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Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 10/2014, Volume 82, Issue 10, pp. 2691 - 2702
ABSTRACT Nonribosomal peptide synthetases (NRPSs) are multimodular proteins capable of producing important peptide natural products. Using an assembly line... 
enterobactin | natural product biosynthesis | secondary metabolism | acyl‐carrier proteins | structural biology | siderophores | enzyme structure | Siderophores | Enzyme structure | Acyl-carrier proteins | Natural product biosynthesis | Enterobactin | Secondary metabolism | Structural biology | COLI ENTEROBACTIN SYNTHETASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COENZYME-A | acyl-carrier proteins | CONFORMATIONAL-CHANGES | BIOPHYSICS | STRUCTURAL BASIS | BIOSYNTHESIS | MBTH-LIKE PROTEINS | ENZYME SUPERFAMILY | ACETYL-COA SYNTHETASE | LIGASE | Multienzyme Complexes - metabolism | Peptide Synthases - genetics | Peptide Synthases - chemistry | Databases, Protein | Escherichia coli - metabolism | Conserved Sequence | Enterobactin - biosynthesis | Carrier Proteins - chemistry | Protein Interaction Domains and Motifs | Recombinant Proteins - metabolism | Amino Acid Sequence | Biocatalysis | Escherichia coli - enzymology | Computational Biology | Models, Molecular | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Mutant Proteins - metabolism | Multienzyme Complexes - genetics | Amino Acid Motifs | Multienzyme Complexes - chemistry | Peptide Synthases - metabolism | Proline - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Mutant Proteins - chemistry | Escherichia coli Proteins - genetics | Protein Processing, Post-Translational | Software | Escherichia coli Proteins - chemistry | Lysine - chemistry | Biological products | Peptides | Ligases | Analysis | Physiological aspects | Proline | Protein binding | Index Medicus
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0128569
Cereulide synthetase is a two-protein nonribosomal peptide synthetase system that produces a potent emetic toxin in virulent strains of Bacillus cereus. The... 
EMETIC TOXIN | ASSEMBLY-LINE | ANTIBIOTIC VALINOMYCIN | NONRIBOSOMAL PEPTIDE SYNTHETASES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CARRIER PROTEIN DOMAINS | BIOSYNTHETIC MACHINERY | MBTH-LIKE PROTEINS | BACILLUS-CEREUS | IN-VITRO RECONSTITUTION | Diphosphates - metabolism | Bacterial Proteins - chemistry | Peptide Synthases - isolation & purification | Keto Acids - metabolism | Protein Subunits - metabolism | Amino Acids - metabolism | Protein Subunits - isolation & purification | Depsipeptides - metabolism | Adenosine Triphosphate - metabolism | Enzyme Inhibitors - chemistry | Mass Spectrometry | Escherichia coli - metabolism | Chromatography, Liquid | NADP - metabolism | Depsipeptides - chemistry | Protein Structure, Tertiary | Biocatalysis | Depsipeptides - antagonists & inhibitors | Bacillus cereus - metabolism | Enzyme Inhibitors - pharmacology | Depsipeptides - biosynthesis | Peptide Synthases - metabolism | Bacterial Proteins - metabolism | Protein Biosynthesis - drug effects | Kinetics | Macromolecular Substances - metabolism | Physiological aspects | Chemical properties | Peptides | Gastrointestinal agents | Ligases | Valinomycin | Residues | Food contamination & poisoning | Macromolecules | Chains | Biochemistry | Biosynthesis | Molecular chains | Substrates | Proteins | Acids | E coli | Scientific imaging | NADP | Adenylation | Chemical synthesis | Cereulide | Potassium | Mass spectrometry | Crystal structure
Journal Article
Journal of Industrial Microbiology & Biotechnology, ISSN 1367-5435, 3/2019, Volume 46, Issue 3, pp. 515 - 536
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 11/2018, Volume 200, Issue 21
One mechanism by which bacteria and fungi produce bioactive natural products is the use of nonribosomal peptide synthetases (NRPSs). Many NRPSs in bacteria... 
Combinatorial biosynthesis | Nonribosomal peptide synthetase | MbtH-like protein | Myxococcus xanthus | Natural products | nonribosomal peptide synthetase | ADENYLATION | ACTIVATION | DOMAIN | TRANSCRIPTION | MICROBIOLOGY | IDENTIFICATION | natural products | combinatorial biosynthesis | STRUCTURAL BASIS | BIOSYNTHESIS | CLUSTER | DELETIONS
Journal Article
ACS SYNTHETIC BIOLOGY, ISSN 2161-5063, 08/2019, Volume 8, Issue 8, pp. 1776 - 1787
Filamentous fungi are known producers of bioactive natural products, low molecular weight molecules that arise from secondary metabolism. MbtH-like proteins... 
ADENYLATION | DOMAIN | SORBICILLIN BIOSYNTHESIS | BIOCHEMICAL RESEARCH METHODS | IDENTIFICATION | GENOME | Penicillium chrysogenum | fungal natural products | MbtH-like protein | PENICILLIUM | GENE-CLUSTER | secondary metabolism | SEQUENCE | ENTEROBACTIN | nonribosomal peptide synthetases | EXPRESSION
Journal Article