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Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40311
Dendritic cells (DC) can achieve cross-presentation of naturally-occurring tumor-associated antigens after phagocytosis and processing of dying tumor cells.... 
METASTATIC MELANOMA | HUMAN TUMOR-ANTIGEN | HLA-A2 MELANOMAS | B16 MELANOMA | MULTIDISCIPLINARY SCIENCES | IN-VIVO | APOPTOTIC CELLS | VACCINATION | PHASE-II | CROSS-PRESENTATION | LYMPHOCYTES | MART-1 Antigen - immunology | Melanoma - metabolism | Gamma Rays | HLA-A2 Antigen - immunology | Antigen Presentation - radiation effects | Dendritic Cells - immunology | Humans | Phagocytosis - immunology | Gene Expression Regulation, Neoplastic - immunology | Interferon-gamma - metabolism | Antigen Presentation - immunology | Phagocytosis - radiation effects | Microscopy, Confocal | Macrophages - metabolism | Melanoma - immunology | Interferon-gamma - immunology | CD8-Positive T-Lymphocytes - metabolism | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - radiation effects | MART-1 Antigen - biosynthesis | HLA-A2 Antigen - metabolism | CD8-Positive T-Lymphocytes - immunology | Dendritic Cells - metabolism | Macrophages - immunology | Biotechnology | Peptides | CD8 antigen | Antigen processing | Irradiated | Clinical trials | Confocal microscopy | Mesothelioma | Lymphocytes T | Vaccines | Macrophages | Cancer therapies | Phagocytes | Killer cells | Lymphocytes | Immunotherapy | Stains | Antigen presentation | Antigens | Medical research | Dendritic cells | Granulocyte-macrophage colony-stimulating factor | Tumor cells | Melanoma | BCG | Cultures | Patients | Bladder cancer | Microscopy | Antigen-presenting cells | Antigen (tumor-associated) | Cell lines | Antitumor activity | Interferon | Histocompatibility antigen HLA | Phagocytosis | Tumors | Cancer | Apoptosis | Antibodies | Melanocytes | MART-1 antigen | gamma Radiation | gamma -Interferon
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 10/2014, Volume 96, Issue 4, pp. 633 - 645
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 2010, Volume 225, Issue 1, pp. 22 - 33
Abstract Immunotherapy is a promising new treatment for patients suffering from glioma, in particular glioblastoma multiforme (GBM). However, tumour cells use... 
Neurology | Allergy and Immunology | IDO | Immunomodulation | Immunotherapy | Glioblastoma | TGF-β | PDL-1 | T cells | GLIOMA-CELLS | FAS LIGAND | HLA-G EXPRESSION | PHASE-I/II TRIAL | IMMUNE ESCAPE | lmmunotherapy | IMMUNOLOGY | NEUROSCIENCES | MALIGNANT GLIOMA | TGF-beta | GROWTH-FACTOR-BETA | INTERFERON-GAMMA | CENTRAL-NERVOUS-SYSTEM | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Fas Ligand Protein - metabolism | Flow Cytometry - methods | Transforming Growth Factor beta2 - metabolism | Humans | HLA Antigens - genetics | Interferon-gamma - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - pharmacology | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | T-Lymphocytes - drug effects | Antigens, Neoplasm - metabolism | Cytotoxicity, Immunologic - drug effects | B7-H1 Antigen | Oligonucleotide Array Sequence Analysis - methods | Gene Expression Profiling - methods | Lectins - pharmacology | Histocompatibility Antigens Class I - genetics | HLA-G Antigens | HLA Antigens - metabolism | Gene Expression Regulation - drug effects | Glioblastoma - immunology | Glioblastoma - pathology | Cell Line, Tumor | Antigens, CD - pharmacology | MART-1 Antigen | T-Lymphocytes - immunology | Cell Proliferation - drug effects | HLA-A2 Antigen - metabolism | Cytotoxicity, Immunologic - immunology | Fas Ligand Protein - genetics | Interferon-gamma - pharmacology | Cell research | Histocompatibility antigens | Messenger RNA | HLA histocompatibility antigens | Lectins | Biochemistry | Transforming growth factors | Glioblastoma multiforme | Apoptosis | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Histocompatibility Antigens Class I | Gene Expression Profiling | Life Sciences | Flow Cytometry | Immunology | Neoplasm Proteins | Transforming Growth Factor beta2 | Interferon-gamma | Antigens, Neoplasm | T-Lymphocytes | Gene Expression Regulation | Fas Ligand Protein | HLA-A2 Antigen | Indoleamine-Pyrrole 2,3,-Dioxygenase | HLA Antigens | RNA, Messenger | Antigens, CD | Cytotoxicity, Immunologic | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e89897
Antitumor vaccination using synthetic long peptides (SLP) is an additional therapeutic strategy currently under development. It aims to activate tumor-specific... 
IMMUNITY | MULTIDISCIPLINARY SCIENCES | PROTEASOME | VACCINE | ANTIGEN PRESENTATION | ENDOPLASMIC-RETICULUM | EXOGENOUS ANTIGENS | CANCER-IMMUNOTHERAPY | INDUCTION | T-LYMPHOCYTES | PRESENTATION PATHWAY | Endoplasmic Reticulum-Associated Degradation | Dendritic Cells - immunology | Humans | Valosin Containing Protein | Antigens, Neoplasm - chemistry | Endosomes - metabolism | Lysosomes - metabolism | Peptides - chemical synthesis | ATP-Binding Cassette Transporters - metabolism | Membrane Proteins - metabolism | Dendritic Cells - metabolism | Endocytosis - immunology | MART-1 Antigen - chemistry | MART-1 Antigen - immunology | Peptides - chemistry | Antigens, Neoplasm - immunology | Peptides - immunology | Cell Cycle Proteins - metabolism | Adenosine Triphosphatases - metabolism | Antigen Presentation - immunology | Antigens - chemistry | Protein Transport | SEC Translocation Channels | Cross-Priming - immunology | Models, Biological | Antigens - immunology | Kinetics | Proteasome Endopeptidase Complex - metabolism | Cancer vaccines | Histocompatibility antigens | Peptides | Dendritic cells | HLA histocompatibility antigens | T cells | Health aspects | CD8 antigen | Vaccination | Cytotoxicity | Amino acids | Confocal microscopy | Biochemistry | Lymphocytes T | Vaccines | Confocal | Cytosol | Machinery | Proteins | Immunology | Lymphocytes | Immunotherapy | Subunit structure | Immune system | Translocation | Antigen presentation | Antigens | T cell receptors | Major histocompatibility complex | Microscopy | Antigen-presenting cells | Quality control | Histocompatibility antigen HLA | Endoplasmic reticulum | Cytoplasm | Cancer | Endosomes | Tumors
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 13, pp. 3285 - 3296
Purpose: Patients with cancer benefit increasingly from T-cell-based therapies, such as adoptive T-cell transfer, checkpoint blockade, or vaccination. We have... 
IMMUNIZATION | ONCOLOGY | FUNCTIONAL COMPETENCE | PERSISTENCE | CLONOTYPES | TUMOR-REGRESSION | ANTIGEN-SPECIFIC EFFECTOR | SELF-ANTIGEN | IDENTIFICATION | CANCER | PEPTIDE VACCINE | MART-1 Antigen - therapeutic use | Stem Cells - immunology | Humans | Lipids - immunology | Adoptive Transfer | Immunologic Memory - drug effects | Freund's Adjuvant - immunology | Freund's Adjuvant - therapeutic use | Cancer Vaccines - therapeutic use | Lymphocyte Activation - immunology | Antigens, Neoplasm - therapeutic use | MART-1 Antigen - immunology | HLA-A2 Antigen - immunology | Antigens, Neoplasm - immunology | Melanoma - pathology | Lipids - therapeutic use | Cancer Vaccines - immunology | Cell Differentiation - immunology | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | Melanoma - immunology | CD8-Positive T-Lymphocytes - drug effects | Stem Cells - drug effects | T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Flow cytometry | Transcription | Peptides | CD8 antigen | Vaccination | Differentiation (biology) | Effector cells | Lymphocytes T | Vaccines | Cancer vaccines | T-cell receptor | Lymphocytes | CpG islands | Immunization | Immunological memory | Memory cells | Melanoma | T cell receptors | Cell differentiation | Patients | Computer memory | Cytometry | Immune checkpoint | Experimental design | Stem cells | Kinetics | Cancer
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2015, Volume 194, Issue 7, pp. 3487 - 3500
TCR alpha- and beta-chains cooperatively recognize peptide -MHC complexes. It has been shown that a "chain-centric" TCR hemichain can, by itself, dictate... 
METASTATIC MELANOMA | CANCER REGRESSION | SELF-PEPTIDE | ENHANCED ANTITUMOR-ACTIVITY | T-CELL-RECEPTOR | HIGH-AFFINITY | ANTIGEN-PRESENTING CELLS | GENE-TRANSFER | IMMUNOLOGY | DIRECTED EVOLUTION | MOLECULAR-BASIS | Recombinant Fusion Proteins - immunology | T-Lymphocyte Subsets - immunology | Complementarity Determining Regions - genetics | Receptors, Antigen, T-Cell - chemistry | HLA-A2 Antigen - genetics | Humans | Protein Multimerization | Epitopes, T-Lymphocyte - genetics | Recombinant Fusion Proteins - metabolism | Complementarity Determining Regions - chemistry | MART-1 Antigen - metabolism | Peptide Fragments - immunology | Epitopes, T-Lymphocyte - immunology | Complementarity Determining Regions - metabolism | Peptide Fragments - genetics | MART-1 Antigen - chemistry | Amino Acid Sequence | Cell Line | Peptide Fragments - metabolism | Transduction, Genetic | HLA-A2 Antigen - immunology | Receptors, Antigen, T-Cell - metabolism | Immunophenotyping | Receptors, Antigen, T-Cell, alpha-beta - genetics | Epitopes, T-Lymphocyte - chemistry | HLA-A2 Antigen - chemistry | Peptide Fragments - chemistry | T-Lymphocyte Subsets - metabolism | MART-1 Antigen - genetics | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Receptors, Antigen, T-Cell - genetics | Receptors, Antigen, T-Cell, alpha-beta - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 44, pp. 37269 - 37281
Journal Article