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Blood Cells, Molecules and Diseases, ISSN 1079-9796, 2010, Volume 45, Issue 1, pp. 67 - 74
Phagocytes engulf foreign cells but not ‘self’ in part because self cells express CD47 as a ligand for signal regulatory protein SIRPα, which inhibits... 
SIRP | Red blood cells | Stem cells | CD47 | Polymorphisms | Macrophages | Phagocytosis | Circulation | RECOGNITION | MEMBRANE | INTEGRIN-ASSOCIATED PROTEIN | Stern cells | RECEPTOR-MEDIATED PHAGOCYTOSIS | ADHESION | FC-RECEPTOR | SIGNAL-REGULATORY PROTEIN | HEMATOPOIETIC STEM-CELLS | RED-BLOOD-CELLS | MOUSE MACROPHAGES | HEMATOLOGY
Journal Article
Autophagy, ISSN 1554-8627, 11/2015, Volume 11, Issue 11, pp. 1956 - 1977
An accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads to stress conditions. To mitigate such circumstances, stressed cells... 
ER stress | unfolded protein response | protein aggregates | autophagy | lysosome | Autophagy | Protein aggregates | Lysosome | Unfolded protein response | TRANSCRIPTION FACTORS | MEDIATED AUTOPHAGY | INDUCED APOPTOSIS | INTRACELLULAR CALCIUM | XBP1 MESSENGER-RNA | ENDOPLASMIC-RETICULUM STRESS | QUALITY-CONTROL | CELL-DEATH | CELL BIOLOGY | NF-KAPPA-B
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2018, Volume 38, Issue 7, pp. 1479 - 1492
OBJECTIVE—Atherosclerosis is a chronic multifactorial and inflammatory disease of large and medium arteries and the leading cause of cardiovascular diseases... 
atherosclerosis | endothelial cells | macrophages | inflammation | sphingolipids | INDUCED ACTIVATION | MEDIATED EXPRESSION | NECROSIS-FACTOR-ALPHA | CERAMIDE | LIPOPROTEIN RETENTION | CELL-DEATH | SYNTHASE 2 | NRF2 | NEUTRAL SPHINGOMYELINASE-2 | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | UP-REGULATION | Index Medicus | 10018 | 10030 | 10035 | 10012 | Basic Sciences
Journal Article
Circulation, ISSN 0009-7322, 05/2012, Volume 125, Issue 19, pp. 2323 - 2333
Background-cGMP phosphodiesterase type 5 protein is upregulated in myocardial hypertrophy. However, it has never been ascertained whether phosphodiesterase... 
fibrosis | phosphodiesterase inhibitors heart failure | diabetes mellitus type 2 | cardiac magnetic resonance imaging | diabetic diastolic heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | PULMONARY-HYPERTENSION | ENDOTHELIAL DYSFUNCTION | SILDENAFIL CITRATE | AORTIC-STENOSIS | DIASTOLIC HEART-FAILURE | HYPERTROPHY | FLOW-MEDIATED DILATATION | NITRIC-OXIDE | VALVE-REPLACEMENT | PERIPHERAL VASCULAR DISEASE | TYPE-5 INHIBITION | Piperazines - administration & dosage | Diabetic Cardiomyopathies - drug therapy | Follow-Up Studies | Phosphodiesterase 5 Inhibitors - adverse effects | Humans | Middle Aged | Sulfones - adverse effects | Magnetic Resonance Imaging - methods | Male | Purines - administration & dosage | Torsion, Mechanical | Sildenafil Citrate | Hypertrophy, Left Ventricular - pathology | Purines - adverse effects | Cardiac Imaging Techniques - methods | Hypertrophy, Left Ventricular - drug therapy | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Diabetes Mellitus, Type 2 - complications | Phosphodiesterase 5 Inhibitors - administration & dosage | Treatment Outcome | Piperazines - adverse effects | Diabetic Cardiomyopathies - pathology | Aged | Ventricular Remodeling - drug effects | Sulfones - administration & dosage | Care and treatment | Magnetic resonance imaging | Cardiomyopathy | Clinical trials | Diagnosis | Phosphodiesterases | Heart diseases | Health aspects | Methods | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 11/2011, Volume 11, Issue 11, pp. 2405 - 2413
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 358, Issue 2, pp. 170 - 179
Highlights • Baicalein, a natural compound, causes tumor suppression of cancer cells both in vitro and in vivo. • Baicalein upregulates DDIT4 which inhibits... 
Hematology, Oncology and Palliative Medicine | Baicalein | mTOR | Cellular stress | IRF1 | DDIT4 | MTOR | APOPTOSIS | DNA-DAMAGE RESPONSE | WOGONIN | P53 | LIPOXYGENASE | ONCOLOGY | PATHWAY | COLORECTAL-CANCER | RESISTANCE | STRESS | REDD1 | Neoplasms - metabolism | Up-Regulation | TOR Serine-Threonine Kinases - metabolism | Humans | Gene Expression Profiling | Antineoplastic Agents - administration & dosage | Tumor Suppressor Protein p53 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplasms - genetics | Time Factors | Female | Transcription, Genetic | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | Flavanones - pharmacology | Tumor Suppressor Protein p53 - metabolism | Transcription Factors - genetics | Flavanones - administration & dosage | Transcription Factors - metabolism | Protein Kinase Inhibitors - administration & dosage | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Prevention | Chemotherapy | Growth | Cancer cells | Cancer | TOR protein | Phosphorylation | Transcription | p53 Protein | Clinical trials | Kinases | Anticancer properties | Proteins | Cell growth | Platinum | Rodents | Inhibition | Charitable foundations | Deoxyribonucleic acid--DNA | RNA-mediated interference | Breast cancer | Tumor cell lines | Gene expression | Polymerase chain reaction | Ribonucleic acids | Cell lines | Interferon | Tumors | Index Medicus | baicalein | cellular stress
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 44, pp. 10371 - 10385
This paper explores the computer modelling aided design and synthesis of beta-N-acetylhexosaminidase inhibitors along with their applicability to human disease... 
BREAST-CANCER | DENSITY FUNCTIONALS | 8 STEREOISOMERS | HEXOSAMINIDASE INHIBITORS | COMBINATORIAL LIBRARIES | CHEMISTRY, ORGANIC | MEDIATED DEGRADATION | TAY-SACHS | EXTRACELLULAR-MATRIX | IN-VITRO ASSAY | SCALABLE SYNTHESES
Journal Article