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biochemistry & molecular biology (2) 2
btb domain (2) 2
cullin proteins - antagonists & inhibitors (2) 2
cullin proteins - chemistry (2) 2
drug design (2) 2
hect, homologous with e6-associated protein c-terminus (2) 2
humans (2) 2
index medicus (2) 2
math, meprin and traf homology (2) 2
poz, pox virus and zinc finger (2) 2
protein structure, quaternary (2) 2
protein structure, tertiary (2) 2
ring, really interesting new gene (2) 2
spop, speckle-type poz protein (2) 2
tramtrack (2) 2
ubiquitination (2) 2
abiotic stress (1) 1
anaphase-promoting complex (1) 1
antioxidant response (1) 1
apc (1) 1
apc/c, anaphase-promoting complex/cyclosome (1) 1
arabidopsis (1) 1
arabidopsis-thaliana (1) 1
are, antioxidant-response element (1) 1
article (1) 1
asb, ankyrin repeat and socs-box (1) 1
assembly (1) 1
aux, auxin (1) 1
back, btb and c-terminal kelch (1) 1
bcr, btb–cul3–rbx1 (1) 1
behavioral disciplines and activities (1) 1
biochemical society focused meeting (1) 1
biotic stress (1) 1
bp, β-propeller (1) 1
brassica rapa (1) 1
bric-à-brac (1) 1
broad complex (1) 1
btb, bric-a-brac (1) 1
btb, bric-a-brac/tramtrack/broad complex (1) 1
btb, broad complex (1) 1
btb, broad complex/tramtrack/bric-à-brac (1) 1
c, anaphase-promoting complex (1) 1
cancer (1) 1
cancer-therapy (1) 1
cand1, cullin-associated nedd8-dissociated protein 1 (1) 1
cbfβ, core binding factor β (1) 1
cdc, cell division cycle (1) 1
cell signalling (1) 1
cell-cycle (1) 1
cks1, cyclin-dependent protein kinase regulatory subunit 1 (1) 1
coi1, coronatine-insensitive protein 1 (1) 1
cop9 signalosome (1) 1
cpd, compound (1) 1
cph, conserved within cul7, parc and herc2 (1) 1
crbn, cereblon (1) 1
crl, cullin–ring e3 ubiquitin ligase (1) 1
crl, cullin–ring ligase (1) 1
cross-tolerance (1) 1
csa, cockayne syndrome a (1) 1
csn, cop9 signalosome complex (1) 1
ctd, c-terminal domain (1) 1
cul, cullin (1) 1
cullin proteins - genetics (1) 1
cullin proteins - physiology (1) 1
cyclosome (1) 1
dcaf, ddb1–cul4a-associated factor (1) 1
ddb, damage-specific dna-binding protein (1) 1
degradation (1) 1
drought tolerance (1) 1
drug discovery - methods (1) 1
ectopic expression (1) 1
education (1) 1
elobc, elonginb–elonginc complex (1) 1
endoplasmic-reticulum (1) 1
f-box proteins (1) 1
fbw (1) 1
fbw/fbxw, f-box/wd repeat-containing protein (1) 1
fbxl, f-box (1) 1
fbxl, f-box/leucine-rich motif-containing protein (1) 1
fbxo, f-box (1) 1
fbxo, f-box/other domain-containing protein (1) 1
fbxw, f-box (1) 1
food and beverages (1) 1
fp, fluorescence polarization (1) 1
fungi (1) 1
gene expression (1) 1
genetics & heredity (1) 1
ghr, growth hormone receptor (1) 1
herc2, hect domain- and rld domain-containing e3 ubiquitin protein ligase 2 (1) 1
hif-1α, hypoxia-inducible factor 1α (1) 1
iaa, indole-3-acetic acid (1) 1
interaction motif (1) 1
intracellular signaling peptides and proteins - antagonists & inhibitors (1) 1
intracellular signaling peptides and proteins - chemistry (1) 1
intracellular signaling peptides and proteins - physiology (1) 1
itc, isothermal titration calorimetry (1) 1
iκb, inhibitor of nf-κb (1) 1
ja-ile, jasmonoyl-isoleucine (1) 1
jaz1, jasmonate (1) 1
jaz1, jasmonate/zim domain protein 1 (1) 1
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Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 02/2014, Volume 42, Issue 1, pp. 103 - 107
E3 ubiquitin ligases that direct substrate proteins to the ubiquitin-proteasome system are promising, though largely unexplored drug targets both because of... 
Cell signalling | Degradation | Drug design | Antioxidant response | Ubiquitylation | Cancer | Protein Structure, Tertiary | Cullin Proteins - antagonists & inhibitors | Protein Structure, Secondary | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cullin Proteins - physiology | Molecular Targeted Therapy | Multiprotein Complexes - antagonists & inhibitors | Multiprotein Complexes - physiology | Cullin Proteins - chemistry | Multiprotein Complexes - chemistry | Ubiquitination | Intracellular Signaling Peptides and Proteins - chemistry | Drug Design | Protein Structure, Quaternary | Intracellular Signaling Peptides and Proteins - physiology | Kelch-Like ECH-Associated Protein 1 | Rbx, RING box protein | CRL, Cullin–RING ligase | HECT, homologous with E6-associated protein C-terminus | BTB, broad complex | drug design | Nrf2, nuclear factor erythroid 2-related factor 2 | bric-à-brac | RING, really interesting new gene | KEAP1, Kelch-like ECH-associated protein 1 | Biochemical Society Focused Meeting | degradation | BACK, BTB and C-terminal Kelch | antioxidant response | POZ, pox virus and zinc finger | KLHL, Kelch-like | cell signalling | ARE, antioxidant-response element | MATH, meprin and TRAF (tumour-necrosis-factor-receptor-associated factor) homology | cancer | SPOP, speckle-type POZ protein | ubiquitylation | tramtrack
Journal Article
Current Genomics, ISSN 1389-2029, 05/2013, Volume 14, Issue 3, pp. 214 - 223
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 06/2016, Volume 7, p. 923
Response to stress represents a highly complex mechanism in plants involving a plethora of genes and gene families. It has been established that plants use... 
BTB domain | Biotic stress | Abiotic stress | Arabidopsis | MATH domain | Rice | PROTEIN FAMILY | TRANSCRIPTION FACTOR FAMILY | PIRIFORMOSPORA-INDICA | SALINITY STRESS | rice | PLASMA-MEMBRANE | abiotic stress | DROUGHT TOLERANCE | PLANT SCIENCES | LEGUME CROPS | TRANSGENIC RICE | biotic stress | ECTOPIC EXPRESSION | CROSS-TOLERANCE
Journal Article
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