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Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 513 - 524
BIK (BCL2-interacting killer) is a pro-apoptotic BH3 (BCL2 homology domain 3)-only protein and a member of the BCL2 protein family. It was proposed recently... 
BCL2-interacting killer (BIK) | Extracellularsignal-regulated kinase 1/2 (ERK1/2) | BCL2-interacting mediator of cell death (BIM) | Cell cycle | Apoptosis | Proteasome | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Neoplasms - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | G1 Phase - drug effects | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins - biosynthesis | Proteolysis - drug effects | Ubiquitination - drug effects | Bcl-2-Like Protein 11 | RNA Interference | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Neoplasm Proteins - genetics | Apoptosis Regulatory Proteins - biosynthesis | Proto-Oncogene Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Neoplasms - enzymology | Proteasome Endopeptidase Complex - chemistry | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins - genetics | Cyclin-Dependent Kinase 6 - metabolism | MAP Kinase Kinase 2 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Apoptosis Regulatory Proteins - metabolism | Neoplasms - drug therapy | Membrane Proteins - biosynthesis | MAP Kinase Signaling System - drug effects | Membrane Proteins - antagonists & inhibitors | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Stability - drug effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Proteasome Endopeptidase Complex - metabolism | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 539 - 550
PDE4s (type 4 cyclic nucleotide phosphodiesterases) are divided into long and short forms by the presence or absence of conserved N-terminal domains termed... 
Dimer | Oligomerization | CAMP | Cyclic nucleotide phosphodiesterase 4 (PDE4) | Phosphodiesterase | DOMAIN | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | dimer | GEL-FILTRATION | DENSITY GRADIENT CENTRIFUGATION | cyclic nucleotide phosphodiesterase 4 (PDE4) | ROD CGMP-PHOSPHODIESTERASE-6 | cAMP | CGMP-BINDING | oligomerization | PHOSPHATIDIC-ACID BINDING | phosphodiesterase | CATALYTIC SITE | Phosphorylation | Molecular Weight | Humans | Protein Multimerization | Cercopithecus aethiops | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Cytosol - enzymology | Cyclic AMP-Dependent Protein Kinases - genetics | Isoenzymes - metabolism | HEK293 Cells | Conserved Sequence | Luminescent Proteins - chemistry | Protein Interaction Domains and Motifs | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Dimerization | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Isoenzymes - genetics | Rats | Recombinant Proteins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Recombinant Fusion Proteins - chemistry | Animals | Cytosol - metabolism | Luminescent Proteins - genetics | Protein Processing, Post-Translational | Enzyme Activation | COS Cells | Luminescent Proteins - metabolism | Index Medicus | PDE4
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1761, Volume 289, Issue 18, pp. 12457 - 12466
Background: Most commercial TNF inhibitors are biomacromolecules. Results: A lead compound named C87 was identified using computer-aided drug design and could... 
RHEUMATOID-ARTHRITIS | Computer Modeling | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR SUPERFAMILY | Inflammation | CELL-DEATH | JNK ACTIVATION | PEPTIDOMIMETICS | Surface Plasmon Resonance (SPR) | AUTOIMMUNE-DISEASES | Cell Death | Tumor Necrosis Factor (TNF) | THERAPEUTIC TARGET | Cell Signaling | Small Molecules | TNF-ALPHA | BINDING | GALACTOSAMINE | Surface Plasmon Resonance | Tumor Necrosis Factor-alpha - metabolism | Small Molecule Libraries - pharmacology | Hepatitis, Animal - prevention & control | Humans | Hepatitis, Animal - genetics | Structure-Activity Relationship | Receptors, Tumor Necrosis Factor, Type I - metabolism | Dose-Response Relationship, Drug | Hepatitis, Animal - metabolism | Inflammation - metabolism | Caspases - metabolism | MAP Kinase Kinase 4 - metabolism | Protein Binding - drug effects | Molecular Structure | Disease Models, Animal | Cell Survival - drug effects | Jurkat Cells | Blotting, Western | Hydrazones - chemistry | Hydrazones - pharmacology | Small Molecule Libraries - chemistry | Tumor Necrosis Factor-alpha - pharmacology | Animals | Signal Transduction - drug effects | K562 Cells | Cell Line, Tumor | HL-60 Cells | Inflammation - genetics | Thiazoles - chemistry | Inflammation - prevention & control | Mice | Mice, Inbred BALB C | Thiazoles - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | Immunology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1761, Volume 289, Issue 18, pp. 12202 - 12216
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1761, Volume 289, Issue 18, pp. 12886 - 12895
Background: S100B is overexpressed in malignant melanoma and contributes to cancer progression. Results: The S100B-RSK complex was found to be Ca2+-dependent,... 
WILD-TYPE | S100 Proteins | ACTIVATION | Calcium | BIOCHEMISTRY & MOLECULAR BIOLOGY | Melanoma | RECEPTOR | RSK | BINDING PROTEIN | P53 | FAMILY | Calcium Binding Proteins | MAP Kinases (MAPKs) | MAGNETIC-RESONANCE-SPECTROSCOPY | Cancer | ERK | GLYCATION END-PRODUCTS | S100B(BETA-BETA)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1782, Volume 289, Issue 21, pp. 15118 - 15129
Triggering receptor expressed on myeloid cells 1 (TREM-1) is a superimmunoglobulin receptor expressed on myeloid cells that plays an important role in the... 
MITOCHONDRIAL FUSION | APOPTOSIS | KAPPA-B ACTIVATION | NECROSIS-FACTOR | GROWTH-RESPONSE 2 | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-ASSOCIATED MACROPHAGES | TREM-1 EXPRESSION | TRANSCRIPTION FACTOR | EGR FAMILY | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | Early Growth Response Protein 2 - genetics | Humans | Caspase 3 - metabolism | Cell Survival - genetics | Apoptosis - genetics | Gene Expression Profiling | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | RNA Interference | Apoptosis Regulatory Proteins - genetics | Cell Line | MAP Kinase Kinase 1 - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | MAP Kinase Kinase 1 - metabolism | Mitochondria - metabolism | Macrophages - cytology | Mitochondria - drug effects | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Membrane Glycoproteins - genetics | Macrophages - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Triggering Receptor Expressed on Myeloid Cells-1 | Early Growth Response Protein 2 - metabolism | Mice | Receptors, Immunologic - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Receptors, Immunologic - metabolism | Index Medicus | Immunology | Cell Death | Tumor | Inflammation | Macrophages | Lipopolysaccharide (LPS) | Macrophage
Journal Article
Oral Diseases, ISSN 1354-523X, 07/2011, Volume 17, Issue 5, pp. 469 - 475
Oral Diseases (2011) 17 , 469–475 Objectives:  The aim of this study was to evaluate the role of tolfenamic acid (Tol) and ampiroxicam (Amp) in the apoptotic... 
apoptosis | tolfenamic acid | myeloid cell leukemia‐1 | salivary mucoepidermoid carcinoma | Myeloid cell leukemia-1 | Salivary mucoepidermoid carcinoma | Tolfenamic acid | Apoptosis | ACTIVATION | MCL-1 | DOWN-REGULATION | HOMOHARRINGTONINE | BREAST-CANCER | IN-VITRO | REPRESSION | DENTISTRY, ORAL SURGERY & MEDICINE | GROWTH | myeloid cell leukemia-1 | DIFFERENTIATION | EXPRESSION | Immunohistochemistry | Extracellular Signal-Regulated MAP Kinases - pharmacology | RNA, Small Interfering - genetics | Nucleic Acid Synthesis Inhibitors - pharmacology | ortho-Aminobenzoates - pharmacology | Apoptosis - drug effects | Coloring Agents | Humans | G1 Phase - drug effects | Tetrazolium Salts | Transfection | Caspase 3 - drug effects | Thiazoles | Thiazines - pharmacology | Antineoplastic Agents - pharmacology | Indoles | Tumor Cells, Cultured | Sp1 Transcription Factor - pharmacology | JNK Mitogen-Activated Protein Kinases - pharmacology | Plicamycin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | p38 Mitogen-Activated Protein Kinases - pharmacology | Blotting, Western | Cyclooxygenase Inhibitors - pharmacology | Carcinoma, Mucoepidermoid - pathology | Myeloid Cell Leukemia Sequence 1 Protein | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Enzyme Activation | Cell Nucleus - drug effects | Salivary Gland Neoplasms - pathology | Messenger RNA | Carcinoma | Analysis | Toluene | Oncology, Experimental | DNA polymerases | Research | Cancer | Proteins | Cell growth | Kinases | Dentistry
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 09/2011, Volume 109, Issue 3, pp. 164 - 174
Journal Article