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1. Full Text Potent immune modulation by medi6383, an engineered human ox40 ligand igg4p fc fusion protein
by Oberst, Michael D and Auge, Catherine and Morris, Chad and Kentner, Stacy and Mulgrew, Kathy and McGlinchey, Kelly and Hair, James and Hanabuchi, Shino and Du, Qun and Damschroder, Melissa and Feng, Hui and Eck, Steven and Buss, Nicholas and de Haan, Lolke and Pierce, Andrew J and Park, Haesun and Sylwester, Andrew and Axthelm, Michael K and Picker, Louis and Morris, Nicholas P and Weinberg, Andrew and Hammond, Scott A
Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2018, Volume 17, Issue 5, pp. 1024 - 1038
Ligation of OX40 (CD134, TNFRSF4) on activated T cells by its natural ligand (OX40L, CD252, TNFSF4) enhances cellular survival, proliferation, and effector... 
EFFECTOR | ONCOLOGY | BLOCKS | EXPANSION | REGULATORY T-CELLS | COSTIMULATION | SUPPRESSION | CD134 | CUTTING EDGE | Recombinant Fusion Proteins - immunology | T-Lymphocytes, Regulatory - metabolism | Receptors, OX40 - agonists | OX40 Ligand - genetics | Recombinant Fusion Proteins - pharmacology | Immunoglobulin Fc Fragments - metabolism | OX40 Ligand - metabolism | Humans | Protein Multimerization - immunology | Macaca mulatta | Receptors, OX40 - immunology | T-Lymphocytes, Regulatory - immunology | Lymphocyte Activation - immunology | Receptors, OX40 - metabolism | Immunoglobulin Fc Fragments - immunology | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | HEK293 Cells | Female | Cytotoxicity, Immunologic - drug effects | Cytokines - immunology | Cytokines - metabolism | Recombinant Fusion Proteins - chemistry | Animals | Immunoglobulin G - genetics | OX40 Ligand - immunology | Lymphocyte Activation - drug effects | Cell Line, Tumor | T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | Immunoglobulin Fc Fragments - genetics | Immunoglobulin G - metabolism | Cytolytic activity | Cell proliferation | Toxicity | CD8 antigen | Cytotoxicity | Lymphocytes T | Immunity | Proteins | Receptors | Cell growth | Lymphocytes | Peripheral blood | Primates | CD25 antigen | Fusion protein | Recombinant | Immunological memory | Memory cells | Cell survival | Cytokines | Immunomodulation | T cell receptors | CD134 antigen | CD4 antigen | Fc receptors | Ox40L protein | Lymphocytes B | Tumor necrosis factor | Ligands | Tumors | OX40 | fusion protein | OX40 ligand | MEDI6383 | immunotherapy
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