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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2011, Volume 108, Issue 32, pp. E440 - E449
Astrocytes regulate synaptic connectivity in the CNS through secreted signals. Here we identified two astrocyte-secreted proteins, hevin and SPARC, as... 
Extracellular matrix | Synaptic cleft 1 | Matricellular protein | Osteonectin | SPARC-Like | osteonectin | SC1 | synaptic cleft 1 | RAT | EXTRACELLULAR-MATRIX GLYCOPROTEIN | INTEGRIN | MULTIDISCIPLINARY SCIENCES | RECEPTOR | matricellular protein | CELL-SURVIVAL | SUPERIOR COLLICULUS | SPARC-Like 1 | EXPRESSION | extracellular matrix | SUPERFICIAL LAYERS | BRAIN | Central Nervous System - ultrastructure | Central Nervous System - metabolism | Extracellular Matrix Proteins - deficiency | Humans | Superior Colliculi - ultrastructure | Calcium-Binding Proteins - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Retinal Ganglion Cells - metabolism | Retinal Ganglion Cells - cytology | Osteonectin - deficiency | Synapses - metabolism | HEK293 Cells | Neurogenesis - drug effects | Extracellular Matrix Proteins - metabolism | Astrocytes - cytology | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Astrocytes - drug effects | Retinal Ganglion Cells - ultrastructure | Synapses - drug effects | Extracellular Matrix Proteins - chemistry | Superior Colliculi - metabolism | Extracellular Matrix Proteins - antagonists & inhibitors | Superior Colliculi - drug effects | Osteonectin - metabolism | Rats | Calcium-Binding Proteins - deficiency | Synapses - ultrastructure | Osteonectin - chemistry | Rats, Sprague-Dawley | Astrocytes - ultrastructure | Animals | Central Nervous System - cytology | Superior Colliculi - cytology | Mice | Retinal Ganglion Cells - drug effects | Astrocytes - secretion | Proteins | Brain | Rodents | Cells | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 12/2017, Volume 74, Issue 23, pp. 4269 - 4277
Periostin is a matricellular protein that is composed of a multi-domain structure with an amino-terminal EMI domain, a tandem repeat of four FAS 1 domains, and... 
Life Sciences | Biomedicine, general | Biochemistry, general | EMI | FAS 1 | Tenascin | Life Sciences, general | Collagen | Fibronectin | Cell Biology | BMP-1 | LYSYL OXIDASE | CORNEAL DYSTROPHIES | CANCER-ASSOCIATED FIBROBLASTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERIODONTAL-LIGAMENT | AGENT TARGETING PERIOSTIN | EPITHELIAL OVARIAN-CARCINOMA | CELL BIOLOGY | GROWTH-FACTOR-BETA | MATRICELLULAR PROTEIN | COLLAGEN FIBRILLOGENESIS | ACUTE MYOCARDIAL-INFARCTION | Cell Adhesion Molecules - genetics | Tenascin - genetics | Humans | Tenascin - metabolism | Bone Morphogenetic Protein 1 - genetics | Nephroblastoma Overexpressed Protein - genetics | Protein Isoforms - metabolism | Connective Tissue - anatomy & histology | Collagen - genetics | Protein Interaction Domains and Motifs | Bone Morphogenetic Protein 1 - metabolism | Gene Expression | Signal Transduction | Proteoglycans - metabolism | Cell Adhesion Molecules - metabolism | Connective Tissue - metabolism | Fibronectins - metabolism | Nephroblastoma Overexpressed Protein - metabolism | Protein Interaction Mapping | Laminin - genetics | Collagen - metabolism | Protein Binding | Fibronectins - genetics | Laminin - metabolism | Protein Isoforms - genetics | Oxidases | Fibronectins | Crosslinked polymers | Laminin | Architecture | Protein binding | Construction | Collagen (type I) | Homeostasis | Crosslinking | Amino acids | Tissues | Lysyl oxidase | Connective tissues | Proteins | Electromagnetic interference | Extracellular matrix | Bone morphogenetic proteins | Assembly | Binding sites
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 2013, Volume 304, Issue 6, pp. L415 - L427
Zemans RL, McClendon J, Aschner Y, Briones N, Young SK, Lau LF, Kahn M, Downey GP. Role of beta-catenin-regulated CCN matricellular proteins in epithelial... 
β-catenin | Transmigration | Lung epithelium | CCN matricellular proteins | Neutrophils | Lung injury | beta-catenin | IMMEDIATE-EARLY GENE | PHYSIOLOGY | transmigration | BINDING-PROTEIN | CELL-PROLIFERATION | MESENCHYMAL TRANSITION | RESPIRATORY-DISTRESS-SYNDROME | IN-VITRO | lung injury | RESPIRATORY SYSTEM | lung epithelium | GROWTH-FACTOR | NEUTROPHIL TRANSMIGRATION | IDIOPATHIC PULMONARY-FIBROSIS | neutrophils | INDUCED CARDIOMYOCYTE DEATH | CCN Intercellular Signaling Proteins - physiology | CCN Intercellular Signaling Proteins - genetics | Coculture Techniques | Humans | E1A-Associated p300 Protein - physiology | E1A-Associated p300 Protein - metabolism | Cysteine-Rich Protein 61 - metabolism | Transendothelial and Transepithelial Migration | Respiratory Mucosa - immunology | Cysteine-Rich Protein 61 - physiology | Female | Acute Lung Injury - metabolism | beta Catenin - physiology | Neutrophils - metabolism | Proto-Oncogene Proteins - metabolism | Gene Expression | Signal Transduction | Cysteine-Rich Protein 61 - genetics | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Neutrophils - physiology | Proto-Oncogene Proteins - genetics | Acute Lung Injury - pathology | beta Catenin - metabolism | Animals | CCN Intercellular Signaling Proteins - metabolism | Proto-Oncogene Proteins - physiology | Acute Lung Injury - immunology | Mice | Respiratory Mucosa - metabolism
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 06/2008, Volume 104, Issue 3, pp. 721 - 732
Journal Article
AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, 03/2015, Volume 185, Issue 3, pp. 786 - 797
Periostin actively contributes to tissue injury, fibrosis, atherosclerosis, and inflammatory diseases; however, its role in hepatic fibrosis is unclear.... 
NICHE COMPONENT | CELLS | ATTENUATES LIVER FIBROSIS | OSTEOPONTIN | GROWTH | MATRICELLULAR PROTEINS | EXTRACELLULAR-MATRIX | PATHOLOGY | CANCER | PROGRESSION | TENASCIN-C
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 46, pp. 17953 - 17970
Connective tissue growth factor (CTGF; now often referred to as CCN2) is a secreted protein predominantly expressed during development, in various pathological... 
extracellular matrix protein | TGF-BETA | PROTEIN | connective tissue growth factor (CTGF) | protein processing | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein chemistry | recombinant protein expression | CELL-ADHESION | matricellular protein | FAMILY | protein structure | FC-RECEPTOR | NOV | CCN protein | FACTOR CTGF | LUNG FIBROBLASTS | fibrosis | CCN2 | EXPRESSION | BINDING | PULMONARY-FIBROSIS | Cyr61
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 32, pp. 23075 - 23089
Journal Article
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 06/2008, Volume 104, Issue 3, pp. 721 - 732
Within the tumor microenvironment is a dynamic exchange between cancer cells and their surrounding stroma. This complex biologic system requires carefully... 
SPARC | DIFFERENTIAL EXPRESSION | desmoplasia | angiogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | matricellular protein | SPARC-NULL MICE | SECRETED PROTEIN | CELL BIOLOGY | OSTEONECTIN MESSENGER-RNA | HEPATOCELLULAR-CARCINOMA | POOR-PROGNOSIS | SQUAMOUS-CELL CARCINOMA | HUMAN-MELANOMA CELLS | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | tumor microenvironment
Journal Article