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Hepatology (Baltimore, Md.), ISSN 0270-9139, 8/2018, Volume 68, Issue 2, pp. 599 - 615
Cholestatic liver injury is an important clinical problem with limited understanding of disease pathologies. Exosomes are small extracellular vesicles released... 
Mdr2 | S1PR2 | bile acids | cholestasis | CCl4
Journal Article
Journal of Hepatology, ISSN 0168-8278, 07/2019, Volume 71, Issue 1, pp. 153 - 162
Progressive familial intrahepatic cholestasis type 3 (PFIC3), for which there are limited therapeutic options, often leads to end-stage liver disease before... 
Adeno-associated virus | Progressive familial intrahepatic cholestasis | MDR2 | ABCB4 | AAV | PFIC type 3 | PFIC3 | Correction cholestatic phenotype | MDR3 | AAV8 | Gene therapy | HOMOZYGOUS DISRUPTION | IMMUNE-RESPONSE | HEPATOCYTES | ADENOASSOCIATED VIRUS | MDR2 P-GLYCOPROTEIN | BILIARY DIVERSION | IN-VIVO | MOUSE MODEL | DISEASE | GASTROENTEROLOGY & HEPATOLOGY | BILE
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions... 
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | RAT-LIVER | SALT EXPORT PUMP | GROWTH-FACTOR 19 | ORGANIC ANION TRANSPORTERS | 90-PERCENT PARTIAL-HEPATECTOMY | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS | FAMILIAL INTRAHEPATIC CHOLESTASIS | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, 10/2018, Volume 188, Issue 10, pp. 2264 - 2280
Activation of the secretin (Sct)/secretin receptor (SR) axis stimulates ductular reaction and liver fibrosis, which are hallmarks of cholangiopathies. Our aim... 
EPITHELIAL-CELLS | GENE-EXPRESSION | LIGATION | PROLIFERATION | PATHOLOGY | RAT CHOLANGIOCYTES | MDR2(-/-) MICE | CELLULAR SENESCENCE | SECRETIN | FUNCTIONAL-HETEROGENEITY | PRIMARY SCLEROSING CHOLANGITIS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 5, pp. 2207 - 2212
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 07/2019, Volume 33, Issue 7, pp. 7995 - 8007
Chronic liver inflammation (CLI) is a risk factor for development of hepatocellular carcinoma (HCC). Galectin-1 (Gal1) is involved in the regulation of... 
CELLS | ACTIVATION | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HCC | INDUCTION | GLYCOSYLATION | CANCER | CELL BIOLOGY | EFFECTOR | OVEREXPRESSION | Ntrk2 | OSTEOPONTIN | Mdr2 | GENE | BIOLOGY | Spp1 | S100a4
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2014, Volume 62, Issue 4, pp. 871 - 878
Graphical abstract 
Gastroenterology and Hepatology | Schistosoma mansoni infection | Bile acids | Liver fibrosis | Anti-inflammatory/anti-fibrotic therapy | Hepatic granulomas | ACTIVATION | NORURSODEOXYCHOLIC ACID | IMMUNOPATHOLOGY | KNOCKOUT MICE | BILIARY-SECRETION | URSODEOXYCHOLIC ACID | PHYSIOLOGICAL-PROPERTIES | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | POLARIZATION | BILE-ACIDS | Immunohistochemistry | Inflammation - pathology | Liver Cirrhosis - immunology | Cholagogues and Choleretics - pharmacology | Ursodeoxycholic Acid - analogs & derivatives | Schistosomiasis mansoni - immunology | Inflammation - drug therapy | T-Lymphocytes - drug effects | Disease Models, Animal | Schistosomiasis mansoni - physiopathology | Liver Cirrhosis - drug therapy | Liver Cirrhosis - etiology | Cholagogues and Choleretics - metabolism | Schistosomiasis mansoni - complications | Treatment Outcome | Inflammation - immunology | Granuloma - pathology | Ursodeoxycholic Acid - pharmacology | Animals | Lymphocyte Activation - drug effects | Liver Cirrhosis - pathology | Granuloma - drug therapy | Granuloma - immunology | T-Lymphocytes - immunology | Mice | Liver Cirrhosis - physiopathology | Schistosomiasis mansoni - pathology | Ursodeoxycholic Acid - metabolism | Drug Monitoring | Ursodiol | Liver diseases | ALT, alanine aminotransferase | HP, hydroxyproline | Mdr2, canalicular phospholipid export pump | BMDC, bone marrow derived dendritic cells | BMDM, bone marrow derived macrophages | M-CSF, macrophage colony-stimulating factor | multidrug resistance protein 2 | norUDCA, 24-nor-ursodeoxycholic acid | anti-fibrotic therapy | Abcb4 | B. glabrata, Biomphalaria glabrata | UDCA, ursodeoxycholic acid | S. mansoni, Schistosoma mansoni | Anti-inflammatory | AP, alkaline phosphatase
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 1/2016, Volume 63, Issue 1, pp. 95 - 106
Balance of labile methyl groups (choline, methionine, betaine, and folate) is important for normal liver function. Quantitatively, a significant use of labile... 
nuclear receptors | non-alcoholic fatty liver disease | LRH-1 | Mdr2 | methionine-choline deficient diet | Gnmt
Journal Article
Journal Article