X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (8730) 8730
Publication (1247) 1247
Book Review (821) 821
Book Chapter (74) 74
Dissertation (60) 60
Conference Proceeding (43) 43
Government Document (9) 9
Magazine Article (2) 2
Newspaper Article (2) 2
Book / eBook (1) 1
Data Set (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (7312) 7312
humans (6352) 6352
mdm2 (4416) 4416
p53 (3790) 3790
tumor suppressor protein p53 - metabolism (3562) 3562
animals (2709) 2709
oncology (2572) 2572
proto-oncogene proteins c-mdm2 - metabolism (2373) 2373
apoptosis (2346) 2346
cancer (2173) 2173
cell biology (2160) 2160
biochemistry & molecular biology (2127) 2127
tumor suppressor protein p53 - genetics (2097) 2097
female (1882) 1882
mice (1817) 1817
proto-oncogene proteins c-mdm2 (1802) 1802
proto-oncogene proteins c-mdm2 - genetics (1716) 1716
cell line, tumor (1574) 1574
male (1539) 1539
expression (1404) 1404
nuclear proteins (1343) 1343
proteins (1329) 1329
tumor proteins (1299) 1299
protein (1237) 1237
proto-oncogene proteins - metabolism (1179) 1179
mutation (1110) 1110
activation (1095) 1095
middle aged (1068) 1068
p53 protein (1010) 1010
dna-damage (1000) 1000
phosphorylation (999) 999
mdm2 protein (994) 994
proto-oncogene proteins - genetics (983) 983
tumors (973) 973
cell cycle (955) 955
adult (893) 893
protein binding (893) 893
research (888) 888
gene expression (863) 863
in-vivo (854) 854
aged (853) 853
gene (836) 836
dna damage (805) 805
degradation (796) 796
immunohistochemistry (780) 780
signal transduction (744) 744
genetic aspects (741) 741
genetics & heredity (725) 725
pathway (724) 724
ubiquitination (701) 701
cell line (697) 697
article (695) 695
nuclear proteins - metabolism (682) 682
proto-oncogene proteins c-mdm2 - antagonists & inhibitors (675) 675
apoptosis - drug effects (671) 671
analysis (663) 663
gene expression regulation, neoplastic (637) 637
cells (627) 627
tumor cells, cultured (622) 622
pathology (602) 602
wild-type p53 (580) 580
antineoplastic agents - pharmacology (578) 578
cell proliferation (547) 547
transfection (539) 539
prognosis (533) 533
genes, p53 (525) 525
molecular sequence data (520) 520
binding (508) 508
multidisciplinary sciences (507) 507
biology (494) 494
nuclear proteins - genetics (490) 490
tumor suppressor protein p53 - chemistry (488) 488
amplification (487) 487
mutations (486) 486
genes (482) 482
health aspects (477) 477
gene amplification (467) 467
tumor suppressor genes (465) 465
amino acid sequence (460) 460
inhibition (460) 460
ubiquitin (451) 451
tumor suppressor protein p53 - physiology (446) 446
blotting, western (439) 439
tumor-suppressor (439) 439
transcriptional activation (430) 430
physiological aspects (413) 413
aged, 80 and over (411) 411
embryonic lethality (407) 407
neoplasms (405) 405
cyclin-dependent kinase inhibitor p21 (396) 396
dna (396) 396
research article (393) 393
transcription (387) 387
cells, cultured (380) 380
imidazoles - pharmacology (372) 372
binding sites (371) 371
piperazines - pharmacology (371) 371
growth (362) 362
oncoprotein mdm2 (362) 362
chemotherapy (359) 359
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (8673) 8673
Chinese (85) 85
French (28) 28
Japanese (16) 16
German (13) 13
Russian (10) 10
Polish (8) 8
Spanish (6) 6
Korean (5) 5
Portuguese (5) 5
Czech (3) 3
Persian (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Molecular Cell, ISSN 1097-2765, 09/2010, Volume 39, Issue 6, pp. 963 - 974
The melanoma antigen (MAGE) family consists of more than 60 genes, many of which are cancer-testis antigens that are highly expressed in cancer and play a... 
NECDIN GENE | EMERGING ROLES | MELANOMA | KAP1 | CANCER/TESTIS ANTIGENS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MDM2 INTERACTION | HOMOLOGOUS RECOMBINATION | CANCER-IMMUNOTHERAPY | CELL-LINES | EXPRESSION | CELL BIOLOGY | Melanoma-Specific Antigens - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Crystallography, X-Ray | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | RING Finger Domains | Tripartite Motif-Containing Protein 28 | Ubiquitination | Cell Nucleus - metabolism | Transfection | Protein Structure, Quaternary | Antigens, Neoplasm - metabolism | Carrier Proteins - chemistry | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | Antigens, Neoplasm - genetics | Cell Line | Biocatalysis | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Recombinant Proteins - genetics | Ubiquitin-Protein Ligases - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Melanoma-Specific Antigens - metabolism | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | Melanoma-Specific Antigens - genetics | Protein Binding - physiology | Ubiquitin | Antigens | Ligases | Crystals | Melanoma | Structure | Tumor proteins | Protein binding | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 03/2017, Volume 8, Issue 1, pp. 14687 - 14687
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1239 - 1247
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human... 
MEDICINE, RESEARCH & EXPERIMENTAL | N-RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR ACTIVITY | STAPLED P53 | BRAF | MALIGNANT-MELANOMA | P53 PATHWAY | CELL-DEATH | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | IN-VIVO | Up-Regulation | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Skin Neoplasms - chemistry | Male | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - transplantation | Proto-Oncogene Proteins - biosynthesis | Tumor Suppressor Protein p53 - physiology | Cell-Penetrating Peptides - pharmacology | Nuclear Proteins - biosynthesis | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Cell Line, Tumor - metabolism | Melanoma - chemistry | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Stem Cell Assay | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - etiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Melanoma - secondary | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Melanoma, Experimental - genetics | GTP Phosphohydrolases - genetics | Keratinocytes - metabolism | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Signal Transduction - physiology | Mice | Nuclear Proteins - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Melanoma | Diagnosis | Research | Gene expression | Identification and classification | Skin cancer | Proteins | Cell growth | Mutation | Cell cycle | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2007, Volume 50, Issue 15, pp. 3457 - 3464
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 03/2015, Volume 54, Issue 10, pp. 2960 - 2965
Journal Article
Oncogene, ISSN 0950-9232, 01/2019, Volume 38, Issue 5, pp. 731 - 746
Journal Article
Oncogene, ISSN 0950-9232, 09/2011, Volume 30, Issue 37, pp. 3918 - 3929
The BH3 mimetic ABT737 induces autophagy by competitively disrupting the inhibitory interaction between the BH3 domain of Beclin 1 and the anti-apoptotic... 
autophagy | ABT737 | Bcl-2 family protein | Beclin 1 | APOPTOSIS | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | BH3-ONLY PROTEIN | IKK | INDUCTION | CELL-DEATH | P53 | CELL BIOLOGY | PROMOTE LONGEVITY | ONCOLOGY | GENETICS & HEREDITY | BCL-2 FAMILY | Phosphorylation | Nitriles - pharmacology | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Autophagy - drug effects | Biphenyl Compounds - pharmacology | I-kappa B Kinase - metabolism | Nitrophenols - pharmacology | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Benzopyrans - pharmacology | Oncogene Protein v-akt - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Beclin-1 | Tumor Suppressor Protein p53 - metabolism | Glycogen Synthase Kinase 3 - metabolism | Sulfonamides - pharmacology | Membrane Proteins - agonists | Piperazines - pharmacology | Signal Transduction - drug effects | Apoptosis Regulatory Proteins - agonists | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Sirtuins - metabolism | Acetyl-CoA Carboxylase - metabolism | Autophagy (Cytology) | Cellular proteins | Care and treatment | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Cancer | Proteins | Signal transduction | Biomimetics | Cellular biology | Gene expression | Sirtuins | TOR protein | MDM2 protein | Bcl-2 protein | Glycogen synthase kinase 3 | AKT protein | Dephosphorylation | IKK protein | p53 protein | Allosteric properties | NF- Kappa B protein | Bcl-x protein | I Kappa B kinase | Lipid kinase | Phagocytosis | Ubiquitin-protein ligase | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2013, Volume 135, Issue 31, pp. 11623 - 11633
Journal Article
by Chu, Y and Yang, X
Oncogene, ISSN 0950-9232, 03/2011, Volume 30, Issue 9, pp. 1108 - 1116
SUMOylation governs numerous cellular processes and is essential to most eukaryotic life. Despite increasing recognition of the importance of this process, an... 
Mdm2 | TRIM proteins | sumoylation | SUMOE3 ligase | PML | p53 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PML NUCLEAR-BODIES | DNA-DAMAGE | REGULATES P53 | FAMILY PROTEINS | SUMO E3 ligase | UBIQUITIN LIGASES | CELL BIOLOGY | RET FINGER PROTEIN | ONCOLOGY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | C-JUN | Immunoprecipitation | Transcription Factors - chemistry | Humans | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - genetics | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Small Ubiquitin-Related Modifier Proteins - chemistry | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Sumoylation | RNA, Small Interfering | Ubiquitin-Protein Ligases - genetics | Microscopy, Fluorescence | Promyelocytic Leukemia Protein | Physiological aspects | Tumor suppressor genes | Research | Tumor proteins | Ligases | Proteins | Enzymes | Biochemistry | Cellular biology | Gene expression | Index Medicus
Journal Article