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by Zhang, Y and Li, R and Meng, Y and Li, S and Donelan, W and Zhao, Y and Qi, L and Zhang, M and Wang, X and Cui, T and Yang, L.-J and Tang, D
Diabetes (New York, N.Y.), ISSN 1939-327X, 2013, Volume 63, Issue 2, pp. 514 - 525
.... This effect was possibly mediated by irisin-induced phosphorylation of the p38 mitogen-activated protein kinase (p38 MAPK... 
OBESITY | GENE | ENDOCRINOLOGY & METABOLISM | MUSCLE | RECEPTOR | PROLIFERATION | DIFFERENTIATION | EXPRESSION | FAT-CELL | EXERCISE | ADIPOSE-TISSUE | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins
Journal Article
Science, ISSN 0036-8075, 02/2017, Volume 355, Issue 6327, pp. 836 - 842
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 464, Issue 7287, pp. 427 - 430
.... Induction of ERK signalling requires direct binding of the drug to the ATP-binding site of one kinase of the dimer and is dependent on RAS activity... 
SELECTIVE INHIBITOR | ACTIVATION | MELANOMA | MECHANISM | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HETERODIMERIZATION | KINASE INHIBITOR | B-RAF | CRAF | ONCOGENIC BRAF | Neoplasms - metabolism | ras Proteins - genetics | Phosphorylation | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | Transcriptional Activation - drug effects | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Adenosine Triphosphate - metabolism | Indoles - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Cell Line | raf Kinases - chemistry | Catalytic Domain | Neoplasms - enzymology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Care and treatment | Enzyme inhibitors | Gene mutations | Cellular signal transduction | Genetic aspects | Research | Health aspects | Cancer | Proteins | Competition | Drugs | Mutation | Kinases | Tumors | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 550, Issue 7674, pp. 133 - 136
.... p21-activated kinases (PAKs) become activated in cells with acquired drug resistance and have a... 
METASTATIC MELANOMA | MEK | EPITHELIAL-CELLS | PHOSPHORYLATION | PATHWAY | RAF | P21-ACTIVATED-KINASE-1 | MULTIDISCIPLINARY SCIENCES | KINASE | MECHANISMS | THERAPIES | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | p21-Activated Kinases - antagonists & inhibitors | Melanoma - enzymology | JNK Mitogen-Activated Protein Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Proto-Oncogene Proteins c-raf - chemistry | Female | beta Catenin - chemistry | Phosphorylation - drug effects | p21-Activated Kinases - genetics | JNK Mitogen-Activated Protein Kinases - chemistry | Enzyme Activation - drug effects | p21-Activated Kinases - metabolism | beta Catenin - metabolism | Proto-Oncogene Proteins c-raf - metabolism | Mitogen-Activated Protein Kinase Kinases - chemistry | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Drug Resistance, Neoplasm - drug effects | Melanoma | Physiological aspects | Cellular signal transduction | Drug resistance | Observations | Health aspects | Mitogen-activated protein kinases | TOR protein | Therapy | Phosphorylation | Activation | Metastasis | Drug development | Kinases | Cancer therapies | Metastases | Proteins | β-catenin | Signal transduction | Inhibition | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Patients | Signaling | Protein arrays | Molecular modelling | Biopsy | Cell lines | Apoptosis
Journal Article
Cancer, ISSN 0008-543X, 2014, Volume 120, Issue 22, pp. 3446 - 3456
The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple... 
mitogen‐activated protein kinase (MAPK) | mitogen‐activated protein kinase‐kinase (MEK) | signaling | colorectal cancer | ovarian cancer | v‐raf murine sarcoma viral oncogene homolog (BRAF) | melanoma | extracellular signal‐regulated kinase (ERK) | Extracellular signal-regulated kinase (ERK) | Signaling | V-raf murine sarcoma viral oncogene homolog (BRAF) | Colorectal cancer | Melanoma | Mitogen-activated protein kinase (MAPK) | Mitogen-activated protein kinase-kinase (MEK) | Ovarian cancer | mitogen-activated protein kinase-kinase (MEK) | mitogen-activated protein kinase (MAPK) | v-raf murine sarcoma viral oncogene homolog (BRAF) | extracellular signal-regulated kinase (ERK) | RNA INTERFERENCE SCREEN | ACTIVATED PROTEIN-KINASE | BRAF(V600E) INHIBITION | ACQUIRED-RESISTANCE | POTENTIAL MECHANISM | TUMOR HETEROGENEITY | CELL LUNG-CANCER | MET AMPLIFICATION | ONCOLOGY | SIGNALING PATHWAY | BRAF MUTATIONS | Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | MAP Kinase Signaling System - physiology | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - physiology | Calcium Signaling | Neoplasms - drug therapy | Care and treatment | Usage | Rapamycin | Protein kinases | Health aspects | Tumors | MEK | BRAF | MAPK | ERK
Journal Article
Seminars in Immunology, ISSN 1044-5323, 2014, Volume 26, Issue 3, pp. 237 - 245
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 532, Issue 7597, pp. 122 - 126
Journal Article
The Plant cell, ISSN 1040-4651, 10/2007, Volume 19, Issue 10, pp. 3266 - 3279
Journal Article