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Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 32, pp. 23322 - 23330
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2015, Volume 290, Issue 44, pp. 26661 - 26674
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 03/2012, Volume 11, Issue 3, pp. 720 - 729
The MEK1 and MEK2 inhibitor GSK1120212 is currently in phase II/III clinical development. To identify predictive biomarkers, sensitivity to GSK1120212 was... 
ONCOLOGY | SELUMETINIB AZD6244 | PATHWAY | COLORECTAL-CANCER | TYROSINE KINASE | BCR-ABL | MARKERS | CELL-LINES | TUMOR-GROWTH | EGF RECEPTOR | ADDICTION | ras Proteins - genetics | Dual Specificity Phosphatase 6 - genetics | Prognosis | Oligonucleotide Array Sequence Analysis | Humans | Transcriptome | Cell Survival - genetics | ras Proteins - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | raf Kinases - metabolism | Pyrimidinones - chemistry | MAP Kinase Kinase 1 - genetics | Protein Kinase Inhibitors - chemistry | Biomarkers, Tumor - metabolism | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Gene Expression Regulation, Neoplastic - drug effects | raf Kinases - genetics | MAP Kinase Kinase 2 - genetics | Cell Survival - drug effects | MAP Kinase Kinase 1 - antagonists & inhibitors | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - metabolism | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Antineoplastic Agents - chemistry | Blotting, Western | Phosphatidylinositol 3-Kinases - genetics | Dual Specificity Phosphatase 6 - metabolism | Drug Resistance, Neoplasm - genetics | MAP Kinase Kinase 2 - antagonists & inhibitors | Cell Line, Tumor | Biomarkers, Tumor - genetics | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Mutation | Pyridones - chemistry | Pyridones - pharmacology | Drug Resistance, Neoplasm - drug effects
Journal Article
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 02/2011, Volume 34, Issue 2, pp. 201 - 212
Journal Article
Science, ISSN 0036-8075, 02/2017, Volume 355, Issue 6327, pp. 836 - 842
Journal Article
BMC Genomics, ISSN 1471-2164, 05/2015, Volume 16, Issue 1, p. 386
Background: The mitogen-activated protein kinase (MAPK) cascade consists of three types of reversibly phosphorylated kinases, namely, MAPK, MAPK kinase... 
MAPKKK | Abiotic stress | MAPKK | Biotic stress | Cucumis sativus | MAPK | Plant hormones | PROTEIN-KINASE GENE | ARABIDOPSIS-THALIANA | SATIVUS | CASCADE | PLANT-RESISTANCE | SIGNALING PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SEQUENCE | GENETICS & HEREDITY | BRASSICA-NAPUS L | EXPRESSION | RICE | Gene Duplication | Mitogen-Activated Protein Kinase Kinases - genetics | Genomics | Molecular Sequence Data | Cucumis sativus - genetics | Gene Expression Profiling | Cucumis sativus - physiology | Phylogeny | Promoter Regions, Genetic - genetics | Mitogen-Activated Protein Kinases - chemistry | MAP Kinase Kinase Kinases - chemistry | Mitogen-Activated Protein Kinase Kinases - metabolism | MAP Kinase Signaling System - genetics | Conserved Sequence | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Multigene Family - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Genome, Plant - genetics | MAP Kinase Kinase Kinases - genetics | Stress, Physiological - genetics | Protein-Serine-Threonine Kinases - genetics | Chromosome Mapping | MAP Kinase Kinase Kinases - metabolism | Cucumis sativus - growth & development | Amino Acid Motifs | Mitogen-Activated Protein Kinase Kinases - chemistry | Sequence Alignment | MAP Kinase Signaling System - drug effects | Cucumis sativus - cytology | Mitogen-Activated Protein Kinases - genetics | Protein-Serine-Threonine Kinases - chemistry | Plant Growth Regulators - pharmacology | Evolution, Molecular | Mitogen-Activated Protein Kinases - metabolism | Hardiness | Genetic aspects | Plants | Properties | Protein kinases | Identification and classification | Cucumbers | Amino acids | Mitogens
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2013, Volume 70, pp. 758 - 767
The benzo[ ]pyrimido-[5,4- ]diazepine-6(11 )-one core was discovered as a novel ERK5 (also known as MAPK7 and BMK1) inhibitor scaffold, previously. Further... 
ERK5 inhibitor | Benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-one | Kinase selectivity | Benzo[e]pyrimido-[5,4-b]diazepine-6(11H)- one | CELLS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | INHIBITOR SELECTIVITY | POLO-LIKE-KINASE-1 | LRRK2 | PARKINSON DISEASE | PROSTATE-CANCER | IN-VIVO | EXPRESSION | CARCINOMA | Protein Kinase Inhibitors - chemical synthesis | Pyrimidines - chemical synthesis | Humans | Cells, Cultured | Azepines - chemical synthesis | Models, Molecular | Structure-Activity Relationship | Mitogen-Activated Protein Kinase 7 - metabolism | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Pyrimidines - chemistry | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Azepines - pharmacology | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Azepines - chemistry | Mitogen-Activated Protein Kinase 7 - antagonists & inhibitors | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Molecular Structure | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Serine-Threonine Kinases - metabolism | Medical colleges | Phosphotransferases | Epidermal growth factor | PLK, polo-like kinase | EGF, epidermal growth factor | PML, promyelocytic leukemia protein | X-phos, 2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-biphenyl | DIEA, N,N-diisopropylethylamine | DMA, N,N-dimethylacetamide | ERK5, extracelluar-signal-regulated kinase 5 | LRRK2, leucine rich repeat kinase 2 | BMK1, big MAP kinase 1 | ERK5, mitogen-activated protein kinase 7 | RSK, ribosomal S6 kinase | SAR, structure–activity relationship | Pd2(dba)3, tris(dibenzylideneacetone)dipalladium- | HCC, hepatocellular carcinoma | Original | DCAMKL2, doublecortin and CaM kinase-like 2 | MAPK, mitogen-activated protein kinase | MEK5, MAP kinase kinase 5
Journal Article