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1. Full Text Genome-wide identification of post-translational modulators of transcription factor activity in human B cells
by Rajbhandari, Presha and Shen, Qiong and Margolin, Adam A and Wang, Kai and Klein, Ulf and Dalla-Favera, Riccardo and Alvarez, Mariano J and Califano, Andrea and Nemenman, Ilya and Saito, Masumichi and Basso, Katia and Bisikirska, Brygida C and Lim, Wei Keat
Nature Biotechnology, ISSN 1087-0156, 09/2009, Volume 27, Issue 9, pp. 829 - 837
The ability of a transcription factor (TF) to regulate its targets is modulated by a variety of genetic and epigenetic mechanisms, resulting in highly... 
PROTEIN | BCL6 | CHROMATIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | REGULATORY NETWORKS | C-MYC | TRANSDUCTION | EXPRESSION PROFILES | BINDING | DISCOVERY | CYCLE | Phosphorylation | Homeodomain Proteins - metabolism | Humans | Protein Processing, Post-Translational - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Microarray Analysis | Protein Stability | Histone Deacetylase 1 - genetics | B-Lymphocytes - metabolism | MEF2 Transcription Factors | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Reproducibility of Results | Basic Helix-Loop-Helix Transcription Factors - genetics | Myogenic Regulatory Factors - genetics | Signal Transduction | MADS Domain Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | B-Lymphocytes - physiology | Myogenic Regulatory Factors - metabolism | Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Homeodomain Proteins - genetics | MADS Domain Proteins - metabolism | Transcription Factors - metabolism | Systems Biology - methods | Algorithms | Cell Line, Tumor | Models, Genetic | Proto-Oncogene Proteins c-myc - genetics | Histone Deacetylase 1 - metabolism | Post-translational modification | Transcription factors | Physiological aspects | Genetic aspects | B cells | Research | Properties | Biotechnology | Signal transduction | Cellular biology | Genomics
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2. Full Text Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state
by Fu, Ji-Dong and Stone, Nicole R and Liu, Lei and Spencer, C. Ian and Qian, Li and Hayashi, Yohei and Delgado-Olguin, Paul and Ding, Sheng and Bruneau, Benoit G and Srivastava, Deepak
Stem Cell Reports, ISSN 2213-6711, 09/2013, Volume 1, Issue 3, pp. 235 - 247
Summary Direct reprogramming of adult somatic cells into alternative cell types has been shown for several lineages. We previously showed that GATA4, MEF2C,... 
CARDIAC TRANSCRIPTION FACTORS | PLURIPOTENT STEM-CELLS | HEART | MYOCARDIN | DEFINED FACTORS | COFACTOR | INDUCTION | FOG-2 | TBX5 | EXPRESSION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Embryonic Stem Cells - metabolism | MEF2 Transcription Factors - genetics | Embryonic Stem Cells - cytology | Humans | T-Box Domain Proteins - biosynthesis | Gene Expression Regulation, Developmental - genetics | Cell Differentiation - genetics | Nuclear Proteins - biosynthesis | Trans-Activators - genetics | MEF2 Transcription Factors - biosynthesis | Trans-Activators - biosynthesis | Nuclear Proteins - genetics | Cellular Reprogramming - genetics | Fibroblasts - metabolism | GATA4 Transcription Factor - biosynthesis | Signal Transduction | GATA4 Transcription Factor - genetics | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | T-Box Domain Proteins - genetics | Cell Lineage | Animals | Myocytes, Cardiac - metabolism | Mice | DNA-Binding Proteins - biosynthesis | Transforming Growth Factor beta - metabolism
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3. Full Text Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors
by Nam, Young-Jae and Lubczyk, Christina and Bhakta, Minoti and Zang, Tong and Fernandez-Perez, Antonio and McAnally, John and Bassel-Duby, Rhonda and Olson, Eric N and Munshi, Nikhil V
Development (Cambridge), ISSN 0950-1991, 11/2014, Volume 141, Issue 22, pp. 4267 - 4278
Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H), Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced... 
Direct reprogramming | Mouse | Pacemaker | Cardiomyocyte | HEART FIELD | DEFINED FACTORS | CARDIOMYOCYTE-LIKE CELLS | MYOCYTES | NODE | DEVELOPMENTAL BIOLOGY | FATE | GENE REGULATORY NETWORKS | Immunohistochemistry | MEF2 Transcription Factors - genetics | Fibroblasts - physiology | Heart - embryology | DNA Primers - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cell Differentiation - physiology | Real-Time Polymerase Chain Reaction | Fibroblasts - metabolism | Green Fluorescent Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | GATA4 Transcription Factor - metabolism | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Myocytes, Cardiac - cytology | Embryonic Induction - physiology | GATA4 Transcription Factor - genetics | Transcription Factors - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Action Potentials - physiology | Transcription Factors - metabolism | Animals | Analysis of Variance | Myocytes, Cardiac - physiology | MEF2 Transcription Factors - metabolism | Fibroblasts - cytology | Mice | Stem Cells and Regeneration
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4. Full Text Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes
by Ma, Leina and Liu, Jia and Liu, Limei and Duan, Guangjie and Wang, Qingliang and Xu, Yanmin and Xia, Feng and Shan, Juanjuan and Shen, Junjie and Yang, Zhi and Bie, Ping and Cui, Youhong and Bian, Xiu-Wu and Prieto, Jesus and Avila, Matías A and Qian, Cheng
Cancer Research, ISSN 0008-5472, 03/2014, Volume 74, Issue 5, pp. 1452 - 1462
The underlying molecular pathogenesis in hepatocellular carcinoma remains poorly understood. The transcription factor MEF2D promotes survival in various cell... 
Cell Division - genetics | Cell Line | G2 Phase - genetics | MEF2 Transcription Factors - genetics | Cell Proliferation | Prognosis | Liver Neoplasms - genetics | Humans | Down-Regulation - genetics | Hep G2 Cells | Animals | Mice, Nude | Carcinoma, Hepatocellular - genetics | Carcinoma, Hepatocellular - pathology | HEK293 Cells | Cell Line, Tumor | Liver Neoplasms - pathology | Mice | Mice, Inbred BALB C | HeLa Cells | Transcription, Genetic - genetics | Gene Expression Regulation, Neoplastic - genetics
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5. Full Text MEF2 transcription factors are key regulators of sprouting angiogenesis
by Sacilotto, Natalia and Chouliaras, Kira M and Nikitenko, Leonid L and Lu, Yao Wei and Fritzsche, Martin and Wallace, Marsha D and Nornes, Svanhild and García-Moreno, Fernando and Payne, Sophie and Bridges, Esther and Liu, Ke and Biggs, Daniel and Ratnayaka, Indrika and Herbert, Shane P and Molnár, Zoltán and Harris, Adrian L and Davies, Benjamin and Bond, Gareth L and Bou-Gharios, George and Schwarz, John J and De Val, Sarah
Genes and Development, ISSN 0890-9369, 10/2016, Volume 30, Issue 20, pp. 2297 - 2309
Angiogenesis, the fundamental process by which new blood vessels form from existing ones, depends on precise spatial and temporal gene expression within... 
Dll4 regulation | MEF2 transcription factors | HLX regulation | Sprouting angiogenesis | sprouting angiogenesis | VEGF | MYOGENESIS | MOUSE | NOTCH | ENHANCER | RECEPTOR | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | SOX17 | ENDOTHELIAL-CELLS | VASCULAR INTEGRITY | GENETICS & HEREDITY | GENE-EXPRESSION | MEF2 Transcription Factors - genetics | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Retina - embryology | Gene Expression Regulation, Developmental | MEF2 Transcription Factors - chemistry | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Endothelial Cells - physiology | Histone Deacetylases - genetics | Signal Transduction | Membrane Proteins - genetics | Neovascularization, Physiologic - genetics | Cells, Cultured | Histone Deacetylases - metabolism | Zebrafish | Animals | Endothelial Cells - cytology | Embryo, Nonmammalian | MEF2 Transcription Factors - metabolism | Neovascularization, Pathologic - genetics | Enhancer Elements, Genetic - genetics | Mice | Endothelial Cells - enzymology | Transcription factors | Research | Neovascularization | Gene expression | Research Paper
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6. Full Text Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
by Martorell‐Riera, Alejandro and Segarra‐Mondejar, Marc and Muñoz, Juan P and Ginet, Vanessa and Olloquequi, Jordi and Pérez‐Clausell, Jeús and Palacín, Manuel and Reina, Manuel and Puyal, Julien and Zorzano, Antonio and Soriano, Francesc X
The EMBO Journal, ISSN 0261-4189, 10/2014, Volume 33, Issue 20, pp. 2388 - 2407
Mitochondrial fusion and fission is a dynamic process critical for the maintenance of mitochondrial function and cell viability. During excitotoxicity neuronal... 
neuron | excitotoxicity | transcriptional regulation | mitochondrial dynamics | PROTEOLYTIC CLEAVAGE | MITOFUSIN 2 | INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NMDA RECEPTOR ACTIVATION | MAMMALIAN-CELLS | CELL BIOLOGY | FOREBRAIN NEURONS | NITRIC-OXIDE | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CEREBRAL-ISCHEMIA | Dynamins - metabolism | MEF2 Transcription Factors - genetics | Calcium - metabolism | Humans | Homeostasis | Male | Mitochondrial Proteins - genetics | Mitochondrial Dynamics - physiology | Mitochondrial Proteins - metabolism | Cell Death | Neurons - physiology | Models, Animal | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Cell Line | Membrane Proteins - genetics | Down-Regulation | Cells, Cultured | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | Dynamins - genetics | Rats | Rats, Sprague-Dawley | Animals | MEF2 Transcription Factors - metabolism | Mutation | Mitochondria - physiology | Mitochondria | Mitochondrial DNA | Toxicity | Neurons | Neurodegenerative Diseases | Malalties neurodegeneratives | Mitocondris
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7. Full Text Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
by Homminga, Irene and Pieters, Rob and Langerak, Anton W and de Rooi, Johan J and Stubbs, Andrew and Verstegen, Monique and Vuerhard, Maartje and Buijs-Gladdines, Jessica and Kooi, Clarissa and Klous, Petra and van Vlierberghe, Pieter and Ferrando, Adolfo A and Cayuela, Jean Michel and Verhaaf, Brenda and Beverloo, H. Berna and Horstmann, Martin and de Haas, Valerie and Wiekmeijer, Anna-Sophia and Pike-Overzet, Karin and Staal, Frank J.T and de Laat, Wouter and Soulier, Jean and Sigaux, Francois and Meijerink, Jules P.P
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 4, pp. 484 - 497
To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed... 
TRANSFORMATION | FUSION | NOTCH1 | ONCOLOGY | GENE-EXPRESSION | C-MYC | ACTIVATION MECHANISM | TARGET GENE | IDENTIFICATION | HOMEOBOX GENE | CANCER | CELL BIOLOGY | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Thyroid Nuclear Factor 1 | Cell Proliferation | Humans | Child, Preschool | Infant | Male | Female | Transcription, Genetic | Nuclear Proteins - genetics | Child | MEF2 Transcription Factors | Oncogenes | Transcription Factors - physiology | Myogenic Regulatory Factors - genetics | MADS Domain Proteins - genetics | Myogenic Regulatory Factors - physiology | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | Homeodomain Proteins - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Gene Rearrangement | Adolescent | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - etiology | Nuclear Proteins - physiology | Genome, Human | Homeodomain Proteins - physiology | MADS Domain Proteins - physiology | Cluster Analysis | Oncology, Experimental | Genomics | Genetic aspects | Acute lymphocytic leukemia | Children | Research | DNA binding proteins | T cells | Health aspects | Cancer
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8. Full Text Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming
by Wang, Li and Liu, Ziqing and Yin, Chaoying and Asfour, Huda and Chen, Olivia and Li, Yanzhen and Bursac, Nenad and Liu, Jiandong and Qian, Li
Circulation Research, ISSN 0009-7330, 01/2015, Volume 116, Issue 2, pp. 237 - 244
RATIONALE:Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers great opportunities for cardiac disease modeling and cardiac... 
fibroblasts | Mef2c protein | regeneration | transcription factors | Tbx5 protein | gene expression/regulation | Gata4 protein | myocytes | cardiac | myocytes, cardiac | VENTRAL MORPHOGENESIS | DEFINED FACTORS | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOMYOCYTE-LIKE CELLS | CONDUCTION SYSTEM | HEART TUBE FORMATION | TRANSCRIPTION FACTOR TBX5 | IN-VITRO | HUMAN FIBROBLASTS | PERIPHERAL VASCULAR DISEASE | MUTATIONS | HOLT-ORAM-SYNDROME | HEMATOLOGY | GATA4 Transcription Factor - biosynthesis | MEF2 Transcription Factors - genetics | Animals | Myocytes, Cardiac - physiology | Cells, Cultured | T-Box Domain Proteins - biosynthesis | GATA4 Transcription Factor - genetics | Mice, Transgenic | MEF2 Transcription Factors - biosynthesis | Mice | T-Box Domain Proteins - genetics | Cellular Reprogramming - physiology | cell reprogramming | iCM | Mef2c | regulation | Gata4 | Tbx5 | cardiac myocyte | gene expression
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9. Full Text MEF2 transcription factors regulate distinct gene programs in mammalian skeletal muscle differentiation
by Estrella, Nelsa L and Desjardins, Cody A and Nocco, Sarah E and Clark, Amanda L and Maksimenko, Yevgeniy and Naya, Francisco J
Journal of Biological Chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 2, pp. 1256 - 1268
Skeletal muscle differentiation requires precisely coordinated transcriptional regulation of diverse gene programs that ultimately give rise to the specialized... 
MIGRATION | PROTEIN | MYOD | COSTAMERE | SARCOMERE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | NETWORKS | IDENTIFICATION | EXPRESSION | BINDING | Mammals - genetics | MEF2 Transcription Factors - genetics | Mammals - growth & development | Muscle, Skeletal - growth & development | Cercopithecus aethiops | MEF2 Transcription Factors - antagonists & inhibitors | Cell Differentiation - genetics | Myoblasts - metabolism | Animals | Protein Isoforms - biosynthesis | Gene Expression Regulation, Developmental | Myoblasts - cytology | Muscle Development - genetics | Drosophila - growth & development | MEF2 Transcription Factors - biosynthesis | Mice | COS Cells | Drosophila - genetics | Evolution, Molecular | Protein Isoforms - genetics | Gene Regulation | Transcription Factor | Differentiation | Transcriptomics | RNA Interference (RNAi) | Myogenesis
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10. Full Text Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival
by Beier, Ulf H and Angelin, Alessia and Akimova, Tatiana and Wang, Liqing and Liu, Yujie and Xiao, Haiyan and Koike, Maya A and Hancock, Saege A and Bhatti, Tricia R and Han, Rongxiang and Jiao, Jing and Veasey, Sigrid C and Sims, Carrie A and Baur, Joseph A and Wallace, Douglas C and Hancock, Wayne W
FASEB Journal, ISSN 0892-6638, 06/2015, Volume 29, Issue 6, pp. 2315 - 2326
Conventional T (Tcon) cells and Foxp3(+) T-regulatory (Treg) cells are thought to have differing metabolic requirements, but little is known of mitochondrial... 
Transplant survival | Histone deacetylase | Immunometabo-lism | Immunoregulation | Immunity | MEMORY DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFECTOR FUNCTION | immunity | transplant survival | histone deacetylase | ENHANCER FACTOR-2 MEF2 | CELL BIOLOGY | immunometabolism | INFLAMMATION | CARDIAC-HYPERTROPHY | BIOLOGY | immunoregulation | DIFFERENTIATION | EXPRESSION | MOLECULAR-MECHANISMS | LYMPHOCYTES | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Graft Survival - immunology | Reactive Oxygen Species - metabolism | Sirtuin 3 - metabolism | Gene Expression Profiling | Mitochondria - immunology | Histone Deacetylases - immunology | Mice, 129 Strain | T-Lymphocytes, Regulatory - immunology | Mitochondria - genetics | T-Lymphocytes - metabolism | Forkhead Transcription Factors - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Energy Metabolism - genetics | Transcription Factors - immunology | MEF2 Transcription Factors - immunology | Repressor Proteins - metabolism | Sirtuin 3 - genetics | Histone Deacetylases - genetics | Mice, Inbred C57BL | Oxidative Phosphorylation | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Energy Metabolism - immunology | Mitochondria - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Sirtuin 3 - immunology | Animals | Graft Survival - genetics | Repressor Proteins - immunology | MEF2 Transcription Factors - metabolism | T-Lymphocytes - immunology | Mice, Inbred BALB C | Research Communication
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11. Full Text MEF2 transcription factors: Developmental regulators and emerging cancer genes
by Pon, Julia R and Marra, Marco A
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 3, pp. 2297 - 2312
The MEF2 transcription factors have roles in muscle, cardiac, skeletal, vascular, neural, blood and immune system cell development through their effects on... 
MEF2 | Transcription factor | Developmental biology | Gene regulation | Cancer | Cell Differentiation - genetics | Oncogenes - genetics | Cell Proliferation - genetics | MEF2 Transcription Factors - genetics | Animals | Neoplasms - genetics | Humans | Gene Expression Regulation, Developmental - genetics | Mice | Gene Expression Regulation, Neoplastic - genetics
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12. Full Text Genome-wide identification and characterization of functional neuronal activity-dependent enhancers
by Malik, Athar N and Malik, Athar N and Vierbuchen, Thomas and Vierbuchen, Thomas and Hemberg, Martin and Hemberg, Martin and Rubin, Alex A and Rubin, Alex A and Ling, Emi and Ling, Emi and Couch, Cameron H and Couch, Cameron H and Stroud, Hume and Stroud, Hume and Spiegel, Ivo and Spiegel, Ivo and Farh, Kyle Kai-How and Farh, Kyle K.ai-How and Harmin, David A and Harmin, David A and Greenberg, Michael E and Greenberg, Michael E
Nature neuroscience, ISSN 1097-6256, 10/2014, Volume 17, Issue 10, pp. 1330 - 1339
Experience-dependent gene transcription is required for nervous system development and function. However, the DNA regulatory elements that control this program... 
STIMULATION | GENE | NARP | TRANSCRIPTION | SYNAPSE DEVELOPMENT | MECHANISMS | RECEPTORS | EXPRESSION | NEUROSCIENCES | Oncogene Proteins v-fos - metabolism | Genome-Wide Association Study | MEF2 Transcription Factors - genetics | Embryo, Mammalian | Gene Expression Regulation - genetics | Visual Cortex - cytology | Humans | Mice, Inbred C57BL | 2-Amino-5-phosphonovalerate - pharmacology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Mutation - genetics | Gene Expression Regulation - drug effects | CREB-Binding Protein - metabolism | Animals | Time Factors | Potassium Chloride - pharmacology | Neurons - physiology | MEF2 Transcription Factors - metabolism | Mice | Tetrodotoxin - pharmacology | Neurons - drug effects | Jumonji Domain-Containing Histone Demethylases - metabolism | Genetic research | Neural transmission | Genetic aspects | Genetic transcription | Research
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13. Full Text High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling
by Zhao, Yuanbiao and Londono, Pilar and Cao, Yingqiong and Sharpe, Emily J and Proenza, Catherine and O'Rourke, Rebecca and Jones, Kenneth L and Jeong, Mark Y and Walker, Lori A and Buttrick, Peter M and McKinsey, Timothy A and Song, Kunhua
Nature Communications, ISSN 2041-1723, 09/2015, Volume 6, Issue 1, p. 8243
Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C,... 
MOUSE FIBROBLASTS | HEART | CARDIAC FIBROBLASTS | CELLS | IN-VITRO | MEF2C | CONVERSION | MULTIDISCIPLINARY SCIENCES | GROWTH | GATA4 | EXPRESSION | Immunohistochemistry | MEF2 Transcription Factors - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Cellular Reprogramming Techniques - methods | Myocytes, Cardiac - cytology | Signal Transduction | Embryo, Mammalian | GATA4 Transcription Factor - genetics | T-Box Domain Proteins - genetics | Blotting, Western | rho-Associated Kinases - antagonists & inhibitors | Action Potentials | Animals | Sequence Analysis, RNA | Chromatin Immunoprecipitation | Fibrosis | Myocytes, Cardiac - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Fibroblasts - cytology | Mice | MicroRNAs - genetics | Cellular Reprogramming - genetics | Real-Time Polymerase Chain Reaction | Fibroblasts - metabolism
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14. Full Text Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
by Wu, Zhidan and Wu, Hai and Olson, Eric N and Tarr, Paul T and Boss, Olivier and Puigserver, Pere and Michael, Laura F and Lowell, Bradford B and Bassel-Duby, Rhonda and Zhang, Chen