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Journal of Neuroscience, ISSN 0270-6474, 03/2004, Volume 24, Issue 13, pp. 3370 - 3378
The mechanisms of action of human synthetic and naturally secreted cell-derived amyloid beta-peptide (Abeta)(1-42) on the induction of long-term potentiation... 
Metabotropic glutamate receptors | Cdk5 | JNK | LTP | Amyloid β-protein | Alzheimer's disease | p38 MAPK | Hippocampus | NEURONAL APOPTOSIS | hippocampus | ALZHEIMERS-DISEASE | MAP KINASE | metabotropic glutamate receptors | amyloid beta-protein | SYNAPTIC PLASTICITY | FREQUENCY STIMULATION | AREA CA1 | NEUROSCIENCES | IN-VITRO | PATHWAY | MICE | PRECURSOR PROTEIN | Receptors, Metabotropic Glutamate - drug effects | Cyclin-Dependent Kinases - metabolism | Amyloid beta-Peptides - pharmacology | Humans | Amyloid beta-Peptides - secretion | Peptide Fragments - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Ovary - cytology | Excitatory Postsynaptic Potentials - drug effects | Cyclin-Dependent Kinases - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Long-Term Potentiation - drug effects | Amyloid beta-Peptides - genetics | JNK Mitogen-Activated Protein Kinases | Long-Term Potentiation - physiology | Receptor, Metabotropic Glutamate 5 | Female | Electric Stimulation - methods | Peptide Fragments - genetics | p38 Mitogen-Activated Protein Kinases | CHO Cells | Ovary - metabolism | Cricetinae | Enzyme Inhibitors - pharmacology | Peptide Fragments - secretion | Rats | Excitatory Amino Acid Antagonists - pharmacology | Cyclin-Dependent Kinase 5 | Animals | Ovary - secretion | Hippocampus - physiology | In Vitro Techniques | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinases - metabolism | Plasticity | Development | amyloid β-protein | Repair
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 5, pp. 3381 - 3391
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Cancer, ISSN 0008-543X, 11/2014, Volume 120, Issue 22, pp. 3446 - 3456
The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple... 
mitogen‐activated protein kinase (MAPK) | mitogen‐activated protein kinase‐kinase (MEK) | signaling | colorectal cancer | ovarian cancer | v‐raf murine sarcoma viral oncogene homolog (BRAF) | melanoma | extracellular signal‐regulated kinase (ERK) | Extracellular signal-regulated kinase (ERK) | Signaling | V-raf murine sarcoma viral oncogene homolog (BRAF) | Colorectal cancer | Melanoma | Mitogen-activated protein kinase (MAPK) | Mitogen-activated protein kinase-kinase (MEK) | Ovarian cancer | mitogen-activated protein kinase-kinase (MEK) | mitogen-activated protein kinase (MAPK) | v-raf murine sarcoma viral oncogene homolog (BRAF) | extracellular signal-regulated kinase (ERK) | RNA INTERFERENCE SCREEN | ACTIVATED PROTEIN-KINASE | BRAF(V600E) INHIBITION | ACQUIRED-RESISTANCE | POTENTIAL MECHANISM | TUMOR HETEROGENEITY | CELL LUNG-CANCER | MET AMPLIFICATION | ONCOLOGY | SIGNALING PATHWAY | BRAF MUTATIONS | Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | MAP Kinase Signaling System - physiology | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - physiology | Calcium Signaling | Neoplasms - drug therapy | Care and treatment | Usage | Rapamycin | Protein kinases | Health aspects | Tumors | MEK | BRAF | MAPK | ERK
Journal Article
BMC Plant Biology, ISSN 1471-2229, 08/2014, Volume 14, Issue 1, pp. 219 - 219
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
2004, Methods in Molecular Biology, ISBN 0896039986, Volume 250, xi, 332
Mitogen-activated protein kinase (MAPK) signaling cascades initiate highly significant cellular processes and are involved in a large number of diseases,... 
Cellular signal transduction | Research | Methodology | Protein kinases | Biochemistry, general | Biochemistry | Life Sciences
Book
BMC Genomics, ISSN 1471-2164, 05/2015, Volume 16, Issue 1, p. 386
Background: The mitogen-activated protein kinase (MAPK) cascade consists of three types of reversibly phosphorylated kinases, namely, MAPK, MAPK kinase... 
MAPKKK | Abiotic stress | MAPKK | Biotic stress | Cucumis sativus | MAPK | Plant hormones | PROTEIN-KINASE GENE | ARABIDOPSIS-THALIANA | SATIVUS | CASCADE | PLANT-RESISTANCE | SIGNALING PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SEQUENCE | GENETICS & HEREDITY | BRASSICA-NAPUS L | EXPRESSION | RICE | Gene Duplication | Mitogen-Activated Protein Kinase Kinases - genetics | Genomics | Molecular Sequence Data | Cucumis sativus - genetics | Gene Expression Profiling | Cucumis sativus - physiology | Phylogeny | Promoter Regions, Genetic - genetics | Mitogen-Activated Protein Kinases - chemistry | MAP Kinase Kinase Kinases - chemistry | Mitogen-Activated Protein Kinase Kinases - metabolism | MAP Kinase Signaling System - genetics | Conserved Sequence | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Multigene Family - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Genome, Plant - genetics | MAP Kinase Kinase Kinases - genetics | Stress, Physiological - genetics | Protein-Serine-Threonine Kinases - genetics | Chromosome Mapping | MAP Kinase Kinase Kinases - metabolism | Cucumis sativus - growth & development | Amino Acid Motifs | Mitogen-Activated Protein Kinase Kinases - chemistry | Sequence Alignment | MAP Kinase Signaling System - drug effects | Cucumis sativus - cytology | Mitogen-Activated Protein Kinases - genetics | Protein-Serine-Threonine Kinases - chemistry | Plant Growth Regulators - pharmacology | Evolution, Molecular | Mitogen-Activated Protein Kinases - metabolism | Hardiness | Genetic aspects | Plants | Properties | Protein kinases | Identification and classification | Cucumbers | Amino acids | Mitogens
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 2007, Volume 1773, Issue 8, pp. 1311 - 1340
Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit many of the responses that are evoked in cells by changes in... 
Mkk1 | Ssk2 | Signal propagation | Mkk2 | Yeast | Budding yeast | Kss1 | Ste20 | Signaling fidelity | Pheromone response | Filamentous growth response | Smk1 | MAPKK | MAPKKKK | Hyperosmotic stress response | Signal transduction mechanisms | Ste7 | Pbs2 | Baker's yeast | Mitogen_activated protein kinase kinase kinase kinase | Bck1 | p21_activated protein kinase | Snf1 | Meiosis and sporulation | Spatial and temporal regulation | Ste11 | Tpk3 | Tpk2 | Tpk1 | Mitogen_activated protein kinase kinase | PKA | Cell wall integrity | 5′_AMP_activated protein kinase | MAPK | Ssk22 | Pkc1 | Fus3 | Mitogen_activated protein kinase | MAPKKK | Signaling | Hog1 | Mpk1/Slt2 | 3′,5′_cyclic AMP_dependent protein kinase | Mitogen_activated protein kinase kinase kinase | AMPK | PAK | Saccharomyces cerevisiae | CELL-WALL INTEGRITY | filamentous growth response | hyperosmotic stress response | CELL BIOLOGY | P21_activated protein kinase | KELCH-REPEAT PROTEINS | mitogen_activated protein kinase kinase | BIOCHEMISTRY & MOLECULAR BIOLOGY | signaling fidelity | CYCLIN-DEPENDENT KINASE | yeast | MITOGEN-ACTIVATED PROTEIN | G-BETA-GAMMA | PHEROMONE RESPONSE PATHWAY | cell wall integrity | DUAL-SPECIFICITY PHOSPHATASE | 5'_AMP_activated protein kinase | mitogen_activated protein kinase kinase kinase kinase | budding yeast | signaling | 3',5'_cyclic AMP_dependent protein kinase | signal transduction mechanisms | HIGH-AFFINITY INTERACTION | spatial and temporal regulation | NUCLEOTIDE EXCHANGE FACTOR | meiosis and sporulation | SPORULATION-SPECIFIC GENES | signal propagation | mitogen_activated protein kinase kinase kinase | pheromone response | mitogen_activated protein kinase | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | MAP Kinase Signaling System - physiology | Protein Biosynthesis | Cell Cycle | Models, Biological | Saccharomyces cerevisiae - genetics | Transcription, Genetic | Enzyme Activation | Saccharomyces cerevisiae - growth & development | Protein kinases
Journal Article