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Blood Cells, Molecules, and Diseases, ISSN 1079-9796, 08/2019, p. 102356
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2014, Volume 127, Issue 15, pp. 2825 - 2837
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 03/2018, Volume 78, Issue 3, pp. 579 - 590.e4
Langerhans cell histiocytosis (LCH) is a disorder of myeloid neoplasia of dendritic cells that affects 1 in 200,000 children <15 years of age and even fewer... 
pathogenesis | targeted therapy | MAP2K1 | genetics | Langerhans cell histiocytosis | B-Raf inhibitor | mosaicism | ERK pathway | vemurafenib | precision medicine | BRAF | LIVER-TRANSPLANTATION | BRAF V600E MUTATION | MAP2K1 MUTATIONS | DERMATOLOGY | ERDHEIM-CHESTER DISEASE | SCLEROSING CHOLANGITIS | BRAF(V600E) MUTATION | MOLLUSCUM CONTAGIOSUM | CLINICAL-IMPLICATIONS | HIGH PREVALENCE
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 02/2016, Volume 14, Issue 2, pp. 207 - 215
The identification of somatic genetic alterations that confer sensitivity to pharmacologic inhibitors has led to new cancer therapies. To identify mutations... 
MAP2K1 | MEK | Lung Cancer | NSCLC | Targeted Therapy
Journal Article
BLOOD, ISSN 0006-4971, 07/2017, Volume 130, Issue 4, pp. 514 - 526
Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm associated with somatic mutations in the genes involved in the RAF/MEK/extracellular... 
MAP2K1 | HISTIOCYTOSIS | DENDRITIC CELLS | K-RAS | MACROPHAGE-LINEAGE | MONOCYTES | SUBSETS | MUTATIONS | MEVALONATE PATHWAY | HEMATOLOGY | LANGERHANS CELLS
Journal Article
JAMA Dermatology, ISSN 2168-6068, 02/2019, Volume 155, Issue 2, pp. 256 - 257
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 03/2019, Volume 104, Issue 3, pp. 576 - 586
Mutations in genes of the RAS-BRAF-MAPK-ERK pathway have not been fully explored in patients with chronic lymphocytic leukemia. We, therefore, analyzed the... 
SURVIVAL | HAIRY-CELL LEUKEMIA | CLL | ACTIVATION | MAP2K1 | EVOLUTION | MELANOMA | RESISTANCE | HEMATOLOGY | TP53 | SF3B1
Journal Article
Pediatric and Developmental Pathology, ISSN 1093-5266, 10/2019, Volume 22, Issue 5, pp. 449 - 455
Langerhans cell histiocytosis (LCH) is a rare disease presenting with usually a localized disease but sometimes a widespread aggressive disorder especially in... 
mutation | THERAPY | childhood | Langerhans cell histiocytosis | PEDIATRICS | BRAF | MAP2K1 MUTATIONS | PATHOLOGY
Journal Article
Cerebral Cortex, ISSN 1047-3211, 04/2019, Volume 29, Issue 4, pp. 1509 - 1519
Abstract β-Catenin has been implicated in major depressive disorder (MDD), which is associated with synaptic plasticity and dendritic arborization. MicroRNAs... 
major depression disorder | β-catenin | miR-214 | intranasal administration | beta-catenin | BDNF | INVOLVEMENT | MECHANISMS | STRENGTH | CELL-GROWTH | NEUROSCIENCES | INHIBITION | GLUTAMATE | CTNNB1 | MEK1 MAP2K1 | N-CADHERIN
Journal Article
European Respiratory Journal, ISSN 0903-1936, 06/2016, Volume 47, Issue 6, pp. 1629 - 1631
Interstitial lung diseases (ILDs) comprise a heterogeneous group of rare respiratory disorders characterised by diffuse pulmonary infiltrates and destruction... 
LCH | MAP2K1 | LYMPHANGIOLEIOMYOMATOSIS | RARE | RAS | RESPIRATORY SYSTEM | DISEASE | TSC2 | NRAS MUTATIONS | HIGH PREVALENCE | SIROLIMUS
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2016, Volume 34, Issue 25, pp. 3023 - 3030
Journal Article
Thyroid, ISSN 1050-7256, 09/2019, Volume 29, Issue 9, pp. 1279 - 1285
Background: Genetic alterations activating the mitogen-activated protein kinase (MAPK) signaling pathway, most commonly BRAF and RAS mutations, are common in... 
Thyroid Cancer and Nodules | TRANSFORMATION | DIAGNOSIS | MAP2K1 | RAS-like | LANDSCAPE | papillary thyroid cancer | MEK1 mutations | ENDOCRINOLOGY & METABOLISM | thyroid cancer | KINASE KINASE | CANCER
Journal Article