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humans (141) 141
phosphorylation (138) 138
animals (121) 121
mapkap kinase-2 (119) 119
biochemistry & molecular biology (109) 109
index medicus (95) 95
protein-serine-threonine kinases - metabolism (91) 91
cell biology (84) 84
mice (56) 56
signal transduction (51) 51
intracellular signaling peptides and proteins (47) 47
mapkap kinase 2 (47) 47
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intracellular signaling peptides and proteins - metabolism (42) 42
enzyme activation (39) 39
expression (35) 35
stress (35) 35
tumor-necrosis-factor (34) 34
activation (33) 33
in-vivo (33) 33
p38 mitogen-activated protein kinases (33) 33
rats (33) 33
enzyme inhibitors - pharmacology (32) 32
identification (32) 32
p38 mitogen-activated protein kinases - metabolism (31) 31
protein-serine-threonine kinases - antagonists & inhibitors (31) 31
protein-serine-threonine kinases - genetics (31) 31
molecular sequence data (30) 30
protein kinases (30) 30
amino acid sequence (29) 29
cells, cultured (29) 29
heat shock proteins (29) 29
mk2 (29) 29
biophysics (28) 28
heat-shock proteins (28) 28
analysis (27) 27
gene-expression (27) 27
p38 (27) 27
proteins (27) 27
activated protein-kinase (26) 26
apoptosis (26) 26
map kinase (26) 26
article (25) 25
intracellular signaling peptides and proteins - antagonists & inhibitors (25) 25
kinases (25) 25
mitogen-activated protein kinases - metabolism (25) 25
mapkap-k2 (22) 22
calcium-calmodulin-dependent protein kinases - metabolism (21) 21
hsp27 (21) 21
research article (21) 21
rna, messenger - metabolism (21) 21
tnf-alpha (21) 21
cancer (20) 20
chemistry, medicinal (20) 20
inflammation (20) 20
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hela cells (19) 19
mitogen-activated protein kinases (19) 19
pathway (19) 19
protein kinase inhibitors - pharmacology (19) 19
protein kinases - metabolism (19) 19
cells (18) 18
chemistry, organic (18) 18
nuclear export (18) 18
signal-transduction (18) 18
binding sites (17) 17
gene expression (17) 17
heat-shock (17) 17
heat-shock proteins - metabolism (17) 17
hsp27 heat-shock proteins - metabolism (17) 17
cell line, tumor (16) 16
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multidisciplinary sciences (16) 16
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research (16) 16
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intracellular signaling peptides and proteins - genetics (15) 15
phosphorylation - drug effects (15) 15
physiological aspects (15) 15
cytokines (14) 14
imidazoles - pharmacology (14) 14
mammalian-cells (14) 14
map kinase signaling system (14) 14
mapkap kinase (14) 14
structure-activity relationship (14) 14
substrate specificity (14) 14
crystallography, x-ray (13) 13
enzyme activation - drug effects (13) 13
female (13) 13
in-vitro (13) 13
k cq biochemistry & molecular biology (13) 13
mitogens (13) 13
p38 map kinase (13) 13
protein kinase inhibitors - chemistry (13) 13
pyridines - pharmacology (13) 13
rna, messenger - genetics (13) 13
biology (12) 12
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Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/1999, Volume 18, Issue 18, pp. 4969 - 4980
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2006, Volume 281, Issue 33, pp. 23658 - 23667
MAPK-activated protein kinase 2 (MAPKAP K2 or MK2) is one of several kinases directly regulated by p38 MAPK. A role for p38 MAPK in the pathology of Alzheimer... 
TUMOR-NECROSIS-FACTOR | IN-VITRO | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAPKAP KINASE-2 | CENTRAL-NERVOUS-SYSTEM | MICE | AMYLOID PRECURSOR PROTEIN | TNF-ALPHA | P38 KINASE | BRAIN | TAU-HYPERPHOSPHORYLATION | Protein Kinases - metabolism | Neurons - pathology | Phosphorylation | Protein Kinases - genetics | Coculture Techniques | Humans | Protein-Serine-Threonine Kinases | Astrocytes - pathology | Cerebral Cortex - pathology | Astrocytes - enzymology | Lipopolysaccharides - antagonists & inhibitors | Cerebral Cortex - cytology | Alzheimer Disease - pathology | Chemokines - antagonists & inhibitors | Inflammation Mediators - metabolism | Interferon-gamma - antagonists & inhibitors | Inflammation Mediators - antagonists & inhibitors | Protein Kinases - deficiency | p38 Mitogen-Activated Protein Kinases - metabolism | Protein Kinases - biosynthesis | Disease Models, Animal | Astrocytes - cytology | Cell Line | Cerebral Cortex - enzymology | Chemokines - secretion | Microglia - secretion | Mice, Inbred C57BL | Cytokines - secretion | Intracellular Signaling Peptides and Proteins | Microglia - enzymology | Rats | Mice, Transgenic | Alzheimer Disease - enzymology | Down-Regulation - genetics | Mice, Knockout | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Peptide Fragments - antagonists & inhibitors | Neurons - enzymology | Mice | Cytokines - antagonists & inhibitors | Alzheimer Disease - genetics
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 07/2013, Volume 33, Issue 13, pp. 2586 - 2602
The mitogen-activated protein kinase (MAPK)-activated protein kinases 2 and 3 (MK2/3) represent protein kinases downstream of the p38 MAPK. Using MK2/3... 
SIGNAL-TRANSDUCTION | P38 | MAPKAP KINASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RETICULUM CA2+-ATPASE | METABOLIC ADAPTATION | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | SLOW-TWITCH | CALCIUM-TRANSPORT | EXERCISE | CELL BIOLOGY
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 12/2015, Volume 89, pp. 34 - 46
The development and progression of liver cancer are characterized by increased levels of reactive oxygen species (ROS). ROS-induced oxidative stress impairs... 
Reactive oxygen species | Hydrogen peroxide | Free radicals | MAPKAPK2 | Hepatocellular carcinoma | EBP50/NHERF-1 | Cholangiocarcinoma | EGFR | EBE50/NHERF-1 | AKT ACTIVATION | PHOSPHORYLATION | ASSOCIATING PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR RECEPTOR | HEAT-SHOCK PROTEINS | HEPATOCELLULAR-CARCINOMA | EPIDERMAL-GROWTH-FACTOR | ENDOCRINOLOGY & METABOLISM | MAPKAP KINASE-2 | PHOSPHOPROTEIN 50 EBP50 | EXPRESSION | Oxidants - pharmacology | Immunoprecipitation | Prognosis | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Middle Aged | Male | Intracellular Signaling Peptides and Proteins - metabolism | Immunoenzyme Techniques | HSP27 Heat-Shock Proteins - genetics | Neoplasm Grading | Biliary Tract Neoplasms - metabolism | Female | Liver Neoplasms - pathology | Biliary Tract Neoplasms - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Tumor Cells, Cultured | Biliary Tract Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - metabolism | Biliary Tract Neoplasms - pathology | Liver Neoplasms - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | Hydrogen Peroxide - pharmacology | Liver Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - genetics | Lymphatic Metastasis | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Two-Hybrid System Techniques | Signal Transduction - drug effects | Liver Neoplasms - metabolism | HSP27 Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinases - genetics | Aged | Cell Proliferation - drug effects | Oxidative Stress - drug effects | Neoplasm Staging | Mitogen-Activated Protein Kinases - metabolism | Oxidative stress | Glycosaminoglycans | Liver | Heat shock proteins | Development and progression | Anticoagulants (Medicine) | Antioxidants | Liver cancer | Cancer cells | Physiological aspects | Mitogens | Protein kinases | Epidermal growth factor | Cell death | Heme | Life Sciences | Human health and pathology | Hépatology and Gastroenterology | Cancer
Journal Article
Cell Stress and Chaperones, ISSN 1355-8145, 11/2019, Volume 24, Issue 6, pp. 1127 - 1136
Developing male germ cells are extremely sensitive to heat stress; consequently, anatomic and physiologic adaptations have evolved to maintain proper... 
Biomedicine, general | Biochemistry, general | Neurosciences | Spermatogenesis | Cell Biology | HspA1L | Biomedicine | Immunology | Stress signaling | MK2 | Heat shock protein | Cancer Research | MAPKAP kinase 2
Journal Article
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article