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Journal of Biological Chemistry, ISSN 0021-9258, 08/2009, Volume 284, Issue 34, pp. 23001 - 23011
Fibroblasts degrade type I collagen, the major extracellular protein found in mammals, during events ranging from bulk tissue resorption to invasion through... 
1-MATRIX METALLOPROTEINASE | TYPE-1 MATRIX-METALLOPROTEINASE | SUBSTRATE DEGRADATION | GELATINASE-A | CELL-MIGRATION | CYSTEINE PROTEINASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TARGETED MUTATION | EXTRACELLULAR-MATRIX | DEFICIENT MICE | MEDIATED INHIBITION | Matrix Metalloproteinase 9 - physiology | Matrix Metalloproteinase 8 - physiology | Matrix Metalloproteinase 2 - physiology | Tissue Inhibitor of Metalloproteinase-2 - genetics | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - genetics | Plasminogen - pharmacology | Matrix Metalloproteinase 16 - genetics | Membrane Proteins - metabolism | Fibroblasts - metabolism | Matrix Metalloproteinase 8 - genetics | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis | Matrix Metalloproteinase 13 - genetics | Mice, Inbred C57BL | Cells, Cultured | Platelet-Derived Growth Factor - pharmacology | Microscopy, Electron | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Tissue Inhibitor of Metalloproteinase-2 - physiology | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase 14 - physiology | Animals | Matrix Metalloproteinase 16 - physiology | Matrix Metalloproteinase 13 - physiology | Fibroblasts - drug effects | Fluorescent Antibody Technique | Matrix Metalloproteinase 14 - genetics | Cell Proliferation - drug effects | Mice | Collagenases - metabolism | Molecular Basis of Cell and Developmental Biology
Journal Article
Matrix biology, ISSN 0945-053X, 2011, Volume 30, Issue 2, pp. 145 - 153
Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix... 
MMP | ADAMTS | Interglobular domain | Chondroitin-sulfate-2 region | Aggrecan catabolism | RHEUMATOID-ARTHRITIS | PROTEOLYTIC CLEAVAGE | CLEAVAGE SITE | ACTIVATION MECHANISMS | LARGE AGGREGATING PROTEOGLYCAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | HUMAN ARTICULAR-CARTILAGE | MATRIX METALLOPROTEINASES | OSTEOARTHRITIC CARTILAGE | ONCOSTATIN-M | Matrix Metalloproteinases, Secreted - metabolism | Interleukin-1beta - pharmacology | Phenylmercuric Acetate - pharmacology | Matrix Metalloproteinase 12 - genetics | Cartilage - drug effects | Oncostatin M - pharmacology | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 7 - metabolism | Cattle | Isoenzymes - metabolism | Matrix Metalloproteinase 8 - metabolism | Gelatinases - metabolism | Matrix Metalloproteinase 1 - genetics | Recombinant Proteins - metabolism | Endopeptidases - metabolism | Matrix Metalloproteinase 8 - genetics | Peptide Fragments - metabolism | Isoenzymes - genetics | Matrix Metalloproteinase 2 - metabolism | Matrix Metalloproteinase 3 - metabolism | Aggrecans - metabolism | Matrix Metalloproteinase 12 - metabolism | Cartilage - metabolism | Aggrecans - genetics | ADAM Proteins - metabolism | Enzyme Precursors - metabolism | Matrix Metalloproteinase 7 - genetics | Animals | Endopeptidases - genetics | Matrix Metalloproteinases, Secreted - genetics | Phenylmercuric Acetate - analogs & derivatives | ADAM Proteins - genetics | Cartilage - enzymology | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 08/2006, Volume 8, Issue 5, pp. R142 - R142
Excess proteolysis of the extracellular matrix (ECM) of articular cartilage is a key characteristic of arthritis. The main enzymes involved belong to the... 
IN-VITRO | ONCOSTATIN-M | MATRIX-METALLOPROTEINASE | PROTECTS CARTILAGE | GENE-EXPRESSION | PROTEOGLYCAN CATABOLISM | ARTICULAR CHONDROCYTES | NECROSIS-FACTOR-ALPHA | EXTRACELLULAR-MATRIX | RHEUMATOLOGY | BOVINE NASAL CARTILAGE | Matrix Metalloproteinase 12 - genetics | Gene Expression Profiling | Gene Expression Regulation, Enzymologic - physiology | Metalloproteases - metabolism | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Nasal Septum - cytology | Cattle | Matrix Metalloproteinase 9 - genetics | Matrix Metalloproteinase 16 - genetics | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Up-Regulation - physiology | Cartilage - cytology | Cartilage - physiology | Matrix Metalloproteinase 1 - genetics | Organ Culture Techniques | Tissue Inhibitor of Metalloproteinase-3 - genetics | Matrix Metalloproteinase 2 - metabolism | Matrix Metalloproteinase 13 - genetics | Matrix Metalloproteinase 16 - metabolism | Metalloproteases - genetics | Matrix Metalloproteinase 3 - metabolism | Matrix Metalloproteinase 12 - metabolism | Matrix Metalloproteinase 14 - metabolism | Matrix Metalloproteinase 13 - metabolism | Down-Regulation - physiology | Collagen - metabolism | Matrix Metalloproteinase 2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | ADAM Proteins - metabolism | Animals | Homeostasis - physiology | Matrix Metalloproteinase 14 - genetics | ADAM Proteins - genetics | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 05/2016, Volume 68, Issue 5, pp. 1111 - 1123
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 5, pp. e0127063 - e0127063
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal... 
CELLS | TUMOR INVASION | INFLAMMATORY-BOWEL-DISEASE | MATRIX-METALLOPROTEINASE INHIBITORS | MATRIX-METALLOPROTEINASE-9 MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | GELATINASE-B | GROWTH | GENE-EXPRESSION | DOWN-REGULATION | TNF-ALPHA | Dextran Sulfate | Epitope Mapping | Colitis, Ulcerative - enzymology | Allosteric Regulation | Colorectal Neoplasms - genetics | Humans | Colitis, Ulcerative - genetics | Gene Expression Regulation, Neoplastic | Rats, Inbred Lew | Male | Antineoplastic Agents - metabolism | Matrix Metalloproteinase 9 - metabolism | Antineoplastic Agents - isolation & purification | Matrix Metalloproteinase 9 - genetics | Antibodies, Monoclonal, Humanized - biosynthesis | Antibodies, Monoclonal, Humanized - isolation & purification | Antibodies, Monoclonal, Humanized - pharmacology | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Colitis, Ulcerative - drug therapy | Drug Evaluation, Preclinical | Disease Models, Animal | Recombinant Proteins - metabolism | Colorectal Neoplasms - enzymology | Signal Transduction | Rats | Recombinant Proteins - genetics | Matrix Metalloproteinase Inhibitors - metabolism | Recombinant Proteins - administration & dosage | Xenograft Model Antitumor Assays | Matrix Metalloproteinase Inhibitors - pharmacology | Animals | Colitis, Ulcerative - chemically induced | Mice, Nude | Hybridomas - immunology | Mice | Colorectal Neoplasms - pathology | Matrix Metalloproteinase Inhibitors - isolation & purification | Matrix Metalloproteinase 9 - administration & dosage | Monoclonal antibodies | Inflammation | Metastasis | Health aspects | Colorectal cancer | Ulcerative colitis | Drugs | Animal models | Inflammatory bowel diseases | Matrix metalloproteinases | Disease | Toxicity | Colorectal carcinoma | Biology | Biochemistry | Matrix metalloproteinase | Drug development | Kinases | Metastases | Allosteric properties | Rodents | Surgery | Sodium sulfate | Xenografts | Tumorigenesis | Metalloproteinase | Inhibition | Drug therapy | Growth factors | Medical research | Cytokines | Neutrophils | Stroma | Metabolism | Patients | Gelatinase B | Inflammatory bowel disease | Dextran | Inhibitors | Sodium | Sulfate | Tumors | Cancer | Apoptosis | Index Medicus
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2010, Volume 70, Issue 6, pp. 2224 - 2234
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2006, Volume 26, Issue 43, pp. 10939 - 10948
Journal Article
Genes and Development, ISSN 0890-9369, 10/2006, Volume 20, Issue 19, pp. 2673 - 2686
Carcinoma cells initiate the metastatic cascade by inserting invasive pseudopodia through breaches in the basement membrane (BM), a specialized barrier of... 
Matrix metalloproteinases | MT-MMPs | Type IV collagen | Invasion | Basement membrane | Cancer | COVALENT CROSS-LINK | ACTIVATION | basement membrane | COLLAGEN-IV | type IV collagen | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | MT1-MMP | invasion | GELATINASE-A | EPITHELIUM | GENETICS & HEREDITY | cancer | EXTRACELLULAR-MATRIX | INHIBITORS | matrix metalloproteinases | Neoplasms - metabolism | RNA, Small Interfering - genetics | Basement Membrane - ultrastructure | Humans | Matrix Metalloproteinase 15 - genetics | Cercopithecus aethiops | Extracellular Matrix - metabolism | Cell Movement - physiology | Matrix Metalloproteinase 16 - genetics | Neoplasms - physiopathology | Basement Membrane - enzymology | Collagen Type IV - metabolism | Cell Line | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Matrix Metalloproteinase 15 - metabolism | Neoplasm Invasiveness | Matrix Metalloproteinase 16 - metabolism | Rats | Matrix Metalloproteinase 14 - metabolism | Matrix Metalloproteinases, Membrane-Associated - genetics | Mutation - genetics | Tissue Inhibitor of Metalloproteinases - metabolism | Extracellular Matrix - ultrastructure | Animals | Matrix Metalloproteinase 14 - genetics | Cell Line, Tumor | Basement Membrane - physiology | Mice | Matrix Metalloproteinases, Membrane-Associated - metabolism | Neoplasms - pathology | COS Cells | Antimitotic agents | Proteolysis | Collagen | Analysis | Physiological aspects | Membrane, Basement | Genetic aspects | Research | Antineoplastic agents | Structure | Research Paper
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 8, p. e42714
The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-beta 1/Smad2 axis, via its cognate... 
RENAL FIBROSIS | LUNG FIBROSIS | COLLAGEN | MULTIDISCIPLINARY SCIENCES | GROWTH | INTERSTITIAL FIBROSIS | TISSUE INHIBITORS | SMOOTH-MUSCLE-CELLS | NITRIC-OXIDE PATHWAY | HORMONE RELAXIN | FIBROBLASTS | Relaxin - metabolism | Matrix Metalloproteinases - genetics | Receptors, G-Protein-Coupled - metabolism | Humans | Male | Receptors, Peptide - genetics | Matrix Metalloproteinase 9 - metabolism | Relaxin - genetics | Matrix Metalloproteinase 9 - genetics | Fibroblasts - metabolism | Cell Line | Matrix Metalloproteinase 2 - metabolism | Matrix Metalloproteinase 13 - genetics | Cells, Cultured | Rats | Kidney - cytology | Signal Transduction - genetics | Extracellular Signal-Regulated MAP Kinases | Rats, Sprague-Dawley | Matrix Metalloproteinase 13 - metabolism | Mice, Knockout | Matrix Metalloproteinase 2 - genetics | Animals | Cyclic GMP - metabolism | Nitric Oxide Synthase Type I - metabolism | Signal Transduction - physiology | Fibroblasts - cytology | Mice | Nitric Oxide Synthase Type I - genetics | Receptors, G-Protein-Coupled - genetics | Matrix Metalloproteinases - metabolism | Nitric Oxide - metabolism | Receptors, Peptide - metabolism | Physiological aspects | Genetic aspects | Research | Transforming growth factors | Metalloenzymes | Nitric oxide | Neurosciences | Phosphorylation | Matrix metalloproteinases | Guanosine | Smooth muscle | Genomes | Arthritis | Biochemistry | Matrix metalloproteinase | Guanylate cyclase | Western blotting | Signal transduction | Arginine | Gelatin | Rodents | Cyclic GMP | Fibroblasts | Metalloproteinase | Interstitial collagenase | Kidneys | Extracellular signal-regulated kinase | Collagenase 3 | Nitric-oxide synthase | Gelatinase B | NG-Nitroarginine methyl ester | Gelatinase A | Signaling | Inhibitors | Human performance | Collagen | Isoforms | Fibrosis | Skin | Aberration | Molecular biology | Ornithine
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