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Cancer Biology & Therapy, ISSN 1538-4047, 09/2018, Volume 19, Issue 9, pp. 786 - 796
Inhibitors of PARP1 are approved therapeutic agents in ovarian carcinomas. We determined whether the novel clinically relevant CHK1 inhibitor SRA737 interacted... 
PARP | CHK1 | MEK1/2 | Autophagy | DNA damage | HDAC | LETHALITY | ONCOLOGY | DNA-DAMAGE
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 10/2019, p. 101907
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2014, Volume 127, Issue 15, pp. 2825 - 2837
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 28, pp. 19847 - 19860
The link between ERK1/2 activity and cisplatin cytotoxicity, in association with the cell cycle, in ovarian cancer cell lines resistant (A2780cis; SK-OV-3) and... 
ERK1/2 signaling pathway | Cisplatin resistance | MEK1/2 inhibitor | Ovarian cancer cells | Cell cycle
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 07/2019, Volume 87, Issue 7, pp. 588 - 595
Journal Article
Journal Article
Journal of Virology, ISSN 0022-538X, 2016, Volume 90, Issue 22, pp. 10271 - 10283
The mitogen-activated protein kinase kinase/extracellular regulated kinase (MEK1/2/ERK1/2) cascade is involved in the replication of several members of the... 
REPLICATION | INHIBITION | VIROLOGY | E2 GLYCOPROTEIN | ENVELOPE PROTEIN | INFECTION | MEK1 | IDENTIFICATION | EXPRESSION | ERK
Journal Article
by Wu, RS and Qiu, EH and Zhu, JJ and Wang, JR and Lin, HL
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 01/2018, Volume 22, Issue 1, pp. 150 - 157
OBJECTIVE: Extra-cellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway is widely involved in cell proliferation and... 
PROFILES | BIOMARKER | Proliferation | MAPK | Ras/Raf/MEK/ERK | ERK/MAPK PATHWAY | Nasopharyngeal carcinoma | INVASION | MEK1/2 | THYROID-CANCER | miR-101 | RESISTANCE | PHARMACOLOGY & PHARMACY | MEK1 | EXPRESSION | Apoptosis
Journal Article
Drug Delivery, ISSN 1071-7544, 01/2019, Volume 26, Issue 1, pp. 680 - 688
Neuroprotection has proven clinically unsuccessful in subarachnoid hemorrhage. We believe that this is because the major component in the early damage pathway,... 
cremophor EL | Basilar artery | endothelin-1 | optimal dose | MEK1/2 | U0126 | MIDDLE CEREBRAL-ARTERY | RAT | KINASE | ISCHEMIA | B RECEPTORS | SUBARACHNOID HEMORRHAGE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | MEK1 | DIMETHYL-SULFOXIDE | INHIBITOR | UP-REGULATION
Journal Article
International Journal of Environmental Research and Public Health, ISSN 1661-7827, 10/2017, Volume 14, Issue 10, p. 1284
Humans are inevitably exposed to ubiquitous phthalate esters (PAEs). In utero exposure to di-n-butyl phthalate (DBP) induces abnormal development of the testis... 
Cell proliferation | Testicular cells | MEK1/2 | Prenatal DBP exposure | Bax | Bcl‐2 | Ras related dexamethasone induced 1 (Rasd1) | Apoptosis | Bcl-2 | MALE REPRODUCTIVE DEVELOPMENT | cell proliferation | prenatal DBP exposure | DYSGENESIS SYNDROME | FETAL TESTIS | apoptosis | PROLIFERATION | SERTOLI-CELLS | TRACT | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | DI(N-BUTYL) PHTHALATE | DISRUPTION | testicular cells | ras related dexamethasone induced 1 (Rasd1) | DIBUTYL PHTHALATE | PROGRAMMING WINDOW | Testis - metabolism | Maternal-Fetal Exchange | ras Proteins - metabolism | MAP Kinase Kinase 1 - metabolism | Male | MAP Kinase Kinase 2 - metabolism | Testis - growth & development | Rats, Sprague-Dawley | Testis - drug effects | Endocrine Disruptors - toxicity | Pregnancy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Testis - pathology | Female | Dibutyl Phthalate - toxicity | Butyl phthalate | Bax protein | Bcl-2 protein | Toxicity | Sperm | Esters | Kinases | Anogenital | Proteins | Signal transduction | Cell growth | Corn oil | Rodents | Seminiferous tubule | Drug dosages | n-Butyl phthalate | Reproductive systems | Dexamethasone | Rats | MAP kinase | Exploration | Exposure | Intrauterine exposure | Offspring | Phthalate esters | Protein kinase | Reproductive system | Testes | Laboratory animals | Index Medicus | MEK1 | Occupational Health and Environmental Health | Medical and Health Sciences | Medicin och hälsovetenskap | Hälsovetenskaper | Arbetsmedicin och miljömedicin | prenatal DBP exposure; testicular cells; ras related dexamethasone induced 1 (Rasd1); MEK1/2; Bcl-2; Bax; cell proliferation; apoptosis | Health Sciences
Journal Article
Cancers, ISSN 2072-6694, 10/2019, Volume 11, Issue 10, p. 1533
Heat Shock Factor 1 (HSF1) is a key regulator of gene expression during acute environmental stress that enables the cell survival, which is also involved in... 
xenoestrogen | estrogen | Heat Shock Factor 1 | bisphenol A | MEK1/2
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 06/2019, Volume 195, pp. 174 - 181
In this report, we designed and synthesized a series of cobalt(II)-Schiff base complexes (CoSBC) with competent MEK1 (mitogen-activated protein kinase... 
ATP-noncompetitive MEK1 inhibitors | Molecular docking | Cobalt(II)-Schiff base complexes
Journal Article