X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (21902) 21902
Publication (3598) 3598
Book Review (109) 109
Book Chapter (59) 59
Conference Proceeding (21) 21
Dissertation (10) 10
Book / eBook (2) 2
Data Set (2) 2
Magazine Article (2) 2
Presentation (1) 1
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (13205) 13205
index medicus (12953) 12953
humans (12109) 12109
mice (6465) 6465
phosphorylation (6056) 6056
map kinase (5176) 5176
signal transduction (4905) 4905
extracellular signal-regulated map kinases - metabolism (4859) 4859
rats (4673) 4673
cell biology (4652) 4652
male (4530) 4530
map kinase signaling system - drug effects (4388) 4388
biochemistry & molecular biology (4379) 4379
cells, cultured (4144) 4144
apoptosis (3779) 3779
activation (3727) 3727
cell line, tumor (3628) 3628
enzyme inhibitors - pharmacology (3592) 3592
expression (3540) 3540
female (3241) 3241
signal transduction - drug effects (3215) 3215
kinases (3029) 3029
oncology (3014) 3014
proteins (2894) 2894
cell line (2709) 2709
mitogen-activated protein kinases - metabolism (2566) 2566
phosphorylation - drug effects (2526) 2526
neurosciences (2415) 2415
map kinase signaling system (2393) 2393
apoptosis - drug effects (2301) 2301
protein kinase inhibitors - pharmacology (2278) 2278
article (2169) 2169
cancer (2169) 2169
pharmacology & pharmacy (2166) 2166
gene expression (2107) 2107
activated protein-kinase (2035) 2035
map kinase signaling system - physiology (2022) 2022
p38 mitogen-activated protein kinases - metabolism (2014) 2014
rats, sprague-dawley (1919) 1919
extracellular signal-regulated map kinases - antagonists & inhibitors (1911) 1911
cell proliferation - drug effects (1904) 1904
inflammation (1826) 1826
mitogen-activated protein kinase 1 - metabolism (1799) 1799
enzyme activation (1797) 1797
gene-expression (1781) 1781
dose-response relationship, drug (1749) 1749
extracellular signal-regulated kinase (1747) 1747
research (1741) 1741
flavonoids - pharmacology (1735) 1735
research article (1713) 1713
enzyme activation - drug effects (1695) 1695
blotting, western (1671) 1671
cells (1661) 1661
inhibition (1660) 1660
proto-oncogene proteins c-akt - metabolism (1611) 1611
analysis (1610) 1610
protein kinases (1604) 1604
immunology (1549) 1549
cell proliferation (1494) 1494
mitogen-activated protein kinases - antagonists & inhibitors (1482) 1482
multidisciplinary sciences (1480) 1480
nf-kappa-b (1466) 1466
in-vitro (1423) 1423
medicine (1385) 1385
phosphatidylinositol 3-kinases - metabolism (1374) 1374
mice, inbred c57bl (1372) 1372
p38 mitogen-activated protein kinases - antagonists & inhibitors (1369) 1369
pathway (1368) 1368
rodents (1360) 1360
pyridines - pharmacology (1324) 1324
erk (1306) 1306
signal transduction - physiology (1301) 1301
oxidative stress (1296) 1296
imidazoles - pharmacology (1293) 1293
physiological aspects (1293) 1293
proliferation (1285) 1285
physiology (1274) 1274
time factors (1225) 1225
mitogen-activated protein kinase 3 - metabolism (1203) 1203
cell survival - drug effects (1195) 1195
nf-kappa b - metabolism (1179) 1179
growth (1177) 1177
science (1176) 1176
transfection (1141) 1141
endocrinology & metabolism (1138) 1138
in-vivo (1130) 1130
nitriles - pharmacology (1105) 1105
mutation (1102) 1102
rna, messenger - metabolism (1084) 1084
biology (1075) 1075
receptor (1061) 1061
antineoplastic agents - pharmacology (1059) 1059
protein-kinase (1042) 1042
cytokines (1036) 1036
phosphatidylinositol 3-kinases - antagonists & inhibitors (1032) 1032
butadienes - pharmacology (1028) 1028
signaling (1020) 1020
disease models, animal (1012) 1012
health aspects (1000) 1000
pathways (991) 991
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (21842) 21842
Chinese (63) 63
Japanese (11) 11
Russian (6) 6
German (5) 5
French (4) 4
Dutch (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Cancer Research, ISSN 0008-5472, 10/2004, Volume 64, Issue 19, pp. 7099 - 7109
Journal Article
Circulation Research, ISSN 0009-7330, 01/2009, Volume 104, Issue 1, pp. 15 - 18
Ischemic postconditioning (IPoC) reduces infarct size following ischemia/reperfusion. Whether or not phosphorylation of RISK (reperfusion injury salvage... 
PERMEABILITY TRANSITION PORE | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTECTION | REPERFUSION | reperfusion injury | NECROSIS-FACTOR-ALPHA | ADENOSINE RECEPTORS | infarct size | INHIBITION | MYOCARDIAL INFARCT SIZE | cardioprotection | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | MOUSE HEARTS | SIGNAL TRANSDUCER | Glycogen Synthase Kinase 3 - physiology | MAP Kinase Kinase 2 - physiology | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta | Ribosomal Protein S6 Kinases, 70-kDa - physiology | MAP Kinase Kinase 1 - physiology | Myocardial Reperfusion Injury - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Protein Processing, Post-Translational - drug effects | Swine | Mitogen-Activated Protein Kinase 3 - biosynthesis | Myocardial Infarction - pathology | Swine, Miniature | Phosphorylation - drug effects | Myocardial Infarction - enzymology | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Glycogen Synthase Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 1 - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Coronary Occlusion - enzymology | Enzyme Induction | Proto-Oncogene Proteins c-akt - physiology | Enzyme Activation - drug effects | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Proto-Oncogene Proteins c-akt - biosynthesis | Animals | Androstadienes - pharmacology | Myocardial Reperfusion | MAP Kinase Kinase 2 - antagonists & inhibitors | Coronary Occlusion - pathology | Phosphatidylinositol 3-Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Myocardial Reperfusion Injury - prevention & control | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, deletion and activation of results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and... 
CELLCYCLE | SIGNALING | INACTIVATION | SUPPRESSOR | SIGNATURES | ONCOLOGY | SRC | ADENOCARCINOMA | SENSITIVITY | MUTATIONS | LKB1/STK11 | EXPRESSION | TUMORIGENESIS | CELL BIOLOGY | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer
Journal Article
Science, ISSN 0036-8075, 02/2017, Volume 355, Issue 6327, pp. 836 - 842
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2012, Volume 318, Issue 16, pp. 2105 - 2115
The activation of transforming growth factor-β1(TGF-β1)/Smad signaling pathway and increased expression of connective tissue growth factor (CTGF) induced by... 
TGFβ1 | Angiotensin II | Atrial fibroblasts | TRAF6 | CTGF | MAPKs | TGFΒ1 | Heart Atria - pathology | Gene Expression - drug effects | Heart Atria - drug effects | Transforming Growth Factor beta1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Fibrosis - metabolism | MAP Kinase Kinase 4 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 4 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | TNF Receptor-Associated Factor 6 - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Fibroblasts - metabolism | Angiotensin II - pharmacology | Fibrosis - genetics | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Heart Atria - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | TNF Receptor-Associated Factor 6 - metabolism | MAP Kinase Kinase 4 - genetics | Connective Tissue Growth Factor - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Angiotensin II - physiology | Connective Tissue Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Cancer, ISSN 0008-543X, 06/2017, Volume 123, Issue S11, pp. 2118 - 2129
The identification of driver mutations in melanoma has changed the field of cancer treatment. BRAF and NRAS mutations are predominant in melanoma and lead to... 
targeted therapy | phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT) pathway | BRAF inhibitors | mitogen‐activated protein kinase kinase (MEK) inhibitors | immunotherapy | melanoma | mitogen‐activated protein kinase (MAPK) pathway | phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway | mitogen-activated protein kinase kinase (MEK) inhibitors | mitogen-activated protein kinase (MAPK) pathway | MUTANT MELANOMA | PD-L1 EXPRESSION | ACQUIRED-RESISTANCE | OPEN-LABEL | MEK INHIBITORS | METASTATIC MELANOMA | PHASE-II TRIAL | ONCOLOGY | CUTANEOUS MELANOMA | BRAF INHIBITOR RESISTANCE | RAF INHIBITORS | Niacinamide - analogs & derivatives | Immunotherapy - methods | Skin Neoplasms - drug therapy | Humans | Ipilimumab | Antibodies, Monoclonal - therapeutic use | Drug Resistance, Neoplasm | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Kinase 1 - genetics | Melanoma - genetics | Benzimidazoles - therapeutic use | MAP Kinase Kinase 1 - antagonists & inhibitors | Antibodies, Monoclonal, Humanized - therapeutic use | Drug Administration Schedule | Signal Transduction | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Pyrimidines - therapeutic use | Quinazolines - therapeutic use | Melanoma - drug therapy | Skin Neoplasms - genetics | Indoles - therapeutic use | CTLA-4 Antigen - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Therapy | Melanoma | MAP kinase | AKT protein | Drug resistance | Kinases | Cancer therapies | Patients | 1-Phosphatidylinositol 3-kinase | Metastases | Signal transduction | Inhibitors | Pathways | New combinations | Effectors | Mutation | Cancer
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2005, Volume 288, Issue 2, pp. 971 - 976
Pharmacological activation of the prosurvival kinases Akt and ERK-1/2 at reperfusion, after a period of lethal ischemia, protects the heart against... 
Myocardial infarction | Phosphatidylinositol 3-kinase-Akt | Reperfusion injury | Mitogen-activated protein kinases | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | phosphatidylinositol 3-kinase-Akt | HEARTS | myocardial infarction | INJURY | reperfusion injury | MITOCHONDRIAL PERMEABILITY TRANSITION | mitogen-activated protein kinases | PORE | PERIPHERAL VASCULAR DISEASE | RADICALS | Phosphorylation | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Myocardial Reperfusion Injury - pathology | Myocardial Infarction - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Myocardium - pathology | MAP Kinase Kinase 2 - metabolism | Myocardial Infarction - metabolism | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-akt | Myocardial Reperfusion Injury - metabolism | Myocardium - enzymology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Ischemic Preconditioning, Myocardial | MAP Kinase Kinase 2 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article