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Oncogene, ISSN 0950-9232, 09/2008, Volume 27, Issue 38, pp. 5138 - 5147
A family of Mastermind-like (MAML) genes encodes critical transcriptional co-activators for Notch signaling, an evolutionarily conserved pathway with numerous... 
MEF2C | Mastermind-like co-activator | Wnt/β-catenin | Notch | p53 | NEUROGENIC LOCUS MASTERMIND | COMPLEX | PROTEIN | DROSOPHILA MASTERMIND | MAML1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZONE B-CELLS | NOTCH PATHWAY | GENETIC CIRCUITRY | CELL BIOLOGY | ONCOLOGY | Wnt/beta-catenin | IN-VIVO | GENETICS & HEREDITY | CSL | Humans | Multiprotein Complexes | Cell Communication - physiology | MADS Domain Proteins - deficiency | Trans-Activators - chemistry | Trans-Activators - physiology | Colonic Neoplasms - physiopathology | Tumor Suppressor Protein p53 - physiology | Adenocarcinoma - physiopathology | beta Catenin - physiology | Cell Differentiation - physiology | MEF2 Transcription Factors | DNA-Binding Proteins - physiology | Receptors, Notch - physiology | Muscular Diseases - pathology | Myogenic Regulatory Factors - physiology | Organ Specificity | DNA-Binding Proteins - chemistry | Mice, Knockout | Protein Interaction Mapping | Tumor Suppressor Proteins - physiology | Animals | Receptors, Notch - chemistry | Signal Transduction - physiology | Mice | Transcription Factors | Transcriptional Activation - physiology | Muscular Diseases - genetics | MADS Domain Proteins - physiology | Cellular signal transduction | Genetic aspects | Research | Genetic transcription | Health aspects | Cancer | Proteins | Signal transduction | Cellular biology | Gene expression
Journal Article
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), ISSN 0302-9743, 2015, Volume 8971, pp. 222 - 227
Journal Article
Discrete Mathematics, ISSN 0012-365X, 03/2018, Volume 341, Issue 3, pp. 665 - 671
We study variants of Mastermind, a popular board game in which the objective is sequence reconstruction. In this two-player game, the so-called constructs a... 
Combinatorial games | Mastermind | Query complexity | MATHEMATICS | NUMBER | GAME
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 03/2015, Volume 16, Issue 3, pp. 353 - 359
Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular... 
chemotherapy resistance | Notch signaling pathway | Hes1 | cancer stem cell | non-canonical Notch | metastasis | Cancer stem cell | Chemotherapy resistance | Metastasis | Non-canonical Notch | basic helix-loop-helix | ABC | HDACs | OSTEOBLAST DIFFERENTIATION | Suppressor of Hairless | NEURONAL DIFFERENTIATION | TLE | BETA-CATENIN | bHLH | MAML | MASH-1 | CBF1 | PROSTATE-CANCER | histone deacetylases | epithelial-mesenchymal transition | ENHANCES SENSITIVITY | cancer stem cells | dnMAM | Lag1 | GSI | Mammalian achaete-scute homolog-1 | CSL | Runt-related protein 2 | CSCs | Runx2 | PROGENITOR CELLS | OSTEOMIMETIC PROPERTIES | secretase inhibitor | EMT | TRANSCRIPTION REPRESSION | ONCOLOGY | Mastermind-like protein family | transducin-like Enhancer of split | ATP-binding cassette | NICD | SQUAMOUS-CELL CARCINOMA | dominant-negative mastermind | Notch intracellular domain | Transcription Factor HES-1 | Basic Helix-Loop-Helix Transcription Factors - genetics | Homeodomain Proteins - metabolism | Humans | Carcinogenesis - genetics | Apoptosis - genetics | Receptors, Notch - genetics | Signal Transduction - genetics | Epithelial-Mesenchymal Transition - genetics | Homeodomain Proteins - genetics | Drug Resistance, Neoplasm - genetics | Neoplasm Metastasis | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Index Medicus
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 07/2018, Volume 142, Issue 1, pp. 76 - 85.e8
Journal Article
Annals of Diagnostic Pathology, ISSN 1092-9134, 2016, Volume 27, pp. 79 - 82
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2007, Volume 404, Issue 2, pp. 289 - 298
Ligand activation of Notch leads to the release of Notch IC (the intracellular receptor domain), which translocates to the nucleus and interacts with the... 
p300 | Chromatin | Acetylation | Transcription | Mastermind-like protein-1 (MAML1) | Notch | NEUROGENIC LOCUS MASTERMIND | DNA-BINDING | ACTIVATION | PROTEIN | transcription | DROSOPHILA MASTERMIND | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTIONAL COACTIVATOR | chromatin | mastermind-like protein-1 (MAML1) | acetylation | H4N TERMINI | ANKYRIN DOMAIN | Cell Line | Chromatin - metabolism | Receptors, Notch - metabolism | Humans | Trans-Activators | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Proline - chemistry | Spodoptera | DNA-Binding Proteins - metabolism | p300-CBP Transcription Factors - metabolism | Animals | Lysine - metabolism | Transcription Factors | Histones - metabolism | Nuclear Proteins - genetics | DNA, Complementary | iκBα, inhibitory κBα | Suppressor of Hairless | Lag-1 | MEF2C, MADS box transcription enhancer factor 2 | HES, Hairy and Enhancer of Split | MAML1, mastermind-like 1 | DTT, dithiothreitol | CBF1, CCAAT-binding factor 1 | NAP1, nucleosome assembly protein 1 | H, cysteine | HDAC, histone deacetylase | ISWI, imitation-SWI protein | RAM, RBP-jk (recombination signal-binding protein 1 for j-kappa)-associated molecule | CSL, CBF1 | NF-κB, nuclear factor κB | Notch IC, Notch intracellular receptor domain | ANK, ankyrin | HAT, histone acetyltransferase | EMSA, electrophoretic mobility-shift assay | Acf-1, ATP-dependent chromatin assembly and remodelling factor 1 | Hsp90, heat-shock protein of 90 kDa | histidine | GR, glucocoticoid receptor
Journal Article
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, ISSN 0002-9173, 09/2019, Volume 152, Issue 3, pp. 322 - 346
Objectives: The 2017 Workshop of the Society for Hematopathology/European Association for Haematopathology examined the role of molecular genetics in the... 
CHRONIC MYELOGENOUS LEUKEMIA | AML | Molecular diagnostics | PROGNOSIS | ACUTE MYELOID-LEUKEMIA | PATHOLOGY | IDENTIFICATION | MASTERMIND-LIKE 2 | Hematopathology | ACUTE LYMPHOBLASTIC-LEUKEMIA | Genetics | MUTATIONS | MINIMAL RESIDUAL DISEASE | EXPRESSION
Journal Article
Nature, ISSN 0028-0836, 11/2009, Volume 462, Issue 7270, pp. 182 - 188
Direct inhibition of transcription factor complexes remains a central challenge in the discipline of ligand discovery. In general, these proteins lack surface... 
PROGENITOR CELLS | ACTIVATION | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | T-CELL LEUKEMIA | C-MYC | GAMMA-SECRETASE INHIBITORS | MUTATIONS | HUMAN HOMOLOG | MASTERMIND | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Transcription Factors - chemistry | Humans | Transcriptional Activation - drug effects | Genome - genetics | Receptor, Notch1 - chemistry | Cell Membrane Permeability | Substrate Specificity | DNA-Binding Proteins - metabolism | Peptides - chemical synthesis | Peptides - metabolism | Protein Binding - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | Binding, Competitive | Protein Structure, Tertiary | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Drosophila Proteins - chemistry | Receptor, Notch1 - metabolism | Genome - drug effects | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Peptides - pharmacology | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Receptor, Notch1 - antagonists & inhibitors | Transcription factors | Research | Ligands (Biochemistry) | Peptide bonds
Journal Article
Cureus, ISSN 2168-8184, 07/2018, Volume 10, Issue 7, p. e3013
Mentorship is an important driver of professional development and scholarship in academic medicine. Several mentorship models have been described in the... 
Medicine | Demographics | Meetings | Self evaluation | Careers | Emergency medical care | Professional development | Volunteers | Professions
Journal Article
Endocrine Journal, ISSN 0918-8959, 2018
We report three cases of thyroid sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE), which is an extremely rare variant of mucoepidermoid carcinoma... 
Mastermind-like transcriptional coactivator 2 | Salivary | Sclerosing mucoepidermoid carcinoma with eosinophilia | Thyroid | Eosinophilic abscess
Journal Article
Genes and Development, ISSN 0890-9369, 06/2002, Volume 16, Issue 11, pp. 1397 - 1411
Signaling through the Notch pathway activates the proteolytic release of the Notch intracellular domain (ICD), a dedicated transcriptional coactivator of CSL... 
Chromatin | Phosphorylation | Proteolysis | Mastermind | Transcription activation | Notch | transcription activation | RNA-POLYMERASE-II | FUNCTIONAL INTERACTION | PROTEIN | DROSOPHILA MASTERMIND | P300 | CYCLIN-DEPENDENT KINASE | DEVELOPMENTAL BIOLOGY | chromatin | NUCLEAR FORM | CAENORHABDITIS-ELEGANS | SIGNALING PATHWAY | GENETICS & HEREDITY | DEGRADATION | phosphorylation | proteolysis | Chromatin - metabolism | Humans | Transcriptional Activation | E1A-Associated p300 Protein | Viral Proteins - metabolism | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Receptors, Notch | Transfection | Genes, Dominant | Transcription, Genetic | Glutamine - chemistry | Membrane Proteins - metabolism | Insect Proteins - metabolism | Fluorescent Antibody Technique, Indirect | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Cell Line | Drosophila Proteins | Insect Proteins - physiology | Signal Transduction | Membrane Proteins - genetics | Glutathione Transferase - metabolism | Nucleosomes - metabolism | Nuclear Proteins - metabolism | DNA - metabolism | Plasmids - metabolism | Blotting, Western | Animals | Xenopus - metabolism | Models, Biological | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Saccharomyces cerevisiae Proteins | Protein Binding | Trans-Activators - metabolism | Mice | Nuclear Proteins - physiology | Transcription Factors | HeLa Cells | Cell Cycle Proteins | Microscopy, Fluorescence | Fungal Proteins - metabolism | Analysis | Genetic research | Physiological aspects | Genetic aspects | Genetic transcription | Recombinant proteins | Research Paper
Journal Article
DEVELOPMENT, ISSN 0950-1991, 07/2019, Volume 146, Issue 14, p. dev170837
Notch signaling plays a pleiotropic role in a variety of cellular processes, including cell fate determination, differentiation, proliferation and apoptosis.... 
DEAD RINGER | SUPPRESSOR | COMPLEX | Enhancer of Split complex | DROSOPHILA MASTERMIND | Drosophila | Notch | Hat-trick | RECEPTOR | DEVELOPMENTAL BIOLOGY | CLEAVAGE | Activation complex | Cell signaling | PATHWAY | GENE-EXPRESSION | NUCLEAR ACCESS | Chromo-domain | BINDING
Journal Article