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Oncogene, ISSN 0950-9232, 05/2007, Volume 26, Issue 22, pp. 3227 - 3239
The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein (MAP) kinase pathway plays a central role in cell proliferation... 
Signal transduction | MAP kinase | ERK1/2 | Cell cycle | G1 phase | SIGNAL-TRANSDUCTION PATHWAYS | signal transduction | cell cycle | EARLY GENE-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE ARREST | INITIATION-FACTOR 4E | DNA-SYNTHESIS | CELL BIOLOGY | NIH 3T3 CELLS | DEPENDENT KINASE | ONCOLOGY | GENETICS & HEREDITY | SMOOTH-MUSCLE-CELLS | MESSENGER-RNA TRANSPORT | MAP Kinase Signaling System - physiology | Cell Proliferation | Mitogen-Activated Protein Kinase 1 - physiology | Mitogen-Activated Protein Kinase 3 - genetics | Humans | Mitogen-Activated Protein Kinase 1 - deficiency | G1 Phase - physiology | S Phase - genetics | Mitogen-Activated Protein Kinase 3 - physiology | Animals | MAP Kinase Signaling System - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | S Phase - physiology | Mitogen-Activated Protein Kinase 3 - deficiency | G1 Phase - genetics | Enzyme Activation - genetics | Enzyme Activation - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Control | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Protein kinases | Genetics | Kinases | Mammals | Cancer | Life Sciences | G1 Phase | S Phase | Biochemistry, Molecular Biology | Enzyme Activation | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | MAP Kinase Signaling System
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7385, pp. 419 - 422
Journal Article
Science Signaling, ISSN 1945-0877, 04/2017, Volume 10, Issue 475, pp. eaah4273 - eaah4273
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 16, pp. 11216 - 11232
Understanding the regulation of cardiomyocyte growth is crucial for the management of adverse ventricular remodeling and heart failure. MicroRNA-378 (miR-378)... 
MUTATIONS CAUSE NOONAN | SIGNALING PATHWAYS | PRESSURE-OVERLOAD | CARDIOMYOCYTE | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPEUTIC TARGET | HEART-FAILURE | GENE-EXPRESSION | DIACYLGLYCEROL-BINDING MOTIFS | NUCLEOTIDE-RELEASING PROTEIN | FOCAL ADHESION KINASE | ras Proteins - genetics | ras Proteins - metabolism | Cardiomegaly - pathology | Glycogen Synthase Kinase 3 beta | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Adrenergic alpha-1 Receptor Agonists - adverse effects | Adrenergic alpha-1 Receptor Agonists - pharmacology | MAP Kinase Signaling System | MAP Kinase Kinase 1 - genetics | Phenylephrine - adverse effects | Phenylephrine - pharmacology | GRB2 Adaptor Protein - genetics | Muscle Proteins - metabolism | Proto-Oncogene Proteins c-raf | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation - genetics | MAP Kinase Kinase Kinases - genetics | Cells, Cultured | Rats | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase Kinases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins c-akt | Animals | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | GRB2 Adaptor Protein - biosynthesis | Cardiomegaly - chemically induced | MicroRNAs - genetics | Cardiomegaly - genetics | Cardiomegaly - metabolism | Molecular Bases of Disease | MAP Kinases (MAPKs) | Molecular Biology | RNA | Ras | Cell Signaling | MicroRNA-378 | Grb2 | Cardiac Hypertrophy
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2012, Volume 318, Issue 16, pp. 2105 - 2115
The activation of transforming growth factor-β1(TGF-β1)/Smad signaling pathway and increased expression of connective tissue growth factor (CTGF) induced by... 
TGFβ1 | Angiotensin II | Atrial fibroblasts | TRAF6 | CTGF | MAPKs | TGFΒ1 | Heart Atria - pathology | Gene Expression - drug effects | Heart Atria - drug effects | Transforming Growth Factor beta1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Fibrosis - metabolism | MAP Kinase Kinase 4 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | MAP Kinase Kinase 4 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | TNF Receptor-Associated Factor 6 - genetics | MAP Kinase Kinase Kinases - antagonists & inhibitors | Fibroblasts - metabolism | Angiotensin II - pharmacology | Fibrosis - genetics | Mitogen-Activated Protein Kinase 3 - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Heart Atria - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | TNF Receptor-Associated Factor 6 - metabolism | MAP Kinase Kinase 4 - genetics | Connective Tissue Growth Factor - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Angiotensin II - physiology | Connective Tissue Growth Factor - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer
Journal Article
The Plant Cell, ISSN 1040-4651, 10/2007, Volume 19, Issue 10, pp. 3266 - 3279
Although the Arabidopsis thaliana genome contains genes encoding 20 mitogen-activated protein kinases (MAPKs) and 10 MAPK kinases (MAPKKs), most of them are... 
Proteins | Yeasts | Pathogens | Genes | Protoplasts | Antibodies | Gene expression regulation | Plants | Plant cells | Seedlings | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BACTERIAL FLAGELLIN | AGROBACTERIUM-MEDIATED TRANSFORMATION | SACCHAROMYCES-CEREVISIAE | PLANT SCIENCES | CELL BIOLOGY | PLANT DEFENSE | FUNCTIONAL-ANALYSIS | GENE-EXPRESSION | HYDROGEN-PEROXIDE | MPK4 ACTIVATION | INNATE IMMUNITY | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Immunoprecipitation | Hydrogen Peroxide - pharmacology | Immunoblotting | MAP Kinase Kinase 3 - genetics | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - metabolism | MAP Kinase Kinase 3 - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Host-Pathogen Interactions | Two-Hybrid System Techniques | Gene Expression Regulation, Plant - drug effects | Signal Transduction - drug effects | Plants, Genetically Modified | Protein Binding - drug effects | Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Pseudomonas syringae - physiology | Mitogen-Activated Protein Kinases - metabolism | Infection | Arabidopsis thaliana | Retrotransposons | Evaluation | Plant defenses | Physiological aspects | Genetic aspects | Gene expression | Plasmodesmata | Health aspects | Protein kinases
Journal Article
Blood, ISSN 0006-4971, 06/2011, Volume 117, Issue 23, pp. 6287 - 6296
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and... 
B-CELLS | CLL | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | APOPTOTIC CELL-DEATH | RITUXIMAB | SURVIVAL SIGNALS | LYMPHOMA | DRUG-RESISTANCE | INHIBITOR | HEMATOLOGY | EXPRESSION | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | B-Cell Activating Factor - metabolism | CD40 Ligand - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Receptors, Antigen, B-Cell - genetics | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Leukemic - genetics | Protein-Tyrosine Kinases - genetics | CD40 Ligand - metabolism | MAP Kinase Signaling System - genetics | Female | Interleukin-4 - genetics | Protein-Tyrosine Kinases - biosynthesis | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Neoplasm Proteins - biosynthesis | Interleukin-4 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Cell Proliferation - drug effects | Lymphoid Neoplasia
Journal Article
Journal Article