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Science Signaling, ISSN 1945-0877, 04/2017, Volume 10, Issue 475, pp. eaah4273 - eaah4273
Journal Article
Oncogene, ISSN 0950-9232, 06/2017, Volume 36, Issue 23, pp. 3334 - 3345
Despite remarkable progress in cutaneous melanoma genomic profiling, the mutational landscape of primary mucosal melanomas (PMM) remains unclear. Forty-six... 
TARGETED THERAPY | MUTANT MELANOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMPROVED SURVIVAL | CANCER | CELL BIOLOGY | MUTATED MELANOMA | GENE FUSIONS | MEK INHIBITION | ONCOLOGY | GENETICS & HEREDITY | RAF INHIBITORS | MUTATIONS | SEQUENCING DATA | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Oncogene Proteins, Fusion - metabolism | Skin Neoplasms - drug therapy | Apoptosis - drug effects | Cyclin-Dependent Kinase 4 - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Kinase 1 - genetics | Biomarkers, Tumor - metabolism | Female | Antineoplastic Agents - pharmacology | Mucous Membrane - drug effects | Tumor Cells, Cultured | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | MAP Kinase Kinase 1 - antagonists & inhibitors | Cyclin-Dependent Kinase 6 - genetics | MAP Kinase Kinase 1 - metabolism | Cyclin-Dependent Kinase 6 - metabolism | Melanoma - pathology | Transcription Factors - genetics | Cyclin-Dependent Kinase 4 - metabolism | Mucous Membrane - metabolism | Skin Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - genetics | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Mucous Membrane - pathology | Animals | Mice, Nude | Oncogene Proteins, Fusion - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Mice | Mitogen-Activated Protein Kinases - metabolism | Care and treatment | Gene mutations | Melanoma | Development and progression | Cellular signal transduction | Genetic aspects | Health aspects
Journal Article
by Pek, M and Yatim, S.M.J.M and Chen, Y and Li, J and Gong, M and Jiang, X and Zhang, F and Zheng, J and Wu, X and Yu, Q
Oncogene, ISSN 0950-9232, 08/2017, Volume 36, Issue 35, pp. 4975 - 4986
Therapeutic strategies against KRAS mutant colorectal cancers are developed using cell line models, which do not accurately represent the transcriptome driven... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | DNA-DAMAGE | TRANSCRIPTION | SYNTHETIC LETHAL INTERACTION | PROLIFERATION | FOXM1 | SUPPRESSION | CELL BIOLOGY | RECEPTOR TYROSINE KINASES | MUTATION STATUS | ONCOLOGY | GENETICS & HEREDITY | CELL-CYCLE | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Diphenylamine - pharmacology | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Cyclin-Dependent Kinase 4 - genetics | Humans | Gene Expression Profiling | Molecular Targeted Therapy | Diphenylamine - analogs & derivatives | Colorectal Neoplasms - drug therapy | Female | Benzamides - pharmacology | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins p21(ras) - metabolism | Colorectal Neoplasms - enzymology | MAP Kinase Kinase Kinases - genetics | HCT116 Cells | Cyclin-Dependent Kinase 6 - genetics | Cyclin-Dependent Kinase 6 - metabolism | MAP Kinase Kinase Kinases - metabolism | Random Allocation | Cyclin-Dependent Kinase 4 - metabolism | Mice, SCID | Piperazines - pharmacology | HT29 Cells | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Care and treatment | Research | Gene mutations | Gene expression | Colorectal cancer | Cell cycle | Cell culture | Toxicity | Epithelial cells | Mitosis | Colorectal carcinoma | Cancer therapies | Cyclin-dependent kinase 4 | K-Ras protein | Metastases | Xenografts | Mutation | Colon | Tumors | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 164 - 178
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1938 - 1938
Chloranthalactone B (CTB), a lindenane-type sesquiterpenoid, was obtained from the Chinese medicinal herb Sarcandra glabra, which is frequently used as a... 
Sesquiterpene | Sarcandra glabra | Chloranthalactone B | Inflammation | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | P38 MAPK | RAW 264.7 CELLS | INDUCED INFLAMMATION | IL-6 EXPRESSION | sesquiterpene | CHEMISTRY, MULTIDISCIPLINARY | AP-1 INACTIVATION | inflammation | SIGNALING PATHWAY | SESQUITERPENE LACTONE | SARCANDRA-GLABRA | NF-KAPPA-B | chloranthalactone B | Tumor Necrosis Factor-alpha - genetics | MAP Kinase Kinase 3 - genetics | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Lactones - pharmacology | MAP Kinase Kinase 6 - genetics | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Interleukin-6 - metabolism | Nitric Oxide - biosynthesis | Interleukin-6 - genetics | Macrophages - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | MAP Kinase Kinase 6 - antagonists & inhibitors | Models, Molecular | MAP Kinase Kinase 3 - metabolism | Macrophages - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 3 - chemistry | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Inflammation - prevention & control | Mice | Dinoprostone - antagonists & inhibitors | MAP Kinase Kinase 6 - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dinoprostone - biosynthesis | MAP Kinase Kinase 3 - antagonists & inhibitors | Transcription Factor AP-1 - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Transcription Factor AP-1 - metabolism | MAP Kinase Kinase 6 - metabolism | Cell Line | Nitric Oxide - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Transcription Factor AP-1 - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | Macrophages - drug effects | Sesquiterpenes - pharmacology | Herbal medicine | Polymerase chain reaction | Kinases
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2008, Volume 105, Issue 43, pp. 16484 - 16489
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2011, Volume 17, Issue 10, pp. 1251 - 1260
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2015, Volume 290, Issue 44, pp. 26661 - 26674
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 32, pp. 23322 - 23330
Journal Article