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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16161 - 16173
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2013, Volume 288, Issue 23, pp. 17030 - 17041
The Ca2(+) sensor STIM1 is crucial for activation of store-operated Ca2(+) entry (SOCE) through transient receptor potential canonical and Orai channels. STIM1... 
P38 MAP-KINASES | KAPPA-B ACTIVATION | CA2+ ENTRY | TRPC1 EXPRESSION | CALCIUM-ENTRY | TARGET SITES | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORAI1 | CHANNELS | CRAC | Phosphorylation - physiology | Capillary Permeability - physiology | AMP-Activated Protein Kinases - metabolism | Membrane Glycoproteins - metabolism | Calcium - metabolism | Receptor, PAR-1 - metabolism | Humans | Capillary Permeability - drug effects | Neoplasm Proteins - metabolism | Aminoimidazole Carboxamide - pharmacology | Gene Knockdown Techniques | Ribonucleotides - pharmacology | Mitogen-Activated Protein Kinase 11 - metabolism | Lung - metabolism | Membrane Proteins - metabolism | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Stromal Interaction Molecule 1 | Mitogen-Activated Protein Kinase 11 - genetics | Calcium Channels | Endothelial Cells - metabolism | Membrane Proteins - genetics | Cells, Cultured | Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics | Receptor, PAR-1 - genetics | Hypoglycemic Agents - pharmacology | Membrane Glycoproteins - genetics | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Endothelial Cells - cytology | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Lung - blood supply | AMP-Activated Protein Kinases - genetics | Phosphorylation | Store-operated Calcium Entry | Signal Transduction | Stromal Interaction Molecule-1 | Endothelial Dysfunction | Thrombin | Vascular Permeability | AMP-activated Kinase (AMPK) | Protease-activated Receptor-1 | p38 MAPK
Journal Article
Journal Article
New Phytologist, ISSN 0028-646X, 7/2014, Volume 203, Issue 2, pp. 592 - 606
Mitogen-activated protein kinase (MAPK) cascades play key roles in plant immune signalling, and elucidating their regulatory functions requires the... 
Proteins | Full papers | Yeasts | Phosphorylation | Transcription factors | Transfection | Protoplasts | Plant biochemistry | Gene expression regulation | Gene expression | Plant cells | mitogen‐activated protein kinase (MAPK) | defence | VQ‐motif | immunity | phosphorylation | signalling | pathogen‐associated molecular pattern (PAMP) | VQ-motif | Pathogen-associated molecular pattern (PAMP) | Mitogen-activated protein kinase (MAPK) | Signalling | Immunity | Defence | FLAGELLIN | mitogen-activated protein kinase (MAPK) | pathogen-associated molecular pattern (PAMP) | PLANT SCIENCES | MAPK CASCADES | BIOSYNTHESIS | GENE-EXPRESSION | SIGMA-FACTOR | TRANSCRIPTION FACTOR | BINDING | DISEASE RESISTANCE | INNATE IMMUNITY | Amino Acid Sequence | Arabidopsis Proteins - genetics | Mitogen-Activated Protein Kinase Kinases - genetics | Mutagenesis, Site-Directed | Plant Diseases - immunology | Arabidopsis - immunology | Molecular Sequence Data | Transcription Factors - genetics | Amino Acid Motifs | Arabidopsis - metabolism | Arabidopsis Proteins - metabolism | Transcription Factors - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Plants, Genetically Modified | Flagellin - genetics | Flagellin - metabolism | Gene Expression Regulation, Plant | Mitogen-Activated Protein Kinases - genetics | Protein Stability | Mitogen-Activated Protein Kinases - metabolism | Arabidopsis thaliana | Immune response | Analysis | Mitogens | Mass spectrometry | Protein kinases | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 5, pp. 3381 - 3391
Journal Article
Journal of Diabetes Investigation, ISSN 2040-1116, 07/2017, Volume 8, Issue 4, pp. 434 - 445
Journal Article
The Plant Journal, ISSN 0960-7412, 09/2010, Volume 63, Issue 6, pp. 1017 - 1030
Summary Mitogen‐activated protein kinase (MAPK) cascades have important functions in plant stress responses and development and are key players in reactive... 
mitogen‐activated protein kinase 3 (MPK3) | Botrytis cinerea | Ralstonia solanacearum | mitogen‐activated protein kinase (MAPK) phosphatase | mitogen‐activated protein kinase 6 (MPK6) | oxidative stress | mitogen-activated protein kinase (MAPK) phosphatase | mitogen-activated protein kinase 3 (MPK3) | mitogen-activated protein kinase 6 (MPK6) | ACTIVATED PROTEIN-KINASE | RALSTONIA-SOLANACEARUM | BOTRYTIS-CINEREA | CELL-DEATH | PLANT SCIENCES | SALICYLIC-ACID | HYDROGEN-PEROXIDE | ABSCISIC-ACID | HYPERSENSITIVE RESPONSE | CATALYTIC ACTIVATION | INNATE IMMUNITY | Arabidopsis Proteins - genetics | Mitogen-Activated Protein Kinase Kinases - genetics | Arabidopsis - enzymology | Immunoprecipitation | Plants, Genetically Modified - genetics | Oxidative Stress - physiology | Oxidative Stress - genetics | Plants, Genetically Modified - enzymology | Mitogen-Activated Protein Kinase Phosphatases - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Botrytis - pathogenicity | Arabidopsis - microbiology | Microscopy, Confocal | Mitogen-Activated Protein Kinase Kinases - metabolism | Plants, Genetically Modified - metabolism | Plants, Genetically Modified - microbiology | Polymerase Chain Reaction | Mitogen-Activated Protein Kinases - genetics | Ralstonia solanacearum - pathogenicity | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Mitogen-Activated Protein Kinases - metabolism | Arabidopsis thaliana | Development and progression | Disease transmission | Phosphatases | Protein kinases | Proteins | Plant diseases | Kinases | Stress | Botany
Journal Article
Annual Review of Cell and Developmental Biology, ISSN 1081-0706, 10/2013, Volume 29, Issue 1, pp. 63 - 79
Journal Article