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Publication DateJournal of Clinical Investigation, ISSN 0021-9738, 05/2018, Volume 128, Issue 5, pp. 2042 - 2047
Mice homozygous for the Tyr208Asn amino acid substitution in the carboxy terminus of Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1)...
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | GENE | TAK1 | AUTOIMMUNITY | INNATE | ACTIVATED PROTEIN-KINASES | STRESS | Inflammation - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Neutrophil Infiltration | Sweet Syndrome - genetics | Signal Transduction - immunology | MAP Kinase Kinase Kinase 5 - metabolism | Disease Models, Animal | Neutrophils - pathology | Sweet Syndrome - immunology | MAP Kinase Kinase Kinase 5 - genetics | Neutrophils - enzymology | MAP Kinase Kinase Kinases - genetics | Neutrophils - immunology | Sweet Syndrome - pathology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Animals | Sweet Syndrome - enzymology | Inflammation - genetics | Mice | Inflammation - enzymology | MAP Kinase Kinase Kinase 5 - immunology | Neutrophils | Physiological aspects | Development and progression | Models | Inflammation | Skin | Autoimmune diseases | Dermatitis | Health aspects | Mitogen-activated protein kinases | Splenomegaly | SHP-1 protein | TAK1 protein | MAP kinase | Homology | Leukocytes (neutrophilic) | Interleukin 1 receptors | Kinases | Amino acid substitution | Clonal deletion | Interleukin 1 | Skin diseases | Syk protein | Mutation | Apoptosis
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | GENE | TAK1 | AUTOIMMUNITY | INNATE | ACTIVATED PROTEIN-KINASES | STRESS | Inflammation - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Neutrophil Infiltration | Sweet Syndrome - genetics | Signal Transduction - immunology | MAP Kinase Kinase Kinase 5 - metabolism | Disease Models, Animal | Neutrophils - pathology | Sweet Syndrome - immunology | MAP Kinase Kinase Kinase 5 - genetics | Neutrophils - enzymology | MAP Kinase Kinase Kinases - genetics | Neutrophils - immunology | Sweet Syndrome - pathology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Animals | Sweet Syndrome - enzymology | Inflammation - genetics | Mice | Inflammation - enzymology | MAP Kinase Kinase Kinase 5 - immunology | Neutrophils | Physiological aspects | Development and progression | Models | Inflammation | Skin | Autoimmune diseases | Dermatitis | Health aspects | Mitogen-activated protein kinases | Splenomegaly | SHP-1 protein | TAK1 protein | MAP kinase | Homology | Leukocytes (neutrophilic) | Interleukin 1 receptors | Kinases | Amino acid substitution | Clonal deletion | Interleukin 1 | Skin diseases | Syk protein | Mutation | Apoptosis
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Loading RightsTrends in Immunology, ISSN 1471-4906, 2013, Volume 34, Issue 7, pp. 307 - 316
Highlights • TAK1 is a central component of NF-κB and MAPK signaling pathways. • TAK1 activation is tightly regulated by multiple modifications. • TAK1...
Allergy and Immunology | innate immune signaling | TAK1 complex | NF-κB pathway | reactive oxygen species | APOPTOSIS | NF-kappa B pathway | ACTIVATED KINASE 1 | IL-1 | PROTEIN-KINASE | IMMUNOLOGY | P38 MAP KINASE | TARGETING TAK1 | UBIQUITIN-DEPENDENT KINASE | TAB1 | NF-KAPPA-B | ADAPTER PROTEIN | Humans | Gene Expression Regulation | Neutrophils - immunology | NF-kappa B - metabolism | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Immunity, Innate | Organ Specificity | Carcinogenesis | MAP Kinase Kinase Kinases - immunology | Mitogen-Activated Protein Kinase Kinases - metabolism | Signal Transduction - immunology | Animals | Neoplasms - immunology | Mice | Apoptosis | T cell receptors | Cytokines | Kinases | Immune system
Allergy and Immunology | innate immune signaling | TAK1 complex | NF-κB pathway | reactive oxygen species | APOPTOSIS | NF-kappa B pathway | ACTIVATED KINASE 1 | IL-1 | PROTEIN-KINASE | IMMUNOLOGY | P38 MAP KINASE | TARGETING TAK1 | UBIQUITIN-DEPENDENT KINASE | TAB1 | NF-KAPPA-B | ADAPTER PROTEIN | Humans | Gene Expression Regulation | Neutrophils - immunology | NF-kappa B - metabolism | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Immunity, Innate | Organ Specificity | Carcinogenesis | MAP Kinase Kinase Kinases - immunology | Mitogen-Activated Protein Kinase Kinases - metabolism | Signal Transduction - immunology | Animals | Neoplasms - immunology | Mice | Apoptosis | T cell receptors | Cytokines | Kinases | Immune system
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Loading RightsJournal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36223 - 36229
The Rip2 kinase contains a caspase recruitment domain and has been implicated in the activation of the transcriptional factor NF-κB downstream of Toll-like...
PEPTIDOGLYCAN | PROTEIN | INNATE IMMUNE-RESPONSES | HOST RECOGNITION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTOR | SYSTEMS | NF-KAPPA-B | TLR4 | MYD88 | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Ubiquitination - drug effects | TNF Receptor-Associated Factor 6 - genetics | Toll-Like Receptors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - microbiology | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Protein Ligases - metabolism | Nod2 Signaling Adaptor Protein - immunology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ubiquitin - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Adjuvants, Immunologic - pharmacology | NF-kappa B - immunology | TNF Receptor-Associated Factor 6 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Enzyme Activation - immunology | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | I-kappa B Kinase - metabolism | Myeloid Differentiation Factor 88 - immunology | Ubiquitin-Conjugating Enzymes - immunology | Tuberculosis - metabolism | Macrophages - immunology | Cells, Cultured | Ubiquitination - immunology | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Tuberculosis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | NF-kappa B - genetics | Tuberculosis - genetics | TNF Receptor-Associated Factor 6 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
PEPTIDOGLYCAN | PROTEIN | INNATE IMMUNE-RESPONSES | HOST RECOGNITION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTOR | SYSTEMS | NF-KAPPA-B | TLR4 | MYD88 | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Ubiquitination - drug effects | TNF Receptor-Associated Factor 6 - genetics | Toll-Like Receptors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - microbiology | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Protein Ligases - metabolism | Nod2 Signaling Adaptor Protein - immunology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ubiquitin - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Adjuvants, Immunologic - pharmacology | NF-kappa B - immunology | TNF Receptor-Associated Factor 6 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Enzyme Activation - immunology | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | I-kappa B Kinase - metabolism | Myeloid Differentiation Factor 88 - immunology | Ubiquitin-Conjugating Enzymes - immunology | Tuberculosis - metabolism | Macrophages - immunology | Cells, Cultured | Ubiquitination - immunology | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Tuberculosis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | NF-kappa B - genetics | Tuberculosis - genetics | TNF Receptor-Associated Factor 6 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
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Loading RightsNature Immunology, ISSN 1529-2908, 03/2015, Volume 16, Issue 4, pp. 354 - 365
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here...
CELLS | FAMILY-MEMBER | INFLAMMATION | TIR8/SIGIRR | INFECTION | IMMUNOLOGY | TOLL | INHIBITOR | EXPRESSION | NEGATIVE REGULATOR | MOLECULES | Inflammation - pathology | Interleukin-1 - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Proto-Oncogene Proteins c-fyn - genetics | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | PTEN Phosphohydrolase - immunology | RNA, Small Interfering - immunology | Receptors, Interleukin-1 - deficiency | Leukocytes, Mononuclear - immunology | c-Mer Tyrosine Kinase | Interleukin-1 - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Proto-Oncogene Proteins - immunology | Proto-Oncogene Proteins c-fyn - immunology | STAT3 Transcription Factor - genetics | Cell Line | PTEN Phosphohydrolase - genetics | Interleukin-18 Receptor alpha Subunit - immunology | Leukocytes, Mononuclear - drug effects | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | RNA-Binding Proteins - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors | Leukocytes, Mononuclear - pathology | TOR Serine-Threonine Kinases - immunology | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Protein Binding | Mice | STAT3 Transcription Factor - immunology | Receptors, Interleukin-1 - antagonists & inhibitors
CELLS | FAMILY-MEMBER | INFLAMMATION | TIR8/SIGIRR | INFECTION | IMMUNOLOGY | TOLL | INHIBITOR | EXPRESSION | NEGATIVE REGULATOR | MOLECULES | Inflammation - pathology | Interleukin-1 - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Proto-Oncogene Proteins c-fyn - genetics | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | PTEN Phosphohydrolase - immunology | RNA, Small Interfering - immunology | Receptors, Interleukin-1 - deficiency | Leukocytes, Mononuclear - immunology | c-Mer Tyrosine Kinase | Interleukin-1 - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Proto-Oncogene Proteins - immunology | Proto-Oncogene Proteins c-fyn - immunology | STAT3 Transcription Factor - genetics | Cell Line | PTEN Phosphohydrolase - genetics | Interleukin-18 Receptor alpha Subunit - immunology | Leukocytes, Mononuclear - drug effects | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | RNA-Binding Proteins - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors | Leukocytes, Mononuclear - pathology | TOR Serine-Threonine Kinases - immunology | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Protein Binding | Mice | STAT3 Transcription Factor - immunology | Receptors, Interleukin-1 - antagonists & inhibitors
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Loading RightsNature Reviews Immunology, ISSN 1474-1733, 08/2013, Volume 13, Issue 9, pp. 679 - 692
Following pathogen infection or tissue damage, the stimulation of pattern recognition receptors on the cell surface and in the cytoplasm of innate immune cells...
RHEUMATOID-ARTHRITIS | INFLAMMATORY RESPONSES | NITRIC-OXIDE SYNTHASE | MAP-KINASE | LIPOPOLYSACCHARIDE ACTIVATION | PHOSPHOTHREONINE LYASE ACTIVITY | IMMUNOLOGY | NF-KAPPA-B | SIGNAL-REGULATED KINASE | DEPENDENT ACTIVATION | TRISTETRAPROLIN-DEFICIENCY | Immunity, Innate - immunology | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Feedback | Humans | Toll-Like Receptors - immunology | Inflammation - immunology | Mitogen-Activated Protein Kinases - immunology | Enzyme Activation | Inflammation - enzymology | MAP Kinase Signaling System - immunology | Physiological aspects | Natural immunity | Genetic aspects | Research | Health aspects | Mitogen-activated protein kinases
RHEUMATOID-ARTHRITIS | INFLAMMATORY RESPONSES | NITRIC-OXIDE SYNTHASE | MAP-KINASE | LIPOPOLYSACCHARIDE ACTIVATION | PHOSPHOTHREONINE LYASE ACTIVITY | IMMUNOLOGY | NF-KAPPA-B | SIGNAL-REGULATED KINASE | DEPENDENT ACTIVATION | TRISTETRAPROLIN-DEFICIENCY | Immunity, Innate - immunology | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Feedback | Humans | Toll-Like Receptors - immunology | Inflammation - immunology | Mitogen-Activated Protein Kinases - immunology | Enzyme Activation | Inflammation - enzymology | MAP Kinase Signaling System - immunology | Physiological aspects | Natural immunity | Genetic aspects | Research | Health aspects | Mitogen-activated protein kinases
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Loading RightsJournal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 21, pp. 17100 - 17108
Naturally occurring Foxp3(+)CD4(+)CD25(+) T regulatory cell (nTreg)-mediated suppression of lung allergic responses is abrogated following ligation of...
KAPPA-B ACTIVATION | TGF-BETA | PROTEIN | INDUCED TNF RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR FOXP3 | AIRWAY HYPERREACTIVITY | LUNG ALLERGIC RESPONSES | COSTIMULATION | LIGAND | CUTTING EDGE | MAP Kinase Kinase 7 - genetics | T-Lymphocytes, Regulatory - metabolism | Asthma - metabolism | MAP Kinase Signaling System - physiology | Immune Tolerance - physiology | MAP Kinase Kinase 7 - immunology | NF-kappa B - immunology | MAP Kinase Kinase 4 - immunology | NF-kappa B - metabolism | Enzyme Activation - immunology | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | MAP Kinase Kinase 7 - metabolism | Phosphorylation - genetics | MAP Kinase Kinase 4 - metabolism | Asthma - immunology | Female | Lung - metabolism | Phosphorylation - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Autoimmune Diseases - metabolism | Immune Tolerance - drug effects | Autoimmune Diseases - immunology | Glucocorticoid-Induced TNFR-Related Protein - metabolism | Glucocorticoid-Induced TNFR-Related Protein - genetics | p38 Mitogen-Activated Protein Kinases - genetics | p38 Mitogen-Activated Protein Kinases - immunology | Enzyme Activation - drug effects | Anthracenes - pharmacology | Asthma - genetics | Mice, Knockout | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice | Protein Kinase Inhibitors - pharmacology | Enzyme Activation - genetics | Lung - immunology | MAP Kinases (MAPKs) | GITR | Signal Transduction | Cell Signaling | CD4+CD25+Foxp3+ T Regulatory Cells | Cellular Immune Response | Asthma | Jun N-terminal Kinase (JNK) | SP600125
KAPPA-B ACTIVATION | TGF-BETA | PROTEIN | INDUCED TNF RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR FOXP3 | AIRWAY HYPERREACTIVITY | LUNG ALLERGIC RESPONSES | COSTIMULATION | LIGAND | CUTTING EDGE | MAP Kinase Kinase 7 - genetics | T-Lymphocytes, Regulatory - metabolism | Asthma - metabolism | MAP Kinase Signaling System - physiology | Immune Tolerance - physiology | MAP Kinase Kinase 7 - immunology | NF-kappa B - immunology | MAP Kinase Kinase 4 - immunology | NF-kappa B - metabolism | Enzyme Activation - immunology | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | MAP Kinase Kinase 7 - metabolism | Phosphorylation - genetics | MAP Kinase Kinase 4 - metabolism | Asthma - immunology | Female | Lung - metabolism | Phosphorylation - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Autoimmune Diseases - metabolism | Immune Tolerance - drug effects | Autoimmune Diseases - immunology | Glucocorticoid-Induced TNFR-Related Protein - metabolism | Glucocorticoid-Induced TNFR-Related Protein - genetics | p38 Mitogen-Activated Protein Kinases - genetics | p38 Mitogen-Activated Protein Kinases - immunology | Enzyme Activation - drug effects | Anthracenes - pharmacology | Asthma - genetics | Mice, Knockout | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice | Protein Kinase Inhibitors - pharmacology | Enzyme Activation - genetics | Lung - immunology | MAP Kinases (MAPKs) | GITR | Signal Transduction | Cell Signaling | CD4+CD25+Foxp3+ T Regulatory Cells | Cellular Immune Response | Asthma | Jun N-terminal Kinase (JNK) | SP600125
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Loading RightsImmunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 475 - 488
Follicular B cell survival requires signaling from BAFFR, a receptor for BAFF and the B cell antigen receptor (BCR). This “tonic” BCR survival signal is...
TACI | AKT | BCMA | IMMUNOLOGY | MATURATION | ACTIVATING FACTOR | AUTOIMMUNE-DISEASE | SYK TYROSINE KINASE | MICE LACKING | FAMILY | ANTIGEN | Oligonucleotide Array Sequence Analysis | Protein-Tyrosine Kinases - metabolism | Cell Survival - genetics | Immunoblotting | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Receptors, Antigen, B-Cell - metabolism | Extracellular Signal-Regulated MAP Kinases - immunology | Phosphatidylinositol 3-Kinases - immunology | Phosphorylation - drug effects | B-Cell Activation Factor Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | 3-Phosphoinositide-Dependent Protein Kinases | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | B-Cell Activation Factor Receptor - immunology | Cell Survival - drug effects | RNA, Untranslated | Mice, Transgenic | Mice, Knockout | B-Cell Activation Factor Receptor - metabolism | Models, Immunological | B-Lymphocytes - immunology | Signal Transduction - drug effects | Mice | CD79 Antigens - immunology | Intracellular Signaling Peptides and Proteins - immunology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Protein-Tyrosine Kinases - immunology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Flow Cytometry | B-Cell Activating Factor - immunology | Protein-Serine-Threonine Kinases - genetics | Cell Survival - immunology | Proteins - immunology | Receptors, Antigen, B-Cell - immunology | CD79 Antigens - metabolism | Proteins - genetics | Receptor Cross-Talk - immunology | B-Lymphocytes - drug effects | Animals | Proteins - metabolism | Tamoxifen - pharmacology | Protein-Serine-Threonine Kinases - immunology | B-Cell Activating Factor - pharmacology | Proteins | Genetic research | Cells | Bone marrow | Antigens | Kinases | Rodents | Immune system
TACI | AKT | BCMA | IMMUNOLOGY | MATURATION | ACTIVATING FACTOR | AUTOIMMUNE-DISEASE | SYK TYROSINE KINASE | MICE LACKING | FAMILY | ANTIGEN | Oligonucleotide Array Sequence Analysis | Protein-Tyrosine Kinases - metabolism | Cell Survival - genetics | Immunoblotting | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Receptors, Antigen, B-Cell - metabolism | Extracellular Signal-Regulated MAP Kinases - immunology | Phosphatidylinositol 3-Kinases - immunology | Phosphorylation - drug effects | B-Cell Activation Factor Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | 3-Phosphoinositide-Dependent Protein Kinases | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | B-Cell Activation Factor Receptor - immunology | Cell Survival - drug effects | RNA, Untranslated | Mice, Transgenic | Mice, Knockout | B-Cell Activation Factor Receptor - metabolism | Models, Immunological | B-Lymphocytes - immunology | Signal Transduction - drug effects | Mice | CD79 Antigens - immunology | Intracellular Signaling Peptides and Proteins - immunology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Protein-Tyrosine Kinases - immunology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Flow Cytometry | B-Cell Activating Factor - immunology | Protein-Serine-Threonine Kinases - genetics | Cell Survival - immunology | Proteins - immunology | Receptors, Antigen, B-Cell - immunology | CD79 Antigens - metabolism | Proteins - genetics | Receptor Cross-Talk - immunology | B-Lymphocytes - drug effects | Animals | Proteins - metabolism | Tamoxifen - pharmacology | Protein-Serine-Threonine Kinases - immunology | B-Cell Activating Factor - pharmacology | Proteins | Genetic research | Cells | Bone marrow | Antigens | Kinases | Rodents | Immune system
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Loading RightsImmunity, ISSN 1074-7613, 04/2017, Volume 46, Issue 4, pp. 635 - 648
Mice carrying a hypomorphic point mutation in the gene ( mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in humans. Here, we...
myeloid cells | SYK | RIPK3 | MLKL | autoinflammation | Ptpn6 | IL-1β | IL-1α | MyD88 | SHP1 | TAK1 | necrosis | RIPK1 | MOTH-EATEN MICE | SIGNALING PATHWAYS | STERILE INFLAMMATION | GENE | APOPTOTIC CELL-DEATH | PHOSPHATASE | IN-VIVO | IMMUNOLOGY | SHP-1 | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Phosphorylation | Interleukin-1alpha - immunology | Skin Diseases - genetics | Humans | Immunoblotting | Interleukin-1alpha - metabolism | Syk Kinase - immunology | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Syk Kinase - genetics | HEK293 Cells | Myeloid Differentiation Factor 88 - immunology | Interleukin-1alpha - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Skin Diseases - metabolism | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Skin Diseases - immunology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Models, Immunological | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Syk Kinase - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Inflammation - genetics | Mutation | Myeloid Differentiation Factor 88 - metabolism | Disease | SHP-1 protein | Crosstalk | Interleukin | Licenses | Interleukin 1 receptors | Kinases | Phosphatase | Inflammatory diseases | Proteins | Coding | Rodents | Interleukin 1 | Post-translation | Bone marrow | Skin diseases | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Activation analysis | Immune system | Tyrosine | TAK1 protein | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Roles | Scaffolding | Point mutation | MyD88 protein | Syk protein
myeloid cells | SYK | RIPK3 | MLKL | autoinflammation | Ptpn6 | IL-1β | IL-1α | MyD88 | SHP1 | TAK1 | necrosis | RIPK1 | MOTH-EATEN MICE | SIGNALING PATHWAYS | STERILE INFLAMMATION | GENE | APOPTOTIC CELL-DEATH | PHOSPHATASE | IN-VIVO | IMMUNOLOGY | SHP-1 | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Phosphorylation | Interleukin-1alpha - immunology | Skin Diseases - genetics | Humans | Immunoblotting | Interleukin-1alpha - metabolism | Syk Kinase - immunology | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Syk Kinase - genetics | HEK293 Cells | Myeloid Differentiation Factor 88 - immunology | Interleukin-1alpha - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Skin Diseases - metabolism | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Skin Diseases - immunology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Models, Immunological | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Syk Kinase - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Inflammation - genetics | Mutation | Myeloid Differentiation Factor 88 - metabolism | Disease | SHP-1 protein | Crosstalk | Interleukin | Licenses | Interleukin 1 receptors | Kinases | Phosphatase | Inflammatory diseases | Proteins | Coding | Rodents | Interleukin 1 | Post-translation | Bone marrow | Skin diseases | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Activation analysis | Immune system | Tyrosine | TAK1 protein | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Roles | Scaffolding | Point mutation | MyD88 protein | Syk protein
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The role of IL‐33 and its receptor ST2 in human nasal epithelium with allergic rhinitis
Clinical & Experimental Allergy, ISSN 0954-7894, 02/2012, Volume 42, Issue 2, pp. 218 - 228
Summary Background Interleukin (IL)‐33 is a novel member of the IL‐1 cytokine family and a ligand for the orphan IL‐1 family receptor ST2. The IL‐33 induces T...
ST2 | human nasal epithelial cells | IL‐33 | allergic rhinitis | signal transduction | Human nasal epithelial cells | Signal transduction | IL-33 | Allergic rhinitis | CYTOKINE | INTERLEUKIN-33 | IMMUNOLOGY | FAMILY | MEMBER | HUMAN EOSINOPHILS | ALLERGY | INNATE IMMUNE-RESPONSES | ENDOTHELIAL-CELLS | DISEASE | HUMAN MAST-CELLS | EXPRESSION | Interleukin-1 Receptor-Like 1 Protein | Interleukin-8 - genetics | Humans | Middle Aged | MAP Kinase Kinase 4 - immunology | Male | NF-kappa B - metabolism | Toll-Like Receptor 9 - agonists | Young Adult | Interleukins - genetics | RNA, Messenger - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukins - biosynthesis | Real-Time Polymerase Chain Reaction | Antiviral Agents - pharmacology | Rhinitis, Allergic, Seasonal - genetics | Interleukin-33 | p38 Mitogen-Activated Protein Kinases - immunology | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Cell Surface - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Adolescent | MAP Kinase Kinase 4 - genetics | Interleukin-8 - immunology | Toll-Like Receptor 9 - metabolism | Receptors, Cell Surface - genetics | RNA, Messenger - immunology | ErbB Receptors - genetics | NF-kappa B - immunology | Toll-Like Receptor 9 - genetics | Nasal Mucosa - pathology | MAP Kinase Signaling System - immunology | Toll-Like Receptor 9 - immunology | MAP Kinase Kinase 4 - metabolism | MAP Kinase Signaling System - genetics | Interleukins - immunology | Adult | Female | Nasal Mucosa - metabolism | Rhinitis, Allergic, Seasonal - pathology | Interleukin-8 - blood | Granulocyte-Macrophage Colony-Stimulating Factor - blood | ErbB Receptors - metabolism | RNA, Messenger - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | Nasal Mucosa - immunology | ErbB Receptors - immunology | Rhinitis, Allergic, Seasonal - blood | Aged | Interferon-gamma - pharmacology | Ligands | Nose | Allergies | Corticoids | Cell culture | Epithelial cells | Mucosa | c-Jun amino-terminal kinase | Atopic dermatitis | Interleukin 1 | Toll-like receptors | Enzyme-linked immunosorbent assay | Interleukin 8 | Epidermal growth factor receptors | Granulocyte-macrophage colony-stimulating factor | Hypersensitivity | Extracellular signal-regulated kinase | MAP kinase | Inflammation | Epithelium | Asthma | Polymerase chain reaction | Play | NF- Kappa B protein | gamma -Interferon | Chemokines
ST2 | human nasal epithelial cells | IL‐33 | allergic rhinitis | signal transduction | Human nasal epithelial cells | Signal transduction | IL-33 | Allergic rhinitis | CYTOKINE | INTERLEUKIN-33 | IMMUNOLOGY | FAMILY | MEMBER | HUMAN EOSINOPHILS | ALLERGY | INNATE IMMUNE-RESPONSES | ENDOTHELIAL-CELLS | DISEASE | HUMAN MAST-CELLS | EXPRESSION | Interleukin-1 Receptor-Like 1 Protein | Interleukin-8 - genetics | Humans | Middle Aged | MAP Kinase Kinase 4 - immunology | Male | NF-kappa B - metabolism | Toll-Like Receptor 9 - agonists | Young Adult | Interleukins - genetics | RNA, Messenger - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukins - biosynthesis | Real-Time Polymerase Chain Reaction | Antiviral Agents - pharmacology | Rhinitis, Allergic, Seasonal - genetics | Interleukin-33 | p38 Mitogen-Activated Protein Kinases - immunology | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Cell Surface - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Adolescent | MAP Kinase Kinase 4 - genetics | Interleukin-8 - immunology | Toll-Like Receptor 9 - metabolism | Receptors, Cell Surface - genetics | RNA, Messenger - immunology | ErbB Receptors - genetics | NF-kappa B - immunology | Toll-Like Receptor 9 - genetics | Nasal Mucosa - pathology | MAP Kinase Signaling System - immunology | Toll-Like Receptor 9 - immunology | MAP Kinase Kinase 4 - metabolism | MAP Kinase Signaling System - genetics | Interleukins - immunology | Adult | Female | Nasal Mucosa - metabolism | Rhinitis, Allergic, Seasonal - pathology | Interleukin-8 - blood | Granulocyte-Macrophage Colony-Stimulating Factor - blood | ErbB Receptors - metabolism | RNA, Messenger - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | Nasal Mucosa - immunology | ErbB Receptors - immunology | Rhinitis, Allergic, Seasonal - blood | Aged | Interferon-gamma - pharmacology | Ligands | Nose | Allergies | Corticoids | Cell culture | Epithelial cells | Mucosa | c-Jun amino-terminal kinase | Atopic dermatitis | Interleukin 1 | Toll-like receptors | Enzyme-linked immunosorbent assay | Interleukin 8 | Epidermal growth factor receptors | Granulocyte-macrophage colony-stimulating factor | Hypersensitivity | Extracellular signal-regulated kinase | MAP kinase | Inflammation | Epithelium | Asthma | Polymerase chain reaction | Play | NF- Kappa B protein | gamma -Interferon | Chemokines
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Loading RightsImmunobiology, ISSN 0171-2985, 2015, Volume 221, Issue 2, pp. 137 - 144
Highlights • LPS induced hPBMCs and LPS induced HUVECs were used as the model systems. • Tricin acted mainly on p38MAPK and PI3K pathways of LPS induced...
Allergy and Immunology | Advanced Basic Science | Lipopolysaccharide | Signaling | Inflammation | Tricin | Flavonoid | CELLS | ACTIVATED PROTEIN-KINASE | TRANSCRIPTION | ADHESION MOLECULES | IMMUNOLOGY | INHIBITION | P38 | GENE-EXPRESSION | TNF-ALPHA | NF-KAPPA-B | Chemokine CCL2 - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | MAP Kinase Kinase 4 - immunology | Oryza - chemistry | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - immunology | Cyclooxygenase 2 - genetics | E-Selectin - genetics | Human Umbilical Vein Endothelial Cells - cytology | Mitogen-Activated Protein Kinase 1 - genetics | Tumor Necrosis Factor-alpha - immunology | Vascular Cell Adhesion Molecule-1 - immunology | Mitogen-Activated Protein Kinase 1 - immunology | Human Umbilical Vein Endothelial Cells - drug effects | Leukocytes, Mononuclear - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - immunology | Proto-Oncogene Proteins c-akt - immunology | Intercellular Adhesion Molecule-1 - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | MAP Kinase Kinase 4 - genetics | Leukocytes, Mononuclear - cytology | Flavonoids - isolation & purification | Plant Extracts - chemistry | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | NF-kappa B - immunology | Human Umbilical Vein Endothelial Cells - immunology | Anti-Inflammatory Agents, Non-Steroidal - isolation & purification | Proto-Oncogene Proteins c-akt - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukocytes, Mononuclear - immunology | MAP Kinase Kinase 4 - antagonists & inhibitors | Vascular Cell Adhesion Molecule-1 - genetics | Flavonoids - pharmacology | Cyclooxygenase 2 - immunology | Mitogen-Activated Protein Kinase 3 - immunology | Intercellular Adhesion Molecule-1 - immunology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Chemokine CCL2 - genetics | E-Selectin - immunology | Phosphatidylinositol 3-Kinases - genetics | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Prevention | Analysis | Endothelium | Flavonoids | Flavones | Bioflavonoids | Mitogens
Allergy and Immunology | Advanced Basic Science | Lipopolysaccharide | Signaling | Inflammation | Tricin | Flavonoid | CELLS | ACTIVATED PROTEIN-KINASE | TRANSCRIPTION | ADHESION MOLECULES | IMMUNOLOGY | INHIBITION | P38 | GENE-EXPRESSION | TNF-ALPHA | NF-KAPPA-B | Chemokine CCL2 - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | MAP Kinase Kinase 4 - immunology | Oryza - chemistry | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - immunology | Cyclooxygenase 2 - genetics | E-Selectin - genetics | Human Umbilical Vein Endothelial Cells - cytology | Mitogen-Activated Protein Kinase 1 - genetics | Tumor Necrosis Factor-alpha - immunology | Vascular Cell Adhesion Molecule-1 - immunology | Mitogen-Activated Protein Kinase 1 - immunology | Human Umbilical Vein Endothelial Cells - drug effects | Leukocytes, Mononuclear - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - immunology | Proto-Oncogene Proteins c-akt - immunology | Intercellular Adhesion Molecule-1 - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | MAP Kinase Kinase 4 - genetics | Leukocytes, Mononuclear - cytology | Flavonoids - isolation & purification | Plant Extracts - chemistry | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | NF-kappa B - immunology | Human Umbilical Vein Endothelial Cells - immunology | Anti-Inflammatory Agents, Non-Steroidal - isolation & purification | Proto-Oncogene Proteins c-akt - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukocytes, Mononuclear - immunology | MAP Kinase Kinase 4 - antagonists & inhibitors | Vascular Cell Adhesion Molecule-1 - genetics | Flavonoids - pharmacology | Cyclooxygenase 2 - immunology | Mitogen-Activated Protein Kinase 3 - immunology | Intercellular Adhesion Molecule-1 - immunology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Chemokine CCL2 - genetics | E-Selectin - immunology | Phosphatidylinositol 3-Kinases - genetics | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Prevention | Analysis | Endothelium | Flavonoids | Flavones | Bioflavonoids | Mitogens
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Loading RightsIUBMB Life, ISSN 1521-6543, 10/2012, Volume 64, Issue 10, pp. 825 - 834
Transforming growth factor β‐activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to...
stress | hypoxia | kinase | innate immunity | inflammation | DNA damage | cell signaling | ubiquitylation | phosphorylation | adaptive immunity | TGF-BETA | GENOTOXIC STRESS | BETA-ACTIVATED KINASE-1 | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | TAK1-BINDING PROTEIN-1 | CELL BIOLOGY | SIGNALING PATHWAY | STRUCTURAL BASIS | POLYUBIQUITIN CHAINS | NF-KAPPA-B | Adaptive Immunity | Cytokines - metabolism | Gene Expression Regulation - immunology | MAP Kinase Kinase Kinases - genetics | Humans | Toll-Like Receptors - immunology | NF-kappa B - immunology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase 4 - immunology | DNA Damage - immunology | Hypoxia - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Signal Transduction - immunology | Animals | NF-kappa B - genetics | Toll-Like Receptors - genetics | MAP Kinase Kinase 4 - genetics | Mice | Cytokines - immunology | Ubiquitin
stress | hypoxia | kinase | innate immunity | inflammation | DNA damage | cell signaling | ubiquitylation | phosphorylation | adaptive immunity | TGF-BETA | GENOTOXIC STRESS | BETA-ACTIVATED KINASE-1 | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | TAK1-BINDING PROTEIN-1 | CELL BIOLOGY | SIGNALING PATHWAY | STRUCTURAL BASIS | POLYUBIQUITIN CHAINS | NF-KAPPA-B | Adaptive Immunity | Cytokines - metabolism | Gene Expression Regulation - immunology | MAP Kinase Kinase Kinases - genetics | Humans | Toll-Like Receptors - immunology | NF-kappa B - immunology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase 4 - immunology | DNA Damage - immunology | Hypoxia - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Signal Transduction - immunology | Animals | NF-kappa B - genetics | Toll-Like Receptors - genetics | MAP Kinase Kinase 4 - genetics | Mice | Cytokines - immunology | Ubiquitin
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