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Seminars in cancer biology, ISSN 1044-579X, 06/2018, Volume 50, pp. 77 - 89
The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are... 
Life Sciences & Biomedicine | Oncology | Science & Technology | DNA Repair - drug effects | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Cell Self Renewal - genetics | Forkhead Box Protein O3 - genetics | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Forkhead Box Protein M1 - genetics | Cell Proliferation - drug effects | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Drug resistance in microorganisms | Chromatin | Endothelial growth factors | Leukemia | DNA damage | Estrogen | Disease susceptibility | Biological response modifiers | T cells | DNA repair | Epidermal growth factor | Nucleotide sequencing | Drug therapy | Protein kinases | Health aspects | Protein binding | Tyrosine | Niacinamide | Superoxide | DNA binding proteins | Cell differentiation | Chemotherapy | Multiprocessing | Gliomas | Stem cells | Interferon | Lymphomas | Adenylic acid | Mitogens | Cancer | DNA sequencing | Index Medicus | AURKA, aurora kinase A | Fox, forkhead box | Bim, B-cell lymphoma 2 interacting mediator | EGF, epidermal growth factor | JNK | BRIP1, BRCA1-interacting protein-terminal helicase 1 | GICs, glioma-initiating cells | MCL, mantle cell lymphoma | PKB, protein kinase B | SCs, stem cells | LEF, T-cell factor | Skp2, S-phase kinase-associated protein 2 | SSBs, single-strand breaks | mTOR, mammalian target of rapamycin | NBS1, Nijmegen breakage syndrome 1 | stress activated protein kinase | MEK, mitogen-activated protein kinase kinase | PIP3, phosphatidylinositol- 3,4,5-trisphosphate | BER, base excision repair | lymphoid enhancer factor | VEGF, vascular endothelial growth factor | AML, acute myeloid leukaemia | ER+ve, estreogen receptor positive | EXO1, exonuclease 1 | EGFR, epidermal growth factor receptor | MDR1, multidrug resistance protein 1 | ChIP-seq, chromatin immunoprecipitation with massively parallel DNA sequencing | ABCB1, ATP-binding cassette sub-family B member 1 | TCF | SOD-2, superoxide dismutase | TKIs, tyrosine kinase inhibitors | PDK, phosphoinositide-dependent kinase | IFNɣ, interferon-ɣ | BRCA2, breast cancer-associated gene 2 | DDR, DNA damage response | Cks1, cyclin-dependent kinases regulatory subunit 1 | ESR1, estrogen receptor alpha gene | NHEJ, non-homologous end joining | XRCC1, X-ray cross-complementing group 1 | OTUB1, OUT domain-containing ubiquitin aldehyde-binding protein 1 | IGF, insulin growth factor | TRAIL, tumour necrosis factor-related apoptosis inducing ligand | ER, estrogen receptor | MRN, MER11-RAD50-NBS1 | BRCA1, breast cancer susceptibility gene product 1 | FasL, fas ligand | RTKs, receptor tyrosine kinases | Sox1, sex determining region Y box 2 | GADD45, DNA damage-inducible protein 45 | MMR, mismatch repair | PI3K, phosphatidylinositol 3-kinase | ROS, reactive oxygen species | NAMPT, nicotinamide-phosphribosyltransferase | miRs, Micro-RNAs | FHRE, forkhead response element | ATM, Ataxia-telangiectasia mutated | NER, nucleotide excision repair | ERK, extracellular signal-regulated kinase | HR, homologous recombination | AMPK, adenosine monophosphate-activated protein kinase | DSBs, double strands breaks | PA, Psammaplysene A | CML, chronic myeloid leukaemia | HCC, hepatocellular carcinoma | Mst1, macrophage stimulating 1 | Rb2, retinoblastoma-related p130 | SAPK, c-Jun N-terminal kinase | CSCs, cancer stem cells
Journal Article
Journal of hepatology, ISSN 0168-8278, 01/2013, Volume 58, Issue 1, pp. 155 - 168
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions... 
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | Index Medicus | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
Clinical cancer research, ISSN 1078-0432, 09/2011, Volume 17, Issue 17, pp. 5674 - 5685
Purpose: Jagged1, a Notch ligand, is expressed on both tumor epithelial and endothelial cells and therefore may be amenable to dual targeting of the tumor... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Proliferation | Epithelial Cells - metabolism | Taxoids - pharmacology | Apoptosis - drug effects | Receptors, Notch - metabolism | Humans | Zinc Finger Protein Gli2 | Ovarian Neoplasms - pathology | Hedgehog Proteins - metabolism | Drug Resistance, Neoplasm | Receptors, Notch - genetics | Molecular Targeted Therapy | Intercellular Signaling Peptides and Proteins - metabolism | Stromal Cells | Hedgehog Proteins - genetics | RNA Interference | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Bridged-Ring Compounds - pharmacology | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Nuclear Proteins - genetics | Ovarian Neoplasms - drug therapy | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - biosynthesis | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Neovascularization, Pathologic - genetics | ATP Binding Cassette Transporter, Sub-Family B | Mice | RNA, Small Interfering | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Calcium-Binding Proteins - genetics | Cell proliferation | chitosan | Animal models | Tumor cells | Chemoresistance | taxanes | Stroma | Malignancy | siRNA | Endothelial cells | Ovarian cancer | Angiogenesis | MDR1 protein | nanoparticles | Microenvironments | Notch protein | Jagged1 protein | Tumors | Index Medicus | chemoresistance | small interfering RNA | Jagged1 | ovarian cancer
Journal Article
Journal Article
Journal Article