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melanocortin-4 receptor (197) 197
science & technology (186) 186
life sciences & biomedicine (181) 181
animals (117) 117
humans (95) 95
obesity (76) 76
male (72) 72
receptor, melanocortin, type 4 - genetics (66) 66
receptor, melanocortin, type 4 - metabolism (53) 53
biological and medical sciences (51) 51
endocrinology & metabolism (51) 51
biochemistry & molecular biology (50) 50
pharmacology & pharmacy (48) 48
medical sciences (39) 39
rats (37) 37
female (36) 36
mice (35) 35
obesity - genetics (29) 29
peptide hormones (29) 29
chemistry, medicinal (28) 28
mutation (28) 28
chemistry (27) 27
physical sciences (26) 26
receptor, melanocortin, type 4 - antagonists & inhibitors (26) 26
analysis (25) 25
genetic aspects (25) 25
neurosciences (24) 24
neurosciences & neurology (24) 24
pharmacology. drug treatments (24) 24
receptor, melanocortin, type 4 - agonists (24) 24
ligands (23) 23
physiological aspects (23) 23
leptin (22) 22
signal transduction (22) 22
structure-activity relationship (22) 22
food intake (21) 21
neuropharmacology (21) 21
neurotransmitters. neurotransmission. receptors (21) 21
peptidergic system. adenosinergic and purinergic systems (21) 21
chemistry, organic (20) 20
intermedin (19) 19
agouti-related protein (18) 18
alpha-msh - pharmacology (18) 18
cell biology (18) 18
hypothalamus (17) 17
melanocortin (17) 17
receptor, melanocortin, type 4 (17) 17
adolescent (16) 16
antagonist (16) 16
body weight (16) 16
obesity - metabolism (16) 16
research (16) 16
fundamental and applied biological sciences. psychology (15) 15
genotype (15) 15
melanocortin mc4 receptors (15) 15
rats, sprague-dawley (15) 15
alpha-msh - analogs & derivatives (14) 14
alpha-msh - metabolism (14) 14
biophysics (14) 14
hek293 cells (14) 14
medicine & public health (14) 14
melanocortin-4 receptors (14) 14
nutrition & dietetics (14) 14
signaling (14) 14
amino acid sequence (13) 13
body mass index (13) 13
child (13) 13
melanocortin-4 (13) 13
adult (12) 12
agriculture (12) 12
agriculture, dairy & animal science (12) 12
metabolic diseases (12) 12
mice, inbred c57bl (12) 12
molecular structure (12) 12
phenotype (12) 12
physiology (12) 12
health aspects (11) 11
hypothalamus - metabolism (11) 11
mice, knockout (11) 11
molecular sequence data (11) 11
oncology (11) 11
original (11) 11
original article (11) 11
piperazines - chemistry (11) 11
piperazines - pharmacology (11) 11
polymorphism, single nucleotide (11) 11
anxiety (10) 10
digestive, oral, and skin physiology (10) 10
disease models, animal (10) 10
genetic research (10) 10
melanocortin-4 receptor gene (10) 10
melanocortin‐4 receptor (10) 10
middle aged (10) 10
mutation - genetics (10) 10
neurons - metabolism (10) 10
polymorphism (10) 10
synthesis (10) 10
agouti-related peptide (9) 9
appetite (9) 9
diabetes (9) 9
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1. Full Text Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte- stimulating hormone (α-MSH)
by McDaniel, Faith K and Molden, Brent M and Mohammad, Sameer and Baldini, Giovanna and McPike, Lakisha and Narducci, Paola and Granell, Susana and Baldini, Giulia
The Journal of biological chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 26, pp. 21873 - 21890
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Threonine - chemistry | Receptor, Melanocortin, Type 4 - chemistry | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Humans | Homeostasis | Cholesterol - metabolism | Serine - chemistry | alpha-MSH - metabolism | Clathrin - chemistry | Clathrin - metabolism | Endosomes - metabolism | Cholesterol - chemistry | Dose-Response Relationship, Drug | Endocytosis | HEK293 Cells | Cell Membrane - metabolism | Mutation | RNA, Small Interfering - metabolism | Index Medicus | Membrane Trafficking | Molecular Bases of Disease | G-protein-coupled Receptors (GPCR) | Obesity | Clathrin | α-MSH | Cholesterol | Melanocortin-4 Receptor (MC4R)
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2. Full Text Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia
by Wang, Meng and Chen, Yijun and Zhu, Ming and Xu, Bingxin and Guo, Wenxuan and Lyu, Yunsong and Zhang, Chao
General and comparative endocrinology, ISSN 0016-6480, 10/2019, Volume 282, pp. 113219 - 113219
Melanocortin-4 receptor | Tilapia | Melanocortin 2 receptor accessory protein 2 | Amino Acid Sequence | Synteny - genetics | Receptor, Melanocortin, Type 4 - chemistry | Signal Transduction | Humans | Receptor, Melanocortin, Type 4 - metabolism | Receptor, Melanocortin, Type 4 - genetics | Phylogeny | Cichlids - metabolism | Tissue Distribution | Animals | HEK293 Cells | Conserved Sequence | Protein Binding | Cell Membrane - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Evolution, Molecular | Index Medicus
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3. Full Text Orange-spotted grouper melanocortin-4 receptor: Modulation of signaling by MRAP2
by Rao, Ying-Zhu and Chen, Rong and Zhang, Yong and Tao, Ya-Xiong
General and comparative endocrinology, ISSN 0016-6480, 12/2019, Volume 284, pp. 113234 - 113234
Epinephelus coioides | Pharmacology | Orange-spotted grouper | Melanocortin receptor accessory protein 2 | Melanocortin-4 receptor | Tissues distribution | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Adaptor Proteins, Signal Transducing - chemistry | Amino Acid Sequence | Signal Transduction | Humans | Gene Expression Regulation | Receptor, Melanocortin, Type 4 - metabolism | Receptor, Melanocortin, Type 4 - genetics | Phylogeny | Animals | Bass - genetics | Base Sequence | Adaptor Proteins, Signal Transducing - genetics | HEK293 Cells | Ligands | Bass - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cyclic AMP - metabolism | Index Medicus
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4. Full Text Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors
by Liang, Jinye and Li, Lei and Jin, Xuanxuan and Xu, Bingxin and Pi, Linyu and Liu, Shangyun and Zhu, Wei and Zhang, Cong and Luan, Bing and Gong, Lulu and Zhang, Chao
Endocrine, ISSN 1355-008X, 7/2018, Volume 61, Issue 1, pp. 94 - 104
Melanocortin-3 receptor | Medicine & Public Health | Melanocortin-4 receptor | Science, Humanities and Social Sciences, multidisciplinary | Internal Medicine | Melanocortin-2 receptor accessory protein 2 | Diabetes | Endocrinology | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Receptors, Melanocortin - drug effects | alpha-MSH - pharmacology | Receptor, Melanocortin, Type 3 - genetics | Humans | Receptor, Melanocortin, Type 3 - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Receptor, Melanocortin, Type 4 - genetics | Signal Transduction - genetics | Mutation - genetics | RNA - genetics | Genetic Variation | Animals | Hypothalamus - metabolism | Plasmids | Carrier Proteins - pharmacology | Computer Simulation | Mice | Neurons - metabolism | Hypothalamus - drug effects | Nucleic Acid Conformation | Medicine, Experimental | Medical research | Usage | Transplantation | Brain research | Stem cells | Proteins | Energy balance | Melanocortin receptors | Homeostasis | Melanocortin MC4 receptors | Mc4r protein | Hypothalamus | Mutation | Gene expression | Ribonucleic acid--RNA | Index Medicus
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5. Full Text Regulation of Melanocortin-4 Receptor Pharmacology by Two Isoforms of Melanocortin Receptor Accessory Protein 2 in Topmouth Culter (Culter alburnus)
by Tao, Min and Ji, Ren-Lei and Huang, Lu and Fan, Si-Yu and Liu, Ting and Liu, Shao-Jun and Tao, Ya-Xiong
Frontiers in endocrinology (Lausanne), ISSN 1664-2392, 08/2020, Volume 11, pp. 538 - 538
melanocortin-4 receptor | signaling | topmouth culter | constitutive activity | melanocortin receptor accessory protein 2 | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Index Medicus
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6. Full Text Molecular cloning and pharmacological characterization of giant panda ( Ailuropoda melanoleuca ) melanocortin-4 receptor
by Wang, Zhi-Qiang and Wang, Wei and Shi, Lin and Chai, Ji-Tian and Zhang, Xin-Jun and Tao, Ya-Xiong
General and comparative endocrinology, ISSN 0016-6480, 2016, Volume 229, pp. 32 - 40
Endocrinology & Metabolism | Binding | Signaling | Melanocortin-4 receptor | Giant panda | Cloning | Life Sciences & Biomedicine | Science & Technology | Animals | Signal Transduction | Humans | Ursidae - genetics | Cloning, Molecular | HEK293 Cells | Receptor, Melanocortin, Type 4 - genetics | Analysis | Endangered species | Physiological aspects | Phylogeny | G proteins | Intermedin | Membrane proteins | Index Medicus
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7. Full Text Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation
by Sharma, Shubh and Garfield, Alastair S and Shah, Bhavik and Kleyn, Patrick and Ichetovkin, Ilia and Moeller, Ida Hatoum and Mowrey, William R and Van der Ploeg, Lex H. T
Molecules (Basel, Switzerland), ISSN 1420-3049, 05/2019, Volume 24, Issue 10, p. 1892
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Index Medicus | melanocortin-4 receptor | cardiovascular profile | peptide agonist | receptor internalization | GαS signaling | receptor desensitization | obesity
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8. Full Text HQSAR and topomer CoMFA for predicting melanocortin-4 receptor binding affinities of trans-4-(4-chlorophenyl) pyrrolidine-3-carboxamides
by Yu, Shuling and Yuan, Jintao and Shi, Jiahua and Ruan, Xiaojiao and Zhang, Ting and Wang, Yanli and Du, Yu
Chemometrics and intelligent laboratory systems, ISSN 0169-7439, 08/2015, Volume 146, pp. 34 - 41
Docking | Hologram QSAR | Binding affinity | Melanocortin-4 receptor | Topomer CoMFA | Piperazinecyclohexanes | Mathematics, Interdisciplinary Applications | Statistics & Probability | Physical Sciences | Chemistry | Technology | Instruments & Instrumentation | Computer Science | Automation & Control Systems | Computer Science, Artificial Intelligence | Mathematics | Chemistry, Analytical | Science & Technology | Alkaloids | Analysis | Chemical properties | Yuan (China)
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9. Full Text Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors
by Yang, Zhao and Tao, Ya-Xiong
Biochimica et biophysica acta. Molecular basis of disease, ISSN 0925-4439, 09/2016, Volume 1862, Issue 9, pp. 1485 - 1494
Agouti-related peptide | Biased signaling | Melanocortin-3 receptor | Melanocortin-4 receptor | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Recombinant Proteins - metabolism | AMP-Activated Protein Kinases - metabolism | Peptide Fragments - metabolism | Central Nervous System - metabolism | Mutagenesis, Site-Directed | Signal Transduction | Receptor, Melanocortin, Type 3 - genetics | Humans | Receptor, Melanocortin, Type 3 - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Receptor, Melanocortin, Type 4 - agonists | Receptor, Melanocortin, Type 4 - genetics | Recombinant Proteins - genetics | Agouti-Related Protein - metabolism | MAP Kinase Signaling System | HEK293 Cells | Ligands | Kinetics | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Receptor, Melanocortin, Type 3 - agonists | Amino Acid Substitution | Protein kinases | Intermedin | Physiological aspects | Cyclic adenylic acid
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10. Full Text Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH
by Yoshida, Tomoaki and Tsuchiya, Atsunori and Kumagai, Masaru and Takeuchi, Suguru and Nojiri, Shunsuke and Watanabe, Takayuki and Ogawa, Masahiro and Itoh, Michiko and Takamura, Masaaki and Suganami, Takayoshi and Ogawa, Yoshihiro and Terai, Shuji
Biochemical and biophysical research communications, ISSN 0006-291X, 10/2020, Volume 530, Issue 4, pp. 665 - 672
Glycine N-Methyltransferase | S-adenosyl-l-methionine | JTE-013 | Melanocortin-4 receptor | S1P-Specific G protein-coupled receptor 2 | S-adenosyl-L-methionine | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Index Medicus
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11. Full Text Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in grass carp (Ctenopharyngodon idella)
by Li, L and Yang, Z and Zhang, Y.-P and