALE | MOLECULAR DOCKING | EXPRESSION | SOMATIC MUTATIONS | BRAIN-TUMORS | Interleukin-1 Receptor Accessory Protein - genetics | MAP Kinase Kinase 7 - genetics | Neoplasms - metabolism | Interleukin-1 - genetics | Interleukin-1 Receptor Accessory Protein - chemistry | Humans | MAP Kinase Kinase 7 - chemistry | Mitogen-Activated Protein Kinase 9 - genetics | Mitogen-Activated Protein Kinase 10 - genetics | MAP Kinase Kinase 7 - metabolism | Interleukin-1 Receptor Accessory Protein - metabolism | Receptors, Interleukin-1 Type I - metabolism | Inflammation - metabolism | MAP Kinase Kinase 4 - metabolism | Neoplasms - genetics | Computer Simulation | Receptors, Interleukin-1 Type I - chemistry | Interleukin-1 - chemistry | Oncogenes | Mitogen-Activated Protein Kinase 9 - chemistry | Interleukin-1 - metabolism | Protein Interaction Maps - immunology | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Computational Biology | Models, Molecular | Inflammation - immunology | Mitogen-Activated Protein Kinase 10 - metabolism | Mitogen-Activated Protein Kinase 10 - chemistry | Mutagenesis | Protein Interaction Maps - genetics | Models, Biological | Neoplasms - immunology | Receptors, Interleukin-1 Type I - genetics | Inflammation - genetics | MAP Kinase Kinase 4 - chemistry | MAP Kinase Kinase 4 - genetics | Polymorphism, Single Nucleotide | Mutation | Complications and side effects | Interleukin-1 | Patient outcomes | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | Risk factors | Genetic polymorphisms | Apoptosis | Index Medicus | Proteins | Cytokines | Disease | Kinases | Cancer
Journal Article
by Pek, M and Yatim, S.M.J.M and Chen, Y and Li, J and Gong, M and Jiang, X and Zhang, F and Zheng, J and Wu, X and Yu, Q
Oncogene, ISSN 0950-9232, 08/2017, Volume 36, Issue 35, pp. 4975 - 4986
Therapeutic strategies against KRAS mutant colorectal cancers are developed using cell line models, which do not accurately represent the transcriptome driven... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | DNA-DAMAGE | TRANSCRIPTION | SYNTHETIC LETHAL INTERACTION | PROLIFERATION | FOXM1 | SUPPRESSION | CELL BIOLOGY | RECEPTOR TYROSINE KINASES | MUTATION STATUS | ONCOLOGY | GENETICS & HEREDITY | CELL-CYCLE | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Diphenylamine - pharmacology | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Cyclin-Dependent Kinase 4 - genetics | Humans | Gene Expression Profiling | Molecular Targeted Therapy | Diphenylamine - analogs & derivatives | Colorectal Neoplasms - drug therapy | Female | Benzamides - pharmacology | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins p21(ras) - metabolism | Colorectal Neoplasms - enzymology | MAP Kinase Kinase Kinases - genetics | HCT116 Cells | Cyclin-Dependent Kinase 6 - genetics | Cyclin-Dependent Kinase 6 - metabolism | MAP Kinase Kinase Kinases - metabolism | Random Allocation | Cyclin-Dependent Kinase 4 - metabolism | Mice, SCID | Piperazines - pharmacology | HT29 Cells | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Care and treatment | Research | Gene mutations | Gene expression | Colorectal cancer | Cell cycle | Cell culture | Toxicity | Epithelial cells | Mitosis | Colorectal carcinoma | Cancer therapies | Cyclin-dependent kinase 4 | K-Ras protein | Metastases | Xenografts | Mutation | Colon | Tumors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19900 - 19909
Accumulating evidence suggests that activation of mitogen-activated protein kinases (MAPKs) and nuclear factor NF-kappa B exacerbates early brain injury (EBI)... 
SIGNALING PATHWAYS | VASOSPASM | LEARNING-DEFICITS | PHOSPHORYLATION | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | MECHANISMS | NF-KAPPA-B | EXPRESSION | PROTECTS | Neurons - pathology | Phosphorylation | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Injections, Intraventricular | Male | Cerebrovascular Trauma - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Transcription Factor RelA - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | MAP Kinase Kinase 4 - metabolism | Neuroprotective Agents - pharmacology | I-kappa B Proteins - antagonists & inhibitors | MAP Kinase Kinase 4 - antagonists & inhibitors | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinases - antagonists & inhibitors | Neurons - drug effects | Subarachnoid Hemorrhage - drug therapy | Disease Models, Animal | NF-KappaB Inhibitor alpha | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Gene Expression Regulation | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Zearalenone - analogs & derivatives | MAP Kinase Kinase Kinases - metabolism | Subarachnoid Hemorrhage - genetics | Subarachnoid Hemorrhage - pathology | Rats, Sprague-Dawley | Stereotaxic Techniques | Subarachnoid Hemorrhage - metabolism | Animals | Transcription Factor RelA - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cerebrovascular Trauma - pathology | MAP Kinase Kinase 4 - genetics | Cerebrovascular Trauma - prevention & control | Protein Kinase Inhibitors - pharmacology | Cerebrovascular Trauma - genetics | Zearalenone - pharmacology | Index Medicus | TAK1 | neuroprotection | 5Z-7-oxozeaenol | subarachnoid hemorrhage | Neurobiology | mitogen-activated protein kinase (MAPK) | apoptosis | brain | NF-κB (NF-KB)
Journal Article
Oncogene, ISSN 0950-9232, 06/2017, Volume 36, Issue 23, pp. 3334 - 3345
Despite remarkable progress in cutaneous melanoma genomic profiling, the mutational landscape of primary mucosal melanomas (PMM) remains unclear. Forty-six... 
TARGETED THERAPY | MUTANT MELANOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMPROVED SURVIVAL | CANCER | CELL BIOLOGY | MUTATED MELANOMA | GENE FUSIONS | MEK INHIBITION | ONCOLOGY | GENETICS & HEREDITY | RAF INHIBITORS | MUTATIONS | SEQUENCING DATA | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Oncogene Proteins, Fusion - metabolism | Skin Neoplasms - drug therapy | Apoptosis - drug effects | Cyclin-Dependent Kinase 4 - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Kinase 1 - genetics | Biomarkers, Tumor - metabolism | Female | Antineoplastic Agents - pharmacology | Mucous Membrane - drug effects | Tumor Cells, Cultured | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | MAP Kinase Kinase 1 - antagonists & inhibitors | Cyclin-Dependent Kinase 6 - genetics | MAP Kinase Kinase 1 - metabolism | Cyclin-Dependent Kinase 6 - metabolism | Melanoma - pathology | Transcription Factors - genetics | Cyclin-Dependent Kinase 4 - metabolism | Mucous Membrane - metabolism | Skin Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - genetics | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Mucous Membrane - pathology | Animals | Mice, Nude | Oncogene Proteins, Fusion - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Mice | Mitogen-Activated Protein Kinases - metabolism | Care and treatment | Gene mutations | Melanoma | Development and progression | Cellular signal transduction | Genetic aspects | Health aspects | Index Medicus
Journal Article
Clinical & Experimental Allergy, ISSN 0954-7894, 02/2012, Volume 42, Issue 2, pp. 218 - 228
Background Interleukin (IL)-33 is a novel member of the IL-1 cytokine family and a ligand for the orphan IL-1 family receptor ST2. The IL-33 induces T helper... 
33 | human nasal epithelial cells | allergic rhinitis | signal transduction | Human nasal epithelial cells | ST2 | Signal transduction | IL-33 | Allergic rhinitis | CYTOKINE | INTERLEUKIN-33 | IMMUNOLOGY | FAMILY | MEMBER | HUMAN EOSINOPHILS | ALLERGY | INNATE IMMUNE-RESPONSES | ENDOTHELIAL-CELLS | DISEASE | HUMAN MAST-CELLS | EXPRESSION | Interleukin-1 Receptor-Like 1 Protein | Interleukin-8 - genetics | Humans | Middle Aged | MAP Kinase Kinase 4 - immunology | Male | NF-kappa B - metabolism | Toll-Like Receptor 9 - agonists | Young Adult | Interleukins - genetics | RNA, Messenger - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukins - biosynthesis | Real-Time Polymerase Chain Reaction | Antiviral Agents - pharmacology | Rhinitis, Allergic, Seasonal - genetics | Interleukin-33 | p38 Mitogen-Activated Protein Kinases - immunology | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Cell Surface - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Adolescent | MAP Kinase Kinase 4 - genetics | Interleukin-8 - immunology | Toll-Like Receptor 9 - metabolism | Receptors, Cell Surface - genetics | RNA, Messenger - immunology | ErbB Receptors - genetics | NF-kappa B - immunology | Toll-Like Receptor 9 - genetics | Nasal Mucosa - pathology | MAP Kinase Signaling System - immunology | Toll-Like Receptor 9 - immunology | MAP Kinase Kinase 4 - metabolism | MAP Kinase Signaling System - genetics | Interleukins - immunology | Adult | Female | Nasal Mucosa - metabolism | Rhinitis, Allergic, Seasonal - pathology | Interleukin-8 - blood | Granulocyte-Macrophage Colony-Stimulating Factor - blood | ErbB Receptors - metabolism | RNA, Messenger - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | Nasal Mucosa - immunology | ErbB Receptors - immunology | Rhinitis, Allergic, Seasonal - blood | Aged | Interferon-gamma - pharmacology | Ligands | Nose | Allergies | Corticoids | Cell culture | Epithelial cells | Mucosa | c-Jun amino-terminal kinase | Atopic dermatitis | Interleukin 1 | Toll-like receptors | Enzyme-linked immunosorbent assay | Interleukin 8 | Epidermal growth factor receptors | Granulocyte-macrophage colony-stimulating factor | Hypersensitivity | Extracellular signal-regulated kinase | MAP kinase | Inflammation | Epithelium | Asthma | Polymerase ch