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Publication DateArthritis Care & Research, ISSN 2151-464X, 08/2013, Volume 65, Issue 8, pp. 1307 - 1315
Objective Autoantibodies against melanoma differentiation–associated protein 5 (MDA‐5) have been described in several Asian dermatomyositis (DM) cohorts, often...
AUTOANTIBODIES | ANTIBODIES | HELICASES | RECOGNITION | POLYMYOSITIS | RIG-I | AUTOANTIGEN | RHEUMATOLOGY | JAPANESE PATIENTS | MDA5 | POLYPEPTIDE | Amino Acyl-tRNA Synthetases - immunology | Lung Diseases, Interstitial - metabolism | Autoantibodies - blood | Humans | Middle Aged | Dermatomyositis - diagnosis | Male | Biomarkers - blood | Myositis - diagnosis | Dermatomyositis - complications | Myositis - immunology | Interferon-Induced Helicase, IFIH1 | Lung Diseases, Interstitial - immunology | Dermatomyositis - immunology | Autoantigens - immunology | DEAD-box RNA Helicases - immunology | Adult | Female | Retrospective Studies
AUTOANTIBODIES | ANTIBODIES | HELICASES | RECOGNITION | POLYMYOSITIS | RIG-I | AUTOANTIGEN | RHEUMATOLOGY | JAPANESE PATIENTS | MDA5 | POLYPEPTIDE | Amino Acyl-tRNA Synthetases - immunology | Lung Diseases, Interstitial - metabolism | Autoantibodies - blood | Humans | Middle Aged | Dermatomyositis - diagnosis | Male | Biomarkers - blood | Myositis - diagnosis | Dermatomyositis - complications | Myositis - immunology | Interferon-Induced Helicase, IFIH1 | Lung Diseases, Interstitial - immunology | Dermatomyositis - immunology | Autoantigens - immunology | DEAD-box RNA Helicases - immunology | Adult | Female | Retrospective Studies
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Loading RightsINTERNAL MEDICINE, ISSN 0918-2918, 2019, Volume 58, Issue 18, pp. 2605 - 2613
Objective Rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation- associated protein 5 (MDA5) antibody potentially presents...
AUTOANTIBODIES | MEDICINE, GENERAL & INTERNAL | disease course | clinically amyopathic dermatomyositis | perilobular opacity | HRCT | anti-melanoma differentiation-associated protein 5 antibody | ORGANIZING PNEUMONIA | COMPUTED-TOMOGRAPHY | ANTI-MDA5 ANTIBODY | rapidly progressive interstitial lung disease | RESPIRATORY-DISTRESS-SYNDROME | Medical personnel | Physicians | Lung diseases | Medical services | Melanoma | Antibodies | Medical records | Patients | Proteins | Consolidation | Computed tomography | Fatalities | Opacity | Differentiation | Alveoli | Original
AUTOANTIBODIES | MEDICINE, GENERAL & INTERNAL | disease course | clinically amyopathic dermatomyositis | perilobular opacity | HRCT | anti-melanoma differentiation-associated protein 5 antibody | ORGANIZING PNEUMONIA | COMPUTED-TOMOGRAPHY | ANTI-MDA5 ANTIBODY | rapidly progressive interstitial lung disease | RESPIRATORY-DISTRESS-SYNDROME | Medical personnel | Physicians | Lung diseases | Medical services | Melanoma | Antibodies | Medical records | Patients | Proteins | Consolidation | Computed tomography | Fatalities | Opacity | Differentiation | Alveoli | Original
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Loading RightsOncoImmunology, ISSN 2162-4011, 10/2015, Volume 4, Issue 10, p. e1029698
The RIG-I-like helicase melanoma differentiation-associated protein 5 (MDA5) is an innate immune receptor for double-stranded viral RNA (dsRNA) that, upon...
pancreatic cancer | RIG-I-like helicases | Immunotherapy | Type I IFN | poly(I:C) | MDA5 | RIG-I ACTIVATION | EFFICACY | RNA | DUCTAL ADENOCARCINOMA | IMMUNOGENIC CELL-DEATH | MODEL | IMMUNOLOGY | CANCER-THERAPY | ONCOLOGY | MICE | T-CELLS | INNATE IMMUNITY
pancreatic cancer | RIG-I-like helicases | Immunotherapy | Type I IFN | poly(I:C) | MDA5 | RIG-I ACTIVATION | EFFICACY | RNA | DUCTAL ADENOCARCINOMA | IMMUNOGENIC CELL-DEATH | MODEL | IMMUNOLOGY | CANCER-THERAPY | ONCOLOGY | MICE | T-CELLS | INNATE IMMUNITY
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Loading RightsAmerican Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2014, Volume 189, Issue 4, pp. 437 - 448
Rationale: Respiratory viral infections can result in the establishment of chronic lung diseases. Understanding the early innate immune mechanisms that...
Respiratory virus | Innate immunity | Chronic lung disease | Paramyxovirus | RECRUITMENT | ACTIVATION | DENDRITIC CELLS | respiratory virus | RESOLUTION | INNATE IMMUNE-RESPONSE | chronic lung disease | RIG-I | NEUTROPHILS | MDA5 | innate immunity | RESPIRATORY SYSTEM | INFECTION | MODULATION | paramyxovirus | CRITICAL CARE MEDICINE | Biomarkers - metabolism | Respirovirus Infections - enzymology | Lung - pathology | Cytokines - metabolism | Sendai virus | Mice, Inbred C57BL | Pneumonia, Viral - pathology | Immunity, Innate | Pneumonia, Viral - immunology | Interferon-Induced Helicase, IFIH1 | Lung - enzymology | Animals | Flow Cytometry | DEAD-box RNA Helicases - deficiency | Pneumonia, Viral - enzymology | Respirovirus Infections - pathology | Chemokines - metabolism | Lung - metabolism | Mice | Bronchoalveolar Lavage Fluid - chemistry | Respirovirus Infections - immunology | Chronic Disease | Real-Time Polymerase Chain Reaction | Lung - immunology | Original
Respiratory virus | Innate immunity | Chronic lung disease | Paramyxovirus | RECRUITMENT | ACTIVATION | DENDRITIC CELLS | respiratory virus | RESOLUTION | INNATE IMMUNE-RESPONSE | chronic lung disease | RIG-I | NEUTROPHILS | MDA5 | innate immunity | RESPIRATORY SYSTEM | INFECTION | MODULATION | paramyxovirus | CRITICAL CARE MEDICINE | Biomarkers - metabolism | Respirovirus Infections - enzymology | Lung - pathology | Cytokines - metabolism | Sendai virus | Mice, Inbred C57BL | Pneumonia, Viral - pathology | Immunity, Innate | Pneumonia, Viral - immunology | Interferon-Induced Helicase, IFIH1 | Lung - enzymology | Animals | Flow Cytometry | DEAD-box RNA Helicases - deficiency | Pneumonia, Viral - enzymology | Respirovirus Infections - pathology | Chemokines - metabolism | Lung - metabolism | Mice | Bronchoalveolar Lavage Fluid - chemistry | Respirovirus Infections - immunology | Chronic Disease | Real-Time Polymerase Chain Reaction | Lung - immunology | Original
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Loading RightsJournal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 02/2019, Volume 37, Issue 3, pp. 750 - 16
Singleton-Merten syndrome, a critical and rare multifactorial disorder that is closely linked to R516Q mutation in MDA5 protein associated with an enhanced...
RMSD - Root mean square deviation | SMS - Singleton-Merten syndrome | RMSF - Root mean square fluctuation | distant ortholog | MDA5 - Melanoma differentiation-associated protein 5 | molecular dynamics | MDA5 | MDS - Molecular Dynamics simulation | mutational signatures | Singleton-Merten syndrome | functional hotspots | Hel/CTD - Helicase and C-terminal domain | DO - Distant ortholog | IN-SILICO ANALYSIS | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIMULATION | IDENTIFICATION | CONSERVATION | FILAMENTS | BIOPHYSICS | GENE | BINDING | WEB SERVER | GAIN
RMSD - Root mean square deviation | SMS - Singleton-Merten syndrome | RMSF - Root mean square fluctuation | distant ortholog | MDA5 - Melanoma differentiation-associated protein 5 | molecular dynamics | MDA5 | MDS - Molecular Dynamics simulation | mutational signatures | Singleton-Merten syndrome | functional hotspots | Hel/CTD - Helicase and C-terminal domain | DO - Distant ortholog | IN-SILICO ANALYSIS | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIMULATION | IDENTIFICATION | CONSERVATION | FILAMENTS | BIOPHYSICS | GENE | BINDING | WEB SERVER | GAIN
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Loading RightsHepatology, ISSN 0270-9139, 02/2015, Volume 61, Issue 2, pp. 460 - 470
Among patients newly infected with hepatitis C virus (HCV), only 20‐30% clear the infection spontaneously. In the remaining 70% the infection persists, causing...
ANTIVIRAL RESPONSE | IFIH1 | STRUCTURAL BASIS | RECEPTOR RIG-I | 5'-TRIPHOSPHATE RNA | DSRNA RECOGNITION | GASTROENTEROLOGY & HEPATOLOGY | FUNCTION MUTATIONS | GENOME-WIDE ASSOCIATION | INNATE IMMUNITY | MDA5 | Humans | Hepatitis C, Chronic - virology | Male | Case-Control Studies | Interferon-Induced Helicase, IFIH1 | Polymorphism, Genetic | DEAD-box RNA Helicases - genetics | Host-Pathogen Interactions - genetics | HEK293 Cells | Female | Hepacivirus - physiology | Remission, Spontaneous | Hepatitis C, Chronic - genetics
ANTIVIRAL RESPONSE | IFIH1 | STRUCTURAL BASIS | RECEPTOR RIG-I | 5'-TRIPHOSPHATE RNA | DSRNA RECOGNITION | GASTROENTEROLOGY & HEPATOLOGY | FUNCTION MUTATIONS | GENOME-WIDE ASSOCIATION | INNATE IMMUNITY | MDA5 | Humans | Hepatitis C, Chronic - virology | Male | Case-Control Studies | Interferon-Induced Helicase, IFIH1 | Polymorphism, Genetic | DEAD-box RNA Helicases - genetics | Host-Pathogen Interactions - genetics | HEK293 Cells | Female | Hepacivirus - physiology | Remission, Spontaneous | Hepatitis C, Chronic - genetics
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Loading RightsJAAD Case Reports, ISSN 2352-5126, 03/2017, Volume 3, Issue 2, pp. 158 - 161
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Loading RightsDevelopmental and Comparative Immunology, ISSN 0145-305X, 01/2018, Volume 78, pp. 71 - 82
MDA5 is the pivotal member of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) and is reported to play a crucial role in type I IFN-mediated...
Bacterial infection | PRR | Lates calcarifer | Melanoma differentiation-associated protein 5 | RLR | Asian seabass | Ontogeny | Poly I:C | Gene expression | MDA5 | Cell Line | Immunity, Maternally-Acquired | Interferon-Induced Helicase, IFIH1 - genetics | Staphylococcal Infections - immunology | Vibrio alginolyticus - immunology | Bass - immunology | Humans | Gene Expression Regulation | Immunity, Innate - genetics | Fish Proteins - metabolism | Interferon-Induced Helicase, IFIH1 - metabolism | Pathogen-Associated Molecular Pattern Molecules - immunology | Vibrio Infections - immunology | Protein Domains - genetics | Fish Proteins - genetics | Animals | Bass - genetics | Cloning, Molecular | Fish Diseases - immunology | Staphylococcus aureus - immunology | Poly I-C - immunology | Genetic research | Embryonic development | Nucleic acids | Analysis | Melanoma | Animal genetics | Antiviral agents | Genes | Antibacterial agents | Organic acids
Bacterial infection | PRR | Lates calcarifer | Melanoma differentiation-associated protein 5 | RLR | Asian seabass | Ontogeny | Poly I:C | Gene expression | MDA5 | Cell Line | Immunity, Maternally-Acquired | Interferon-Induced Helicase, IFIH1 - genetics | Staphylococcal Infections - immunology | Vibrio alginolyticus - immunology | Bass - immunology | Humans | Gene Expression Regulation | Immunity, Innate - genetics | Fish Proteins - metabolism | Interferon-Induced Helicase, IFIH1 - metabolism | Pathogen-Associated Molecular Pattern Molecules - immunology | Vibrio Infections - immunology | Protein Domains - genetics | Fish Proteins - genetics | Animals | Bass - genetics | Cloning, Molecular | Fish Diseases - immunology | Staphylococcus aureus - immunology | Poly I-C - immunology | Genetic research | Embryonic development | Nucleic acids | Analysis | Melanoma | Animal genetics | Antiviral agents | Genes | Antibacterial agents | Organic acids
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Loading RightsInternational Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue...
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
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Loading RightsMicrobiology and Immunology, ISSN 0385-5600, 11/2011, Volume 55, Issue 11, pp. 760 - 767
ABSTRACT Sendai virus (SeV), a pneumotropic virus of rodents, has an accessory protein, V, and the V protein has been shown to interact with MDA5, inhibiting...
Sendai virus‐V protein | MDA5 | Sendai virus-V protein | RECOGNITION | C-PROTEIN | RIG-I | MICROBIOLOGY | IMMUNOLOGY | ANTIVIRAL RESPONSES | INTERFERON | RNA-SYNTHESIS | PARAMYXOVIRUS | VIRAL PATHOGENESIS | REVERSE GENETICS | INNATE IMMUNITY | Cell Line | Immunoprecipitation | Humans | Mutant Proteins - genetics | Viral Proteins - genetics | Mutant Proteins - metabolism | Viral Proteins - metabolism | Interferon-Induced Helicase, IFIH1 | Protein Interaction Mapping | Animals | Interferon Regulatory Factor-3 - metabolism | Protein Binding | Trans-Activators - metabolism | Mice | DEAD-box RNA Helicases - metabolism
Sendai virus‐V protein | MDA5 | Sendai virus-V protein | RECOGNITION | C-PROTEIN | RIG-I | MICROBIOLOGY | IMMUNOLOGY | ANTIVIRAL RESPONSES | INTERFERON | RNA-SYNTHESIS | PARAMYXOVIRUS | VIRAL PATHOGENESIS | REVERSE GENETICS | INNATE IMMUNITY | Cell Line | Immunoprecipitation | Humans | Mutant Proteins - genetics | Viral Proteins - genetics | Mutant Proteins - metabolism | Viral Proteins - metabolism | Interferon-Induced Helicase, IFIH1 | Protein Interaction Mapping | Animals | Interferon Regulatory Factor-3 - metabolism | Protein Binding | Trans-Activators - metabolism | Mice | DEAD-box RNA Helicases - metabolism
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11.
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Mechanisms and pathways of innate immune activation and regulation in health and cancer
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 11/2014, Volume 10, Issue 11, pp. 3270 - 3285
Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs...
IFI16, interferon, gamma-inducible protein 16 | IRF, interferon regulatory factor | CDNs, cyclic dinucleotides | AIM2, absent in melanoma 2 | LT, lethal toxin | MIB, mind bomb | ALRs, AIM2-like receptors | MDP, muramyl dipeptide | LUBAC, linear ubiquitin assembly complex | innate immunity | TRIF, TIR domain-containing adaptor inducing IFN-b | DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | IKK, IkB kinase | MyD88, myeloid differentiation factor 88 | TRAILR, tumor-necrosis factor-related apoptosis-inducing ligand receptor | AMPK, AMP activated protein kinase | LBP, LPS-binding protein | NEMO, NF-kB essential modulator | TRIMs, tripartite motif containing proteins | IKKi, inducible IkB kinase | PKC-d, protein kinase C delta | LRR, leucine-rich repeat | TAK1, TGF-b-activating kinase 1 | RIP, receptor-interacting protein | TBK1, TANK binding kinase 1 | TRIP, TRAF-interacting protein | TLRs, Toll-like receptors | LGP 2, laboratory of genetics and physiology 2 | PKR, dsRNA-dependent protein kinase | PRRs, pathogen recognition receptors | STING, stimulator of interferon gene | GBP5, guanylate-binding protein 5 | RLRs, RIG-I-like receptors | ULK1, autophagy related serine threonine UNC-51- like kinase | TIR, Toll IL-1 receptor | LPS, lipopolysaccharide | TRAF, TNFR-associated factor | Atg16L, autophagy related 16-like | cDC, conventional dendritic cell | MDA5, melanoma differentiation-associated protein 5 | DCs, dendritic cells | CARD, caspase recruitment domain | PRRs | KSHV, Kaposi's sarcoma-associated herpesvirus | RAUL, RTA-associated E3 ligase | CLRs, C-type lectin receptors | pDC, plasmacytoid dendritic cell | MAVS, mitochondrial antiviral signaling protein | inflammation | NAIPs, neuronal apoptosis inhibitory proteins | CYLD, the familial cylindromatosis tumor suppressor gene | SIGIRR, single Ig IL-1-related receptor | ROS, reactive oxygen species | RIG-I, retinoic acid-inducible gene 1 | TANK, TRAF family-member-associated NF-kB activator | ASC, apoptosis-associated speck-like protein containing a CARD | DAMPs, danger-associated molecular patterns | IFN, interferon | TRAM, TRIF-related adaptor molecule | TIRAP, TIR domain-containing adapter protein | iE-DAP, g-D-glutamyl-meso-diaminopimelic acid | PAMPs, pathogen-associated molecular patterns | cGAS, cyclic GMP-AMP synthase | cIAP, cellular inhibitor of apoptosis protein | GSK3β, Glycogen synthase kinase 3β | NOD, nucleotide-binding oligomerization domain | IRAK, interleukin-1 receptor-associated kinase | BMM, bone marrow-derived macrophage | type I interferon | RACK1, receptor for activated C kinase 1 | SARM, sterile a- and armadillo motif-containing protein | SOCS, suppressor of cytokine signaling | CMV, cytomegalovirus | cancer | NLRs, Nod- like receptors | Nrdp1, neuregulin receptor degradation protein 1 | HCC, hepatocellular carcinoma | ER, endoplasmic reticulum | Innate immunity | Inflammation | Type I interferon | Cancer | linear ubiquitin assembly complex | C-type lectin receptors | IKKi | TRIP | TRAF | apoptosis-associated speck-like protein containing a CARD | neuregulin receptor degradation protein 1 | RIG-I | TRAM | CARD | TRIF-related adaptor molecule | dendritic cells | TBK1 | cytomegalovirus | cyclic dinucleotides | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | cellular inhibitor of apoptosis protein | GSK3 | PAMPs | retinoic acid-inducible gene 1 | CDNs | hepatocellular carcinoma | TANK binding kinase 1 | RAUL | GBP5 | Toll IL-1 receptor | cDC | MIB | protein kinase C delta | iE-DAP | CMV | SARM | SIGIRR | IRAK | sterile a- and armadillo motif-containing protein | cyclic GMP-AMP synthase | TNFR-associated factor | autophagy related serine threonine UNC-51-like kinase | AMPK | ULK1 | lipopolysaccharide | TRIF | IRF | RLRs | Nrdp1 | receptor-interacting protein | LPS-binding protein | plasmacytoid dendritic cell | tripartite motif containing proteins | LPS | DAMPs | melanoma differentiation-associated protein 5 | ASC | TAK1 | KSHV | LGP 2 | neuronal apoptosis inhibitory proteins | TRIMs | danger-associated molecular patterns | cGAS | T-CELL DEVELOPMENT | RIG-I-like receptors | lethal toxin | BMM | muramyl dipeptide | interleukin-1 receptor-associated kinase | IKK | AMP activated protein kinase | absent in melanoma 2 | IkB kinase | CYLD | dsRNA-dependent protein kinase | MAVS | Kaposi's sarcoma-associated herpesvirus | TIR domain-containing adaptor inducing IFN-b | STING | TIR | AIM2-like receptors | laboratory of genetics and physiology 2 | DDX41 | IMMUNOLOGY | LRR | MyD88 | nucleotide-binding oligomerization domain | CLRs | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | myeloid differentiation factor 88 | MDP | RACK1 | LBP | TRAF-interacting protein | bone marrow-derived macrophage | NF-KAPPA-B | NOD-LIKE RECEPTOR | NOD | conventional dendritic cell | IFN-BETA PRODUCTION | HCC | TGF-b-activating kinase 1 | inducible IkB kinase | TUMOR-SUPPRESSOR CYLD | TIRAP | Atg16L | mind bomb | pathogen-associated molecular patterns | AIM2 | PKR | SINGLE-STRANDED RNA | TRAF family-member-associated NF-kB activator | ROS | interferon regulatory factor | g-D-glutamyl-meso-diaminopimelic acid | pathogen recognition receptors | NLRs | UBIQUITIN-DEPENDENT KINASE | NEMO | stimulator of interferon gene | RTA-associated E3 ligase | Nod- like receptors | CYTOSOLIC DNA SENSOR | the familial cylindromatosis tumor suppressor gene | tumor-necrosis factor-related apoptosis-inducing ligand receptor | TANK | MDA5 | IFN | mitochondrial antiviral signaling protein | ALRs | IFI16 | DCs | TRAILR | reactive oxygen species | Toll-like receptors | cIAP | TIR domain-containing adapter protein | PATTERN-RECOGNITION RECEPTORS | single Ig IL-1-related receptor | guanylate-binding protein 5 | suppressor of cytokine signaling | autophagy related 16-like | leucine-rich repeat | NF-kB essential modulator | Glycogen synthase kinase 3 | SOCS | interferon | LUBAC | caspase recruitment domain | pDC | NAIPs | receptor for activated C kinase 1 | PKC-d | RIP | gamma-inducible protein 16 | TLRs | endoplasmic reticulum | Immunity, Innate - immunology | Signal Transduction - immunology | Neoplasms - immunology | Humans | Inflammasomes - immunology | RNA Viruses - immunology | Toll-Like Receptors - immunology | Interferon Type I - immunology | DNA Viruses - immunology
IFI16, interferon, gamma-inducible protein 16 | IRF, interferon regulatory factor | CDNs, cyclic dinucleotides | AIM2, absent in melanoma 2 | LT, lethal toxin | MIB, mind bomb | ALRs, AIM2-like receptors | MDP, muramyl dipeptide | LUBAC, linear ubiquitin assembly complex | innate immunity | TRIF, TIR domain-containing adaptor inducing IFN-b | DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | IKK, IkB kinase | MyD88, myeloid differentiation factor 88 | TRAILR, tumor-necrosis factor-related apoptosis-inducing ligand receptor | AMPK, AMP activated protein kinase | LBP, LPS-binding protein | NEMO, NF-kB essential modulator | TRIMs, tripartite motif containing proteins | IKKi, inducible IkB kinase | PKC-d, protein kinase C delta | LRR, leucine-rich repeat | TAK1, TGF-b-activating kinase 1 | RIP, receptor-interacting protein | TBK1, TANK binding kinase 1 | TRIP, TRAF-interacting protein | TLRs, Toll-like receptors | LGP 2, laboratory of genetics and physiology 2 | PKR, dsRNA-dependent protein kinase | PRRs, pathogen recognition receptors | STING, stimulator of interferon gene | GBP5, guanylate-binding protein 5 | RLRs, RIG-I-like receptors | ULK1, autophagy related serine threonine UNC-51- like kinase | TIR, Toll IL-1 receptor | LPS, lipopolysaccharide | TRAF, TNFR-associated factor | Atg16L, autophagy related 16-like | cDC, conventional dendritic cell | MDA5, melanoma differentiation-associated protein 5 | DCs, dendritic cells | CARD, caspase recruitment domain | PRRs | KSHV, Kaposi's sarcoma-associated herpesvirus | RAUL, RTA-associated E3 ligase | CLRs, C-type lectin receptors | pDC, plasmacytoid dendritic cell | MAVS, mitochondrial antiviral signaling protein | inflammation | NAIPs, neuronal apoptosis inhibitory proteins | CYLD, the familial cylindromatosis tumor suppressor gene | SIGIRR, single Ig IL-1-related receptor | ROS, reactive oxygen species | RIG-I, retinoic acid-inducible gene 1 | TANK, TRAF family-member-associated NF-kB activator | ASC, apoptosis-associated speck-like protein containing a CARD | DAMPs, danger-associated molecular patterns | IFN, interferon | TRAM, TRIF-related adaptor molecule | TIRAP, TIR domain-containing adapter protein | iE-DAP, g-D-glutamyl-meso-diaminopimelic acid | PAMPs, pathogen-associated molecular patterns | cGAS, cyclic GMP-AMP synthase | cIAP, cellular inhibitor of apoptosis protein | GSK3β, Glycogen synthase kinase 3β | NOD, nucleotide-binding oligomerization domain | IRAK, interleukin-1 receptor-associated kinase | BMM, bone marrow-derived macrophage | type I interferon | RACK1, receptor for activated C kinase 1 | SARM, sterile a- and armadillo motif-containing protein | SOCS, suppressor of cytokine signaling | CMV, cytomegalovirus | cancer | NLRs, Nod- like receptors | Nrdp1, neuregulin receptor degradation protein 1 | HCC, hepatocellular carcinoma | ER, endoplasmic reticulum | Innate immunity | Inflammation | Type I interferon | Cancer | linear ubiquitin assembly complex | C-type lectin receptors | IKKi | TRIP | TRAF | apoptosis-associated speck-like protein containing a CARD | neuregulin receptor degradation protein 1 | RIG-I | TRAM | CARD | TRIF-related adaptor molecule | dendritic cells | TBK1 | cytomegalovirus | cyclic dinucleotides | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | cellular inhibitor of apoptosis protein | GSK3 | PAMPs | retinoic acid-inducible gene 1 | CDNs | hepatocellular carcinoma | TANK binding kinase 1 | RAUL | GBP5 | Toll IL-1 receptor | cDC | MIB | protein kinase C delta | iE-DAP | CMV | SARM | SIGIRR | IRAK | sterile a- and armadillo motif-containing protein | cyclic GMP-AMP synthase | TNFR-associated factor | autophagy related serine threonine UNC-51-like kinase | AMPK | ULK1 | lipopolysaccharide | TRIF | IRF | RLRs | Nrdp1 | receptor-interacting protein | LPS-binding protein | plasmacytoid dendritic cell | tripartite motif containing proteins | LPS | DAMPs | melanoma differentiation-associated protein 5 | ASC | TAK1 | KSHV | LGP 2 | neuronal apoptosis inhibitory proteins | TRIMs | danger-associated molecular patterns | cGAS | T-CELL DEVELOPMENT | RIG-I-like receptors | lethal toxin | BMM | muramyl dipeptide | interleukin-1 receptor-associated kinase | IKK | AMP activated protein kinase | absent in melanoma 2 | IkB kinase | CYLD | dsRNA-dependent protein kinase | MAVS | Kaposi's sarcoma-associated herpesvirus | TIR domain-containing adaptor inducing IFN-b | STING | TIR | AIM2-like receptors | laboratory of genetics and physiology 2 | DDX41 | IMMUNOLOGY | LRR | MyD88 | nucleotide-binding oligomerization domain | CLRs | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | myeloid differentiation factor 88 | MDP | RACK1 | LBP | TRAF-interacting protein | bone marrow-derived macrophage | NF-KAPPA-B | NOD-LIKE RECEPTOR | NOD | conventional dendritic cell | IFN-BETA PRODUCTION | HCC | TGF-b-activating kinase 1 | inducible IkB kinase | TUMOR-SUPPRESSOR CYLD | TIRAP | Atg16L | mind bomb | pathogen-associated molecular patterns | AIM2 | PKR | SINGLE-STRANDED RNA | TRAF family-member-associated NF-kB activator | ROS | interferon regulatory factor | g-D-glutamyl-meso-diaminopimelic acid | pathogen recognition receptors | NLRs | UBIQUITIN-DEPENDENT KINASE | NEMO | stimulator of interferon gene | RTA-associated E3 ligase | Nod- like receptors | CYTOSOLIC DNA SENSOR | the familial cylindromatosis tumor suppressor gene | tumor-necrosis factor-related apoptosis-inducing ligand receptor | TANK | MDA5 | IFN | mitochondrial antiviral signaling protein | ALRs | IFI16 | DCs | TRAILR | reactive oxygen species | Toll-like receptors | cIAP | TIR domain-containing adapter protein | PATTERN-RECOGNITION RECEPTORS | single Ig IL-1-related receptor | guanylate-binding protein 5 | suppressor of cytokine signaling | autophagy related 16-like | leucine-rich repeat | NF-kB essential modulator | Glycogen synthase kinase 3 | SOCS | interferon | LUBAC | caspase recruitment domain | pDC | NAIPs | receptor for activated C kinase 1 | PKC-d | RIP | gamma-inducible protein 16 | TLRs | endoplasmic reticulum | Immunity, Innate - immunology | Signal Transduction - immunology | Neoplasms - immunology | Humans | Inflammasomes - immunology | RNA Viruses - immunology | Toll-Like Receptors - immunology | Interferon Type I - immunology | DNA Viruses - immunology
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Loading RightsVirus Research, ISSN 0168-1702, 06/2019, Volume 266, pp. 25 - 33
African swine fever virus causes a haemorrhagic fever in domestic pigs and wild boar. The continuing spread in Africa, Europe and Asia threatens the global pig...
Interferon | CD2v | Immune evasion | African swine fever | Pathogenesis | Apoptosis | KAPPA B HOMOLOG | CATALYTIC SUBUNIT | BCL-2 HOMOLOG | DENDRITIC CELLS | LYMPH-NODES | ISOLATE HARBORING DELETIONS | GEORGIA ISOLATE | DOMESTIC PIGS | VIROLOGY | NUCLEAR-FACTOR | GROWTH IN-VITRO | c-GAS, cyclic GMP-AMP Synthase | MDA5, melanoma differentiation-associated protein 5 | MAVs, mitochondrial antiviral-signaling protein | TNF-α, tumour necrosis factor alpha | MHC Class I, major histocompatibility protein class I | apyrimidinic (AP) endonuclease | eIF-2α, eukaryotic translation initiation factor 2 alpha |
Interferon | CD2v | Immune evasion | African swine fever | Pathogenesis | Apoptosis | KAPPA B HOMOLOG | CATALYTIC SUBUNIT | BCL-2 HOMOLOG | DENDRITIC CELLS | LYMPH-NODES | ISOLATE HARBORING DELETIONS | GEORGIA ISOLATE | DOMESTIC PIGS | VIROLOGY | NUCLEAR-FACTOR | GROWTH IN-VITRO | c-GAS, cyclic GMP-AMP Synthase | MDA5, melanoma differentiation-associated protein 5 | MAVs, mitochondrial antiviral-signaling protein | TNF-α, tumour necrosis factor alpha | MHC Class I, major histocompatibility protein class I | apyrimidinic (AP) endonuclease | eIF-2α, eukaryotic translation initiation factor 2 alpha |