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Biochemical Journal, ISSN 0264-6021, 06/2008, Volume 412, Issue 2, pp. 287 - 298
DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2... 
Fibroblast growth factor (FGF) | Transcription | Phosphatase | Mitogen-activated protein kinase phosphatase-3 (MKP-3) | Mitogen-activated protein kinase (MAPK) | Dual-specificity phosphatase 6 (DUSP6) | ACTIVATED PROTEIN-KINASE | transcription | MKP3 | MAP-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | mitogen-activated protein kinase phosphatase-3 (MKP-3) | FAMILY | EMBRYO | IN-VIVO | fibroblast growth factor (FGF) | phosphatase | dual-specificity phosphatase 6 (DUSP6) | EXPRESSION | DUAL-SPECIFICITY PHOSPHATASES | CATALYTIC ACTIVATION | VERTEBRATE LIMB | Dual Specificity Phosphatase 6 - genetics | Proto-Oncogene Proteins c-ets - genetics | Humans | Molecular Sequence Data | Phosphatidylinositol 3-Kinases - metabolism | Fibroblast Growth Factors - metabolism | Base Sequence | Mitogen-Activated Protein Kinase 1 - genetics | Proto-Oncogene Proteins c-ets - metabolism | Transgenes | Binding Sites | Cell Line | Promoter Regions, Genetic | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - genetics | Dual Specificity Phosphatase 6 - metabolism | Sequence Alignment | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - physiology | Mice | Enzyme Activation | Feedback, Physiological - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | MEK, MAPK | SRF, serum-response factor | SRY, sex-determining region Y | PI3K, phosphoinositide 3-kinase | FGFR, FGF receptor | MKP, MAPK phosphatase | βGal, β-galactosidase | Ets, E twenty-six | JNK, c-Jun N-terminal kinase | ERK kinase | DUSP, dual-specificity phosphatase | ChIP, chromatin immunoprecipitation | HH10, Hamburger and Hamilton stage 10 | ERK, extracellular-signal-regulated kinase | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | mRFP, monomeric red fluorescent protein | TNFα, tumour necrosis factor α | IκBα, inhibitor of nuclear factor κB α | EGFP, enhanced green fluorescent protein | NF-κB, nuclear factor κB | PBX1, pre-B-cell leukaemia transcription factor 1 | Elk1, Ets-like kinase 1 | FBS, fetal bovine serum | FKHD, Forkhead mutant | FGF, fibroblast growth factor | RSV, rous sarcoma virus | MKK, MAPK kinase | HA, haemagglutinin | EMSA, electrophoretic mobility-shift assay | ER, oestrogen receptor | AER, apical ectodermal ridge | ConA, concanavalin A | MKKK, MAPK kinase kinase | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Oncogene, ISSN 0950-9232, 03/2001, Volume 20, Issue 13, pp. 1653 - 1660
Journal Article
FASEB Journal, ISSN 0892-6638, 08/2018, Volume 32, Issue 8, pp. 4070 - 4084
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 04/2019, Volume 485, pp. 35 - 43
Intracellular Ca signaling plays an essential role in synaptic plasticity. This study examined the effect of BPA on concentration of intracellular Ca ([Ca ] )... 
Hippocampal neuron | MAPK/ERKs | Bisphenol-A | Intracellular Ca | MAPK/p38
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 04/2019, Volume 485, pp. 35 - 43
Intracellular Ca signaling plays an essential role in synaptic plasticity. This study examined the effect of BPA on concentration of intracellular Ca ([Ca ] )... 
Hippocampal neuron | MAPK/ERKs | Bisphenol-A | Intracellular Ca2 | MAPK/p38
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 613 - 613
Conference Proceeding
Genes and Cancer, ISSN 1947-6019, 2011, Volume 2, Issue 3, pp. 195 - 209
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling pathway that regulates a wide variety of stimulated cellular processes,... 
Nucleus | MEK | Mitochondria | Golgi | MAPK | ERK | mitochondria | Monographs | nucleus
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 11/2017, Volume 235, Issue 2, pp. R43 - R6
Journal Article
Genetics in Medicine, ISSN 1098-3600, 11/2018, Volume 20, Issue 11, pp. 1334 - 1345
PurposeStandardized and accurate variant assessment is essential for effective medical care. To that end, Clinical Genome (ClinGen) Resource clinical domain... 
ClinGen | RASopathy | Ras/MAPK | Noonan | variant interpretation | Genomics | Genes | MAPK | Ras
Journal Article
06/2013
Tumorigenesis is driven by the sequential accumulation of genetic lesions within a cell, each which confer the cell with traits that enable its abnormal... 
RAS | Arhgef2 | 0760 | MAPK signaling | Cancer
Dissertation
Phytotherapy Research, ISSN 0951-418X, 04/2019, Volume 33, Issue 4, pp. 1191 - 1198
The purpose of this study was to investigate the renal protective effect of celastrol on diabetic rats. Furthermore, the mechanism of its action was discussed... 
MAPK/NF‐κB | renal protection | celastrol | diabetic | MAPK/NF-κB | CHEMISTRY, MEDICINAL | NF-kappa B | INFLAMMATION | PHARMACOLOGY & PHARMACY | MAPK | STRESS | NEPHROPATHY | DAMAGE | Index Medicus
Journal Article
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 05/2018, Volume 135, Issue 5, pp. 757 - 777
Journal Article
British Journal of Cancer, ISSN 0007-0920, 03/2004, Volume 90, Issue 5, pp. 1047 - 1052
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 2, pp. 559 - 567
ATF3 (activating transcription factor 3) gene encodes a member of the ATF/CREB (cAMP-response-element-binding protein) family of transcription factors. Its... 
Mitogen activated protein kinase (MAPK) | Activating transcription factor 3 (ATF3) | p38 | Stress response | Stress kinase | MAPK kinase (MKK) | APOPTOSIS | activating transcription factor 3 (ATF3) | stress kinase | PHOSPHORYLATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR-3 | mitogen activated protein kinase (MAPK) | JUN NH2-TERMINAL KINASE | INDUCTION | stress response | VASCULAR ENDOTHELIAL-CELLS | C-JUN | STRESS | INHIBITOR | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Gene Expression Regulation | Activating Transcription Factor 3 - biosynthesis | Cercopithecus aethiops | JNK Mitogen-Activated Protein Kinases - metabolism | Imidazoles - pharmacology | MAP Kinase Kinase 7 - metabolism | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinases - physiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Anisomycin - pharmacology | Flavonoids - pharmacology | Pyridines - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | HeLa Cells | COS Cells | Activating Transcription Factor 3 - genetics | Index Medicus | IL-1β, interleukin 1β | JNK, c-Jun N-terminal kinase | DTT, dithiothreitol | shRNA, small-hairpin RNA | ERK, extracellular-signal-regulated kinase | SAPK, stress-activated protein kinase | DMEM, Dulbecco's modified Eagle's medium | ERK kinase 1 | CREB, CRE-binding protein | RT, reverse transcriptase | gadd153, growth-arrest and DNA-damage-inducible protein 153 | TNFα, tumour necrosis factor α | enhancer-binding protein | EBP-homologous protein 10 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | CRE, cAMP-response element | GST, glutathione S-transferase | HEK-293 cells, human embryonic kidney 293 cells | tetO, tet operator | NF-κB, nuclear factor κB | EBP, CCAAT | DN, dominant negative | FBS, fetal bovine serum | β-Gal, β-galactosidase | MKK, MAPK kinase | HA, haemagglutinin | CA, constitutively active | IP–kinase, immunoprecipitation coupled with kinase | MEK1, MAPK | ATF, activating transcription factor | Chop10, C | TGF-β, transforming growth factor-β | MEF, mouse embryonic fibroblast | MAPK, mitogen-activated protein kinase
Journal Article
Genes and Cancer, ISSN 1947-6019, 2011, Volume 2, Issue 3, pp. 344 - 358
Somatic, gain-of-function mutations in ras genes were the first specific genetic alterations identified in human cancer about 3 decades ago. Studies during the... 
Mutation | Ras | Ras-MAPK pathway | Oncogenes | Cancer | Developmental syndromes | mutation | developmental syndromes | Monographs | oncogenes | cancer
Journal Article