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RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 30, pp. 23737 - 23748
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 04/2017, Volume 18, Issue 4
Idiosyncratic ximelagatran-induced hepatotoxicity has been reported to be associated with human leukocyte antigen (HLA)-DRB1(star)07:01 and ximelagatran has... 
ximelagatran | melagatran | IDT (idiosyncratic drug toxicity) | HLA (human leukocyte antigen) | hepatotoxicity | BIOCHEMISTRY & MOLECULAR BIOLOGY | MD (molecular dynamics) simulation | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | MOLECULES
Journal Article
The Lancet, ISSN 0140-6736, 11/2003, Volume 362, Issue 9397, pp. 1691 - 1698
Journal Article
JAMA, ISSN 0098-7484, 02/2005, Volume 293, Issue 6, pp. 690 - 698
Journal Article
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2003, Volume 349, Issue 18, pp. 1713 - 1721
Journal Article
RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 30, pp. 23737 - 23748
A series of dabigatran derivatives were designed and synthesized to discover effective thrombin inhibitors. All the target compounds were characterized by H-1... 
MEDICINAL CHEMISTRY | TRIAL | MELAGATRAN | ETEXILATE | FLUORINE | KINASE INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | Anticoagulants | Inhibitors | Simulation | Thrombin | Docking | Derivatives | Nuclear magnetic resonance | Crystal structure
Journal Article
JAMA, ISSN 0098-7484, 02/2005, Volume 293, Issue 6, pp. 681 - 689
CONTEXT Ximelagatran, an oral direct thrombin inhibitor with a rapid onset of action and predictable antithrombotic effect, has the potential to be a simple... 
ORAL XIMELAGATRAN | ENOXAPARIN | MEDICINE, GENERAL & INTERNAL | KNEE REPLACEMENT | THERAPY | VENOUS THROMBOEMBOLISM | MELAGATRAN | INTRAVENOUS UNFRACTIONATED HEPARIN | ABSORPTION | INHIBITOR XIMELAGATRAN | SECONDARY PREVENTION | Prodrugs - administration & dosage | Recurrence | Anticoagulants - administration & dosage | Humans | Middle Aged | Male | Venous Thrombosis - complications | Heparin, Low-Molecular-Weight - therapeutic use | Warfarin - administration & dosage | Warfarin - therapeutic use | Aged, 80 and over | Adult | Female | Drug Therapy, Combination | Pulmonary Embolism - complications | Double-Blind Method | Venous Thrombosis - drug therapy | Venous Thrombosis - mortality | Anticoagulants - therapeutic use | Treatment Outcome | Azetidines - administration & dosage | Azetidines - therapeutic use | Benzylamines | Aged | Prodrugs - therapeutic use | Alanine Transaminase - metabolism | Heparin, Low-Molecular-Weight - administration & dosage | Clinical trials | Cardiac arrhythmia | Thrombolytic drugs | Medical treatment | Blood clots | Low-Molecular-Weight/administration & dosage/therapeutic use | Anticoagulants/administration & dosage/therapeutic use | Pulmonary Embolism/complications | Drug Therapy | MEDICIN OCH HÄLSOVETENSKAP | Alanine Transaminase/metabolism | Warfarin/administration & dosage/therapeutic use | 80 and over | Azetidines/administration & dosage/therapeutic use | Combination | Prodrugs/administration & dosage/therapeutic use | Venous Thrombosis/complications/drug therapy/mortality | Heparin | MEDICAL AND HEALTH SCIENCES
Journal Article
Journal Article
Journal of thrombosis and haemostasis, ISSN 1538-7933, 2005, Volume 3, Issue 1, pp. 103 - 111
Background: Dabigatran etexilate is an oral direct thrombin inhibitor undergoing evaluation for the prevention of venous thromboembolism (VTE) following... 
direct thrombin inhibitor | total hip replacement | dabigatran etexilate | total knee replacement | deep vein thrombosis | venous thromboembolism | Deep vein thrombosis | Dabigatran etexilate | Total hip replacement | Total knee replacement | Venous thromboembolism | Direct thrombin inhibitor | XIMELAGATRAN | MELAGATRAN | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | LEG | Arthroplasty, Replacement, Knee - adverse effects | Pyridines - chemistry | Humans | Middle Aged | Thrombin - antagonists & inhibitors | Male | Dabigatran | Benzimidazoles - chemistry | Dose-Response Relationship, Drug | Thromboembolism - prevention & control | Aged, 80 and over | Adult | Female | Odds Ratio | Postoperative Complications | Double-Blind Method | Administration, Oral | Postoperative Period | Enoxaparin - pharmacology | Arthroplasty, Replacement, Hip - adverse effects | Regression Analysis | Anticoagulants - pharmacology | Benzimidazoles - pharmacology | Aged | Pyridines - pharmacology | Anticoagulants/pharmacology | Benzimidazoles/chemistry/pharmacology | Thrombin/antagonists & inhibitors | Oral | Knee/adverse effects | 80 and over | Surgery | Thromboembolism/prevention & control | Drug | Administration | Pyridines/chemistry/pharmacology | Arthroplasty | Replacement | Enoxaparin/pharmacology | Kirurgi | Hip/adverse effects | Dose-Response Relationship
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2004, Volume 142, Issue 8, pp. 1325 - 1331
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 2003, Volume 42, Issue 8, pp. 765 - 777
Background: Ximelagatran is an oral direct thrombin inhibitor currently in clinical development for the prevention and treatment of thromboembolic disorders.... 
Melagatran, drug interactions | Diclofenac, drug interactions | Drug interactions | Diazepam, drug interactions | Ximelagatran, drug interactions | Nifedipine, drug interactions | Research and development | Pharmacogenomics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | TOTAL KNEE REPLACEMENT | VEIN-THROMBOSIS | VENOUS THROMBOEMBOLISM | METABOLISM | TOTAL HIP | HEALTHY MALE-SUBJECTS | DOUBLE-BLIND | MELAGATRAN | PREVENTION | PHARMACOLOGY & PHARMACY | CORONARY-ARTERY | Glycine - analogs & derivatives | Cytochrome P-450 Enzyme Inhibitors | Area Under Curve | Humans | Microsomes, Liver - metabolism | Middle Aged | Thrombin - antagonists & inhibitors | Cytochrome P-450 Enzyme System - metabolism | Azetidines - pharmacology | Prodrugs - metabolism | Drug Interactions | Adult | Azetidines - blood | Microsomes, Liver - enzymology | Glycine - blood | Nordazepam - blood | Amidines - blood | Administration, Oral | Nifedipine - blood | Azetidines - pharmacokinetics | Diclofenac - blood | Anticoagulants - blood | Cross-Over Studies | Cytochrome P-450 Enzyme System - chemistry | Prodrugs - pharmacokinetics | Anticoagulants - pharmacology | Benzylamines | Diazepam - blood | Aged | Anticoagulants - pharmacokinetics | Infusions, Intravenous | In Vitro Techniques | Prodrugs - pharmacology
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2003, Volume 349, Issue 18, pp. 1703 - 1712
Journal Article