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Revue Neurologique, ISSN 0035-3787, 04/2018, Volume 174, pp. S38 - S38
Journal Article
IMMUNITY, ISSN 1074-7613, 07/2015, Volume 43, Issue 1, pp. 41 - 51
The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA... 
RESPONSES | STRANDED-RNA | ACTIVATION | PATTERN-RECOGNITION | VIRUS | METHYLTRANSFERASE | STRUCTURAL BASIS | 5'-TRIPHOSPHATE RNA | IMMUNOLOGY | MDA5 | INSIGHTS
Journal Article
Journal Article
IMMUNITY, ISSN 1074-7613, 08/2008, Volume 29, Issue 2, pp. 178 - 181
Cytoplasmic nonself RNA, such as that generated by invading viruses, is recognized by a family of sensory molecules termed RIG-l-like Receptors (RLRs). Here,... 
RESPONSES | DOUBLE-STRANDED-RNA | DOMAIN | ACID | ANTIVIRAL INNATE IMMUNITY | IMMUNOLOGY | HELICASE | LGP2 | VIRUSES | MDA5
Journal Article
Journal of Cutaneous Pathology, ISSN 0303-6987, 11/2018, Volume 45, Issue 11, pp. 851 - 854
Dermatomyositis is a chronic inflammatory disorder of muscles and skin, presenting with muscle weakness, characteristic rash, and classic serology findings.... 
anti‐MDA5 | dermatomyositis | seronegative | anti-MDA5 | Young Adult | Female | Dermatomyositis - immunology | Interferon-Induced Helicase, IFIH1 - immunology | Humans | Dermatomyositis - pathology | Dermatomyositis | Mucin | Muscles | Serology | Skin | Diagnosis | Dermatitis
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 07/2019, Volume 10
Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes—indicative of viral replication—are potent triggers of the innate... 
OAS | RIG-I | cytoplasmic innate immunity | PKR | ADAR1 | MDA5
Journal Article
Molecules, ISSN 1420-3049, 10/2017, Volume 22, Issue 10, p. 1610
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 02/2019, Volume 139, Issue 2, pp. 391 - 399
Zika virus (ZIKV) has emerged as a global pathogen causing significant public health concern. ZIKV infections in humans principally occur via mosquito bites.... 
VIRUS | HELICASES | RNA | RECOGNITION | BIOLOGY | RIG-I | INFECTION | MEMBRANE ASSOCIATION | MDA5 | DERMATOLOGY
Journal Article
by Kuo, RL and Chen, CJ and Wang, RYL and Huang, HI and Lin, YH and Tam, EH and Tu, WJ and Wu, SE and Shih, SR
JOURNAL OF VIROLOGY, ISSN 0022-538X, 05/2019, Volume 93, Issue 10
Infection by enteroviruses can cause severe neurological complications in humans. The interactions between the enteroviral and host proteins may facilitate the... 
PROTEIN | ACID | RECOGNITION | RIG-I | INDUCTION | MDA5 | RESPONSES | VIROLOGY | INDUCIBLE GENE-I | beta interferon | enterovirus 71 | INFECTION | HELICASE
Journal Article
Circulation: Heart Failure, ISSN 1941-3289, 03/2013, Volume 6, Issue 2, pp. 153 - 155
Journal Article
Annales de Dermatologie et de Venereologie, ISSN 0151-9638, 04/2017, Volume 144, Issue 4, pp. 279 - 283
Background Dermatomyositis associated with anti-MDA-5 autoantibodies is a recently-described clinical entity. Herein we report two lethal cases involving... 
Anti-MDA5 auto-antibodies | Dermatomyositis | Pneumocystis pneumonia
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 06/2019, Volume 16, pp. 105 - 117
The important role of insulin-like growth factor-1 receptor (IGF-1R) in tumorigenesis has been well established. The classical model involves IGF-1R binding to... 
RIG-I | viral RNA sensors | IGF-1R | mitochondrial apoptosis | MDA5
Journal Article
Rheumatology, ISSN 1462-0324, 12/2018, Volume 57, Issue 12, pp. 2114 - 2119
Abstract Objective We aimed to determine the outcome of combination therapy with tofacitinib (TOF) in a case series of refractory rapidly progressive... 
Anti-MDA5 antibody | Immunosuppressive therapy | Tofacitinib | Interstitial lung disease | Prognostic factors | Dermatomyositis | immunosuppressive therapy | AUTOANTIBODIES | interstitial lung disease | anti-MDA5 antibody | PROGNOSIS | POLYMYOSITIS | dermatomyositis | prognostic factors | RHEUMATOLOGY | JAPANESE PATIENTS | PNEUMONIA | tofacitinib
Journal Article
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, ISSN 0145-305X, 01/2018, Volume 78, pp. 71 - 82
MDA5 is the pivotal member o f the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) and is reported to play a crucial role in type I IFN-mediated... 
Lates calcarifer | VIRUS-INFECTION | protein 5 | RIG-I | Ontogeny | Poly I:C | IMMUNOLOGY | Gene expression | IDENTIFICATION | Melanoma differentiation-associated | MDA5 | Bacterial infection | PRR | ANTIVIRAL RESPONSES | FISHERIES | ZOOLOGY | RNA SENSOR MDA5 | INDUCIBLE GENE-I | RECOGNITION RECEPTORS | RLR | Asian seabass | BARRAMUNDI LATES-CALCARIFER | LGP2 | INNATE IMMUNITY
Journal Article
Journal of Veterinary Medical Science, ISSN 0916-7250, 2018
The retinoic acid-inducible gene-I-like receptor (RLR) family is a group of cytosolic RNA helicase proteins that play an important role in sensing viral RNAs.... 
Melanoma differentiation-associated gene 5 (MDA5) | innate immunity | cat | interferon
Journal Article
Journal of Microbiology and Biotechnology, ISSN 1017-7825, 2018, Volume 28, Issue 11, p. 1908
Upon viral infection, the host cell recognizes the invasion through a number of pattern recognition receptors. Melanoma differentiation associated gene 5... 
type I interferon | interferon beta | Hepatitis E virus | MDA5
Journal Article
Journal Article
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