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Experimental Cell Research, ISSN 0014-4827, 10/2019, p. 111662
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 07/2010, Volume 70, Issue 13, pp. 5518 - 5527
The BRAF(V600E) mutation is common in several human cancers, especially melanoma. RG7204 (PLX4032) is a small-molecule inhibitor of BRAF(V600E) kinase activity... 
ONCOGENE | EFFICACY | ONCOLOGY | BRAF | B-RAF | MUTATIONS | TUMORS | RAF/MEK/ERK PATHWAY | KINASES
Journal Article
Cancer Letters, ISSN 0304-3835, 2012, Volume 314, Issue 2, pp. 244 - 255
► Sorafenib increases apoptosis in NPA melanoma cells. ► BRAF protects from apoptosis by a MEK/ERK-independent mechanism. ► PI3K/AKT/mTOR cascade cooperates... 
BRAF | PI3K/AKT/mTOR | MEK/ERK | Melanoma | Apoptosis
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 04/2017, Volume 75, pp. 84 - 93
Midazolam is a positive allosteric modulator at GABA receptor that induces a short hypnosis and neuroplasticity, in which the sequential phosphorylation of... 
MEK-ERK | MKP-3 | Mouse brain | Flumazenil | Hypnosis | Midazolam
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 875 - 892
Most of the current FMS-like tyrosine kinase 3 (FLT3) inhibitors lack selectivity between FLT3 kinase and cKIT kinase as well as the FLT3 wt and internal... 
CELLS | CHEMISTRY, MEDICINAL | TARGETS | MUTATIONS | IDENTIFICATION | CRENOLANIB | SORAFENIB | CANCER | RAF/MEK/ERK PATHWAY | RATIONAL DESIGN
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2018, Volume 500, Issue 4, pp. 873 - 878
To investigate the glycometabolism associated mechanism in invasion and metastasis of pancreatic cancer, We screened out genes involved in anaerobic glycolysis... 
Glycometabolism | HIF-1α | EGFR/MEK/ ERK pathway | Pancreatic cancer | ROS
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 06/2018, Volume 102, pp. 749 - 757
Recent studies highlight the crucial regulatory roles of long non-coding RNAs (lncRNAs) in carcinogenesis. However, involvement of the lncRNA SNHG20 in... 
ADAM10 | miR-140-5p | Cervical cancer | SNHG20 | MEK/ERK | Development and progression | Index Medicus
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 2019
Accumulating findings reveal that long noncoding RNAs (lncRNAs) as crucial regulatory molecules serve vital functions in the progression of hepatocellular... 
invasion | proliferation | cell cycle | migration | HOXD-AS1 | MEK/ERK pathway | hepatocellular carcinoma
Journal Article
JOURNAL OF HEPATOLOGY, ISSN 0168-8278, 11/2011, Volume 55, Issue 5, pp. 1041 - 1048
Background & Aims: Recently, we reported that sorafenib sensitizes hepatocellular carcinoma (HCC) cells to TRAIL through the inhibition of signal transducer... 
CANCER-CELLS | PHOSPHORYLATION | STAT3 | HCC | TUMOR-CELLS | RAF/MEK/ERK PATHWAY | STAT3 ACTIVATION | INHIBITION | BLOCKS | Sorafenib | GROWTH | GASTROENTEROLOGY & HEPATOLOGY | Apoptosis
Journal Article
Artificial Cells, Nanomedicine, and Biotechnology, ISSN 2169-1401, 12/2019, Volume 47, Issue 1, pp. 3839 - 3846
Sinomenine (Sino) is diffusely applied in heal rheumatoid arthritis and neuralgia. Howbeit, the activities of Sino in breast cancer cells remain confused. The... 
Sinomenine | breast cancer | microRNA-29 | PDCD-4 | JNK | MEK/ERK
Journal Article
Oncogene, ISSN 0950-9232, 10/2009, Volume 28, Issue 41, pp. 3597 - 3607
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 05/2009, Volume 34, Issue 6, pp. 1416 - 1426
Journal Article
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2018, Volume 22, Issue 1, pp. 150 - 157
Extra-cellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway is widely involved in cell proliferation and apoptosis.... 
Nasopharyngeal carcinoma | Ras/raf/MEK/ERK | MEKI | Proliferation | MiR-101 | Apoptosis
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2016, Volume 64, Issue 5, pp. 1090 - 1098
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 01/2019, Volume 88, pp. 121 - 131
Ketamine (KET) is an antidepressant and hypnotic drug acting as an antagonist at excitatory NMDA glutamate receptors. The working hypothesis postulated that... 
Neuroplasticity | MEK-ERK | Mouse brain | Ketamine | NF-kB | Hypnosis | FADD
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 09/2019, Volume 18, Issue 9, pp. 1506 - 1519
The approved kinase inhibitors for hepatocellular carcinoma (HCC) are not matched to specific mutations within tumors. This has presented a daunting challenge;... 
HEPATOCELLULAR-CARCINOMA | ACTIVATION | LENVATINIB | P38-GAMMA | METABOLISM | SIGNATURES | ONCOLOGY | KINASE | RESISTANCE | SORAFENIB | RAF/MEK/ERK PATHWAY
Journal Article
Biological Chemistry, ISSN 1431-6730, 07/2010, Volume 391, Issue 7, pp. 791 - 801
Cancer cells are relatively resistant to endoplasmic reticulum (ER) stress-induced apoptosis. However, the underlying mechanisms remain largely unclear. We... 
p27 | cell cycle | endoplasmic reticulum stress | MEK/ERK | miR-221/222
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 07/2019, Volume 115, p. 108885
Finding novel agent for cerebral ischemia therapy is urgently required. In our present study, we aimed to investigate the regulatory mechanism of Ginkgolides B... 
Cerebral ischemia | PC-12 cells | MEK/ERK pathway | Ginkgolides B | Polo-like kinase 1 | PI3K/AKT pathway
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2018, Volume 17, Issue 12, pp. 2622 - 2632
Pancreatic-type ribonucleases (ptRNases) are prevalent secretory enzymes that catalyze the cleavage of RNA. Ribonuclease inhibitor (RI) is a cytosolic protein... 
PROTEIN | MELANOMA | PANCREATIC RIBONUCLEASE | ANGIOGENIN | ONCOLOGY | PHOSPHORYLATION | MAP KINASE | ENDOTHELIAL-CELLS | GROWTH | LIGAND | RAF/MEK/ERK PATHWAY
Journal Article
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