X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (3680) 3680
Book Review (479) 479
Publication (239) 239
Book Chapter (34) 34
Conference Proceeding (11) 11
Dissertation (10) 10
Government Document (3) 3
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (3073) 3073
humans (2633) 2633
p-glycoprotein (1822) 1822
mdr1 (1457) 1457
oncology (1023) 1023
female (994) 994
animals (924) 924
pharmacology & pharmacy (903) 903
male (855) 855
atp-binding cassette, sub-family b, member 1 - genetics (825) 825
multidrug-resistance (810) 810
expression (798) 798
mdr1 gene (782) 782
multidrug resistance (763) 763
cancer (716) 716
drug resistance (714) 714
atp-binding cassette, sub-family b, member 1 - metabolism (668) 668
adult (604) 604
middle aged (594) 594
chemotherapy (546) 546
drug-resistance (522) 522
biochemistry & molecular biology (521) 521
gene expression (496) 496
proteins (415) 415
mice (411) 411
cell line, tumor (408) 408
aged (401) 401
mdr1 protein (400) 400
genetic aspects (390) 390
genotype (377) 377
atp binding cassette transporter, sub-family b (372) 372
p-glycoprotein expression (345) 345
drug resistance, neoplasm (334) 334
cells (326) 326
analysis (324) 324
pharmacokinetics (315) 315
multidrug-resistance gene (313) 313
tumor cells, cultured (306) 306
drug resistance, multiple (305) 305
hematology (303) 303
abcb1 (298) 298
antineoplastic agents - pharmacology (294) 294
apoptosis (290) 290
research (290) 290
genes (284) 284
cell biology (283) 283
polymorphism, single nucleotide (274) 274
mdr1 gene-expression (268) 268
drug resistance, multiple - genetics (262) 262
in-vitro (257) 257
gene (254) 254
polymorphism (251) 251
atp-binding cassette transporters - genetics (249) 249
polymerase chain reaction (248) 248
drug resistance in microorganisms (243) 243
drug resistance, neoplasm - genetics (240) 240
pharmacogenetics (239) 239
rna, messenger - metabolism (236) 236
transporter (233) 233
atp binding cassette transporter, sub-family b - genetics (228) 228
reverse transcriptase polymerase chain reaction (227) 227
gene-expression (225) 225
doxorubicin (221) 221
breast cancer (219) 219
cell line (219) 219
flow cytometry (216) 216
drugs (212) 212
adolescent (208) 208
blood-brain-barrier (208) 208
prognosis (203) 203
health aspects (201) 201
doxorubicin - pharmacology (200) 200
glycoproteins (198) 198
polymorphism, genetic (198) 198
protein (196) 196
transfection (196) 196
gene expression regulation, neoplastic (193) 193
rna, messenger - genetics (193) 193
acute myeloid-leukemia (192) 192
tumors (187) 187
physiological aspects (185) 185
atp-binding cassette transporters - metabolism (183) 183
immunohistochemistry (182) 182
atp-binding cassette, sub-family b, member 1 - biosynthesis (178) 178
dose-response relationship, drug (177) 177
genetics & heredity (177) 177
medicine, research & experimental (177) 177
in-vivo (175) 175
resistance (172) 172
breast-cancer (170) 170
medicine (169) 169
multidisciplinary sciences (168) 168
antineoplastic agents - therapeutic use (167) 167
rats (167) 167
blotting, western (165) 165
research article (165) 165
leukemia (162) 162
neoplasm proteins - genetics (161) 161
efflux (160) 160
care and treatment (159) 159
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (3661) 3661
German (10) 10
Russian (9) 9
French (8) 8
Chinese (6) 6
Korean (5) 5
Polish (5) 5
Japanese (4) 4
Czech (3) 3
Hungarian (2) 2
Portuguese (2) 2
Spanish (2) 2
Afrikaans (1) 1
Croatian (1) 1
Persian (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Clinical Cancer Research, ISSN 1078-0432, 09/2011, Volume 17, Issue 17, pp. 5674 - 5685
Purpose: Jagged1, a Notch ligand, is expressed on both tumor epithelial and endothelial cells and therefore may be amenable to dual targeting of the tumor... 
NUDE-MICE | STEM-CELLS | ANGIOGENESIS | ONCOLOGY | PATHWAY | ENDOTHELIAL-CELLS | PROSTATE-CANCER | GROWTH | GENE-EXPRESSION | ANTISENSE OLIGONUCLEOTIDE | CHITOSAN NANOPARTICLES | Cell Proliferation | Epithelial Cells - metabolism | Taxoids - pharmacology | Apoptosis - drug effects | Receptors, Notch - metabolism | Humans | Zinc Finger Protein Gli2 | Ovarian Neoplasms - pathology | Hedgehog Proteins - metabolism | Drug Resistance, Neoplasm | Receptors, Notch - genetics | Molecular Targeted Therapy | Intercellular Signaling Peptides and Proteins - metabolism | Stromal Cells | Hedgehog Proteins - genetics | RNA Interference | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Bridged-Ring Compounds - pharmacology | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Nuclear Proteins - genetics | Ovarian Neoplasms - drug therapy | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - biosynthesis | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Neovascularization, Pathologic - genetics | ATP Binding Cassette Transporter, Sub-Family B | Mice | RNA, Small Interfering | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Calcium-Binding Proteins - genetics | Cell proliferation | chitosan | Animal models | Tumor cells | Chemoresistance | taxanes | Stroma | Malignancy | siRNA | Endothelial cells | Ovarian cancer | Angiogenesis | MDR1 protein | nanoparticles | Microenvironments | Notch protein | Jagged1 protein | Tumors | Index Medicus | chemoresistance | small interfering RNA | Jagged1 | ovarian cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2000, Volume 97, Issue 12, pp. 6763 - 6768
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. e30246 - e30246
Mechanisms of resistance for HNSCC to cisplatin (CDDP), the foundational chemotherapeutic agent in the treatment of this disease, remain poorly understood. We... 
ADJUVANT CHEMOTHERAPY | BLADDER-CANCER | LUNG-CANCER | MDR1 | ANOIKIS | CISPLATIN | MULTIDISCIPLINARY SCIENCES | NEUROTROPHIC RECEPTOR TRKB | MULTIDRUG-RESISTANCE | NEUROBLASTOMA-CELLS | EXPRESSION | Immunohistochemistry | Brain-Derived Neurotrophic Factor - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Receptor, trkB - genetics | Head and Neck Neoplasms - metabolism | Squamous Cell Carcinoma of Head and Neck | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Enzyme-Linked Immunosorbent Assay | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Cisplatin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | X-Linked Inhibitor of Apoptosis Protein - genetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | Apoptosis Regulatory Proteins - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Drug Resistance, Neoplasm - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Receptor, trkB - metabolism | Proteins | Chemotherapy | Squamous cell carcinoma | RNA | Drug resistance | Cancer | Transcription factors | Genetic suppression | Leukemia | Cytotoxicity | Intracellular signalling | AKT protein | XIAP protein | mRNA | Metastasis | Neuroblastoma | Kinases | Cancer therapies | MDR1 protein | Genotype & phenotype | Angiogenesis | Signal transduction | Pathways | Rodents | Surgery | Inhibition | Autocrine signalling | Neck | Trends | P-Glycoprotein | Medical treatment | Breast cancer | Gene expression | Cisplatin | Brain-derived neurotrophic factor | Medical prognosis | Reagents | Head and neck cancer | Sensitivity enhancement | TrkB receptors | Cytotoxic agents | Prostate cancer | BIM protein | Apoptosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0148093 - e0148093
Chronic myeloid leukemia (CML) is a clonal disorder of hematopoietic stem/progenitor cells that is caused by the Bcr-Abl oncoprotein. Clinical resistance to... 
CHRONIC MYELOGENOUS LEUKEMIA | CANCER-CELLS | MESYLATE | BCL-2 | ARREST | PHOSPHORYLATION | K562 CELLS | MULTIDISCIPLINARY SCIENCES | KINASE | CYCLE PROGRESSION | INDUCTION | Apoptosis - drug effects | Imatinib Mesylate - pharmacology | Tubulin Modulators - pharmacology | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Gene Expression Regulation, Leukemic - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Sulfonamides - pharmacology | Fusion Proteins, bcr-abl - genetics | Mitochondria - genetics | Signal Transduction - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Antineoplastic Agents - pharmacology | Sarcosine - analogs & derivatives | Fusion Proteins, bcr-abl - metabolism | Sarcosine - pharmacology | Antimitotic agents | Physiological aspects | Genetic aspects | Research | Chronic myeloid leukemia | Tubulins | Drug therapy | Antineoplastic agents | BCR protein | Phosphorylation | Bax protein | Bcl-2 protein | Leukemia | AKT protein | mRNA | Kinases | Cyclin B1 | Anticancer properties | Proteins | MDR1 protein | Cell growth | Tubulin | Bcl-x protein | Cell cycle | Inhibition | Fusion protein | Imatinib | Myeloid leukemia | Stat3 protein | Extracellular signal-regulated kinase | Caspase | Abl protein | Progenitor cells | Mcl-1 protein | Hemopoiesis | Cells (biology) | Antitumor activity | Cancer | Apoptosis | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 04/2007, Volume 26, Issue 19, pp. 2736 - 2746
Y-box-binding protein 1 (YB-1), which is a member of the DNA-binding protein family containing a cold-shock domain, has pleiotropic functions in response to... 
Akt | Ovarian carcinoma | Microarray | Y-box-binding protein-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ovarian carcinoma | DRUG-RESISTANCE | CELL BIOLOGY | microarray | PROGNOSTIC-FACTOR | MESSENGER-RNA | ONCOLOGY | TRANSCRIPTION FACTOR YB-1 | DNA | MDR1 GENE-EXPRESSION | GENETICS & HEREDITY | MELANOMA-CELLS | CHEMOKINE RECEPTORS | TUMOR-GROWTH | ENDOTHELIAL GROWTH-FACTOR | Oligonucleotide Array Sequence Analysis | Humans | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Male | Transplantation, Heterologous | Gene Expression Profiling | Proto-Oncogene Proteins c-akt - genetics | DNA-Binding Proteins - metabolism | Ovarian Neoplasms - genetics | Cell Nucleus - metabolism | Biomarkers, Tumor - metabolism | Female | Multidrug Resistance-Associated Proteins - genetics | Receptors, CXCR4 - genetics | Transcription, Genetic | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | DNA-Binding Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Blotting, Western | Protein Transport | Receptors, CXCR4 - metabolism | Animals | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Y-Box-Binding Protein 1 | Mice | Mice, Inbred BALB C | Multidrug Resistance-Associated Proteins - metabolism | Care and treatment | Genetic aspects | Research | Binding proteins | Health aspects | Protein kinases | Oncogenes | Ovarian cancer | Proteins | Genetics | Genetic markers | Gene expression | Binding sites | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2007, Volume 21, Issue 14, pp. 3937 - 3948
The recently reported structures of the bacterial multidrug exporter Sav1866 suggest a domain architecture in which both nucleotide- binding domains ( NBDs) of... 
ABC protein | MDR1 | ABCB1 | Drug efflux | ATP binding cassette transporter | DRUG-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | NUCLEOTIDE-BINDING DOMAIN | ATP-BINDING | CELL BIOLOGY | drug efflux | ABC-TRANSPORTER | BIOLOGY | RESISTANCE | TRANSMEMBRANE DOMAINS | CYSTIC-FIBROSIS | HEMOLYSIN-B | CATALYTIC CYCLE | Protein Binding - genetics | Humans | Bacterial Proteins - chemistry | Escherichia coli Proteins - physiology | ATP-Binding Cassette Transporters - physiology | Cysteine - genetics | Nucleotides - chemistry | ATP-Binding Cassette Transporters - chemistry | ATP-Binding Cassette Transporters - genetics | Membrane Proteins - physiology | Haemophilus influenzae - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cell Line | Mutagenesis, Site-Directed | Membrane Proteins - genetics | Bacterial Proteins - genetics | Haemophilus influenzae - genetics | Protein Structure, Tertiary - genetics | Bacterial Proteins - physiology | Nucleotides - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Membrane Proteins - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Haemophilus influenzae - physiology | Escherichia coli Proteins - genetics | ATP Binding Cassette Transporter, Sub-Family B | Structural Homology, Protein | Drug Resistance, Multiple, Bacterial - genetics | Escherichia coli Proteins - chemistry | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2015, Volume 10, Issue 1, pp. e0116747 - e0116747
Cellular mechanisms of multidrug resistance (MDR) are related to ABC transporters, apoptosis, antioxidation, drug metabolism, DNA repair and cell... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER CELLS | STEM-CELLS | MDR1 | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | MUTANT P53 | TUMOR-SUPPRESSOR PROTEIN | DRUG-RESISTANCE | OVARIAN-CANCER | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Drug Resistance, Multiple - drug effects | Genes, Neoplasm | Humans | Apoptosis - genetics | Epithelial-Mesenchymal Transition - drug effects | Gene Expression Profiling | DNA Repair - genetics | Epithelial-Mesenchymal Transition - genetics | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | MCF-7 Cells | Neoplastic Stem Cells - metabolism | Inhibitory Concentration 50 | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | DNA Repair - drug effects | Drug Resistance, Multiple - genetics | Tumor Suppressor Protein p53 - metabolism | Signal Transduction - genetics | Down-Regulation - drug effects | Cell Shape - drug effects | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Signal Transduction - drug effects | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Physiological aspects | Drug resistance in microorganisms | Anthracyclines | Tumor proteins | Intermediate filament proteins | Genes | Bcl-2 protein | AKT protein | Cytotoxicity | Drug resistance | Cancer therapies | Doxorubicin | Cell morphology | Proteins | CD44 antigen | Drug metabolism | Repair | Drug dosages | Deoxyribonucleic acid--DNA | Enzymes | Ploidy | BRCA1 protein | Gene expression | Metabolism | 1-Phosphatidylinositol 3-kinase | Chemotherapy | Pharmacy | Stem cells | Mutation | Codons | Surface markers | Cell proliferation | Transcription | Mesenchyme | Gene regulation | Cytology | Kinases | DNA repair | Cell surface | E-cadherin | MDR1 protein | Clonal deletion | Rodents | Cell cycle | Deletion | Pharmaceutical sciences | Glutathione | Multidrug resistance | Breast cancer | Medicine | Hypotheses | Gene amplification | Apoptosis | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
FEBS Letters, ISSN 0014-5793, 2007, Volume 581, Issue 5, pp. 935 - 938
Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal structure of Sav1866... 
Mdr1 | Outward-facing conformation | Transport protein | Multidrug ABC transporter | ATP-bound state | AMP-PNP | ABC | TMD | multidrug resistance 1 gene | sodium dodecyl sulfate polyacrylamide electrophoresis | ATP binding cassette | SDS–PAGE | ADP | NBD | nucleotide binding domain | adenosine-5′-(β,γ-imido)triphosphate | transmembrane domain | adenosine diphosphate | adenosine triphosphate | ATP | transport protein | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | STATE | outward-facing conformation | MODEL | ATP-BINDING | ATPASES | CELL BIOLOGY | BIOPHYSICS | multidrug ABC transporter | HUMAN P-GLYCOPROTEIN | Recombinant Proteins - metabolism | Staphylococcus aureus - genetics | Drug Stability | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Crystallography, X-Ray | Recombinant Proteins - genetics | Adenylyl Imidodiphosphate - chemistry | ATP-Binding Cassette Transporters - chemistry | ATP-Binding Cassette Transporters - genetics | Adenylyl Imidodiphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | Bacterial Proteins - metabolism | Protein Conformation | Adenosine Triphosphatases - genetics | Staphylococcus aureus - metabolism | Staphylococcus aureus | Television broadcasting industry | Index Medicus
Journal Article
Journal Article
Journal Article