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Oncotarget, ISSN 1949-2553, 08/2019, Volume 10, Issue 49, pp. 5007 - 5010
MDMX (MDM4) is emerging as an important breast cancer (BC) biomarker, and oncoprotein, that can be targeted in combination with its well-known family member... 
Journal Article
Genes and Cancer, ISSN 1947-6019, 2012, Volume 3, Issue 3-4, pp. 264 - 273
p53 is an important tumor suppressor, functioning as a transcriptional activator and repressor. Upon receiving signals from multiple stress related pathways,... 
translation | Mdm4 | Hdm2 | transcription | Monographs
Journal Article
Translational Cancer Research, ISSN 2218-676X, 08/2012, Volume 1, Issue 2, pp. 88 - 99
p53, a critical tumor suppressor, is activated by various cellular stresses to prevent and repair damages that can lead to tumor development. In response to... 
MDM2 | MDM4 | HDMX | MDMX | p53 | ONCOLOGY
Journal Article
Oncotarget, ISSN 1949-2553, 01/2018, Volume 9, Issue 7, pp. 7282 - 7297
Although cell-cycle arrest, senescence and apoptosis remain as major canonical activities of p53 in tumor suppression, the emerging role of p53 in metabolism... 
Adipose tissues | Mdm4 | Metabolism | Mdmx | P53
Journal Article
Asian Pacific Journal of Cancer Prevention : APJCP, ISSN 1513-7368, 2017, Volume 18, Issue 4, pp. 1133 - 1138
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 569, Issue 7757, pp. 503 - 508
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 68, pp. 112825 - 112840
Murine double minute 4 protein (MDMX) is crucial for the regulation of the tumor suppressor protein p53. Phosphorylation of the N-terminal domain of MDMX is... 
Molecular dynamics | MDMX/MDM4 | Protein-protein interaction | Phosphotyrosine | P53 | SUPPRESSOR TRANSACTIVATION DOMAIN | MOLECULAR-DYNAMICS | DESIGN | PROTEIN | STABILITY | PARAMETERS | molecular dynamics | p53 | CELL BIOLOGY | phosphotyrosine | STRUCTURAL BASIS | protein-protein interaction | ANALYSIS WORKBENCH | BINDING | MODULATION
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 61, pp. 103996 - 104006
Increased levels of inhibitors of the p53 tumor suppressor such as Mdm2 and Mdm4 drive tumor development and thus serve as targets for therapeutic... 
Mouse model | CRISPR/Cas9 | Mdm4 co-amplification | Def-Capn3 nucleolar pathway | Ribosome small subunit processome | mouse model | ribosome small subunit processome | PRE-RIBOSOMAL-RNA | CELL BIOLOGY | MDM2-DEFICIENT MICE | CANCER GENOMICS | RESCUE | LETHALITY | PATHWAY | REGULATE P53 | DEGRADATION | MDM4 | TUMORIGENESIS
Journal Article
Genes and Cancer, ISSN 1947-6019, 2010, Volume 1, Issue 4, pp. 360 - 368
Neuroendocrine tumors (NETs) comprise a group of rare tumors derived from the diffuse neuroendocrine system or islet endocrine cells of the pancreas. The... 
MDM2 | MDM4 | WIP1 | Neuroendocrine tumor | P53 | neuroendocrine tumor | Original | p53
Journal Article
Oncogene, ISSN 1476-5594, 2014, Volume 34, Issue 7, pp. 846 - 856
The oncogene Mdmx is overexpressed in many man malignancies, and together with Mdm2, negatively regulates the p53 tumor suppressor. However, a p53-independent... 
COMPLEX | STRAND BREAK REPAIR | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | TUMOR-FORMATION | HISTONE H2AX | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | S-PHASE | DEGRADATION | ATM ACTIVATION | EXPRESSION | Neoplasms - metabolism | Genomic Instability | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | DNA Repair Enzymes - genetics | DNA Repair - genetics | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | DNA Repair Enzymes - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | DNA Damage - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Proto-Oncogene Proteins - metabolism | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | DNA-Binding Proteins - genetics | Mice, Knockout | Animals | Mice | Neoplasms - pathology | Physiological aspects | Genetic research | Genetic aspects | Genomes | Research | Tumor proteins | Genetic regulation | Health aspects | Oncogenes | Signal transduction | Tumorigenesis | Gene expression | DNA repair | DNA damage | Cancer | MDM2 protein | Phosphorylation | Chromatin | Phenotypes | Transformation | Threonine | p53 Protein | Serine | Kinases | Genomic instability | MRE11 protein | Tumor suppressor genes | Deoxyribonucleic acid--DNA | Glutamine | Mdm2 | Mdm4 | genome instability | DNA damage response | Mdmx | p53
Journal Article
Molecular cancer research : MCR, ISSN 1541-7786, 3/2017, Volume 15, Issue 3, pp. 328 - 339
Dysfunctionality of the p53 tumor suppressor is a major cause of therapeutic drug resistance in cancer. Recently we reported that mutant, but otherwise... 
Serine-20 phosphorylation | V172F missense mutation | MDM2 | MDM4 | cisplatin resistance | p53
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2008, Volume 98, Issue 1, pp. 4 - 8
Journal Article
癌症生物学与医学:英文版, ISSN 2095-3941, 2017, Volume 14, Issue 4, pp. 387 - 395
Objective: To determine the influence of the single nucleotide polymorphism (SNP) rs4245739 on the binding and expression of microRNAs and subsequent MDM4... 
MDM4 | MicroRNA | Rs4245739 | Clinical relevance | ER-negative breast cancer | MDM4 SNP34091 RS4245739 | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG | RISK | POLYMORPHISM | clinical relevance | GENETIC-VARIATION | ONCOLOGY | microRNA | BINDING-SITE | MIR-184 | GENOME-WIDE ASSOCIATION
Journal Article
by Wu, ZP and Chen, DM and Wang, K and Cao, CC and Xu, XL
FRONTIERS IN ONCOLOGY, ISSN 2234-943X, 11/2019, Volume 9, p. 1260
Clear cell renal cell carcinoma (ccRCC), the most common histological subtype of kidney cancer, shows poor prognosis, and non-sensitivity to radiotherapy or... 
ceRNA | clear cell renal cell carcinoma | SNHG12 | ONCOLOGY | MDM4 | MECHANISMS | miR-129-5p | P53 | Genetic aspects | Carcinoma, Renal cell | RNA | Cancer
Journal Article
Current Aging Science, ISSN 1874-6098, 01/2014, Volume 7, Issue 2, pp. 91 - 100
Journal Article
Oncogene, ISSN 0950-9232, 09/2016, Volume 35, Issue 36, pp. 4798 - 4806
Cisplatin is an important antitumor agent, but its clinical utility is often limited by multifactorial mechanism of resistance. Loss of tumor suppressor p53... 
Ubiquitin | RNA | Genetic aspects | Comparative analysis | Tumor proteins | Cisplatin | Tumors | Oncology | Mutation | Gene expression | DNA damage | Binding sites | MDM2 | MDM4 | Stability | Cisplatin resistance | p53 | V172F mutation
Journal Article