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dna replication (192) 192
index medicus (183) 183
cell biology (117) 117
biochemistry & molecular biology (107) 107
mcm2-7 helicase (105) 105
cell cycle proteins - metabolism (87) 87
saccharomyces-cerevisiae (81) 81
animals (80) 80
humans (80) 80
s-phase (80) 80
mcm2-7 (71) 71
cell cycle (69) 69
budding yeast (63) 63
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proteins (61) 61
dna (53) 53
complex (51) 51
article (49) 49
deoxyribonucleic acid--dna (49) 49
saccharomyces cerevisiae proteins - metabolism (49) 49
minichromosome maintenance proteins - metabolism (48) 48
phosphorylation (48) 48
dna helicase (45) 45
genetics & heredity (45) 45
protein binding (45) 45
dna helicases - metabolism (42) 42
dormant origins (42) 42
initiation (42) 42
excess mcm2-7 (40) 40
dna-replication (39) 39
helicase (39) 39
cdc45 (37) 37
chromatin (36) 36
eukaryotic dna-replication (36) 36
cell cycle proteins - genetics (34) 34
chromatin - metabolism (34) 34
nuclear proteins - metabolism (34) 34
replication origin (34) 34
saccharomyces cerevisiae - genetics (34) 34
minichromosome maintenance proteins (33) 33
multidisciplinary sciences (33) 33
replication (33) 33
saccharomyces cerevisiae - metabolism (33) 33
cell-cycle (32) 32
research (32) 32
origin recognition complex (31) 31
biology (29) 29
dna biosynthesis (29) 29
cell cycle proteins - chemistry (28) 28
dna - metabolism (28) 28
analysis (27) 27
cancer (27) 27
mutation (27) 27
protein (27) 27
structural basis (27) 27
molecular biology (26) 26
dna replication - physiology (25) 25
mcm2-7 complex (25) 25
dna replication - genetics (24) 24
mice (24) 24
minichromosome maintenance proteins - genetics (24) 24
dna damage (23) 23
human-cells (23) 23
polymerase-alpha (23) 23
s phase (23) 23
yeast (23) 23
physiological aspects (22) 22
chromosomal proteins, non-histone - metabolism (21) 21
orc (21) 21
saccharomyces cerevisiae proteins - genetics (21) 21
amino acid sequence (20) 20
biochemistry (20) 20
dna-binding proteins - chemistry (20) 20
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binding (19) 19
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dna-binding proteins - genetics (19) 19
genomes (19) 19
minichromosome maintenance proteins - chemistry (19) 19
cmg helicase (18) 18
protein-serine-threonine kinases - metabolism (18) 18
replication initiation (18) 18
saccharomyces cerevisiae proteins - chemistry (18) 18
xenopus egg extracts (18) 18
activation (17) 17
biophysics (17) 17
cell division (17) 17
kinases (17) 17
molecular sequence data (17) 17
origin dna (17) 17
cyclin-dependent kinases (16) 16
mcm2–7 (16) 16
mechanism (16) 16
minichromosome maintenance complex component 7 (16) 16
atp-hydrolysis (15) 15
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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2015, Volume 112, Issue 36, pp. 11223 - 11228
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2017, Volume 24, Issue 3, pp. 316 - 324
Journal Article
NATURE, ISSN 0028-0836, 06/2014, Volume 510, Issue 7504, pp. 293 - 293
Efficient duplication of the genome requires the concerted action of helicase and DNA polymerases at replication forks(1) to avoid stalling of the replication... 
SISTER-CHROMATID COHESION | MCM2-7 HELICASE | COMPLEX | ACTIVATION | REPLICATION | PROTEIN | METABOLISM | GINS | MULTIDISCIPLINARY SCIENCES | STOICHIOMETRY | PROGRESSION | Minichromosome Maintenance Proteins - metabolism | Protein Multimerization | Molecular Sequence Data | Multienzyme Complexes - metabolism | Crystallography, X-Ray | Saccharomyces cerevisiae - ultrastructure | DNA Helicases - ultrastructure | DNA-Directed DNA Polymerase - chemistry | Minichromosome Maintenance Proteins - chemistry | Protein Subunits - metabolism | DNA-Binding Proteins - metabolism | Protein Structure, Quaternary | Conserved Sequence | Saccharomyces cerevisiae Proteins - ultrastructure | Amino Acid Sequence | DNA Helicases - chemistry | Catalytic Domain | Models, Molecular | DNA Replication | Nuclear Proteins - metabolism | DNA Polymerase I - chemistry | Microscopy, Electron | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Amino Acid Motifs | Multienzyme Complexes - chemistry | DNA-Binding Proteins - ultrastructure | DNA Helicases - metabolism | DNA Polymerase I - ultrastructure | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Protein Subunits - chemistry | DNA-Directed DNA Polymerase - metabolism | DNA Polymerase I - metabolism | Saccharomyces cerevisiae Proteins - chemistry
Journal Article
Genes and Development, ISSN 0890-9369, 2014, Volume 28, Issue 15, pp. 1653 - 1666
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2013, Volume 20, Issue 8, pp. 944 - 951
Journal Article
Cell, ISSN 0092-8674, 2011, Volume 146, Issue 6, pp. 931 - 941
The eukaryotic replicative DNA helicase, CMG, unwinds DNA by an unknown mechanism. In some models, CMG encircles and translocates along one strand of DNA while... 
MCM2-7 HELICASE | HEXAMERIC HELICASE | MINICHROMOSOME MAINTENANCE PROTEIN | COMPLEX | ORIGIN | CDC45 | MECHANISM | STRUCTURAL BASIS | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERSTRAND CROSS-LINK | CELL BIOLOGY | DNA Helicases - metabolism | Animals | Xenopus - metabolism | Models, Biological | DNA, Single-Stranded - metabolism | S Phase | DNA Replication | DNA - metabolism | Amphibians | DNA | Analysis
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 05/2019, Volume 10, Issue 1, pp. 2159 - 14
Accurate DNA replication is tightly regulated in eukaryotes to ensure genome stability during cell division and is performed by the multi-protein replisome. At... 
MCM2-7 HELICASE | FORCE | SINGLE-MOLECULE | HIGH-THROUGHPUT | CMG HELICASE | MULTIDISCIPLINARY SCIENCES | DYNAMICS | TIME | STERIC EXCLUSION | STRAND | REVEALS | DNA biosynthesis | DNA helicase | Eukaryotes | Drosophila | Random walk | Cdc45 protein | Cell division | Unwinding | Replication | Genomes | Deoxyribonucleic acid--DNA | Recombinant
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, p. 10708
Journal Article