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life sciences & biomedicine (19) 19
science & technology (19) 19
phosphorylation (18) 18
animals (17) 17
humans (16) 16
biochemistry & molecular biology (15) 15
protein-serine-threonine kinases - metabolism (12) 12
cell line (9) 9
mice (9) 9
cell biology (8) 8
mapk, mitogen-activated protein kinase (8) 8
p38 (7) 7
p38 mitogen-activated protein kinases - metabolism (6) 6
protein-serine-threonine kinases - genetics (6) 6
research article (6) 6
erk (5) 5
erk, extracellular-signal-regulated kinase (5) 5
intracellular signaling peptides and proteins - metabolism (5) 5
jnk, c-jun n-terminal kinase (5) 5
mitogen-activated protein kinases - metabolism (5) 5
amino acid sequence (4) 4
enzyme activation (4) 4
inflammation (4) 4
intracellular signaling peptides and proteins (4) 4
map kinase (4) 4
mapkap kinase 2 (4) 4
msk, mitogen- and stress-activated protein kinase (4) 4
pkb, protein kinase b (4) 4
protein kinase (4) 4
protein kinases (4) 4
sapk, stress-activated protein kinase (4) 4
signal transduction - physiology (4) 4
ampk, amp-activated protein kinase (3) 3
apoptosis (3) 3
egf, epidermal growth factor (3) 3
enzyme inhibitors - pharmacology (3) 3
gsk3, glycogen synthase kinase 3 (3) 3
gst, glutathione s-transferase (3) 3
lps, lipopolysaccharide (3) 3
map kinase signaling system (3) 3
map kinase signaling system - drug effects (3) 3
mapk (3) 3
mef, mouse embryonic fibroblast (3) 3
mitogen-activated protein kinase kinases - metabolism (3) 3
molecular sequence data (3) 3
p38 mitogen-activated protein kinases (3) 3
pka, camp-dependent protein kinase (3) 3
pkc, protein kinase c (3) 3
protein kinase inhibitors - pharmacology (3) 3
protein-serine-threonine kinases - antagonists & inhibitors (3) 3
review (3) 3
signal transduction (3) 3
substrate specificity (3) 3
transcription factors - metabolism (3) 3
biophysics (2) 2
c-jun n-terminal kinase (2) 2
cardiovascular system & cardiology (2) 2
cdk, cyclin-dependent protein kinase (2) 2
cell line, tumor (2) 2
cell nucleus - enzymology (2) 2
chk, checkpoint kinase (2) 2
ck, casein kinase (2) 2
csk, c-terminal src kinase (2) 2
cyclic amp - metabolism (2) 2
cyclic amp response element-binding protein - metabolism (2) 2
cytokine production (2) 2
dmem, dulbecco's modified eagle's medium (2) 2
epidermal growth factor (2) 2
er, endoplasmic reticulum (2) 2
extracellular signal-regulated kinase (2) 2
extracellular-signal regulated kinase (2) 2
fibroblasts - drug effects (2) 2
gapdh, glyceraldehyde-3-phosphate dehydrogenase (2) 2
gfp, green fluorescent protein (2) 2
glycogen synthase kinase 3 (2) 2
hek, human embryonic kidney (2) 2
hsp27, heat-shock protein of 27 kda (2) 2
insulin (2) 2
intracellular signaling peptides and proteins - antagonists & inhibitors (2) 2
isoenzymes - genetics (2) 2
isoenzymes - metabolism (2) 2
jnk mitogen-activated protein kinases (2) 2
kinases (2) 2
life sciences (2) 2
lipopolysaccharides - pharmacology (2) 2
map kinase signaling system - physiology (2) 2
mapk-activated protein kinase (2) 2
mapkap (2) 2
mapkap, mapk-activated protein kinase (2) 2
mapkap-k, mapk-activated protein kinase (2) 2
mapkap-k2, mapk-activated protein kinase 2 (2) 2
mice, knockout (2) 2
mitogen-activated protein kinase (2) 2
mitogen-activated protein kinase 1 - metabolism (2) 2
mitogens (2) 2
mk2 (2) 2
mkk1, mapk kinase-1 (2) 2
nitric oxide (2) 2
p38 mapk (2) 2
ph, pleckstrin homology (2) 2
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Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article
Journal Article
FEBS letters, ISSN 0014-5793, 08/2004, Volume 572, Issue 1-3, pp. 177 - 183
...‐activated protein kinase (p38 MAPK) and the classical MAP kinase cascade. In wild‐type cells, p38 MAPK and extracellular signal... 
PMA, phorbol-12-myristate 13-acetate | CRE, cyclic AMP-response element | c-Jun N-terminal kinase | E1A, early adenovirus protein 1A | GST, glutathione S-transferase | Extracellular signal-regulated protein kinase | EGF, epidermal growth factor | TNF, tumour necrosis factor | bZIP, basic region-leucine zipper | AP-1, activating protein 1 | ERK, extracellular signal-regulated protein kinase | HAT, histone acetyl transferase | JNK, c-Jun N-terminal kinase | MAPKAP-K2, MAPK-activated protein kinase 2 | Tumour necrosis factor | Rb, retinoblastoma protein | Epidermal growth factor | p38 | ATF-2, activating transcription factor-2 | MAPK, mitogen-activated protein kinase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | MAP Kinase Signaling System - physiology | Mitogen-Activated Protein Kinase Kinases - genetics | Phosphorylation | Tetradecanoylphorbol Acetate - pharmacology | Embryo, Mammalian | Fibroblasts - physiology | MAP Kinase Kinase 7 | Mitogen-Activated Protein Kinase Kinases - metabolism | p38 Mitogen-Activated Protein Kinases | Phosphopeptides - chemistry | Peptide Fragments - metabolism | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - deficiency | Mice, Knockout | Mitogen-Activated Protein Kinases - deficiency | Transcription Factors - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Peptide Fragments - chemistry | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 8 | Signal Transduction - drug effects | Activating Transcription Factor 2 | Fibroblasts - drug effects | Cyclic AMP Response Element-Binding Protein - metabolism | Phosphopeptides - metabolism | Anisomycin - pharmacology | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Mice | Mitogen-Activated Protein Kinases - metabolism | Cyclic adenylic acid | Glutathione transferase | Mitogens | Protein kinases
Journal Article
Journal Article
Biochemical journal, ISSN 0264-6021, 04/2005, Volume 387, Issue 2, pp. 507 - 517
MSK1 (mitogen- and stress-activated protein kinase) is a kinase activated in cells downstream of both the ERK1/2... 
MSK2 | Mitogen- and stress-activated protein kinase (MSK1) | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) | P38 | Extracellular-signal-regulated kinase (ERK) | P90 ribosomal S6 kinase (RSK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Mutagenesis, Site-Directed | Humans | Molecular Sequence Data | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | Mitogens | Mitogen-Activated Protein Kinase 1 - metabolism | mitogen- and stress-activated protein kinase (MSK1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1, 3-phosphoinositide-dependent protein kinase 1 | GST, glutathione S-transferase | HEK-293 cells, human embryonic kidney 293 cells | RSK, p90 ribosomal S6 kinase | extracellular-signal-regulated kinase (ERK) | ERK, extracellular-signal-regulated kinase | MALDI–TOF, matrix-assisted laser-desorption ionization–time of flight | PEI, polyethyleneimine | p38 | DMEM, Dulbecco's modified Eagle's medium | MAPKAP-K, MAPK-activated protein kinase | MEF, mouse embryonic fibroblast | PH domain, pleckstrin homology domain | MSK, mitogen- and stress-activated protein kinase | p90 ribosomal S6 kinase (RSK) | PIP3, phosphatidylinositol 3,4,5-trisphosphate | MAPK, mitogen-activated protein kinase | PKA, PKB, PKC and PKG, protein kinases A, B, C and G respectively | TFA, trifluoroacetic acid
Journal Article
Biochemical journal, ISSN 0264-6021, 02/2014, Volume 458, Issue 1, pp. 41 - 56
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK... 
Amino Acid Sequence | Phosphorylation | Humans | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Protein Prenylation | Serine - metabolism | Animals | Adenylate Kinase - metabolism | HEK293 Cells | Cysteine - metabolism | Mice | Protein-Serine-Threonine Kinases - metabolism | STRAD, STE20-related kinase adaptor | ACC, acetyl-CoA carboxylase | PI3K, phosphoinositide 3-kinase | SIK3, salt-inducible kinase 3 | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | ARK5, AMPK-related protein kinase 5 | EDL, extensor digitorum longus | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | RSK, ribosomal S6 kinase | DMEM, Dulbecco's modified Eagle's medium | NUAK1, NUAK family, SNF1-like kinase | phenformin | BRSK, BR serine | SAD-A | threonine kinase | mTOR, mammalian target of rapamycin | Bub2 | HSP90, heat-shock protein 90 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | SAD-B kinase | MARK4, MAP | signal transduction | 5-amino-4-imidazolecarboxamide riboside (AICAR) | PKA, cAMP-dependent protein kinase | HA, haemagglutinin | BiP, immunoglobulin heavy-chain-binding protein | PH, pleckstrin homology | raptor, regulatory associated protein of mTOR | Cdc16) domain family, member 1 | TBC1D1, TBC (Tre-2 | BDNF, brain-derived neurotrophic factor | ACTH, adrenocorticotropic hormone | MAPKAPK, MAPKAP (MAPK-activated protein) kinase | MEF, mouse embryonic fibroblast | AICAR, 5-amino-4-imidazolecarboxamide riboside | AMP-activated protein kinase-related kinase (AMPK-related kinase) | monoclonal antibody | microtubule affinity-regulating kinase 4 | ER, endoplasmic reticulum | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Biochemical journal, ISSN 0264-6021, 01/2006, Volume 393, Issue 1, pp. 1 - 6
The identification of all the substrates of every protein kinase is one of the major challenges of post-genomic research... 
Mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) | Protein kinase B (PKB) | Glycogen synthase kinase 3 (GSK3) | Serum- and glucocorticoid-induced protein kinase (SGK) | Kinase substrate tracking and elucidation (KESTREL) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Reproducibility of Results | Animals | Peptide Mapping | Biochemistry - methods | Substrate Specificity | Protein Kinases - deficiency | CRMP, collapsin-response mediator protein | PI3K, phosphoinositide 3-kinase | SAKS1, SAPK-substrate 1 | TNF, tumour necrosis factor | hnRNP, heterogeneous nuclear ribonucleoprotein | PNGase, peptide N-glycanase | PDK1, 3-phosphoinositide-dependent kinase 1 | HEK, human embryonic kidney | Review | JNK, c-Jun N-terminal kinase | EF2, elongation factor 2 | UBA, ubiquitin-associated | KSHV, Kaposi sarcoma-associated herpesvirus | UBX, ubiquitin-like | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | SAPK, stress-activated protein kinase | MKK1, MAPK kinase-1 | protein kinase B (PKB) | EF2K, EF2 kinase | HSP27, heat-shock protein of 27 kDa | METTL1, methyltransferase-like protein 1 | glycogen synthase kinase 3 (GSK3) | FLNc, filamin C | NDRG, N-myc downstream-regulated gene product | VCP, valosin-containing protein | GSK3, glycogen synthase kinase 3 | SGK, serum- and glucocorticoid-induced protein kinase | IGF-1, insulin-like growth factor 1 | KESTREL, kinasesubstrate tracking and elucidation | MAPKAP-K2, MAPK-activated protein kinase-2 | CDK, cyclin-dependent protein kinase | CRHSP24, calcium-regulated heatshock protein of 24 kDa | PIC, pro-inflammatory cytokine | LPS, lipopolysaccharide | kinase substrate tracking and elucidation (KESTREL) | mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) | ARE, AU-rich element | CapZIP, CapZ-interacting protein | serum- and glucocorticoid-induced protein kinase (SGK) | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 01/2006, Volume 393, Issue 1, pp. 129 - 139