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Progress in biophysics and molecular biology, ISSN 0079-6107, 06/2019
The largest biomass of channel proteins is located in unicellular organisms and bacteria that have no organs. However, orchestrated bidirectional ionic... 
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 04/2005, Volume 288, Issue 4, pp. 846 - 854
Large, Ca2+-activated K+ channels (BK), comprised of α- and β-subunits, mediate K+ secretion during high flow rates in distal nephron segments. Because the... 
Flow-mediated K | Distal nephron | secretion | Maxi K
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 08/2009, Volume 297, Issue 2, pp. 420 - 428
On a low-Na+ diet (LNa+), urinary Na+ loss is prevented by aldosterone-induced Na+ reabsorption through epithelial Na+ channels (ENaC) in the connecting... 
BK channel | Mineralocorticoids | Potassium secretion | Maxi K | Adrenal cortex | adrenal cortex | mineralocorticoids | potassium secretion | maxi K
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 10/2019, Volume 1864, Issue 10, pp. 1525 - 1535
Oxysterols, oxidization products of cholesterol, are regarded as bioactive lipids affecting various physiological functions. However, little is known of their... 
Ca2+ activated potassium channel | Maxi K channel | slo1 | Oxysterol | Heterologous expression | HOMEOSTASIS | VOLTAGE | STIMULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 24(S)-HYDROXYCHOLESTEROL | CELL BIOLOGY | SIDE-CHAIN OXYSTEROLS | BIOPHYSICS | METABOLISM | DEPRESSION-LIKE BEHAVIOR | CHOLESTEROL 24-HYDROXYLASE | ACTIVATED POTASSIUM CHANNEL | BRAIN
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, ISSN 0363-6143, 02/2016, Volume 310, Issue 4, pp. C243 - C259
Flow-induced K secretion (FIKS) in the aldosterone-sensitive distal nephron (ASDN) is mediated by large-conductance, Ca2+ / stretch-activated BK channels... 
MAXI-K | PHYSIOLOGY | potassium transport | LARGE-CONDUCTANCE VOLTAGE | INTERCALATED CELL SUBTYPES | RENAL DISTAL TUBULE | SURFACE EXPRESSION | DEPENDENT PROTEIN-KINASE | WNK kinases | CA2+-ACTIVATED K+ CHANNEL | CELL BIOLOGY | kidney | CORTICAL COLLECTING TUBULE | mechanoregulation | cilia | ACTIVATED POTASSIUM CHANNEL | APICAL MEMBRANE
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 09/2018, Volume 315, Issue 3, pp. F503 - F511
G protein pathway suppressor 2 (GPS2) is a multifunctional protein and transcriptional regulation factor that is involved in the G protein MAPK signaling... 
BK channel | GPS2 | Lysosomal pathway | ERK1/2 signaling | ACTIVATION | PHYSIOLOGY | BKCA CHANNEL | WNK4 KINASE | MAMMALIAN-CELLS | GH CELLS | BETA | MAXI-K CHANNEL | SMOOTH-MUSCLE | CORTICAL COLLECTING DUCT | lysosomal pathway | UROLOGY & NEPHROLOGY
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2004, Volume 101, Issue 35, pp. 12922 - 12927
The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of... 
cochlea | MAXI-K | OUTER HAIR-CELLS | INNER-EAR | THYROID-HORMONE | GUINEA-PIG COCHLEA | MULTIDISCIPLINARY SCIENCES | CYSTEINE-STRING PROTEIN | KCNQ4 | DOMINANT DEAFNESS | MOTOR PROTEIN | K+ CHANNEL | EXPRESSION
Journal Article
Circulation Research, ISSN 0009-7330, 06/2009, Volume 104, Issue 12, pp. 1364 - 1372
The Ca- and voltage-dependent K (maxi-K) channel β1-subunit mRNA is particularly abundant in cardiomyocytes but its functional role is unknown. This is... 
Hypoxia inducible factor-2 | Hypoxic preconditioning | Small interfering RNA | Maxi-K channel | 1-subunit | Cardiomyocyte
Journal Article
Clinical Science, ISSN 0143-5221, 01/2018, Volume 132, Issue 2, pp. 173 - 183
Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+, and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is... 
DISTAL NEPHRON | MEDICINE, RESEARCH & EXPERIMENTAL | NA-CL COTRANSPORTER | 11-BETA-HYDROXYSTEROID DEHYDROGENASE | REGULATING FACTOR NHERF2 | GLUCOCORTICOID-INDUCIBLE KINASE | CATION CHANNEL | CA2+ CHANNEL | FUNCTIONAL-CHARACTERIZATION | MAXI-K CHANNELS | APICAL MEMBRANE
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 01/2017, Volume 312, Issue 1, pp. F143 - F156
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 12/2012, Volume 303, Issue 11, pp. F1563 - F1571
Cornelius RJ, Wen D, Hatcher LI, Sansom SC. Bicarbonate promotes BK-alpha/beta 4-mediated K excretion in the renal distal nephron. Am J Physiol Renal Physiol... 
PHYSIOLOGY | intercalated cells | RAT-KIDNEY | alkalosis | POTASSIUM EXCRETION | potassium secretion | collecting duct | BK CHANNEL | CORTICAL COLLECTING DUCT | acidosis | UROLOGY & NEPHROLOGY | ACID-BASE | distal nephron | KALIURETIC RESPONSE | APICAL MEMBRANE | THICK ASCENDING LIMB | maxi K | CONNECTING TUBULE
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 02/2008, Volume 105, Issue 8, pp. 3140 - 3144
Acid-sensing ion channels (ASICs) are neuronal non-voltage-gated cation channels that are activated when extracellular pH falls. They contribute to sensory... 
NA+ CHANNEL | CHARYBDOTOXIN | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | CALCIUM | HIGH-CONDUCTANCE | RECEPTOR | MAXI-K CHANNELS | HIPPOCAMPAL-NEURONS | PROTONS | SUBUNIT
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Journal Article
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